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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PARD3-LYAR

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PARD3-LYAR
FusionPDB ID: 62710
FusionGDB2.0 ID: 62710
HgeneTgene
Gene symbol

PARD3

LYAR

Gene ID

56288

55646

Gene namepar-3 family cell polarity regulatorLy1 antibody reactive
SynonymsASIP|Baz|PAR3|PAR3alpha|PARD-3|PARD3A|PPP1R118|SE2-5L16|SE2-5LT1|SE2-5T2ZC2HC2|ZLYAR
Cytomap

10p11.22-p11.21

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionpartitioning defective 3 homologCTCL tumor antigen se2-5PAR3-alphaatypical PKC isotype-specific interacting proteinbazookapar-3 family cell polarity regulator alphapar-3 partitioning defective 3 homologprotein phosphatase 1, regulatory subunit 118cell growth-regulating nucleolar proteinLy1 antibody reactive homolog
Modification date2020032720200313
UniProtAcc.

Q9NX58

Ensembl transtripts involved in fusion geneENST idsENST00000340077, ENST00000346874, 
ENST00000350537, ENST00000374773, 
ENST00000374776, ENST00000374788, 
ENST00000374789, ENST00000374790, 
ENST00000374794, ENST00000545260, 
ENST00000545693, ENST00000374768, 
ENST00000466092, ENST00000544292, 
ENST00000343470, ENST00000452476, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score33 X 20 X 14=92406 X 6 X 4=144
# samples 498
** MAII scorelog2(49/9240*10)=-4.23703919730085
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PARD3 [Title/Abstract] AND LYAR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PARD3(35103804)-LYAR(4276496), # samples:4
Anticipated loss of major functional domain due to fusion event.PARD3-LYAR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PARD3-LYAR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PARD3-LYAR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PARD3-LYAR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PARD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LYAR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DH-A669-01APARD3chr10

35103804

-LYARchr4

4276496

-
ChimerDB4LGGTCGA-DH-A669-02APARD3chr10

35103804

-LYARchr4

4276496

-
ChimerDB4LGGTCGA-DH-A669PARD3chr10

35103803

-LYARchr4

4276496

-
ChimerDB4LGGTCGA-DH-A669PARD3chr10

35103804

-LYARchr4

4276496

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545260PARD3chr1035103804-ENST00000343470LYARchr44276496-13494501981160320
ENST00000545260PARD3chr1035103804-ENST00000452476LYARchr44276496-13464501981160320
ENST00000545693PARD3chr1035103804-ENST00000343470LYARchr44276496-13494501981160320
ENST00000545693PARD3chr1035103804-ENST00000452476LYARchr44276496-13464501981160320
ENST00000350537PARD3chr1035103804-ENST00000343470LYARchr44276496-13454461941156320
ENST00000350537PARD3chr1035103804-ENST00000452476LYARchr44276496-13424461941156320
ENST00000346874PARD3chr1035103804-ENST00000343470LYARchr44276496-13454461941156320
ENST00000346874PARD3chr1035103804-ENST00000452476LYARchr44276496-13424461941156320
ENST00000374789PARD3chr1035103804-ENST00000343470LYARchr44276496-13454461941156320
ENST00000374789PARD3chr1035103804-ENST00000452476LYARchr44276496-13424461941156320
ENST00000374790PARD3chr1035103804-ENST00000343470LYARchr44276496-13454461941156320
ENST00000374790PARD3chr1035103804-ENST00000452476LYARchr44276496-13424461941156320
ENST00000374794PARD3chr1035103804-ENST00000343470LYARchr44276496-13454461941156320
ENST00000374794PARD3chr1035103804-ENST00000452476LYARchr44276496-13424461941156320
ENST00000374788PARD3chr1035103804-ENST00000343470LYARchr44276496-13454461941156320
ENST00000374788PARD3chr1035103804-ENST00000452476LYARchr44276496-13424461941156320
ENST00000374776PARD3chr1035103804-ENST00000343470LYARchr44276496-13454461941156320
ENST00000374776PARD3chr1035103804-ENST00000452476LYARchr44276496-13424461941156320
ENST00000340077PARD3chr1035103804-ENST00000343470LYARchr44276496-13494501981160320
ENST00000340077PARD3chr1035103804-ENST00000452476LYARchr44276496-13464501981160320
ENST00000374773PARD3chr1035103804-ENST00000343470LYARchr44276496-13454461941156320
ENST00000374773PARD3chr1035103804-ENST00000452476LYARchr44276496-13424461941156320
ENST00000545260PARD3chr1035103803-ENST00000343470LYARchr44276496-13494501981160320
ENST00000545260PARD3chr1035103803-ENST00000452476LYARchr44276496-13464501981160320
ENST00000545693PARD3chr1035103803-ENST00000343470LYARchr44276496-13494501981160320
ENST00000545693PARD3chr1035103803-ENST00000452476LYARchr44276496-13464501981160320
ENST00000350537PARD3chr1035103803-ENST00000343470LYARchr44276496-13454461941156320
ENST00000350537PARD3chr1035103803-ENST00000452476LYARchr44276496-13424461941156320
ENST00000346874PARD3chr1035103803-ENST00000343470LYARchr44276496-13454461941156320
ENST00000346874PARD3chr1035103803-ENST00000452476LYARchr44276496-13424461941156320
ENST00000374789PARD3chr1035103803-ENST00000343470LYARchr44276496-13454461941156320
ENST00000374789PARD3chr1035103803-ENST00000452476LYARchr44276496-13424461941156320
ENST00000374790PARD3chr1035103803-ENST00000343470LYARchr44276496-13454461941156320
ENST00000374790PARD3chr1035103803-ENST00000452476LYARchr44276496-13424461941156320
ENST00000374794PARD3chr1035103803-ENST00000343470LYARchr44276496-13454461941156320
ENST00000374794PARD3chr1035103803-ENST00000452476LYARchr44276496-13424461941156320
ENST00000374788PARD3chr1035103803-ENST00000343470LYARchr44276496-13454461941156320
ENST00000374788PARD3chr1035103803-ENST00000452476LYARchr44276496-13424461941156320
ENST00000374776PARD3chr1035103803-ENST00000343470LYARchr44276496-13454461941156320
ENST00000374776PARD3chr1035103803-ENST00000452476LYARchr44276496-13424461941156320
ENST00000340077PARD3chr1035103803-ENST00000343470LYARchr44276496-13494501981160320
ENST00000340077PARD3chr1035103803-ENST00000452476LYARchr44276496-13464501981160320
ENST00000374773PARD3chr1035103803-ENST00000343470LYARchr44276496-13454461941156320
ENST00000374773PARD3chr1035103803-ENST00000452476LYARchr44276496-13424461941156320

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545260ENST00000343470PARD3chr1035103804-LYARchr44276496-0.0044477230.99555224
ENST00000545260ENST00000452476PARD3chr1035103804-LYARchr44276496-0.0044129510.995587
ENST00000545693ENST00000343470PARD3chr1035103804-LYARchr44276496-0.0044477230.99555224
ENST00000545693ENST00000452476PARD3chr1035103804-LYARchr44276496-0.0044129510.995587
ENST00000350537ENST00000343470PARD3chr1035103804-LYARchr44276496-0.0043485670.9956514
ENST00000350537ENST00000452476PARD3chr1035103804-LYARchr44276496-0.0043211950.99567884
ENST00000346874ENST00000343470PARD3chr1035103804-LYARchr44276496-0.0043485670.9956514
ENST00000346874ENST00000452476PARD3chr1035103804-LYARchr44276496-0.0043211950.99567884
ENST00000374789ENST00000343470PARD3chr1035103804-LYARchr44276496-0.0043485670.9956514
ENST00000374789ENST00000452476PARD3chr1035103804-LYARchr44276496-0.0043211950.99567884
ENST00000374790ENST00000343470PARD3chr1035103804-LYARchr44276496-0.0043485670.9956514
ENST00000374790ENST00000452476PARD3chr1035103804-LYARchr44276496-0.0043211950.99567884
ENST00000374794ENST00000343470PARD3chr1035103804-LYARchr44276496-0.0043485670.9956514
ENST00000374794ENST00000452476PARD3chr1035103804-LYARchr44276496-0.0043211950.99567884
ENST00000374788ENST00000343470PARD3chr1035103804-LYARchr44276496-0.0043485670.9956514
ENST00000374788ENST00000452476PARD3chr1035103804-LYARchr44276496-0.0043211950.99567884
ENST00000374776ENST00000343470PARD3chr1035103804-LYARchr44276496-0.0043485670.9956514
ENST00000374776ENST00000452476PARD3chr1035103804-LYARchr44276496-0.0043211950.99567884
ENST00000340077ENST00000343470PARD3chr1035103804-LYARchr44276496-0.0044477230.99555224
ENST00000340077ENST00000452476PARD3chr1035103804-LYARchr44276496-0.0044129510.995587
ENST00000374773ENST00000343470PARD3chr1035103804-LYARchr44276496-0.0043485670.9956514
ENST00000374773ENST00000452476PARD3chr1035103804-LYARchr44276496-0.0043211950.99567884
ENST00000545260ENST00000343470PARD3chr1035103803-LYARchr44276496-0.0044477230.99555224
ENST00000545260ENST00000452476PARD3chr1035103803-LYARchr44276496-0.0044129510.995587
ENST00000545693ENST00000343470PARD3chr1035103803-LYARchr44276496-0.0044477230.99555224
ENST00000545693ENST00000452476PARD3chr1035103803-LYARchr44276496-0.0044129510.995587
ENST00000350537ENST00000343470PARD3chr1035103803-LYARchr44276496-0.0043485670.9956514
ENST00000350537ENST00000452476PARD3chr1035103803-LYARchr44276496-0.0043211950.99567884
ENST00000346874ENST00000343470PARD3chr1035103803-LYARchr44276496-0.0043485670.9956514
ENST00000346874ENST00000452476PARD3chr1035103803-LYARchr44276496-0.0043211950.99567884
ENST00000374789ENST00000343470PARD3chr1035103803-LYARchr44276496-0.0043485670.9956514
ENST00000374789ENST00000452476PARD3chr1035103803-LYARchr44276496-0.0043211950.99567884
ENST00000374790ENST00000343470PARD3chr1035103803-LYARchr44276496-0.0043485670.9956514
ENST00000374790ENST00000452476PARD3chr1035103803-LYARchr44276496-0.0043211950.99567884
ENST00000374794ENST00000343470PARD3chr1035103803-LYARchr44276496-0.0043485670.9956514
ENST00000374794ENST00000452476PARD3chr1035103803-LYARchr44276496-0.0043211950.99567884
ENST00000374788ENST00000343470PARD3chr1035103803-LYARchr44276496-0.0043485670.9956514
ENST00000374788ENST00000452476PARD3chr1035103803-LYARchr44276496-0.0043211950.99567884
ENST00000374776ENST00000343470PARD3chr1035103803-LYARchr44276496-0.0043485670.9956514
ENST00000374776ENST00000452476PARD3chr1035103803-LYARchr44276496-0.0043211950.99567884
ENST00000340077ENST00000343470PARD3chr1035103803-LYARchr44276496-0.0044477230.99555224
ENST00000340077ENST00000452476PARD3chr1035103803-LYARchr44276496-0.0044129510.995587
ENST00000374773ENST00000343470PARD3chr1035103803-LYARchr44276496-0.0043485670.9956514
ENST00000374773ENST00000452476PARD3chr1035103803-LYARchr44276496-0.0043211950.99567884

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>62710_62710_1_PARD3-LYAR_PARD3_chr10_35103803_ENST00000340077_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_2_PARD3-LYAR_PARD3_chr10_35103803_ENST00000340077_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_3_PARD3-LYAR_PARD3_chr10_35103803_ENST00000346874_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_4_PARD3-LYAR_PARD3_chr10_35103803_ENST00000346874_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_5_PARD3-LYAR_PARD3_chr10_35103803_ENST00000350537_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_6_PARD3-LYAR_PARD3_chr10_35103803_ENST00000350537_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_7_PARD3-LYAR_PARD3_chr10_35103803_ENST00000374773_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_8_PARD3-LYAR_PARD3_chr10_35103803_ENST00000374773_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_9_PARD3-LYAR_PARD3_chr10_35103803_ENST00000374776_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_10_PARD3-LYAR_PARD3_chr10_35103803_ENST00000374776_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_11_PARD3-LYAR_PARD3_chr10_35103803_ENST00000374788_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_12_PARD3-LYAR_PARD3_chr10_35103803_ENST00000374788_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_13_PARD3-LYAR_PARD3_chr10_35103803_ENST00000374789_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_14_PARD3-LYAR_PARD3_chr10_35103803_ENST00000374789_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_15_PARD3-LYAR_PARD3_chr10_35103803_ENST00000374790_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_16_PARD3-LYAR_PARD3_chr10_35103803_ENST00000374790_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_17_PARD3-LYAR_PARD3_chr10_35103803_ENST00000374794_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_18_PARD3-LYAR_PARD3_chr10_35103803_ENST00000374794_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_19_PARD3-LYAR_PARD3_chr10_35103803_ENST00000545260_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_20_PARD3-LYAR_PARD3_chr10_35103803_ENST00000545260_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_21_PARD3-LYAR_PARD3_chr10_35103803_ENST00000545693_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_22_PARD3-LYAR_PARD3_chr10_35103803_ENST00000545693_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_23_PARD3-LYAR_PARD3_chr10_35103804_ENST00000340077_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_24_PARD3-LYAR_PARD3_chr10_35103804_ENST00000340077_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_25_PARD3-LYAR_PARD3_chr10_35103804_ENST00000346874_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_26_PARD3-LYAR_PARD3_chr10_35103804_ENST00000346874_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_27_PARD3-LYAR_PARD3_chr10_35103804_ENST00000350537_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_28_PARD3-LYAR_PARD3_chr10_35103804_ENST00000350537_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_29_PARD3-LYAR_PARD3_chr10_35103804_ENST00000374773_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_30_PARD3-LYAR_PARD3_chr10_35103804_ENST00000374773_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_31_PARD3-LYAR_PARD3_chr10_35103804_ENST00000374776_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_32_PARD3-LYAR_PARD3_chr10_35103804_ENST00000374776_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_33_PARD3-LYAR_PARD3_chr10_35103804_ENST00000374788_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_34_PARD3-LYAR_PARD3_chr10_35103804_ENST00000374788_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_35_PARD3-LYAR_PARD3_chr10_35103804_ENST00000374789_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_36_PARD3-LYAR_PARD3_chr10_35103804_ENST00000374789_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_37_PARD3-LYAR_PARD3_chr10_35103804_ENST00000374790_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_38_PARD3-LYAR_PARD3_chr10_35103804_ENST00000374790_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_39_PARD3-LYAR_PARD3_chr10_35103804_ENST00000374794_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_40_PARD3-LYAR_PARD3_chr10_35103804_ENST00000374794_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_41_PARD3-LYAR_PARD3_chr10_35103804_ENST00000545260_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_42_PARD3-LYAR_PARD3_chr10_35103804_ENST00000545260_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_43_PARD3-LYAR_PARD3_chr10_35103804_ENST00000545693_LYAR_chr4_4276496_ENST00000343470_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

>62710_62710_44_PARD3-LYAR_PARD3_chr10_35103804_ENST00000545693_LYAR_chr4_4276496_ENST00000452476_length(amino acids)=320AA_BP=83
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:35103804/chr4:4276496)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LYAR

Q9NX58

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131). In addition, inhibits NF-kappa-B-mediated expression of proinflammatory cytokines (PubMed:31413131). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity). {ECO:0000250|UniProtKB:Q08288, ECO:0000269|PubMed:24495227, ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:28686580, ECO:0000269|PubMed:31413131}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLYARchr10:35103803chr4:4276496ENST00000343470510175_219143.0380.0Coiled coilOntology_term=ECO:0000255
TgeneLYARchr10:35103803chr4:4276496ENST00000452476510175_219143.0380.0Coiled coilOntology_term=ECO:0000255
TgeneLYARchr10:35103804chr4:4276496ENST00000343470510175_219143.0380.0Coiled coilOntology_term=ECO:0000255
TgeneLYARchr10:35103804chr4:4276496ENST00000452476510175_219143.0380.0Coiled coilOntology_term=ECO:0000255
TgeneLYARchr10:35103803chr4:4276496ENST00000343470510168_379143.0380.0Compositional biasNote=Lys-rich
TgeneLYARchr10:35103803chr4:4276496ENST00000452476510168_379143.0380.0Compositional biasNote=Lys-rich
TgeneLYARchr10:35103804chr4:4276496ENST00000343470510168_379143.0380.0Compositional biasNote=Lys-rich
TgeneLYARchr10:35103804chr4:4276496ENST00000452476510168_379143.0380.0Compositional biasNote=Lys-rich

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARD3chr10:35103803chr4:4276496ENST00000340077-1211049_107740.01032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000340077-1211151_117440.01032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000340077-1211201_122440.01032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000340077-1211280_130140.01032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000346874-1241049_107740.01320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000346874-1241151_117440.01320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000346874-1241201_122440.01320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000346874-1241280_130140.01320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000350537-1241049_107740.01311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000350537-1241151_117440.01311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000350537-1241201_122440.01311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000350537-1241280_130140.01311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000374776-1201049_107740.0989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000374776-1201151_117440.0989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000374776-1201201_122440.0989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000374776-1201280_130140.0989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000374788-1251049_107740.01354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000374788-1251151_117440.01354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000374788-1251201_122440.01354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000374788-1251280_130140.01354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000374789-1251049_107740.01357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000374789-1251151_117440.01357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000374789-1251201_122440.01357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000374789-1251280_130140.01357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000374794-1211049_107740.01245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000374794-1211151_117440.01245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000374794-1211201_122440.01245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000374794-1211280_130140.01245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000545260-1231049_107740.01267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000545260-1231151_117440.01267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000545260-1231201_122440.01267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000545260-1231280_130140.01267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000545693-1241049_107740.01341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000545693-1241151_117440.01341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000545693-1241201_122440.01341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000545693-1241280_130140.01341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000340077-1211049_107740.01032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000340077-1211151_117440.01032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000340077-1211201_122440.01032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000340077-1211280_130140.01032.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000346874-1241049_107740.01320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000346874-1241151_117440.01320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000346874-1241201_122440.01320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000346874-1241280_130140.01320.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000350537-1241049_107740.01311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000350537-1241151_117440.01311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000350537-1241201_122440.01311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000350537-1241280_130140.01311.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000374776-1201049_107740.0989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000374776-1201151_117440.0989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000374776-1201201_122440.0989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000374776-1201280_130140.0989.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000374788-1251049_107740.01354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000374788-1251151_117440.01354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000374788-1251201_122440.01354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000374788-1251280_130140.01354.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000374789-1251049_107740.01357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000374789-1251151_117440.01357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000374789-1251201_122440.01357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000374789-1251280_130140.01357.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000374794-1211049_107740.01245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000374794-1211151_117440.01245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000374794-1211201_122440.01245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000374794-1211280_130140.01245.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000545260-1231049_107740.01267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000545260-1231151_117440.01267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000545260-1231201_122440.01267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000545260-1231280_130140.01267.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000545693-1241049_107740.01341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000545693-1241151_117440.01341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000545693-1241201_122440.01341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103804chr4:4276496ENST00000545693-1241280_130140.01341.0Coiled coilOntology_term=ECO:0000255
HgenePARD3chr10:35103803chr4:4276496ENST00000340077-121984_104240.01032.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103803chr4:4276496ENST00000346874-124984_104240.01320.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103803chr4:4276496ENST00000350537-124984_104240.01311.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103803chr4:4276496ENST00000374776-120984_104240.0989.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103803chr4:4276496ENST00000374788-125984_104240.01354.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103803chr4:4276496ENST00000374789-125984_104240.01357.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103803chr4:4276496ENST00000374794-121984_104240.01245.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103803chr4:4276496ENST00000545260-123984_104240.01267.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103803chr4:4276496ENST00000545693-124984_104240.01341.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103804chr4:4276496ENST00000340077-121984_104240.01032.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103804chr4:4276496ENST00000346874-124984_104240.01320.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103804chr4:4276496ENST00000350537-124984_104240.01311.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103804chr4:4276496ENST00000374776-120984_104240.0989.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103804chr4:4276496ENST00000374788-125984_104240.01354.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103804chr4:4276496ENST00000374789-125984_104240.01357.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103804chr4:4276496ENST00000374794-121984_104240.01245.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103804chr4:4276496ENST00000545260-123984_104240.01267.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103804chr4:4276496ENST00000545693-124984_104240.01341.0Compositional biasNote=Lys-rich
HgenePARD3chr10:35103803chr4:4276496ENST00000340077-121271_35940.01032.0DomainPDZ 1
HgenePARD3chr10:35103803chr4:4276496ENST00000340077-121461_54640.01032.0DomainPDZ 2
HgenePARD3chr10:35103803chr4:4276496ENST00000340077-121590_67740.01032.0DomainPDZ 3
HgenePARD3chr10:35103803chr4:4276496ENST00000346874-124271_35940.01320.0DomainPDZ 1
HgenePARD3chr10:35103803chr4:4276496ENST00000346874-124461_54640.01320.0DomainPDZ 2
HgenePARD3chr10:35103803chr4:4276496ENST00000346874-124590_67740.01320.0DomainPDZ 3
HgenePARD3chr10:35103803chr4:4276496ENST00000350537-124271_35940.01311.0DomainPDZ 1
HgenePARD3chr10:35103803chr4:4276496ENST00000350537-124461_54640.01311.0DomainPDZ 2
HgenePARD3chr10:35103803chr4:4276496ENST00000350537-124590_67740.01311.0DomainPDZ 3
HgenePARD3chr10:35103803chr4:4276496ENST00000374776-120271_35940.0989.0DomainPDZ 1
HgenePARD3chr10:35103803chr4:4276496ENST00000374776-120461_54640.0989.0DomainPDZ 2
HgenePARD3chr10:35103803chr4:4276496ENST00000374776-120590_67740.0989.0DomainPDZ 3
HgenePARD3chr10:35103803chr4:4276496ENST00000374788-125271_35940.01354.0DomainPDZ 1
HgenePARD3chr10:35103803chr4:4276496ENST00000374788-125461_54640.01354.0DomainPDZ 2
HgenePARD3chr10:35103803chr4:4276496ENST00000374788-125590_67740.01354.0DomainPDZ 3
HgenePARD3chr10:35103803chr4:4276496ENST00000374789-125271_35940.01357.0DomainPDZ 1
HgenePARD3chr10:35103803chr4:4276496ENST00000374789-125461_54640.01357.0DomainPDZ 2
HgenePARD3chr10:35103803chr4:4276496ENST00000374789-125590_67740.01357.0DomainPDZ 3
HgenePARD3chr10:35103803chr4:4276496ENST00000374794-121271_35940.01245.0DomainPDZ 1
HgenePARD3chr10:35103803chr4:4276496ENST00000374794-121461_54640.01245.0DomainPDZ 2
HgenePARD3chr10:35103803chr4:4276496ENST00000374794-121590_67740.01245.0DomainPDZ 3
HgenePARD3chr10:35103803chr4:4276496ENST00000545260-123271_35940.01267.0DomainPDZ 1
HgenePARD3chr10:35103803chr4:4276496ENST00000545260-123461_54640.01267.0DomainPDZ 2
HgenePARD3chr10:35103803chr4:4276496ENST00000545260-123590_67740.01267.0DomainPDZ 3
HgenePARD3chr10:35103803chr4:4276496ENST00000545693-124271_35940.01341.0DomainPDZ 1
HgenePARD3chr10:35103803chr4:4276496ENST00000545693-124461_54640.01341.0DomainPDZ 2
HgenePARD3chr10:35103803chr4:4276496ENST00000545693-124590_67740.01341.0DomainPDZ 3
HgenePARD3chr10:35103804chr4:4276496ENST00000340077-121271_35940.01032.0DomainPDZ 1
HgenePARD3chr10:35103804chr4:4276496ENST00000340077-121461_54640.01032.0DomainPDZ 2
HgenePARD3chr10:35103804chr4:4276496ENST00000340077-121590_67740.01032.0DomainPDZ 3
HgenePARD3chr10:35103804chr4:4276496ENST00000346874-124271_35940.01320.0DomainPDZ 1
HgenePARD3chr10:35103804chr4:4276496ENST00000346874-124461_54640.01320.0DomainPDZ 2
HgenePARD3chr10:35103804chr4:4276496ENST00000346874-124590_67740.01320.0DomainPDZ 3
HgenePARD3chr10:35103804chr4:4276496ENST00000350537-124271_35940.01311.0DomainPDZ 1
HgenePARD3chr10:35103804chr4:4276496ENST00000350537-124461_54640.01311.0DomainPDZ 2
HgenePARD3chr10:35103804chr4:4276496ENST00000350537-124590_67740.01311.0DomainPDZ 3
HgenePARD3chr10:35103804chr4:4276496ENST00000374776-120271_35940.0989.0DomainPDZ 1
HgenePARD3chr10:35103804chr4:4276496ENST00000374776-120461_54640.0989.0DomainPDZ 2
HgenePARD3chr10:35103804chr4:4276496ENST00000374776-120590_67740.0989.0DomainPDZ 3
HgenePARD3chr10:35103804chr4:4276496ENST00000374788-125271_35940.01354.0DomainPDZ 1
HgenePARD3chr10:35103804chr4:4276496ENST00000374788-125461_54640.01354.0DomainPDZ 2
HgenePARD3chr10:35103804chr4:4276496ENST00000374788-125590_67740.01354.0DomainPDZ 3
HgenePARD3chr10:35103804chr4:4276496ENST00000374789-125271_35940.01357.0DomainPDZ 1
HgenePARD3chr10:35103804chr4:4276496ENST00000374789-125461_54640.01357.0DomainPDZ 2
HgenePARD3chr10:35103804chr4:4276496ENST00000374789-125590_67740.01357.0DomainPDZ 3
HgenePARD3chr10:35103804chr4:4276496ENST00000374794-121271_35940.01245.0DomainPDZ 1
HgenePARD3chr10:35103804chr4:4276496ENST00000374794-121461_54640.01245.0DomainPDZ 2
HgenePARD3chr10:35103804chr4:4276496ENST00000374794-121590_67740.01245.0DomainPDZ 3
HgenePARD3chr10:35103804chr4:4276496ENST00000545260-123271_35940.01267.0DomainPDZ 1
HgenePARD3chr10:35103804chr4:4276496ENST00000545260-123461_54640.01267.0DomainPDZ 2
HgenePARD3chr10:35103804chr4:4276496ENST00000545260-123590_67740.01267.0DomainPDZ 3
HgenePARD3chr10:35103804chr4:4276496ENST00000545693-124271_35940.01341.0DomainPDZ 1
HgenePARD3chr10:35103804chr4:4276496ENST00000545693-124461_54640.01341.0DomainPDZ 2
HgenePARD3chr10:35103804chr4:4276496ENST00000545693-124590_67740.01341.0DomainPDZ 3
TgeneLYARchr10:35103803chr4:4276496ENST000003434705101_26143.0380.0Zinc fingerC2HC LYAR-type 1
TgeneLYARchr10:35103803chr4:4276496ENST0000034347051028_52143.0380.0Zinc fingerC2HC LYAR-type 2
TgeneLYARchr10:35103803chr4:4276496ENST000004524765101_26143.0380.0Zinc fingerC2HC LYAR-type 1
TgeneLYARchr10:35103803chr4:4276496ENST0000045247651028_52143.0380.0Zinc fingerC2HC LYAR-type 2
TgeneLYARchr10:35103804chr4:4276496ENST000003434705101_26143.0380.0Zinc fingerC2HC LYAR-type 1
TgeneLYARchr10:35103804chr4:4276496ENST0000034347051028_52143.0380.0Zinc fingerC2HC LYAR-type 2
TgeneLYARchr10:35103804chr4:4276496ENST000004524765101_26143.0380.0Zinc fingerC2HC LYAR-type 1
TgeneLYARchr10:35103804chr4:4276496ENST0000045247651028_52143.0380.0Zinc fingerC2HC LYAR-type 2


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>589_PARD3_35103804_LYAR_4276496_ranked_0.pdbPARD33510380335103804ENST00000452476LYARchr44276496-
MPAPLAARAPESPAAPPRPASSVPASAAPAALGEGRGPARGGGGMKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKEPVNKE
QDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP
EANGSAGKRSKKKKQRKDSASEEEAHVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITI
320


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PARD3_pLDDT.png
all structure
all structure
LYAR_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PARD3
LYAR


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePARD3chr10:35103803chr4:4276496ENST00000340077-121935_135640.01032.0FRMD4A
HgenePARD3chr10:35103803chr4:4276496ENST00000346874-124935_135640.01320.0FRMD4A
HgenePARD3chr10:35103803chr4:4276496ENST00000350537-124935_135640.01311.0FRMD4A
HgenePARD3chr10:35103803chr4:4276496ENST00000374776-120935_135640.0989.0FRMD4A
HgenePARD3chr10:35103803chr4:4276496ENST00000374788-125935_135640.01354.0FRMD4A
HgenePARD3chr10:35103803chr4:4276496ENST00000374789-125935_135640.01357.0FRMD4A
HgenePARD3chr10:35103803chr4:4276496ENST00000374794-121935_135640.01245.0FRMD4A
HgenePARD3chr10:35103803chr4:4276496ENST00000545260-123935_135640.01267.0FRMD4A
HgenePARD3chr10:35103803chr4:4276496ENST00000545693-124935_135640.01341.0FRMD4A
HgenePARD3chr10:35103804chr4:4276496ENST00000340077-121935_135640.01032.0FRMD4A
HgenePARD3chr10:35103804chr4:4276496ENST00000346874-124935_135640.01320.0FRMD4A
HgenePARD3chr10:35103804chr4:4276496ENST00000350537-124935_135640.01311.0FRMD4A
HgenePARD3chr10:35103804chr4:4276496ENST00000374776-120935_135640.0989.0FRMD4A
HgenePARD3chr10:35103804chr4:4276496ENST00000374788-125935_135640.01354.0FRMD4A
HgenePARD3chr10:35103804chr4:4276496ENST00000374789-125935_135640.01357.0FRMD4A
HgenePARD3chr10:35103804chr4:4276496ENST00000374794-121935_135640.01245.0FRMD4A
HgenePARD3chr10:35103804chr4:4276496ENST00000545260-123935_135640.01267.0FRMD4A
HgenePARD3chr10:35103804chr4:4276496ENST00000545693-124935_135640.01341.0FRMD4A
HgenePARD3chr10:35103803chr4:4276496ENST00000340077-121712_93640.01032.0PRKCI and PRKCZ
HgenePARD3chr10:35103803chr4:4276496ENST00000346874-124712_93640.01320.0PRKCI and PRKCZ
HgenePARD3chr10:35103803chr4:4276496ENST00000350537-124712_93640.01311.0PRKCI and PRKCZ
HgenePARD3chr10:35103803chr4:4276496ENST00000374776-120712_93640.0989.0PRKCI and PRKCZ
HgenePARD3chr10:35103803chr4:4276496ENST00000374788-125712_93640.01354.0PRKCI and PRKCZ
HgenePARD3chr10:35103803chr4:4276496ENST00000374789-125712_93640.01357.0PRKCI and PRKCZ
HgenePARD3chr10:35103803chr4:4276496ENST00000374794-121712_93640.01245.0PRKCI and PRKCZ
HgenePARD3chr10:35103803chr4:4276496ENST00000545260-123712_93640.01267.0PRKCI and PRKCZ
HgenePARD3chr10:35103803chr4:4276496ENST00000545693-124712_93640.01341.0PRKCI and PRKCZ
HgenePARD3chr10:35103804chr4:4276496ENST00000340077-121712_93640.01032.0PRKCI and PRKCZ
HgenePARD3chr10:35103804chr4:4276496ENST00000346874-124712_93640.01320.0PRKCI and PRKCZ
HgenePARD3chr10:35103804chr4:4276496ENST00000350537-124712_93640.01311.0PRKCI and PRKCZ
HgenePARD3chr10:35103804chr4:4276496ENST00000374776-120712_93640.0989.0PRKCI and PRKCZ
HgenePARD3chr10:35103804chr4:4276496ENST00000374788-125712_93640.01354.0PRKCI and PRKCZ
HgenePARD3chr10:35103804chr4:4276496ENST00000374789-125712_93640.01357.0PRKCI and PRKCZ
HgenePARD3chr10:35103804chr4:4276496ENST00000374794-121712_93640.01245.0PRKCI and PRKCZ
HgenePARD3chr10:35103804chr4:4276496ENST00000545260-123712_93640.01267.0PRKCI and PRKCZ
HgenePARD3chr10:35103804chr4:4276496ENST00000545693-124712_93640.01341.0PRKCI and PRKCZ


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Related Drugs to PARD3-LYAR


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PARD3-LYAR


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource