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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PARK2-LANCL1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PARK2-LANCL1
FusionPDB ID: 62748
FusionGDB2.0 ID: 62748
HgeneTgene
Gene symbol

PARK2

LANCL1

Gene ID

5071

10314

Gene nameparkin RBR E3 ubiquitin protein ligaseLanC like 1
SynonymsAR-JP|LPRS2|PARK2|PDJGPR69A|p40
Cytomap

6q26

2q34

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase parkinParkinson disease (autosomal recessive, juvenile) 2, parkinparkinson juvenile disease protein 2parkinson protein 2 E3 ubiquitin protein ligaseparkinson protein 2, E3 ubiquitin protein ligase (parkin)glutathione S-transferase LANCL140 kDa erythrocyte membrane proteinG protein-coupled receptor 69ALanC (bacterial lantibiotic synthetase component C)-like 1LanC (bacterial lantibiotic synthetase component)LanC lantibiotic synthetase component C-like 1
Modification date2020032920200313
UniProtAcc.

O43813

Ensembl transtripts involved in fusion geneENST idsENST00000338468, ENST00000366894, 
ENST00000366892, ENST00000366896, 
ENST00000366897, ENST00000366898, 
ENST00000233714, ENST00000431941, 
ENST00000441020, ENST00000443314, 
ENST00000450366, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 15 X 7=21008 X 4 X 8=256
# samples 218
** MAII scorelog2(21/2100*10)=-3.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PARK2 [Title/Abstract] AND LANCL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PARK2(163148694)-LANCL1(211336800), # samples:1
Anticipated loss of major functional domain due to fusion event.PARK2-LANCL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PARK2-LANCL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PARK2-LANCL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PARK2-LANCL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePARK2

GO:0000209

protein polyubiquitination

12150907|16227987|18541373|19880420

HgenePARK2

GO:0000422

autophagy of mitochondrion

25621951

HgenePARK2

GO:0001933

negative regulation of protein phosphorylation

17512523

HgenePARK2

GO:0006511

ubiquitin-dependent protein catabolic process

12925569|17097639

HgenePARK2

GO:0006513

protein monoubiquitination

20889974

HgenePARK2

GO:0010506

regulation of autophagy

20889974

HgenePARK2

GO:0010821

regulation of mitochondrion organization

21113145

HgenePARK2

GO:0016567

protein ubiquitination

10973942|11439185|12628165|17314283

HgenePARK2

GO:0031648

protein destabilization

19591802|29311685

HgenePARK2

GO:0032232

negative regulation of actin filament bundle assembly

17512523

HgenePARK2

GO:0033132

negative regulation of glucokinase activity

24187134

HgenePARK2

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

17314283|19880420

HgenePARK2

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

11439185|21376232

HgenePARK2

GO:0043388

positive regulation of DNA binding

17314283

HgenePARK2

GO:0043524

negative regulation of neuron apoptotic process

12628165|22511790|23985028

HgenePARK2

GO:0044828

negative regulation by host of viral genome replication

25244949

HgenePARK2

GO:0045944

positive regulation of transcription by RNA polymerase II

23453807

HgenePARK2

GO:0046676

negative regulation of insulin secretion

24187134

HgenePARK2

GO:0051865

protein autoubiquitination

12628165|15728840|16352719|17512523

HgenePARK2

GO:0060548

negative regulation of cell death

15603737

HgenePARK2

GO:0061734

parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

19029340

HgenePARK2

GO:0070534

protein K63-linked ubiquitination

15728840|17314283|19880420|25621951

HgenePARK2

GO:0070936

protein K48-linked ubiquitination

21376232|23858059

HgenePARK2

GO:0070979

protein K11-linked ubiquitination

25621951

HgenePARK2

GO:0085020

protein K6-linked ubiquitination

25621951

HgenePARK2

GO:0090090

negative regulation of canonical Wnt signaling pathway

19591802

HgenePARK2

GO:0090201

negative regulation of release of cytochrome c from mitochondria

19880420|23453807

HgenePARK2

GO:0098779

positive regulation of mitophagy in response to mitochondrial depolarization

20457763

HgenePARK2

GO:0099074

mitochondrion to lysosome transport

24446486

HgenePARK2

GO:1900407

regulation of cellular response to oxidative stress

24446486

HgenePARK2

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

11439185|12150907|23453807

HgenePARK2

GO:1903265

positive regulation of tumor necrosis factor-mediated signaling pathway

23453807

HgenePARK2

GO:1903377

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

17314283

HgenePARK2

GO:1903599

positive regulation of autophagy of mitochondrion

26310625

TgeneLANCL1

GO:0007186

G protein-coupled receptor signaling pathway

10944443


check buttonFusion gene breakpoints across PARK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LANCL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-63-7023-01APARK2chr6

163148694

-LANCL1chr2

211336800

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000366898PARK2chr6163148694-ENST00000443314LANCL1chr2211336800-44671101101228372
ENST00000366898PARK2chr6163148694-ENST00000441020LANCL1chr2211336800-44671101101228372
ENST00000366898PARK2chr6163148694-ENST00000450366LANCL1chr2211336800-44671101101228372
ENST00000366898PARK2chr6163148694-ENST00000233714LANCL1chr2211336800-16011101101228372
ENST00000366898PARK2chr6163148694-ENST00000431941LANCL1chr2211336800-12291101101228373
ENST00000366897PARK2chr6163148694-ENST00000443314LANCL1chr2211336800-44671101101228372
ENST00000366897PARK2chr6163148694-ENST00000441020LANCL1chr2211336800-44671101101228372
ENST00000366897PARK2chr6163148694-ENST00000450366LANCL1chr2211336800-44671101101228372
ENST00000366897PARK2chr6163148694-ENST00000233714LANCL1chr2211336800-16011101101228372
ENST00000366897PARK2chr6163148694-ENST00000431941LANCL1chr2211336800-12291101101228373
ENST00000366896PARK2chr6163148694-ENST00000443314LANCL1chr2211336800-44671101101228372
ENST00000366896PARK2chr6163148694-ENST00000441020LANCL1chr2211336800-44671101101228372
ENST00000366896PARK2chr6163148694-ENST00000450366LANCL1chr2211336800-44671101101228372
ENST00000366896PARK2chr6163148694-ENST00000233714LANCL1chr2211336800-16011101101228372
ENST00000366896PARK2chr6163148694-ENST00000431941LANCL1chr2211336800-12291101101228373
ENST00000366892PARK2chr6163148694-ENST00000443314LANCL1chr2211336800-44601031031221372
ENST00000366892PARK2chr6163148694-ENST00000441020LANCL1chr2211336800-44601031031221372
ENST00000366892PARK2chr6163148694-ENST00000450366LANCL1chr2211336800-44601031031221372
ENST00000366892PARK2chr6163148694-ENST00000233714LANCL1chr2211336800-15941031031221372
ENST00000366892PARK2chr6163148694-ENST00000431941LANCL1chr2211336800-12221031031221373

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366898ENST00000443314PARK2chr6163148694-LANCL1chr2211336800-0.0003625940.99963737
ENST00000366898ENST00000441020PARK2chr6163148694-LANCL1chr2211336800-0.0003625940.99963737
ENST00000366898ENST00000450366PARK2chr6163148694-LANCL1chr2211336800-0.0003625940.99963737
ENST00000366898ENST00000233714PARK2chr6163148694-LANCL1chr2211336800-0.0014162460.9985838
ENST00000366898ENST00000431941PARK2chr6163148694-LANCL1chr2211336800-0.004750680.9952493
ENST00000366897ENST00000443314PARK2chr6163148694-LANCL1chr2211336800-0.0003625940.99963737
ENST00000366897ENST00000441020PARK2chr6163148694-LANCL1chr2211336800-0.0003625940.99963737
ENST00000366897ENST00000450366PARK2chr6163148694-LANCL1chr2211336800-0.0003625940.99963737
ENST00000366897ENST00000233714PARK2chr6163148694-LANCL1chr2211336800-0.0014162460.9985838
ENST00000366897ENST00000431941PARK2chr6163148694-LANCL1chr2211336800-0.004750680.9952493
ENST00000366896ENST00000443314PARK2chr6163148694-LANCL1chr2211336800-0.0003625940.99963737
ENST00000366896ENST00000441020PARK2chr6163148694-LANCL1chr2211336800-0.0003625940.99963737
ENST00000366896ENST00000450366PARK2chr6163148694-LANCL1chr2211336800-0.0003625940.99963737
ENST00000366896ENST00000233714PARK2chr6163148694-LANCL1chr2211336800-0.0014162460.9985838
ENST00000366896ENST00000431941PARK2chr6163148694-LANCL1chr2211336800-0.004750680.9952493
ENST00000366892ENST00000443314PARK2chr6163148694-LANCL1chr2211336800-0.0003575580.9996425
ENST00000366892ENST00000441020PARK2chr6163148694-LANCL1chr2211336800-0.0003575580.9996425
ENST00000366892ENST00000450366PARK2chr6163148694-LANCL1chr2211336800-0.0003575580.9996425
ENST00000366892ENST00000233714PARK2chr6163148694-LANCL1chr2211336800-0.0014216850.9985783
ENST00000366892ENST00000431941PARK2chr6163148694-LANCL1chr2211336800-0.0046195310.9953805

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>62748_62748_1_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366892_LANCL1_chr2_211336800_ENST00000233714_length(amino acids)=372AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_2_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366892_LANCL1_chr2_211336800_ENST00000431941_length(amino acids)=373AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_3_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366892_LANCL1_chr2_211336800_ENST00000441020_length(amino acids)=372AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_4_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366892_LANCL1_chr2_211336800_ENST00000443314_length(amino acids)=372AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_5_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366892_LANCL1_chr2_211336800_ENST00000450366_length(amino acids)=372AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_6_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366896_LANCL1_chr2_211336800_ENST00000233714_length(amino acids)=372AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_7_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366896_LANCL1_chr2_211336800_ENST00000431941_length(amino acids)=373AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_8_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366896_LANCL1_chr2_211336800_ENST00000441020_length(amino acids)=372AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_9_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366896_LANCL1_chr2_211336800_ENST00000443314_length(amino acids)=372AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_10_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366896_LANCL1_chr2_211336800_ENST00000450366_length(amino acids)=372AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_11_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366897_LANCL1_chr2_211336800_ENST00000233714_length(amino acids)=372AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_12_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366897_LANCL1_chr2_211336800_ENST00000431941_length(amino acids)=373AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_13_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366897_LANCL1_chr2_211336800_ENST00000441020_length(amino acids)=372AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_14_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366897_LANCL1_chr2_211336800_ENST00000443314_length(amino acids)=372AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_15_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366897_LANCL1_chr2_211336800_ENST00000450366_length(amino acids)=372AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_16_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366898_LANCL1_chr2_211336800_ENST00000233714_length(amino acids)=372AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_17_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366898_LANCL1_chr2_211336800_ENST00000431941_length(amino acids)=373AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_18_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366898_LANCL1_chr2_211336800_ENST00000441020_length(amino acids)=372AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_19_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366898_LANCL1_chr2_211336800_ENST00000443314_length(amino acids)=372AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

--------------------------------------------------------------

>62748_62748_20_PARK2-LANCL1_PARK2_chr6_163148694_ENST00000366898_LANCL1_chr2_211336800_ENST00000450366_length(amino acids)=372AA_BP=1
MTPEFSQRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLYDVFGDPAYLQLAHGYVKQSLNCLTKRSITFLCGDAGPLAVA
AVLYHKMNNEKQAEDCITRLIHLNKIDPHAPNEMLYGRIGYIYALLFVNKNFGVEKIPQSHIQQICETILTSGENLARKRNFTAKSPLMY
EWYQEYYVGAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVCQLKFPSGNYPPCIGDNRDLLVHWCHGAPGVIYMLIQAYKVFREEK
YLCDAYQCADVIWQYGLLKKGYGLCHGSAGNAYAFLTLYNLTQDMKYLYRACKFAEWCLEYGEHGCRTPDTPFSLFEGMAGTIYFLADLL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:163148694/chr2:211336800)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LANCL1

O43813

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione (PubMed:19528316). {ECO:0000250|UniProtKB:O89112, ECO:0000269|PubMed:19528316}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLANCL1chr6:163148694chr2:211336800ENST00000233714110364_36727.0400.0RegionGlutathione binding
TgeneLANCL1chr6:163148694chr2:211336800ENST00000431941110364_36727.0400.0RegionGlutathione binding
TgeneLANCL1chr6:163148694chr2:211336800ENST00000441020110364_36727.0400.0RegionGlutathione binding
TgeneLANCL1chr6:163148694chr2:211336800ENST0000044331409364_36727.0400.0RegionGlutathione binding
TgeneLANCL1chr6:163148694chr2:211336800ENST00000450366110364_36727.0400.0RegionGlutathione binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePARK2chr6:163148694chr2:211336800ENST00000338468-1111_760275.0DomainUbiquitin-like
HgenePARK2chr6:163148694chr2:211336800ENST00000366894-1111_760275.0DomainUbiquitin-like
HgenePARK2chr6:163148694chr2:211336800ENST00000366896-191_762.3333333333333335317.0DomainUbiquitin-like
HgenePARK2chr6:163148694chr2:211336800ENST00000366897-1111_762.3333333333333335438.0DomainUbiquitin-like
HgenePARK2chr6:163148694chr2:211336800ENST00000366898-1121_762.3333333333333335466.0DomainUbiquitin-like
HgenePARK2chr6:163148694chr2:211336800ENST00000338468-111204_2380275.0RegionSYT11 binding 1
HgenePARK2chr6:163148694chr2:211336800ENST00000338468-111234_4650275.0RegionTRIAD supradomain
HgenePARK2chr6:163148694chr2:211336800ENST00000338468-111257_2930275.0RegionSYT11 binding 2
HgenePARK2chr6:163148694chr2:211336800ENST00000338468-111378_4100275.0RegionREP
HgenePARK2chr6:163148694chr2:211336800ENST00000338468-11177_2370275.0RegionNecessary for PINK1-dependent localization to mitochondria
HgenePARK2chr6:163148694chr2:211336800ENST00000366894-111204_2380275.0RegionSYT11 binding 1
HgenePARK2chr6:163148694chr2:211336800ENST00000366894-111234_4650275.0RegionTRIAD supradomain
HgenePARK2chr6:163148694chr2:211336800ENST00000366894-111257_2930275.0RegionSYT11 binding 2
HgenePARK2chr6:163148694chr2:211336800ENST00000366894-111378_4100275.0RegionREP
HgenePARK2chr6:163148694chr2:211336800ENST00000366894-11177_2370275.0RegionNecessary for PINK1-dependent localization to mitochondria
HgenePARK2chr6:163148694chr2:211336800ENST00000366896-19204_2382.3333333333333335317.0RegionSYT11 binding 1
HgenePARK2chr6:163148694chr2:211336800ENST00000366896-19234_4652.3333333333333335317.0RegionTRIAD supradomain
HgenePARK2chr6:163148694chr2:211336800ENST00000366896-19257_2932.3333333333333335317.0RegionSYT11 binding 2
HgenePARK2chr6:163148694chr2:211336800ENST00000366896-19378_4102.3333333333333335317.0RegionREP
HgenePARK2chr6:163148694chr2:211336800ENST00000366896-1977_2372.3333333333333335317.0RegionNecessary for PINK1-dependent localization to mitochondria
HgenePARK2chr6:163148694chr2:211336800ENST00000366897-111204_2382.3333333333333335438.0RegionSYT11 binding 1
HgenePARK2chr6:163148694chr2:211336800ENST00000366897-111234_4652.3333333333333335438.0RegionTRIAD supradomain
HgenePARK2chr6:163148694chr2:211336800ENST00000366897-111257_2932.3333333333333335438.0RegionSYT11 binding 2
HgenePARK2chr6:163148694chr2:211336800ENST00000366897-111378_4102.3333333333333335438.0RegionREP
HgenePARK2chr6:163148694chr2:211336800ENST00000366897-11177_2372.3333333333333335438.0RegionNecessary for PINK1-dependent localization to mitochondria
HgenePARK2chr6:163148694chr2:211336800ENST00000366898-112204_2382.3333333333333335466.0RegionSYT11 binding 1
HgenePARK2chr6:163148694chr2:211336800ENST00000366898-112234_4652.3333333333333335466.0RegionTRIAD supradomain
HgenePARK2chr6:163148694chr2:211336800ENST00000366898-112257_2932.3333333333333335466.0RegionSYT11 binding 2
HgenePARK2chr6:163148694chr2:211336800ENST00000366898-112378_4102.3333333333333335466.0RegionREP
HgenePARK2chr6:163148694chr2:211336800ENST00000366898-11277_2372.3333333333333335466.0RegionNecessary for PINK1-dependent localization to mitochondria
HgenePARK2chr6:163148694chr2:211336800ENST00000338468-111141_2250275.0Zinc fingerNote=RING-type 0%3B atypical
HgenePARK2chr6:163148694chr2:211336800ENST00000338468-111238_2930275.0Zinc fingerRING-type 1
HgenePARK2chr6:163148694chr2:211336800ENST00000338468-111313_3770275.0Zinc fingerIBR-type
HgenePARK2chr6:163148694chr2:211336800ENST00000338468-111418_4490275.0Zinc fingerRING-type 2%3B atypical
HgenePARK2chr6:163148694chr2:211336800ENST00000366894-111141_2250275.0Zinc fingerNote=RING-type 0%3B atypical
HgenePARK2chr6:163148694chr2:211336800ENST00000366894-111238_2930275.0Zinc fingerRING-type 1
HgenePARK2chr6:163148694chr2:211336800ENST00000366894-111313_3770275.0Zinc fingerIBR-type
HgenePARK2chr6:163148694chr2:211336800ENST00000366894-111418_4490275.0Zinc fingerRING-type 2%3B atypical
HgenePARK2chr6:163148694chr2:211336800ENST00000366896-19141_2252.3333333333333335317.0Zinc fingerNote=RING-type 0%3B atypical
HgenePARK2chr6:163148694chr2:211336800ENST00000366896-19238_2932.3333333333333335317.0Zinc fingerRING-type 1
HgenePARK2chr6:163148694chr2:211336800ENST00000366896-19313_3772.3333333333333335317.0Zinc fingerIBR-type
HgenePARK2chr6:163148694chr2:211336800ENST00000366896-19418_4492.3333333333333335317.0Zinc fingerRING-type 2%3B atypical
HgenePARK2chr6:163148694chr2:211336800ENST00000366897-111141_2252.3333333333333335438.0Zinc fingerNote=RING-type 0%3B atypical
HgenePARK2chr6:163148694chr2:211336800ENST00000366897-111238_2932.3333333333333335438.0Zinc fingerRING-type 1
HgenePARK2chr6:163148694chr2:211336800ENST00000366897-111313_3772.3333333333333335438.0Zinc fingerIBR-type
HgenePARK2chr6:163148694chr2:211336800ENST00000366897-111418_4492.3333333333333335438.0Zinc fingerRING-type 2%3B atypical
HgenePARK2chr6:163148694chr2:211336800ENST00000366898-112141_2252.3333333333333335466.0Zinc fingerNote=RING-type 0%3B atypical
HgenePARK2chr6:163148694chr2:211336800ENST00000366898-112238_2932.3333333333333335466.0Zinc fingerRING-type 1
HgenePARK2chr6:163148694chr2:211336800ENST00000366898-112313_3772.3333333333333335466.0Zinc fingerIBR-type
HgenePARK2chr6:163148694chr2:211336800ENST00000366898-112418_4492.3333333333333335466.0Zinc fingerRING-type 2%3B atypical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PARK2
LANCL1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PARK2-LANCL1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PARK2-LANCL1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource