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level3

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PAX5-ETV6

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PAX5-ETV6
	FusionPDB ID: 62949
	FusionGDB2.0 ID: 62949
		Hgene	Tgene
	Gene symbol	PAX5	ETV6
	Gene ID	5079	2120
	Gene name	paired box 5	ETS variant transcription factor 6
	Synonyms	ALL3\|BSAP	TEL\|TEL/ABL\|THC5
	Cytomap	9p13.2	12p13.2
	Type of gene	protein-coding	protein-coding
	Description	paired box protein Pax-5B-cell lineage specific activatorpaired box homeotic gene 5paired domain gene 5transcription factor PAX 5	transcription factor ETV6ETS translocation variant 6ETS variant 6ETS-related protein Tel1TEL1 oncogeneets variant gene 6 (TEL oncogene)
	Modification date	20200313	20200313
	UniProtAcc	Q02548	P41212
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000358127, ENST00000377847, ENST00000377852, ENST00000377853, ENST00000414447, ENST00000446742, ENST00000520154, ENST00000520281, ENST00000522003, ENST00000523145, ENST00000523241,	ENST00000544715, ENST00000396373,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 15 X 7=1575	21 X 24 X 6=3024
	# samples	10	19
	** MAII score	log2(10/1575*10)=-3.97727992349992 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/3024*10)=-3.99238681589013 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PAX5 [Title/Abstract] AND ETV6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PAX5(37034075)-ETV6(11992072), # samples:1 PAX5(37006469)-ETV6(11992072), # samples:1
Anticipated loss of major functional domain due to fusion event.	PAX5-ETV6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PAX5-ETV6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PAX5-ETV6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PAX5-ETV6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PAX5-ETV6 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. PAX5-ETV6 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. PAX5-ETV6 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. PAX5-ETV6 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. PAX5-ETV6 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. PAX5-ETV6 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ETV6	GO:0000122	negative regulation of transcription by RNA polymerase II	10514502

Fusion gene breakpoints across PAX5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ETV6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	chronic myeloid leukemia	DQ841178	PAX5	chr9	37034075		ETV6	chr12	11992072
ChimerKB3	.	.	PAX5	chr9	37006469	-	ETV6	chr12	11992073	+
ChiTaRS5.0	N/A	DQ841178	PAX5	chr9	37006469	-	ETV6	chr12	11992072	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000358127	PAX5	chr9	37006469	-	ENST00000396373	ETV6	chr12	11992073	+	6102	550	75	1745	556
ENST00000523241	PAX5	chr9	37006469	-	ENST00000396373	ETV6	chr12	11992073	+	6037	485	10	1680	556
ENST00000520154	PAX5	chr9	37006469	-	ENST00000396373	ETV6	chr12	11992073	+	6037	485	10	1680	556
ENST00000377852	PAX5	chr9	37006469	-	ENST00000396373	ETV6	chr12	11992073	+	6037	485	10	1680	556
ENST00000377853	PAX5	chr9	37006469	-	ENST00000396373	ETV6	chr12	11992073	+	6037	485	10	1680	556
ENST00000520281	PAX5	chr9	37006469	-	ENST00000396373	ETV6	chr12	11992073	+	6027	475	0	1670	556
ENST00000414447	PAX5	chr9	37006469	-	ENST00000396373	ETV6	chr12	11992073	+	6027	475	0	1670	556
ENST00000446742	PAX5	chr9	37006469	-	ENST00000396373	ETV6	chr12	11992073	+	5829	277	0	1472	490
ENST00000377847	PAX5	chr9	37006469	-	ENST00000396373	ETV6	chr12	11992073	+	6027	475	0	1670	556
ENST00000358127	PAX5	chr9	37006469	-	ENST00000396373	ETV6	chr12	11992072	+	6102	550	75	1745	556
ENST00000523241	PAX5	chr9	37006469	-	ENST00000396373	ETV6	chr12	11992072	+	6037	485	10	1680	556
ENST00000520154	PAX5	chr9	37006469	-	ENST00000396373	ETV6	chr12	11992072	+	6037	485	10	1680	556
ENST00000377852	PAX5	chr9	37006469	-	ENST00000396373	ETV6	chr12	11992072	+	6037	485	10	1680	556
ENST00000377853	PAX5	chr9	37006469	-	ENST00000396373	ETV6	chr12	11992072	+	6037	485	10	1680	556
ENST00000520281	PAX5	chr9	37006469	-	ENST00000396373	ETV6	chr12	11992072	+	6027	475	0	1670	556
ENST00000414447	PAX5	chr9	37006469	-	ENST00000396373	ETV6	chr12	11992072	+	6027	475	0	1670	556
ENST00000446742	PAX5	chr9	37006469	-	ENST00000396373	ETV6	chr12	11992072	+	5829	277	0	1472	490
ENST00000377847	PAX5	chr9	37006469	-	ENST00000396373	ETV6	chr12	11992072	+	6027	475	0	1670	556

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000358127	ENST00000396373	PAX5	chr9	37006469	-	ETV6	chr12	11992072	+	0.002516128	0.99748385
ENST00000523241	ENST00000396373	PAX5	chr9	37006469	-	ETV6	chr12	11992072	+	0.002713001	0.99728703
ENST00000520154	ENST00000396373	PAX5	chr9	37006469	-	ETV6	chr12	11992072	+	0.002713001	0.99728703
ENST00000377852	ENST00000396373	PAX5	chr9	37006469	-	ETV6	chr12	11992072	+	0.002713001	0.99728703
ENST00000377853	ENST00000396373	PAX5	chr9	37006469	-	ETV6	chr12	11992072	+	0.002713001	0.99728703
ENST00000520281	ENST00000396373	PAX5	chr9	37006469	-	ETV6	chr12	11992072	+	0.002739644	0.99726033
ENST00000414447	ENST00000396373	PAX5	chr9	37006469	-	ETV6	chr12	11992072	+	0.002739644	0.99726033
ENST00000446742	ENST00000396373	PAX5	chr9	37006469	-	ETV6	chr12	11992072	+	0.003013001	0.99698704
ENST00000377847	ENST00000396373	PAX5	chr9	37006469	-	ETV6	chr12	11992072	+	0.002739644	0.99726033

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>62949_62949_1_PAX5-ETV6_PAX5_chr9_37006469_ENST00000358127_ETV6_chr12_11992072_ENST00000396373_length(amino acids)=556AA_BP=158
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGLQPIYWSRDDVAQWLKWAENE
FSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSV
DNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPS
SPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVY
QLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEH

--------------------------------------------------------------

>62949_62949_2_PAX5-ETV6_PAX5_chr9_37006469_ENST00000358127_ETV6_chr12_11992073_ENST00000396373_length(amino acids)=556AA_BP=158
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGLQPIYWSRDDVAQWLKWAENE
FSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSV
DNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPS
SPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVY
QLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEH

--------------------------------------------------------------

>62949_62949_3_PAX5-ETV6_PAX5_chr9_37006469_ENST00000377847_ETV6_chr12_11992072_ENST00000396373_length(amino acids)=556AA_BP=158
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGLQPIYWSRDDVAQWLKWAENE
FSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSV
DNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPS
SPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVY
QLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEH

--------------------------------------------------------------

>62949_62949_4_PAX5-ETV6_PAX5_chr9_37006469_ENST00000377847_ETV6_chr12_11992073_ENST00000396373_length(amino acids)=556AA_BP=158
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGLQPIYWSRDDVAQWLKWAENE
FSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSV
DNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPS
SPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVY
QLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEH

--------------------------------------------------------------

>62949_62949_5_PAX5-ETV6_PAX5_chr9_37006469_ENST00000377852_ETV6_chr12_11992072_ENST00000396373_length(amino acids)=556AA_BP=158
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGLQPIYWSRDDVAQWLKWAENE
FSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSV
DNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPS
SPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVY
QLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEH

--------------------------------------------------------------

>62949_62949_6_PAX5-ETV6_PAX5_chr9_37006469_ENST00000377852_ETV6_chr12_11992073_ENST00000396373_length(amino acids)=556AA_BP=158
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGLQPIYWSRDDVAQWLKWAENE
FSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSV
DNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPS
SPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVY
QLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEH

--------------------------------------------------------------

>62949_62949_7_PAX5-ETV6_PAX5_chr9_37006469_ENST00000377853_ETV6_chr12_11992072_ENST00000396373_length(amino acids)=556AA_BP=158
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGLQPIYWSRDDVAQWLKWAENE
FSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSV
DNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPS
SPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVY
QLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEH

--------------------------------------------------------------

>62949_62949_8_PAX5-ETV6_PAX5_chr9_37006469_ENST00000377853_ETV6_chr12_11992073_ENST00000396373_length(amino acids)=556AA_BP=158
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGLQPIYWSRDDVAQWLKWAENE
FSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSV
DNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPS
SPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVY
QLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEH

--------------------------------------------------------------

>62949_62949_9_PAX5-ETV6_PAX5_chr9_37006469_ENST00000414447_ETV6_chr12_11992072_ENST00000396373_length(amino acids)=556AA_BP=158
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGLQPIYWSRDDVAQWLKWAENE
FSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSV
DNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPS
SPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVY
QLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEH

--------------------------------------------------------------

>62949_62949_10_PAX5-ETV6_PAX5_chr9_37006469_ENST00000414447_ETV6_chr12_11992073_ENST00000396373_length(amino acids)=556AA_BP=158
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGLQPIYWSRDDVAQWLKWAENE
FSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSV
DNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPS
SPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVY
QLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEH

--------------------------------------------------------------

>62949_62949_11_PAX5-ETV6_PAX5_chr9_37006469_ENST00000446742_ETV6_chr12_11992072_ENST00000396373_length(amino acids)=490AA_BP=92
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRIIRTKVQQPPNQPVPASSH
SIGLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHT
QPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQES
YPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSV
SPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPG

--------------------------------------------------------------

>62949_62949_12_PAX5-ETV6_PAX5_chr9_37006469_ENST00000446742_ETV6_chr12_11992073_ENST00000396373_length(amino acids)=490AA_BP=92
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRIIRTKVQQPPNQPVPASSH
SIGLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHT
QPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQES
YPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSV
SPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPG

--------------------------------------------------------------

>62949_62949_13_PAX5-ETV6_PAX5_chr9_37006469_ENST00000520154_ETV6_chr12_11992072_ENST00000396373_length(amino acids)=556AA_BP=158
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGLQPIYWSRDDVAQWLKWAENE
FSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSV
DNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPS
SPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVY
QLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEH

--------------------------------------------------------------

>62949_62949_14_PAX5-ETV6_PAX5_chr9_37006469_ENST00000520154_ETV6_chr12_11992073_ENST00000396373_length(amino acids)=556AA_BP=158
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGLQPIYWSRDDVAQWLKWAENE
FSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSV
DNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPS
SPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVY
QLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEH

--------------------------------------------------------------

>62949_62949_15_PAX5-ETV6_PAX5_chr9_37006469_ENST00000520281_ETV6_chr12_11992072_ENST00000396373_length(amino acids)=556AA_BP=158
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGLQPIYWSRDDVAQWLKWAENE
FSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSV
DNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPS
SPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVY
QLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEH

--------------------------------------------------------------

>62949_62949_16_PAX5-ETV6_PAX5_chr9_37006469_ENST00000520281_ETV6_chr12_11992073_ENST00000396373_length(amino acids)=556AA_BP=158
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGLQPIYWSRDDVAQWLKWAENE
FSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSV
DNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPS
SPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVY
QLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEH

--------------------------------------------------------------

>62949_62949_17_PAX5-ETV6_PAX5_chr9_37006469_ENST00000523241_ETV6_chr12_11992072_ENST00000396373_length(amino acids)=556AA_BP=158
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGLQPIYWSRDDVAQWLKWAENE
FSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSV
DNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPS
SPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVY
QLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEH

--------------------------------------------------------------

>62949_62949_18_PAX5-ETV6_PAX5_chr9_37006469_ENST00000523241_ETV6_chr12_11992073_ENST00000396373_length(amino acids)=556AA_BP=158
MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKV
ATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIGLQPIYWSRDDVAQWLKWAENE
FSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSV
DNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPS
SPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVY
QLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEH

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:37034075/chr12:11992072)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PAX5 Q02548	ETV6 P41212
FUNCTION: Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:10811620, PubMed:27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238). {ECO:0000269\|PubMed:10811620, ECO:0000269\|PubMed:27181361, ECO:0000269\|PubMed:32612238}.; FUNCTION: (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription (PubMed:31941781). Participates also in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity (PubMed:23678172). {ECO:0000269\|PubMed:23678172, ECO:0000269\|PubMed:31941781}.	FUNCTION: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. {ECO:0000269\|PubMed:25581430}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000358127

16_142

158.33333333333334

392.0

DNA binding

Paired

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000377847

16_142

158.33333333333334

329.0

DNA binding

Paired

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000377852

16_142

158.33333333333334

358.0

DNA binding

Paired

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000377853

16_142

158.33333333333334

363.0

DNA binding

Paired

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000414447

16_142

158.33333333333334

349.0

DNA binding

Paired

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000520281

16_142

158.33333333333334

320.0

DNA binding

Paired

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000358127

19_75

158.33333333333334

392.0

Region

PAI subdomain

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000358127

94_142

158.33333333333334

392.0

Region

RED subdomain

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000377847

19_75

158.33333333333334

329.0

Region

PAI subdomain

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000377847

94_142

158.33333333333334

329.0

Region

RED subdomain

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000377852

19_75

158.33333333333334

358.0

Region

PAI subdomain

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000377852

94_142

158.33333333333334

358.0

Region

RED subdomain

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000377853

19_75

158.33333333333334

363.0

Region

PAI subdomain

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000377853

94_142

158.33333333333334

363.0

Region

RED subdomain

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000414447

19_75

158.33333333333334

349.0

Region

PAI subdomain

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000414447

94_142

158.33333333333334

349.0

Region

RED subdomain

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000446742

19_75

92.33333333333333

292.0

Region

PAI subdomain

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000520281

19_75

158.33333333333334

320.0

Region

PAI subdomain

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000520281

94_142

158.33333333333334

320.0

Region

RED subdomain

Tgene

ETV6

chr9:37006469

chr12:11992072

ENST00000396373

339_420

54.333333333333336

453.0

DNA binding

ETS

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000446742

16_142

92.33333333333333

292.0

DNA binding

Paired

Hgene

PAX5

chr9:37006469

chr12:11992072

ENST00000446742

94_142

92.33333333333333

292.0

Region

RED subdomain

Tgene

ETV6

chr9:37006469

chr12:11992072

ENST00000396373

40_124

54.333333333333336

453.0

Domain

PNT

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (283) >>>283.pdbFusion protein BP residue: 92 CIF file (283) >>>283.cif	PAX5	chr9	37006469	-	ETV6	chr12	11992073	+	MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVR PCDISRQLRVSHGCVSKILGRIIRTKVQQPPNQPVPASSHSIGLQPIYWS RDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDV LYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTP RPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRL SPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQES TRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDL AYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWED KESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPG	490
3D view using mol* of 283 (AA BP:92)


PDB file (400) >>>400.pdbFusion protein BP residue: 158 CIF file (400) >>>400.cif	PAX5	chr9	37006469	-	ETV6	chr12	11992073	+	MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVR PCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIA EYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQP VPASSHSIGLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLL LTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEV ILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDP EQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCP ASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDG LHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVY QLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSR ALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEHLESQELDEQI	556
3D view using mol* of 400 (AA BP:158)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PAX5_pLDDT.png

ETV6_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PAX5_ETV6_283_pLDDT.png (AA BP:92)

PAX5_ETV6_283_pLDDT_and_active_sites.png (AA BP:92)

PAX5_ETV6_283_violinplot.png (AA BP:92)

PAX5_ETV6_400_pLDDT.png (AA BP:158)

PAX5_ETV6_400_pLDDT_and_active_sites.png (AA BP:158)

PAX5_ETV6_400_violinplot.png (AA BP:158)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

PAX5_ETV6_283.png

PAX5_ETV6_400.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
283	1.034	317	1.051	876.708	0.543	0.746	0.958	0.827	1.032	0.801	0.704	Chain A: 42,45,46,48,49,50,51,66,69,70,72,73,74,76 ,78,95,96,97,115,117,118,132,133,134,135,136,137,1 40,141,144,145,146,147,148,149,150,152,153,155,156 ,157,159,160,161,162,163,164,372,373,374,375,376,3 77,378,421,422,423,473,476,477,480
400	0.944	74	0.923	109.074	0.452	0.768	1.11	1.085	1.062	1.022	0.783	Chain A: 445,484,490,491,492,493,497,498,500,501,5 42,545,546,549,550,553

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB

ZINC ID

DrugBank ID

Drug name

Docking score

Glide gscore

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID

DrugBank ID

Drug name

Drug type

SMILES

Drug group

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID

mol_MW

dipole

SASA

FOSA

FISA

PISA

WPSA

volume

donorHB

accptHB

Human Oral Absorption

Percent Human Oral Absorption

Rule Of Five

Rule Of Three

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID

Smile

Surface Accessibility

Toxicity

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
ETV6	KAT5, GAB2, ETV6, GRB2, CRKL, ACTA1, HDAC9, FLI1, FBXL6, SKP1, L3MBTL1, IRF8, NCOR1, SIN3A, HDAC3, UBE2I, ELAVL1, PDGFRB, SUMO1, SOCS1, SOCS3, TRAF3, SOX2, HDAC6, PIN1, AP1M1, WDYHV1, LRP6, LRP5, NID2, ETV7, USP7, VPS26B, NFATC2, EGLN3, NKX2-1, TRAF2, AXIN1, ESR2, LMNA, TP53BP1, BRCA1, MDC1, KIAA1429, WWP2, ESR1, BRD4, NFE2L2, MAD2L1, B4GALT2, KLHL9, KLHL13, SUMO2, ARHGAP32, SEC16A, XPOT, PIAS2, CEP152, NUP214, NUP62, NUP98, SEC13, RBM11, ECH1, ZNF146, TRIP6, CEP85, NUP54, TAB3, ALMS1, CEP192, PPIL4, RQCD1, SDCCAG3, NUP88, TBL1Y, KIAA1671, C2orf44, GRPEL1, TNRC6C, MID1IP1, CYLD, ZMYM2, LIMD1, SPATA2, TNRC6B, TIMM13, FLOT1, LGALS3BP, FLOT2, HNRNPUL1,
PAX5	TLE4, DAXX, RUNX1, MYB, ID3, EP300, TBP, RB1, MAPK1, KAT2B, CDKN1B, UBE3A, RAD52, HMGB3, HOXC8, MAPK9, NFYC, FBLN1, GRHL2, DTX2, CSNK2A1, UBE2I, CCNC, BCAS2, C1orf109, GNG13, ZMYM5, SEC14L4, RNF144B, OSGIN1, CIB3, SAE1, STAC, TLK2, HMBOX1, NGLY1, NEIL2, LONRF1, LDLRAP1, LARP4, UBXN7, ACOT12, CKS1B, KLHL38, HGS, CXorf38, KRTAP10-8, PNMA5, KRTAP9-3, UBXN2B, CDK3, BKRF1, HIST1H3A, PAX8, KLHL14,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PAX5
ETV6

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to PAX5-ETV6

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to PAX5-ETV6

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PAX5	C0006413	Burkitt Lymphoma	4	ORPHANET
Hgene	PAX5	C1292769	Precursor B-cell lymphoblastic leukemia	4	ORPHANET
Hgene	PAX5	C0023485	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2	CTD_human
Hgene	PAX5	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	2	CGI;CTD_human;UNIPROT
Hgene	PAX5	C0023452	Childhood Acute Lymphoblastic Leukemia	1	CTD_human
Hgene	PAX5	C0023453	L2 Acute Lymphoblastic Leukemia	1	CTD_human
Hgene	PAX5	C1535926	Neurodevelopmental Disorders	1	CTD_human
Tgene	ETV6	C4015537	THROMBOCYTOPENIA 5	4	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	ETV6	C0023485	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3	CTD_human
Tgene	ETV6	C0040034	Thrombocytopenia	3	CTD_human;GENOMICS_ENGLAND
Tgene	ETV6	C0023480	Leukemia, Myelomonocytic, Chronic	2	ORPHANET
Tgene	ETV6	C1332965	Congenital Mesoblastic Nephroma	2	ORPHANET
Tgene	ETV6	C0006413	Burkitt Lymphoma	1	ORPHANET
Tgene	ETV6	C0013146	Drug abuse	1	CTD_human
Tgene	ETV6	C0013170	Drug habituation	1	CTD_human
Tgene	ETV6	C0013222	Drug Use Disorders	1	CTD_human
Tgene	ETV6	C0023452	Childhood Acute Lymphoblastic Leukemia	1	CTD_human
Tgene	ETV6	C0023453	L2 Acute Lymphoblastic Leukemia	1	CTD_human
Tgene	ETV6	C0023467	Leukemia, Myelocytic, Acute	1	CGI;CTD_human;GENOMICS_ENGLAND
Tgene	ETV6	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Tgene	ETV6	C0038580	Substance Dependence	1	CTD_human
Tgene	ETV6	C0038586	Substance Use Disorders	1	CTD_human
Tgene	ETV6	C0087031	Juvenile-Onset Still Disease	1	CTD_human
Tgene	ETV6	C0236969	Substance-Related Disorders	1	CTD_human
Tgene	ETV6	C0238463	Papillary thyroid carcinoma	1	ORPHANET
Tgene	ETV6	C0376544	Hematopoietic Neoplasms	1	CTD_human
Tgene	ETV6	C0376545	Hematologic Neoplasms	1	CTD_human
Tgene	ETV6	C0740858	Substance abuse problem	1	CTD_human
Tgene	ETV6	C1292769	Precursor B-cell lymphoblastic leukemia	1	ORPHANET
Tgene	ETV6	C1510472	Drug Dependence	1	CTD_human
Tgene	ETV6	C1832388	Platelet Disorder, Familial, with Associated Myeloid Malignancy	1	ORPHANET
Tgene	ETV6	C1838656	Macrocytosis, Familial	1	CTD_human
Tgene	ETV6	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	1	CTD_human
Tgene	ETV6	C3495559	Juvenile arthritis	1	CTD_human
Tgene	ETV6	C3714758	Juvenile psoriatic arthritis	1	CTD_human
Tgene	ETV6	C4316881	Prescription Drug Abuse	1	CTD_human
Tgene	ETV6	C4552091	Polyarthritis, Juvenile, Rheumatoid Factor Negative	1	CTD_human
Tgene	ETV6	C4704862	Polyarthritis, Juvenile, Rheumatoid Factor Positive	1	CTD_human