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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PBRM1-CACNA2D3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PBRM1-CACNA2D3
FusionPDB ID: 62999
FusionGDB2.0 ID: 62999
HgeneTgene
Gene symbol

PBRM1

CACNA2D3

Gene ID

55193

55799

Gene namepolybromo 1calcium voltage-gated channel auxiliary subunit alpha2delta 3
SynonymsBAF180|PB1HSA272268
Cytomap

3p21.1

3p21.1-p14.3

Type of geneprotein-codingprotein-coding
Descriptionprotein polybromo-1BRG1-associated factor 180polybromo-1Dvoltage-dependent calcium channel subunit alpha-2/delta-3calcium channel alpha2-delta3 subunitcalcium channel, voltage-dependent, alpha 2/delta 3 subunitcalcium channel, voltage-dependent, alpha 2/delta subunit 3voltage-gated calcium channel subunit a
Modification date2020031320200313
UniProtAcc.

Q8IZS8

Ensembl transtripts involved in fusion geneENST idsENST00000296302, ENST00000337303, 
ENST00000356770, ENST00000394830, 
ENST00000409057, ENST00000409114, 
ENST00000409767, ENST00000410007, 
ENST00000478261, ENST00000288197, 
ENST00000415676, ENST00000474759, 
ENST00000490478, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 15 X 10=225016 X 13 X 9=1872
# samples 1916
** MAII scorelog2(19/2250*10)=-3.56585367777345
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1872*10)=-3.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PBRM1 [Title/Abstract] AND CACNA2D3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PBRM1(52637537)-CACNA2D3(54420742), # samples:3
Anticipated loss of major functional domain due to fusion event.PBRM1-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PBRM1-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PBRM1-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PBRM1-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PBRM1-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PBRM1-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PBRM1-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PBRM1-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PBRM1-CACNA2D3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PBRM1-CACNA2D3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PBRM1-CACNA2D3 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PBRM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CACNA2D3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A1L7-01APBRM1chr3

52637537

-CACNA2D3chr3

54420742

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394830PBRM1chr352637537-ENST00000415676CACNA2D3chr354420742+6101287928825833983
ENST00000394830PBRM1chr352637537-ENST00000288197CACNA2D3chr354420742+6181287928825833983
ENST00000394830PBRM1chr352637537-ENST00000474759CACNA2D3chr354420742+6185287928825833983
ENST00000394830PBRM1chr352637537-ENST00000490478CACNA2D3chr354420742+6185287928825833983

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394830ENST00000415676PBRM1chr352637537-CACNA2D3chr354420742+0.0009144730.99908555
ENST00000394830ENST00000288197PBRM1chr352637537-CACNA2D3chr354420742+0.0008428410.9991572
ENST00000394830ENST00000474759PBRM1chr352637537-CACNA2D3chr354420742+0.0008408910.9991591
ENST00000394830ENST00000490478PBRM1chr352637537-CACNA2D3chr354420742+0.0008408910.9991591

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>62999_62999_1_PBRM1-CACNA2D3_PBRM1_chr3_52637537_ENST00000394830_CACNA2D3_chr3_54420742_ENST00000288197_length(amino acids)=983AA_BP=1
MVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKV
FVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGD
DDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDT
IFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLT
DDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVD
LSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVS
LADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRIN
LFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIPFSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQ
RKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGDFFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAH
GLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNL

--------------------------------------------------------------

>62999_62999_2_PBRM1-CACNA2D3_PBRM1_chr3_52637537_ENST00000394830_CACNA2D3_chr3_54420742_ENST00000415676_length(amino acids)=983AA_BP=1
MVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKV
FVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGD
DDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDT
IFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLT
DDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVD
LSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVS
LADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRIN
LFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIPFSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQ
RKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGDFFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAH
GLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNL

--------------------------------------------------------------

>62999_62999_3_PBRM1-CACNA2D3_PBRM1_chr3_52637537_ENST00000394830_CACNA2D3_chr3_54420742_ENST00000474759_length(amino acids)=983AA_BP=1
MVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKV
FVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGD
DDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDT
IFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLT
DDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVD
LSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVS
LADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRIN
LFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIPFSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQ
RKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGDFFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAH
GLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNL

--------------------------------------------------------------

>62999_62999_4_PBRM1-CACNA2D3_PBRM1_chr3_52637537_ENST00000394830_CACNA2D3_chr3_54420742_ENST00000490478_length(amino acids)=983AA_BP=1
MVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKV
FVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGD
DDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDT
IFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLT
DDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRLLYEEGKKRRKPNYSSVD
LSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVS
LADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRIN
LFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIPFSTGPVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQ
RKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGDFFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAH
GLLDPYNAFLSAVKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52637537/chr3:54420742)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CACNA2D3

Q8IZS8

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-1730630_633926.33333333333341690.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-1728630_633926.33333333333341583.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-1628630_633894.33333333333341603.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-1830630_633926.33333333333341583.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-1729630_633926.33333333333341635.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-1830630_633941.33333333333341653.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-1829630_633941.33333333333341598.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-1729630_633926.33333333333341610.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-1730200_270926.33333333333341690.0DomainBromo 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-1730400_470926.33333333333341690.0DomainBromo 3
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-1730538_608926.33333333333341690.0DomainBromo 4
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-173064_134926.33333333333341690.0DomainBromo 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-1730676_746926.33333333333341690.0DomainBromo 5
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-1730792_862926.33333333333341690.0DomainBromo 6
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-1728200_270926.33333333333341583.0DomainBromo 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-1728400_470926.33333333333341583.0DomainBromo 3
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-1728538_608926.33333333333341583.0DomainBromo 4
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-172864_134926.33333333333341583.0DomainBromo 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-1728676_746926.33333333333341583.0DomainBromo 5
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-1728792_862926.33333333333341583.0DomainBromo 6
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-1628200_270894.33333333333341603.0DomainBromo 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-1628400_470894.33333333333341603.0DomainBromo 3
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-1628538_608894.33333333333341603.0DomainBromo 4
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-162864_134894.33333333333341603.0DomainBromo 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-1628676_746894.33333333333341603.0DomainBromo 5
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-1628792_862894.33333333333341603.0DomainBromo 6
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-1830200_270926.33333333333341583.0DomainBromo 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-1830400_470926.33333333333341583.0DomainBromo 3
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-1830538_608926.33333333333341583.0DomainBromo 4
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-183064_134926.33333333333341583.0DomainBromo 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-1830676_746926.33333333333341583.0DomainBromo 5
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-1830792_862926.33333333333341583.0DomainBromo 6
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-1729200_270926.33333333333341635.0DomainBromo 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-1729400_470926.33333333333341635.0DomainBromo 3
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-1729538_608926.33333333333341635.0DomainBromo 4
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-172964_134926.33333333333341635.0DomainBromo 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-1729676_746926.33333333333341635.0DomainBromo 5
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-1729792_862926.33333333333341635.0DomainBromo 6
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-1830200_270941.33333333333341653.0DomainBromo 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-1830400_470941.33333333333341653.0DomainBromo 3
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-1830538_608941.33333333333341653.0DomainBromo 4
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-183064_134941.33333333333341653.0DomainBromo 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-1830676_746941.33333333333341653.0DomainBromo 5
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-1830792_862941.33333333333341653.0DomainBromo 6
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-1829200_270941.33333333333341598.0DomainBromo 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-1829400_470941.33333333333341598.0DomainBromo 3
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-1829538_608941.33333333333341598.0DomainBromo 4
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-182964_134941.33333333333341598.0DomainBromo 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-1829676_746941.33333333333341598.0DomainBromo 5
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-1829792_862941.33333333333341598.0DomainBromo 6
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-1729200_270926.33333333333341610.0DomainBromo 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-1729400_470926.33333333333341610.0DomainBromo 3
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-1729538_608926.33333333333341610.0DomainBromo 4
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-172964_134926.33333333333341610.0DomainBromo 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-1729676_746926.33333333333341610.0DomainBromo 5
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-1729792_862926.33333333333341610.0DomainBromo 6
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000288197238256_438107.01092.0DomainVWFA
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000288197238452_549107.01092.0DomainNote=Cache
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000415676339256_438107.01092.0DomainVWFA
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000415676339452_549107.01092.0DomainNote=Cache
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000474759238256_438107.01092.0DomainVWFA
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000474759238452_549107.01092.0DomainNote=Cache
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000490478137256_43813.0998.0DomainVWFA
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000490478137452_54913.0998.0DomainNote=Cache
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000288197238262_266107.01092.0MotifNote=MIDAS-like motif
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000415676339262_266107.01092.0MotifNote=MIDAS-like motif
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000474759238262_266107.01092.0MotifNote=MIDAS-like motif
TgeneCACNA2D3chr3:52637537chr3:54420742ENST00000490478137262_26613.0998.0MotifNote=MIDAS-like motif
TgeneCACNA2D3chr3:52637537chr3:54420742ENST000002881972381090_1091107.01092.0Topological domainCytoplasmic
TgeneCACNA2D3chr3:52637537chr3:54420742ENST000004156763391090_1091107.01092.0Topological domainCytoplasmic
TgeneCACNA2D3chr3:52637537chr3:54420742ENST000004747592381090_1091107.01092.0Topological domainCytoplasmic
TgeneCACNA2D3chr3:52637537chr3:54420742ENST000004904781371090_109113.0998.0Topological domainCytoplasmic
TgeneCACNA2D3chr3:52637537chr3:54420742ENST0000049047813729_106813.0998.0Topological domainExtracellular
TgeneCACNA2D3chr3:52637537chr3:54420742ENST000002881972381069_1089107.01092.0TransmembraneHelical
TgeneCACNA2D3chr3:52637537chr3:54420742ENST000004156763391069_1089107.01092.0TransmembraneHelical
TgeneCACNA2D3chr3:52637537chr3:54420742ENST000004747592381069_1089107.01092.0TransmembraneHelical
TgeneCACNA2D3chr3:52637537chr3:54420742ENST000004904781371069_108913.0998.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-17301468_1599926.33333333333341690.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-17281468_1599926.33333333333341583.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-16281468_1599894.33333333333341603.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-18301468_1599926.33333333333341583.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-17291468_1599926.33333333333341635.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-18301468_1599941.33333333333341653.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-18291468_1599941.33333333333341598.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-17291468_1599926.33333333333341610.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-17301379_1447926.33333333333341690.0DNA bindingHMG box
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-17281379_1447926.33333333333341583.0DNA bindingHMG box
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-16281379_1447894.33333333333341603.0DNA bindingHMG box
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-18301379_1447926.33333333333341583.0DNA bindingHMG box
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-17291379_1447926.33333333333341635.0DNA bindingHMG box
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-18301379_1447941.33333333333341653.0DNA bindingHMG box
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-18291379_1447941.33333333333341598.0DNA bindingHMG box
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-17291379_1447926.33333333333341610.0DNA bindingHMG box
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-17301156_1272926.33333333333341690.0DomainBAH 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000296302-1730956_1074926.33333333333341690.0DomainBAH 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-17281156_1272926.33333333333341583.0DomainBAH 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000337303-1728956_1074926.33333333333341583.0DomainBAH 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-16281156_1272894.33333333333341603.0DomainBAH 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000356770-1628956_1074894.33333333333341603.0DomainBAH 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-18301156_1272926.33333333333341583.0DomainBAH 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000394830-1830956_1074926.33333333333341583.0DomainBAH 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-17291156_1272926.33333333333341635.0DomainBAH 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000409057-1729956_1074926.33333333333341635.0DomainBAH 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-18301156_1272941.33333333333341653.0DomainBAH 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000409114-1830956_1074941.33333333333341653.0DomainBAH 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-18291156_1272941.33333333333341598.0DomainBAH 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000409767-1829956_1074941.33333333333341598.0DomainBAH 1
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-17291156_1272926.33333333333341610.0DomainBAH 2
HgenePBRM1chr3:52637537chr3:54420742ENST00000410007-1729956_1074926.33333333333341610.0DomainBAH 1
TgeneCACNA2D3chr3:52637537chr3:54420742ENST0000028819723829_1068107.01092.0Topological domainExtracellular
TgeneCACNA2D3chr3:52637537chr3:54420742ENST0000041567633929_1068107.01092.0Topological domainExtracellular
TgeneCACNA2D3chr3:52637537chr3:54420742ENST0000047475923829_1068107.01092.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PBRM1
CACNA2D3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PBRM1-CACNA2D3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PBRM1-CACNA2D3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource