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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PBRM1-NT5DC2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PBRM1-NT5DC2
	FusionPDB ID: 63007
	FusionGDB2.0 ID: 63007
		Hgene	Tgene
	Gene symbol	PBRM1	NT5DC2
	Gene ID	55193	64943
	Gene name	polybromo 1	5'-nucleotidase domain containing 2
	Synonyms	BAF180\|PB1	-
	Cytomap	3p21.1	3p21.1
	Type of gene	protein-coding	protein-coding
	Description	protein polybromo-1BRG1-associated factor 180polybromo-1D	5'-nucleotidase domain-containing protein 2
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000296302, ENST00000337303, ENST00000356770, ENST00000394830, ENST00000409057, ENST00000409114, ENST00000409767, ENST00000410007,	ENST00000490681, ENST00000307076, ENST00000307092, ENST00000422318, ENST00000459839,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 15 X 10=2250	10 X 8 X 7=560
	# samples	19	11
	** MAII score	log2(19/2250*10)=-3.56585367777345 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/560*10)=-2.34792330342031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PBRM1 [Title/Abstract] AND NT5DC2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PBRM1(52702514)-NT5DC2(52559311), # samples:2
Anticipated loss of major functional domain due to fusion event.	PBRM1-NT5DC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PBRM1-NT5DC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PBRM1-NT5DC2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. PBRM1-NT5DC2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. PBRM1-NT5DC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PBRM1-NT5DC2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PBRM1-NT5DC2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across PBRM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NT5DC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRC	TCGA-AK-3455-01A	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-
ChimerDB4	LIHC	TCGA-DD-A1EA-01A	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000356770	PBRM1	chr3	52702514	-	ENST00000307092	NT5DC2	chr3	52559311	-	1042	387	3	941	312
ENST00000356770	PBRM1	chr3	52702514	-	ENST00000307076	NT5DC2	chr3	52559311	-	1025	387	3	941	312
ENST00000356770	PBRM1	chr3	52702514	-	ENST00000422318	NT5DC2	chr3	52559311	-	1023	387	3	941	312
ENST00000356770	PBRM1	chr3	52702514	-	ENST00000459839	NT5DC2	chr3	52559311	-	942	387	3	941	312
ENST00000296302	PBRM1	chr3	52702514	-	ENST00000307092	NT5DC2	chr3	52559311	-	1041	386	2	940	312
ENST00000296302	PBRM1	chr3	52702514	-	ENST00000307076	NT5DC2	chr3	52559311	-	1024	386	2	940	312
ENST00000296302	PBRM1	chr3	52702514	-	ENST00000422318	NT5DC2	chr3	52559311	-	1022	386	2	940	312
ENST00000296302	PBRM1	chr3	52702514	-	ENST00000459839	NT5DC2	chr3	52559311	-	941	386	2	940	313
ENST00000337303	PBRM1	chr3	52702514	-	ENST00000307092	NT5DC2	chr3	52559311	-	1042	387	3	941	312
ENST00000337303	PBRM1	chr3	52702514	-	ENST00000307076	NT5DC2	chr3	52559311	-	1025	387	3	941	312
ENST00000337303	PBRM1	chr3	52702514	-	ENST00000422318	NT5DC2	chr3	52559311	-	1023	387	3	941	312
ENST00000337303	PBRM1	chr3	52702514	-	ENST00000459839	NT5DC2	chr3	52559311	-	942	387	3	941	312
ENST00000410007	PBRM1	chr3	52702514	-	ENST00000307092	NT5DC2	chr3	52559311	-	1042	387	3	941	312
ENST00000410007	PBRM1	chr3	52702514	-	ENST00000307076	NT5DC2	chr3	52559311	-	1025	387	3	941	312
ENST00000410007	PBRM1	chr3	52702514	-	ENST00000422318	NT5DC2	chr3	52559311	-	1023	387	3	941	312
ENST00000410007	PBRM1	chr3	52702514	-	ENST00000459839	NT5DC2	chr3	52559311	-	942	387	3	941	312
ENST00000409057	PBRM1	chr3	52702514	-	ENST00000307092	NT5DC2	chr3	52559311	-	1042	387	3	941	312
ENST00000409057	PBRM1	chr3	52702514	-	ENST00000307076	NT5DC2	chr3	52559311	-	1025	387	3	941	312
ENST00000409057	PBRM1	chr3	52702514	-	ENST00000422318	NT5DC2	chr3	52559311	-	1023	387	3	941	312
ENST00000409057	PBRM1	chr3	52702514	-	ENST00000459839	NT5DC2	chr3	52559311	-	942	387	3	941	312
ENST00000409114	PBRM1	chr3	52702514	-	ENST00000307092	NT5DC2	chr3	52559311	-	1042	387	3	941	312
ENST00000409114	PBRM1	chr3	52702514	-	ENST00000307076	NT5DC2	chr3	52559311	-	1025	387	3	941	312
ENST00000409114	PBRM1	chr3	52702514	-	ENST00000422318	NT5DC2	chr3	52559311	-	1023	387	3	941	312
ENST00000409114	PBRM1	chr3	52702514	-	ENST00000459839	NT5DC2	chr3	52559311	-	942	387	3	941	312
ENST00000409767	PBRM1	chr3	52702514	-	ENST00000307092	NT5DC2	chr3	52559311	-	1042	387	3	941	312
ENST00000409767	PBRM1	chr3	52702514	-	ENST00000307076	NT5DC2	chr3	52559311	-	1025	387	3	941	312
ENST00000409767	PBRM1	chr3	52702514	-	ENST00000422318	NT5DC2	chr3	52559311	-	1023	387	3	941	312
ENST00000409767	PBRM1	chr3	52702514	-	ENST00000459839	NT5DC2	chr3	52559311	-	942	387	3	941	312

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000356770	ENST00000307092	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006406125	0.9935939
ENST00000356770	ENST00000307076	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006745168	0.99325484
ENST00000356770	ENST00000422318	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006448066	0.99355197
ENST00000356770	ENST00000459839	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.003846748	0.9961533
ENST00000296302	ENST00000307092	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006643425	0.9933565
ENST00000296302	ENST00000307076	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.007009293	0.99299073
ENST00000296302	ENST00000422318	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006696967	0.99330306
ENST00000296302	ENST00000459839	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.004045625	0.9959544
ENST00000337303	ENST00000307092	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006406125	0.9935939
ENST00000337303	ENST00000307076	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006745168	0.99325484
ENST00000337303	ENST00000422318	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006448066	0.99355197
ENST00000337303	ENST00000459839	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.003846748	0.9961533
ENST00000410007	ENST00000307092	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006406125	0.9935939
ENST00000410007	ENST00000307076	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006745168	0.99325484
ENST00000410007	ENST00000422318	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006448066	0.99355197
ENST00000410007	ENST00000459839	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.003846748	0.9961533
ENST00000409057	ENST00000307092	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006406125	0.9935939
ENST00000409057	ENST00000307076	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006745168	0.99325484
ENST00000409057	ENST00000422318	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006448066	0.99355197
ENST00000409057	ENST00000459839	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.003846748	0.9961533
ENST00000409114	ENST00000307092	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006406125	0.9935939
ENST00000409114	ENST00000307076	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006745168	0.99325484
ENST00000409114	ENST00000422318	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006448066	0.99355197
ENST00000409114	ENST00000459839	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.003846748	0.9961533
ENST00000409767	ENST00000307092	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006406125	0.9935939
ENST00000409767	ENST00000307076	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006745168	0.99325484
ENST00000409767	ENST00000422318	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.006448066	0.99355197
ENST00000409767	ENST00000459839	PBRM1	chr3	52702514	-	NT5DC2	chr3	52559311	-	0.003846748	0.9961533

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63007_63007_1_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000296302_NT5DC2_chr3_52559311_ENST00000307076_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_2_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000296302_NT5DC2_chr3_52559311_ENST00000307092_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_3_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000296302_NT5DC2_chr3_52559311_ENST00000422318_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_4_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000296302_NT5DC2_chr3_52559311_ENST00000459839_length(amino acids)=313AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_5_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000337303_NT5DC2_chr3_52559311_ENST00000307076_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_6_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000337303_NT5DC2_chr3_52559311_ENST00000307092_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_7_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000337303_NT5DC2_chr3_52559311_ENST00000422318_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_8_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000337303_NT5DC2_chr3_52559311_ENST00000459839_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_9_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000356770_NT5DC2_chr3_52559311_ENST00000307076_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_10_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000356770_NT5DC2_chr3_52559311_ENST00000307092_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_11_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000356770_NT5DC2_chr3_52559311_ENST00000422318_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_12_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000356770_NT5DC2_chr3_52559311_ENST00000459839_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_13_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000409057_NT5DC2_chr3_52559311_ENST00000307076_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_14_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000409057_NT5DC2_chr3_52559311_ENST00000307092_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_15_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000409057_NT5DC2_chr3_52559311_ENST00000422318_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_16_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000409057_NT5DC2_chr3_52559311_ENST00000459839_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_17_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000409114_NT5DC2_chr3_52559311_ENST00000307076_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_18_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000409114_NT5DC2_chr3_52559311_ENST00000307092_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_19_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000409114_NT5DC2_chr3_52559311_ENST00000422318_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_20_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000409114_NT5DC2_chr3_52559311_ENST00000459839_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_21_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000409767_NT5DC2_chr3_52559311_ENST00000307076_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_22_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000409767_NT5DC2_chr3_52559311_ENST00000307092_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_23_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000409767_NT5DC2_chr3_52559311_ENST00000422318_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_24_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000409767_NT5DC2_chr3_52559311_ENST00000459839_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_25_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000410007_NT5DC2_chr3_52559311_ENST00000307076_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_26_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000410007_NT5DC2_chr3_52559311_ENST00000307092_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_27_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000410007_NT5DC2_chr3_52559311_ENST00000422318_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

>63007_63007_28_PBRM1-NT5DC2_PBRM1_chr3_52702514_ENST00000410007_NT5DC2_chr3_52559311_ENST00000459839_length(amino acids)=312AA_BP=0
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRI
INTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLN

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52702514/chr3:52559311)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000296302

1468_1599

128.0

1690.0

Compositional bias

Note=Pro-rich

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000296302

630_633

128.0

1690.0

Compositional bias

Note=Poly-Asp

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000337303

1468_1599

128.0

1583.0

Compositional bias

Note=Pro-rich

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000337303

630_633

128.0

1583.0

Compositional bias

Note=Poly-Asp

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000356770

1468_1599

128.0

1603.0

Compositional bias

Note=Pro-rich

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000356770

630_633

128.0

1603.0

Compositional bias

Note=Poly-Asp

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000394830

1468_1599

128.0

1583.0

Compositional bias

Note=Pro-rich

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000394830

630_633

128.0

1583.0

Compositional bias

Note=Poly-Asp

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409057

1468_1599

128.0

1635.0

Compositional bias

Note=Pro-rich

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409057

630_633

128.0

1635.0

Compositional bias

Note=Poly-Asp

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409114

1468_1599

128.0

1653.0

Compositional bias

Note=Pro-rich

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409114

630_633

128.0

1653.0

Compositional bias

Note=Poly-Asp

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409767

1468_1599

128.0

1598.0

Compositional bias

Note=Pro-rich

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409767

630_633

128.0

1598.0

Compositional bias

Note=Poly-Asp

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000410007

1468_1599

128.0

1610.0

Compositional bias

Note=Pro-rich

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000410007

630_633

128.0

1610.0

Compositional bias

Note=Poly-Asp

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000296302

1379_1447

128.0

1690.0

DNA binding

HMG box

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000337303

1379_1447

128.0

1583.0

DNA binding

HMG box

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000356770

1379_1447

128.0

1603.0

DNA binding

HMG box

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000394830

1379_1447

128.0

1583.0

DNA binding

HMG box

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409057

1379_1447

128.0

1635.0

DNA binding

HMG box

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409114

1379_1447

128.0

1653.0

DNA binding

HMG box

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409767

1379_1447

128.0

1598.0

DNA binding

HMG box

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000410007

1379_1447

128.0

1610.0

DNA binding

HMG box

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000296302

1156_1272

128.0

1690.0

Domain

BAH 2

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000296302

200_270

128.0

1690.0

Domain

Bromo 2

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000296302

400_470

128.0

1690.0

Domain

Bromo 3

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000296302

538_608

128.0

1690.0

Domain

Bromo 4

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000296302

64_134

128.0

1690.0

Domain

Bromo 1

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000296302

676_746

128.0

1690.0

Domain

Bromo 5

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000296302

792_862

128.0

1690.0

Domain

Bromo 6

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000296302

956_1074

128.0

1690.0

Domain

BAH 1

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000337303

1156_1272

128.0

1583.0

Domain

BAH 2

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000337303

200_270

128.0

1583.0

Domain

Bromo 2

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000337303

400_470

128.0

1583.0

Domain

Bromo 3

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000337303

538_608

128.0

1583.0

Domain

Bromo 4

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000337303

64_134

128.0

1583.0

Domain

Bromo 1

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000337303

676_746

128.0

1583.0

Domain

Bromo 5

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000337303

792_862

128.0

1583.0

Domain

Bromo 6

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000337303

956_1074

128.0

1583.0

Domain

BAH 1

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000356770

1156_1272

128.0

1603.0

Domain

BAH 2

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000356770

200_270

128.0

1603.0

Domain

Bromo 2

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000356770

400_470

128.0

1603.0

Domain

Bromo 3

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000356770

538_608

128.0

1603.0

Domain

Bromo 4

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000356770

64_134

128.0

1603.0

Domain

Bromo 1

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000356770

676_746

128.0

1603.0

Domain

Bromo 5

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000356770

792_862

128.0

1603.0

Domain

Bromo 6

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000356770

956_1074

128.0

1603.0

Domain

BAH 1

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000394830

1156_1272

128.0

1583.0

Domain

BAH 2

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000394830

200_270

128.0

1583.0

Domain

Bromo 2

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000394830

400_470

128.0

1583.0

Domain

Bromo 3

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000394830

538_608

128.0

1583.0

Domain

Bromo 4

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000394830

64_134

128.0

1583.0

Domain

Bromo 1

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000394830

676_746

128.0

1583.0

Domain

Bromo 5

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000394830

792_862

128.0

1583.0

Domain

Bromo 6

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000394830

956_1074

128.0

1583.0

Domain

BAH 1

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409057

1156_1272

128.0

1635.0

Domain

BAH 2

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409057

200_270

128.0

1635.0

Domain

Bromo 2

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409057

400_470

128.0

1635.0

Domain

Bromo 3

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409057

538_608

128.0

1635.0

Domain

Bromo 4

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409057

64_134

128.0

1635.0

Domain

Bromo 1

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409057

676_746

128.0

1635.0

Domain

Bromo 5

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409057

792_862

128.0

1635.0

Domain

Bromo 6

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409057

956_1074

128.0

1635.0

Domain

BAH 1

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409114

1156_1272

128.0

1653.0

Domain

BAH 2

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409114

200_270

128.0

1653.0

Domain

Bromo 2

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409114

400_470

128.0

1653.0

Domain

Bromo 3

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409114

538_608

128.0

1653.0

Domain

Bromo 4

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409114

64_134

128.0

1653.0

Domain

Bromo 1

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409114

676_746

128.0

1653.0

Domain

Bromo 5

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409114

792_862

128.0

1653.0

Domain

Bromo 6

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409114

956_1074

128.0

1653.0

Domain

BAH 1

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409767

1156_1272

128.0

1598.0

Domain

BAH 2

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409767

200_270

128.0

1598.0

Domain

Bromo 2

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409767

400_470

128.0

1598.0

Domain

Bromo 3

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409767

538_608

128.0

1598.0

Domain

Bromo 4

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409767

64_134

128.0

1598.0

Domain

Bromo 1

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409767

676_746

128.0

1598.0

Domain

Bromo 5

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409767

792_862

128.0

1598.0

Domain

Bromo 6

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000409767

956_1074

128.0

1598.0

Domain

BAH 1

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000410007

1156_1272

128.0

1610.0

Domain

BAH 2

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000410007

200_270

128.0

1610.0

Domain

Bromo 2

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000410007

400_470

128.0

1610.0

Domain

Bromo 3

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000410007

538_608

128.0

1610.0

Domain

Bromo 4

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000410007

64_134

128.0

1610.0

Domain

Bromo 1

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000410007

676_746

128.0

1610.0

Domain

Bromo 5

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000410007

792_862

128.0

1610.0

Domain

Bromo 6

Hgene

PBRM1

chr3:52702514

chr3:52559311

ENST00000410007

956_1074

128.0

1610.0

Domain

BAH 1

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

AA seq

Len(AA seq)

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PBRM1_pLDDT.png

NT5DC2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PBRM1
NT5DC2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to PBRM1-NT5DC2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PBRM1-NT5DC2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source