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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PBRM1-TMEM110

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PBRM1-TMEM110
FusionPDB ID: 63011
FusionGDB2.0 ID: 63011
HgeneTgene
Gene symbol

PBRM1

TMEM110

Gene ID

55193

375346

Gene namepolybromo 1STIM activating enhancer
SynonymsBAF180|PB1TMEM110
Cytomap

3p21.1

3p21.1

Type of geneprotein-codingprotein-coding
Descriptionprotein polybromo-1BRG1-associated factor 180polybromo-1Dstore-operated calcium entry regulator STIMATESTIM-activating enhancer encoded by TMEM110transmembrane protein 110
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000296302, ENST00000337303, 
ENST00000356770, ENST00000394830, 
ENST00000409057, ENST00000409114, 
ENST00000409767, ENST00000410007, 
ENST00000464769, ENST00000355083, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 15 X 10=22504 X 2 X 3=24
# samples 194
** MAII scorelog2(19/2250*10)=-3.56585367777345
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PBRM1 [Title/Abstract] AND TMEM110 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PBRM1(52584437)-TMEM110(52889460), # samples:2
Anticipated loss of major functional domain due to fusion event.PBRM1-TMEM110 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PBRM1-TMEM110 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PBRM1-TMEM110 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PBRM1-TMEM110 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PBRM1-TMEM110 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PBRM1-TMEM110 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PBRM1-TMEM110 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PBRM1-TMEM110 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PBRM1-TMEM110 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PBRM1-TMEM110 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTMEM110

GO:0032237

activation of store-operated calcium channel activity

26322679|26644574

TgeneTMEM110

GO:0035584

calcium-mediated signaling using intracellular calcium source

26644574

TgeneTMEM110

GO:0070886

positive regulation of calcineurin-NFAT signaling cascade

26644574


check buttonFusion gene breakpoints across PBRM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM110 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-8085-01APBRM1chr3

52584437

-TMEM110chr3

52889460

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356770PBRM1chr352584437-ENST00000355083TMEM110chr352889460-91024639353631786
ENST00000296302PBRM1chr352584437-ENST00000355083TMEM110chr352889460-93624899256231873
ENST00000337303PBRM1chr352584437-ENST00000355083TMEM110chr352889460-90424579353031766
ENST00000410007PBRM1chr352584437-ENST00000355083TMEM110chr352889460-91234660353841793
ENST00000409057PBRM1chr352584437-ENST00000355083TMEM110chr352889460-91984735354591818
ENST00000409114PBRM1chr352584437-ENST00000355083TMEM110chr352889460-92524789355131836
ENST00000409767PBRM1chr352584437-ENST00000355083TMEM110chr352889460-90874624353481781

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356770ENST00000355083PBRM1chr352584437-TMEM110chr352889460-0.0002026040.9997974
ENST00000296302ENST00000355083PBRM1chr352584437-TMEM110chr352889460-0.0004289940.999571
ENST00000337303ENST00000355083PBRM1chr352584437-TMEM110chr352889460-0.0002745870.9997254
ENST00000410007ENST00000355083PBRM1chr352584437-TMEM110chr352889460-0.00075430.99924576
ENST00000409057ENST00000355083PBRM1chr352584437-TMEM110chr352889460-0.0002090530.99979097
ENST00000409114ENST00000355083PBRM1chr352584437-TMEM110chr352889460-0.0003688360.99963117
ENST00000409767ENST00000355083PBRM1chr352584437-TMEM110chr352889460-0.0002790820.9997209

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63011_63011_1_PBRM1-TMEM110_PBRM1_chr3_52584437_ENST00000296302_TMEM110_chr3_52889460_ENST00000355083_length(amino acids)=1873AA_BP=1630
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGE
KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHG
LVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLA
SELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEERAAKVAEQQE
RERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGL
PGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAE
SNSISKWDQTLAVKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVSVLVEW
QQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFWVVDNFLMRKG

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>63011_63011_2_PBRM1-TMEM110_PBRM1_chr3_52584437_ENST00000337303_TMEM110_chr3_52889460_ENST00000355083_length(amino acids)=1766AA_BP=1523
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGE
KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHG
LVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLA
SELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGVMNQGVAPMV
GTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAVKRFR
EPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQC
GAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFWVVDNFLMRKGKTKAKLEERGANQDSRN

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>63011_63011_3_PBRM1-TMEM110_PBRM1_chr3_52584437_ENST00000356770_TMEM110_chr3_52889460_ENST00000355083_length(amino acids)=1786AA_BP=1543
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMSNKRAVQGGRLSAITMALQYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFYQLYDT
VRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQA
KKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIE
HNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKL
NEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVL
HKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQE
HMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSE
DSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDY
YNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKN
TDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEET
EHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFR
KPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKIN
MSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGV
PGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGL
SAESNSISKWDQTLAVKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVSVL
VEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFWVVDNFLM

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>63011_63011_4_PBRM1-TMEM110_PBRM1_chr3_52584437_ENST00000409057_TMEM110_chr3_52889460_ENST00000355083_length(amino acids)=1818AA_BP=1575
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGE
KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI
SSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHG
LVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESR
YNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLA
SELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGMMGGYPPGLP
PLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPV
IQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAVKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTE
EDPCSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNP
IENPDLKLAIVMLIVPFFVNALMFWVVDNFLMRKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDVEEDLRR

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>63011_63011_5_PBRM1-TMEM110_PBRM1_chr3_52584437_ENST00000409114_TMEM110_chr3_52889460_ENST00000355083_length(amino acids)=1836AA_BP=1593
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEI
LLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQP
HIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSA
KTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYND
MWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCR
PTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSE
VIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKK
AEYEERAAKVAEQQERERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPP
GQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAVKRFREPKHERRPWRIWFLDTSKQA
IGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSV
VFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFWVVDNFLMRKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEIL

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>63011_63011_6_PBRM1-TMEM110_PBRM1_chr3_52584437_ENST00000409767_TMEM110_chr3_52889460_ENST00000355083_length(amino acids)=1781AA_BP=1538
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKI
LFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILE
KLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMD
MEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDD
EGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEI
LLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQP
HIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSA
KTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYND
MWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCR
PTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSE
VIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKK
AEYEGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESN
SISKWDQTLAVKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQ
WESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFWVVDNFLMRKGKT

--------------------------------------------------------------

>63011_63011_7_PBRM1-TMEM110_PBRM1_chr3_52584437_ENST00000410007_TMEM110_chr3_52889460_ENST00000355083_length(amino acids)=1793AA_BP=1550
MGSKRRRATSPSSSVSGDFDDGHHSVSTPGPSRKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQ
PIDLMKIQQKLKMEEYDDVNLLTADFQLLFNNAKSYYKPDSPEYKAACKLWDLYLRTRNEFVQKGEADDEDDDEDGQDNQGTVTEGSSPA
YLKEILEQLLEAIVVATNPSGRLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVF
KDANSIKKIFYMKKAEIEHHEMAKSSLRMRTPSNLAAARLTGPSHSKGSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAA
LAAARYEEGESEAESITSFMDVSNPFYQLYDTVRSCRNNQGQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKNQEYETLDHLEC
DLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGR
RLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPD
DDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQD
IDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAV
DPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHN
DVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAEK
EVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANAD
KGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPI
FIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVD
DEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKE
GSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPP
HHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAY
LKYIEGLSAESNSISKWDQTLAVKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVG
VRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFW

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52584437/chr3:52889460)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-29301468_15991632.33333333333331690.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-2930630_6331632.33333333333331690.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-2728630_6331525.33333333333331583.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-2728630_6331545.33333333333331603.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-2930630_6331525.33333333333331583.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-2829630_6331577.33333333333331635.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-2930630_6331595.33333333333331653.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-2829630_6331540.33333333333331598.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-2829630_6331552.33333333333331610.0Compositional biasNote=Poly-Asp
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-29301379_14471632.33333333333331690.0DNA bindingHMG box
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-27281379_14471525.33333333333331583.0DNA bindingHMG box
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-27281379_14471545.33333333333331603.0DNA bindingHMG box
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-29301379_14471525.33333333333331583.0DNA bindingHMG box
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-28291379_14471577.33333333333331635.0DNA bindingHMG box
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-29301379_14471595.33333333333331653.0DNA bindingHMG box
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-28291379_14471540.33333333333331598.0DNA bindingHMG box
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-28291379_14471552.33333333333331610.0DNA bindingHMG box
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-29301156_12721632.33333333333331690.0DomainBAH 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-2930200_2701632.33333333333331690.0DomainBromo 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-2930400_4701632.33333333333331690.0DomainBromo 3
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-2930538_6081632.33333333333331690.0DomainBromo 4
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-293064_1341632.33333333333331690.0DomainBromo 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-2930676_7461632.33333333333331690.0DomainBromo 5
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-2930792_8621632.33333333333331690.0DomainBromo 6
HgenePBRM1chr3:52584437chr3:52889460ENST00000296302-2930956_10741632.33333333333331690.0DomainBAH 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-27281156_12721525.33333333333331583.0DomainBAH 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-2728200_2701525.33333333333331583.0DomainBromo 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-2728400_4701525.33333333333331583.0DomainBromo 3
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-2728538_6081525.33333333333331583.0DomainBromo 4
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-272864_1341525.33333333333331583.0DomainBromo 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-2728676_7461525.33333333333331583.0DomainBromo 5
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-2728792_8621525.33333333333331583.0DomainBromo 6
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-2728956_10741525.33333333333331583.0DomainBAH 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-27281156_12721545.33333333333331603.0DomainBAH 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-2728200_2701545.33333333333331603.0DomainBromo 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-2728400_4701545.33333333333331603.0DomainBromo 3
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-2728538_6081545.33333333333331603.0DomainBromo 4
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-272864_1341545.33333333333331603.0DomainBromo 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-2728676_7461545.33333333333331603.0DomainBromo 5
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-2728792_8621545.33333333333331603.0DomainBromo 6
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-2728956_10741545.33333333333331603.0DomainBAH 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-29301156_12721525.33333333333331583.0DomainBAH 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-2930200_2701525.33333333333331583.0DomainBromo 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-2930400_4701525.33333333333331583.0DomainBromo 3
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-2930538_6081525.33333333333331583.0DomainBromo 4
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-293064_1341525.33333333333331583.0DomainBromo 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-2930676_7461525.33333333333331583.0DomainBromo 5
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-2930792_8621525.33333333333331583.0DomainBromo 6
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-2930956_10741525.33333333333331583.0DomainBAH 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-28291156_12721577.33333333333331635.0DomainBAH 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-2829200_2701577.33333333333331635.0DomainBromo 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-2829400_4701577.33333333333331635.0DomainBromo 3
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-2829538_6081577.33333333333331635.0DomainBromo 4
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-282964_1341577.33333333333331635.0DomainBromo 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-2829676_7461577.33333333333331635.0DomainBromo 5
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-2829792_8621577.33333333333331635.0DomainBromo 6
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-2829956_10741577.33333333333331635.0DomainBAH 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-29301156_12721595.33333333333331653.0DomainBAH 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-2930200_2701595.33333333333331653.0DomainBromo 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-2930400_4701595.33333333333331653.0DomainBromo 3
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-2930538_6081595.33333333333331653.0DomainBromo 4
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-293064_1341595.33333333333331653.0DomainBromo 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-2930676_7461595.33333333333331653.0DomainBromo 5
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-2930792_8621595.33333333333331653.0DomainBromo 6
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-2930956_10741595.33333333333331653.0DomainBAH 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-28291156_12721540.33333333333331598.0DomainBAH 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-2829200_2701540.33333333333331598.0DomainBromo 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-2829400_4701540.33333333333331598.0DomainBromo 3
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-2829538_6081540.33333333333331598.0DomainBromo 4
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-282964_1341540.33333333333331598.0DomainBromo 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-2829676_7461540.33333333333331598.0DomainBromo 5
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-2829792_8621540.33333333333331598.0DomainBromo 6
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-2829956_10741540.33333333333331598.0DomainBAH 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-28291156_12721552.33333333333331610.0DomainBAH 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-2829200_2701552.33333333333331610.0DomainBromo 2
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-2829400_4701552.33333333333331610.0DomainBromo 3
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-2829538_6081552.33333333333331610.0DomainBromo 4
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-282964_1341552.33333333333331610.0DomainBromo 1
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-2829676_7461552.33333333333331610.0DomainBromo 5
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-2829792_8621552.33333333333331610.0DomainBromo 6
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-2829956_10741552.33333333333331610.0DomainBAH 1
TgeneTMEM110chr3:52584437chr3:52889460ENST0000035508308149_15353.333333333333336295.0MotifGXXXG motif
TgeneTMEM110chr3:52584437chr3:52889460ENST0000035508308215_29453.333333333333336295.0Topological domainCytoplasmic
TgeneTMEM110chr3:52584437chr3:52889460ENST0000035508308102_12253.333333333333336295.0TransmembraneHelical
TgeneTMEM110chr3:52584437chr3:52889460ENST0000035508308156_17653.333333333333336295.0TransmembraneHelical
TgeneTMEM110chr3:52584437chr3:52889460ENST0000035508308194_21453.333333333333336295.0TransmembraneHelical
TgeneTMEM110chr3:52584437chr3:52889460ENST000003550830869_8953.333333333333336295.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePBRM1chr3:52584437chr3:52889460ENST00000337303-27281468_15991525.33333333333331583.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52584437chr3:52889460ENST00000356770-27281468_15991545.33333333333331603.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52584437chr3:52889460ENST00000394830-29301468_15991525.33333333333331583.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52584437chr3:52889460ENST00000409057-28291468_15991577.33333333333331635.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52584437chr3:52889460ENST00000409114-29301468_15991595.33333333333331653.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52584437chr3:52889460ENST00000409767-28291468_15991540.33333333333331598.0Compositional biasNote=Pro-rich
HgenePBRM1chr3:52584437chr3:52889460ENST00000410007-28291468_15991552.33333333333331610.0Compositional biasNote=Pro-rich
TgeneTMEM110chr3:52584437chr3:52889460ENST00000355083081_2853.333333333333336295.0Topological domainCytoplasmic
TgeneTMEM110chr3:52584437chr3:52889460ENST000003550830829_4953.333333333333336295.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PBRM1
TMEM110


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PBRM1-TMEM110


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PBRM1-TMEM110


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource