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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PBX1-ILDR2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PBX1-ILDR2
FusionPDB ID: 63024
FusionGDB2.0 ID: 63024
HgeneTgene
Gene symbol

PBX1

ILDR2

Gene ID

5087

387597

Gene namePBX homeobox 1immunoglobulin like domain containing receptor 2
SynonymsCAKUHEDC1orf32|dJ782G3.1
Cytomap

1q23.3

1q24.1

Type of geneprotein-codingprotein-coding
Descriptionpre-B-cell leukemia transcription factor 1homeobox protein PBX1homeobox protein PRLpre-B-cell leukemia homeobox 1immunoglobulin-like domain-containing receptor 2
Modification date2020031320200313
UniProtAcc

P40424

Q71H61

Ensembl transtripts involved in fusion geneENST idsENST00000367897, ENST00000401534, 
ENST00000420696, ENST00000540236, 
ENST00000559240, ENST00000474046, 
ENST00000485769, ENST00000540246, 
ENST00000560641, 		ENST00000271417, 
ENST00000469934, ENST00000525740, 
ENST00000526687, ENST00000528703, 
ENST00000529071, ENST00000529387, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 10 X 5=8006 X 6 X 4=144
# samples 216
** MAII scorelog2(21/800*10)=-1.9296106721086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PBX1 [Title/Abstract] AND ILDR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PBX1(164532548)-ILDR2(166927338), # samples:3
Anticipated loss of major functional domain due to fusion event.PBX1-ILDR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PBX1-ILDR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PBX1-ILDR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PBX1-ILDR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PBX1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ILDR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0YM-01APBX1chr1

164532548

-ILDR2chr1

166927338

-
ChimerDB4BRCATCGA-A2-A0YM-01APBX1chr1

164532548

+ILDR2chr1

166927338

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000420696PBX1chr1164532548+ENST00000271417ILDR2chr1166927338-84764531822326714
ENST00000420696PBX1chr1164532548+ENST00000529387ILDR2chr1166927338-1431453182910242
ENST00000420696PBX1chr1164532548+ENST00000528703ILDR2chr1166927338-26394531822149655
ENST00000420696PBX1chr1164532548+ENST00000526687ILDR2chr1166927338-24924531822002606
ENST00000420696PBX1chr1164532548+ENST00000469934ILDR2chr1166927338-21434531821720512
ENST00000420696PBX1chr1164532548+ENST00000525740ILDR2chr1166927338-24354531821945587
ENST00000420696PBX1chr1164532548+ENST00000529071ILDR2chr1166927338-27594531822269695
ENST00000401534PBX1chr1164532548+ENST00000271417ILDR2chr1166927338-828826502138712
ENST00000401534PBX1chr1164532548+ENST00000529387ILDR2chr1166927338-12432650722240
ENST00000401534PBX1chr1164532548+ENST00000528703ILDR2chr1166927338-245126501961653
ENST00000401534PBX1chr1164532548+ENST00000526687ILDR2chr1166927338-230426501814604
ENST00000401534PBX1chr1164532548+ENST00000469934ILDR2chr1166927338-195526501532510
ENST00000401534PBX1chr1164532548+ENST00000525740ILDR2chr1166927338-224726501757585
ENST00000401534PBX1chr1164532548+ENST00000529071ILDR2chr1166927338-257126502081693
ENST00000559240PBX1chr1164532548+ENST00000271417ILDR2chr1166927338-828826502138712
ENST00000559240PBX1chr1164532548+ENST00000529387ILDR2chr1166927338-12432650722240
ENST00000559240PBX1chr1164532548+ENST00000528703ILDR2chr1166927338-245126501961653
ENST00000559240PBX1chr1164532548+ENST00000526687ILDR2chr1166927338-230426501814604
ENST00000559240PBX1chr1164532548+ENST00000469934ILDR2chr1166927338-195526501532510
ENST00000559240PBX1chr1164532548+ENST00000525740ILDR2chr1166927338-224726501757585
ENST00000559240PBX1chr1164532548+ENST00000529071ILDR2chr1166927338-257126502081693
ENST00000367897PBX1chr1164532548+ENST00000271417ILDR2chr1166927338-828826502138712
ENST00000367897PBX1chr1164532548+ENST00000529387ILDR2chr1166927338-12432650722240
ENST00000367897PBX1chr1164532548+ENST00000528703ILDR2chr1166927338-245126501961653
ENST00000367897PBX1chr1164532548+ENST00000526687ILDR2chr1166927338-230426501814604
ENST00000367897PBX1chr1164532548+ENST00000469934ILDR2chr1166927338-195526501532510
ENST00000367897PBX1chr1164532548+ENST00000525740ILDR2chr1166927338-224726501757585
ENST00000367897PBX1chr1164532548+ENST00000529071ILDR2chr1166927338-257126502081693
ENST00000540236PBX1chr1164532548+ENST00000271417ILDR2chr1166927338-828826502138712
ENST00000540236PBX1chr1164532548+ENST00000529387ILDR2chr1166927338-12432650722240
ENST00000540236PBX1chr1164532548+ENST00000528703ILDR2chr1166927338-245126501961653
ENST00000540236PBX1chr1164532548+ENST00000526687ILDR2chr1166927338-230426501814604
ENST00000540236PBX1chr1164532548+ENST00000469934ILDR2chr1166927338-195526501532510
ENST00000540236PBX1chr1164532548+ENST00000525740ILDR2chr1166927338-224726501757585
ENST00000540236PBX1chr1164532548+ENST00000529071ILDR2chr1166927338-257126502081693

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000420696ENST00000271417PBX1chr1164532548+ILDR2chr1166927338-0.0030378830.99696213
ENST00000420696ENST00000529387PBX1chr1164532548+ILDR2chr1166927338-0.0066351130.99336493
ENST00000420696ENST00000528703PBX1chr1164532548+ILDR2chr1166927338-0.0166561570.9833438
ENST00000420696ENST00000526687PBX1chr1164532548+ILDR2chr1166927338-0.0110266710.9889733
ENST00000420696ENST00000469934PBX1chr1164532548+ILDR2chr1166927338-0.009628840.99037117
ENST00000420696ENST00000525740PBX1chr1164532548+ILDR2chr1166927338-0.009438830.9905612
ENST00000420696ENST00000529071PBX1chr1164532548+ILDR2chr1166927338-0.0153460060.984654
ENST00000401534ENST00000271417PBX1chr1164532548+ILDR2chr1166927338-0.003008990.99699104
ENST00000401534ENST00000529387PBX1chr1164532548+ILDR2chr1166927338-0.0045916530.99540836
ENST00000401534ENST00000528703PBX1chr1164532548+ILDR2chr1166927338-0.0188661180.9811338
ENST00000401534ENST00000526687PBX1chr1164532548+ILDR2chr1166927338-0.0123013140.9876987
ENST00000401534ENST00000469934PBX1chr1164532548+ILDR2chr1166927338-0.0098679680.990132
ENST00000401534ENST00000525740PBX1chr1164532548+ILDR2chr1166927338-0.0108955220.9891045
ENST00000401534ENST00000529071PBX1chr1164532548+ILDR2chr1166927338-0.0172542580.98274577
ENST00000559240ENST00000271417PBX1chr1164532548+ILDR2chr1166927338-0.003008990.99699104
ENST00000559240ENST00000529387PBX1chr1164532548+ILDR2chr1166927338-0.0045916530.99540836
ENST00000559240ENST00000528703PBX1chr1164532548+ILDR2chr1166927338-0.0188661180.9811338
ENST00000559240ENST00000526687PBX1chr1164532548+ILDR2chr1166927338-0.0123013140.9876987
ENST00000559240ENST00000469934PBX1chr1164532548+ILDR2chr1166927338-0.0098679680.990132
ENST00000559240ENST00000525740PBX1chr1164532548+ILDR2chr1166927338-0.0108955220.9891045
ENST00000559240ENST00000529071PBX1chr1164532548+ILDR2chr1166927338-0.0172542580.98274577
ENST00000367897ENST00000271417PBX1chr1164532548+ILDR2chr1166927338-0.003008990.99699104
ENST00000367897ENST00000529387PBX1chr1164532548+ILDR2chr1166927338-0.0045916530.99540836
ENST00000367897ENST00000528703PBX1chr1164532548+ILDR2chr1166927338-0.0188661180.9811338
ENST00000367897ENST00000526687PBX1chr1164532548+ILDR2chr1166927338-0.0123013140.9876987
ENST00000367897ENST00000469934PBX1chr1164532548+ILDR2chr1166927338-0.0098679680.990132
ENST00000367897ENST00000525740PBX1chr1164532548+ILDR2chr1166927338-0.0108955220.9891045
ENST00000367897ENST00000529071PBX1chr1164532548+ILDR2chr1166927338-0.0172542580.98274577
ENST00000540236ENST00000271417PBX1chr1164532548+ILDR2chr1166927338-0.003008990.99699104
ENST00000540236ENST00000529387PBX1chr1164532548+ILDR2chr1166927338-0.0045916530.99540836
ENST00000540236ENST00000528703PBX1chr1164532548+ILDR2chr1166927338-0.0188661180.9811338
ENST00000540236ENST00000526687PBX1chr1164532548+ILDR2chr1166927338-0.0123013140.9876987
ENST00000540236ENST00000469934PBX1chr1164532548+ILDR2chr1166927338-0.0098679680.990132
ENST00000540236ENST00000525740PBX1chr1164532548+ILDR2chr1166927338-0.0108955220.9891045
ENST00000540236ENST00000529071PBX1chr1164532548+ILDR2chr1166927338-0.0172542580.98274577

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63024_63024_1_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000367897_ILDR2_chr1_166927338_ENST00000271417_length(amino acids)=712AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVLLGV
FLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPSDS
TGGSHSVRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGV
MGGSSGASRGPSAMEYNKEDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSG
FYQDDSLEEYYGQRSRSREPLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQ

--------------------------------------------------------------

>63024_63024_2_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000367897_ILDR2_chr1_166927338_ENST00000469934_length(amino acids)=510AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVLLGV
FLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPSDS
TGGSHSVRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGV

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>63024_63024_3_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000367897_ILDR2_chr1_166927338_ENST00000525740_length(amino acids)=585AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLVRKGYRIQADKERDSMKVLYYVEKELAQFDP
ARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNKEDRESFRHSQPRSKSEMLS
RKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSREPLTDADRGWAFSPARRRP
AEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYKAGSSQDDQEDASDDALPPY

--------------------------------------------------------------

>63024_63024_4_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000367897_ILDR2_chr1_166927338_ENST00000526687_length(amino acids)=604AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPVRKGYRIQADKE
RDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNK
EDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSR
EPLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYK

--------------------------------------------------------------

>63024_63024_5_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000367897_ILDR2_chr1_166927338_ENST00000528703_length(amino acids)=653AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVLLGV
FLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQAFRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEED
SNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNKEDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADS
YGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSREPLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDH
SYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYKAGSSQDDQEDASDDALPPYSELELTRGPSYRGRDLPYHSNS

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>63024_63024_6_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000367897_ILDR2_chr1_166927338_ENST00000529071_length(amino acids)=693AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLEWVFVGLVLLGVFLFFVLVGICWCQCCPHSC
CCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPSDSTGGSHSVRKGYRIQADKER
DSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNKE
DRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSRE
PLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYKA

--------------------------------------------------------------

>63024_63024_7_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000367897_ILDR2_chr1_166927338_ENST00000529387_length(amino acids)=240AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ

--------------------------------------------------------------

>63024_63024_8_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000401534_ILDR2_chr1_166927338_ENST00000271417_length(amino acids)=712AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVLLGV
FLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPSDS
TGGSHSVRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGV
MGGSSGASRGPSAMEYNKEDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSG
FYQDDSLEEYYGQRSRSREPLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQ

--------------------------------------------------------------

>63024_63024_9_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000401534_ILDR2_chr1_166927338_ENST00000469934_length(amino acids)=510AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVLLGV
FLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPSDS
TGGSHSVRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGV

--------------------------------------------------------------

>63024_63024_10_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000401534_ILDR2_chr1_166927338_ENST00000525740_length(amino acids)=585AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLVRKGYRIQADKERDSMKVLYYVEKELAQFDP
ARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNKEDRESFRHSQPRSKSEMLS
RKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSREPLTDADRGWAFSPARRRP
AEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYKAGSSQDDQEDASDDALPPY

--------------------------------------------------------------

>63024_63024_11_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000401534_ILDR2_chr1_166927338_ENST00000526687_length(amino acids)=604AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPVRKGYRIQADKE
RDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNK
EDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSR
EPLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYK

--------------------------------------------------------------

>63024_63024_12_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000401534_ILDR2_chr1_166927338_ENST00000528703_length(amino acids)=653AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVLLGV
FLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQAFRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEED
SNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNKEDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADS
YGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSREPLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDH
SYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYKAGSSQDDQEDASDDALPPYSELELTRGPSYRGRDLPYHSNS

--------------------------------------------------------------

>63024_63024_13_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000401534_ILDR2_chr1_166927338_ENST00000529071_length(amino acids)=693AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLEWVFVGLVLLGVFLFFVLVGICWCQCCPHSC
CCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPSDSTGGSHSVRKGYRIQADKER
DSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNKE
DRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSRE
PLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYKA

--------------------------------------------------------------

>63024_63024_14_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000401534_ILDR2_chr1_166927338_ENST00000529387_length(amino acids)=240AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ

--------------------------------------------------------------

>63024_63024_15_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000420696_ILDR2_chr1_166927338_ENST00000271417_length(amino acids)=714AA_BP=90
MEMDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKT
AMVEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVAS
KQGSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVLL
GVFLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPS
DSTGGSHSVRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWS
GVMGGSSGASRGPSAMEYNKEDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAH
SGFYQDDSLEEYYGQRSRSREPLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRS

--------------------------------------------------------------

>63024_63024_16_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000420696_ILDR2_chr1_166927338_ENST00000469934_length(amino acids)=512AA_BP=90
MEMDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKT
AMVEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVAS
KQGSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVLL
GVFLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPS
DSTGGSHSVRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWS

--------------------------------------------------------------

>63024_63024_17_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000420696_ILDR2_chr1_166927338_ENST00000525740_length(amino acids)=587AA_BP=90
MEMDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKT
AMVEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVAS
KQGSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLVRKGYRIQADKERDSMKVLYYVEKELAQF
DPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNKEDRESFRHSQPRSKSEM
LSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSREPLTDADRGWAFSPARR
RPAEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYKAGSSQDDQEDASDDALP

--------------------------------------------------------------

>63024_63024_18_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000420696_ILDR2_chr1_166927338_ENST00000526687_length(amino acids)=606AA_BP=90
MEMDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKT
AMVEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVAS
KQGSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPVRKGYRIQAD
KERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEY
NKEDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSR
SREPLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGT

--------------------------------------------------------------

>63024_63024_19_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000420696_ILDR2_chr1_166927338_ENST00000528703_length(amino acids)=655AA_BP=90
MEMDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKT
AMVEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVAS
KQGSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVLL
GVFLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQAFRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHE
EDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNKEDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFA
DSYGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSREPLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKY
DHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYKAGSSQDDQEDASDDALPPYSELELTRGPSYRGRDLPYHS

--------------------------------------------------------------

>63024_63024_20_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000420696_ILDR2_chr1_166927338_ENST00000529071_length(amino acids)=695AA_BP=90
MEMDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKT
AMVEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVAS
KQGSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLEWVFVGLVLLGVFLFFVLVGICWCQCCPH
SCCCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPSDSTGGSHSVRKGYRIQADK
ERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYN
KEDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRS
REPLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTY

--------------------------------------------------------------

>63024_63024_21_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000420696_ILDR2_chr1_166927338_ENST00000529387_length(amino acids)=242AA_BP=90
MEMDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKT
AMVEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVAS

--------------------------------------------------------------

>63024_63024_22_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000540236_ILDR2_chr1_166927338_ENST00000271417_length(amino acids)=712AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVLLGV
FLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPSDS
TGGSHSVRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGV
MGGSSGASRGPSAMEYNKEDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSG
FYQDDSLEEYYGQRSRSREPLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQ

--------------------------------------------------------------

>63024_63024_23_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000540236_ILDR2_chr1_166927338_ENST00000469934_length(amino acids)=510AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVLLGV
FLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPSDS
TGGSHSVRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGV

--------------------------------------------------------------

>63024_63024_24_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000540236_ILDR2_chr1_166927338_ENST00000525740_length(amino acids)=585AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLVRKGYRIQADKERDSMKVLYYVEKELAQFDP
ARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNKEDRESFRHSQPRSKSEMLS
RKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSREPLTDADRGWAFSPARRRP
AEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYKAGSSQDDQEDASDDALPPY

--------------------------------------------------------------

>63024_63024_25_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000540236_ILDR2_chr1_166927338_ENST00000526687_length(amino acids)=604AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPVRKGYRIQADKE
RDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNK
EDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSR
EPLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYK

--------------------------------------------------------------

>63024_63024_26_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000540236_ILDR2_chr1_166927338_ENST00000528703_length(amino acids)=653AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVLLGV
FLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQAFRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEED
SNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNKEDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADS
YGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSREPLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDH
SYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYKAGSSQDDQEDASDDALPPYSELELTRGPSYRGRDLPYHSNS

--------------------------------------------------------------

>63024_63024_27_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000540236_ILDR2_chr1_166927338_ENST00000529071_length(amino acids)=693AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLEWVFVGLVLLGVFLFFVLVGICWCQCCPHSC
CCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPSDSTGGSHSVRKGYRIQADKER
DSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNKE
DRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSRE
PLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYKA

--------------------------------------------------------------

>63024_63024_28_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000540236_ILDR2_chr1_166927338_ENST00000529387_length(amino acids)=240AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ

--------------------------------------------------------------

>63024_63024_29_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000559240_ILDR2_chr1_166927338_ENST00000271417_length(amino acids)=712AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVLLGV
FLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPSDS
TGGSHSVRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGV
MGGSSGASRGPSAMEYNKEDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSG
FYQDDSLEEYYGQRSRSREPLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQ

--------------------------------------------------------------

>63024_63024_30_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000559240_ILDR2_chr1_166927338_ENST00000469934_length(amino acids)=510AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVLLGV
FLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPSDS
TGGSHSVRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGV

--------------------------------------------------------------

>63024_63024_31_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000559240_ILDR2_chr1_166927338_ENST00000525740_length(amino acids)=585AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLVRKGYRIQADKERDSMKVLYYVEKELAQFDP
ARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNKEDRESFRHSQPRSKSEMLS
RKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSREPLTDADRGWAFSPARRRP
AEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYKAGSSQDDQEDASDDALPPY

--------------------------------------------------------------

>63024_63024_32_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000559240_ILDR2_chr1_166927338_ENST00000526687_length(amino acids)=604AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPVRKGYRIQADKE
RDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNK
EDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSR
EPLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYK

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>63024_63024_33_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000559240_ILDR2_chr1_166927338_ENST00000528703_length(amino acids)=653AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVLLGV
FLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQAFRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEED
SNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNKEDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADS
YGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSREPLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDH
SYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYKAGSSQDDQEDASDDALPPYSELELTRGPSYRGRDLPYHSNS

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>63024_63024_34_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000559240_ILDR2_chr1_166927338_ENST00000529071_length(amino acids)=693AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ
GSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLEWVFVGLVLLGVFLFFVLVGICWCQCCPHSC
CCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPSDSTGGSHSVRKGYRIQADKER
DSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNKE
DRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSRE
PLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYKA

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>63024_63024_35_PBX1-ILDR2_PBX1_chr1_164532548_ENST00000559240_ILDR2_chr1_166927338_ENST00000529387_length(amino acids)=240AA_BP=88
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTAM
VEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQ

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:164532548/chr1:166927338)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PBX1

P40424

ILDR2

Q71H61

FUNCTION: Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 (PubMed:9191052). Binds to the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein (PubMed:9191052). Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 (PubMed:8327485, PubMed:7791786). Acts as a transcriptional activator of PF4 in complex with MEIS1 (PubMed:12609849). Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence (By similarity). In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development (By similarity). Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1) (By similarity). Probably in complex with MEIS2, involved in transcriptional regulation by KLF4 (PubMed:21746878). Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B (By similarity). Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression (By similarity). {ECO:0000250|UniProtKB:P41778, ECO:0000269|PubMed:12609849, ECO:0000269|PubMed:21746878, ECO:0000269|PubMed:7791786, ECO:0000269|PubMed:8327485, ECO:0000269|PubMed:9191052}.; FUNCTION: [Isoform PBX1b]: As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. {ECO:0000250|UniProtKB:P41778}.FUNCTION: May be involved in lipid homeostasis and ER stress pathways. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneILDR2chr1:164532548chr1:166927338ENST00000271417010207_23115.333333333333334640.0Compositional biasNote=Cys-rich
TgeneILDR2chr1:164532548chr1:166927338ENST0000027141701021_16215.333333333333334640.0DomainNote=Ig-like V-type
TgeneILDR2chr1:164532548chr1:166927338ENST00000271417010208_63915.333333333333334640.0Topological domainCytoplasmic
TgeneILDR2chr1:164532548chr1:166927338ENST0000027141701021_18615.333333333333334640.0Topological domainLumenal
TgeneILDR2chr1:164532548chr1:166927338ENST00000271417010187_20715.333333333333334640.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePBX1chr1:164532548chr1:166927338ENST00000367897+28127_13588.33333333333333408.3333333333333Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:166927338ENST00000401534+27127_13588.33333333333333348.0Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:166927338ENST00000420696+29127_13588.33333333333333431.0Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:166927338ENST00000540236+29127_13588.33333333333333421.0Compositional biasNote=Poly-Ala
HgenePBX1chr1:164532548chr1:166927338ENST00000367897+28233_29588.33333333333333408.3333333333333DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:166927338ENST00000401534+27233_29588.33333333333333348.0DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:166927338ENST00000420696+29233_29588.33333333333333431.0DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:166927338ENST00000540236+29233_29588.33333333333333421.0DNA bindingHomeobox%3B TALE-type
HgenePBX1chr1:164532548chr1:166927338ENST00000367897+2840_23288.33333333333333408.3333333333333DomainPBC
HgenePBX1chr1:164532548chr1:166927338ENST00000401534+2740_23288.33333333333333348.0DomainPBC
HgenePBX1chr1:164532548chr1:166927338ENST00000420696+2940_23288.33333333333333431.0DomainPBC
HgenePBX1chr1:164532548chr1:166927338ENST00000540236+2940_23288.33333333333333421.0DomainPBC


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PBX1all structure
ILDR2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PBX1-ILDR2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PBX1-ILDR2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePBX1C0006413Burkitt Lymphoma2CTD_human;ORPHANET
HgenePBX1C0343640African Burkitt's lymphoma2CTD_human
HgenePBX1C1968949Cakut2GENOMICS_ENGLAND
HgenePBX1C4721444Burkitt Leukemia2CTD_human
HgenePBX1C0013146Drug abuse1CTD_human
HgenePBX1C0013170Drug habituation1CTD_human
HgenePBX1C0013222Drug Use Disorders1CTD_human
HgenePBX1C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgenePBX1C0038580Substance Dependence1CTD_human
HgenePBX1C0038586Substance Use Disorders1CTD_human
HgenePBX1C0236969Substance-Related Disorders1CTD_human
HgenePBX1C0431692Bilateral renal hypoplasia1ORPHANET
HgenePBX1C0740858Substance abuse problem1CTD_human
HgenePBX1C1510472Drug Dependence1CTD_human
HgenePBX1C4316881Prescription Drug Abuse1CTD_human
HgenePBX1C4539968CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT SYNDROME WITH OR WITHOUT HEARING LOSS, ABNORMAL EARS, OR DEVELOPMENTAL DELAY1GENOMICS_ENGLAND