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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PCCB-DLG1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PCCB-DLG1
FusionPDB ID: 63168
FusionGDB2.0 ID: 63168
HgeneTgene
Gene symbol

PCCB

DLG1

Gene ID

5096

1739

Gene namepropionyl-CoA carboxylase subunit betadiscs large MAGUK scaffold protein 1
Synonyms-DLGH1|SAP-97|SAP97|hdlg
Cytomap

3q22.3

3q29

Type of geneprotein-codingprotein-coding
Descriptionpropionyl-CoA carboxylase beta chain, mitochondrialPCCase subunit betapropanoyl-CoA:carbon dioxide ligase subunit betapropionyl CoA carboxylase, beta polypeptidepropionyl Coenzyme A carboxylase, beta polypeptidepropionyl-CoA carboxylase beta subunitdisks large homolog 1dJ1061C18.1.1discs large homolog 1, scribble cell polarity complex componentpresynaptic protein SAP97synapse-associated protein 97
Modification date2020031320200327
UniProtAcc.

Q12959

Ensembl transtripts involved in fusion geneENST idsENST00000251654, ENST00000462637, 
ENST00000466072, ENST00000468777, 
ENST00000469217, ENST00000471595, 
ENST00000482086, ENST00000483687, 
ENST00000490504, ENST00000474833, 
ENST00000478469, 		ENST00000485409, 
ENST00000392382, ENST00000422288, 
ENST00000443183, ENST00000448528, 
ENST00000450955, ENST00000452595, 
ENST00000314062, ENST00000346964, 
ENST00000357674, ENST00000419354, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 9 X 4=28814 X 15 X 6=1260
# samples 816
** MAII scorelog2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1260*10)=-2.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PCCB [Title/Abstract] AND DLG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PCCB(136048826)-DLG1(196921460), # samples:3
Anticipated loss of major functional domain due to fusion event.PCCB-DLG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PCCB-DLG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PCCB-DLG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PCCB-DLG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PCCB-DLG1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PCCB-DLG1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PCCB-DLG1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PCCB-DLG1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDLG1

GO:0001935

endothelial cell proliferation

14699157

TgeneDLG1

GO:0007015

actin filament organization

14699157

TgeneDLG1

GO:0030866

cortical actin cytoskeleton organization

14699157

TgeneDLG1

GO:0042391

regulation of membrane potential

12970345

TgeneDLG1

GO:0043268

positive regulation of potassium ion transport

12970345

TgeneDLG1

GO:0070830

bicellular tight junction assembly

17332497

TgeneDLG1

GO:0098609

cell-cell adhesion

14699157

TgeneDLG1

GO:1902473

regulation of protein localization to synapse

23676497

TgeneDLG1

GO:1903078

positive regulation of protein localization to plasma membrane

12970345


check buttonFusion gene breakpoints across PCCB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DLG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A08P-01APCCBchr3

136047699

+DLG1chr3

196921460

-
ChimerDB4BRCATCGA-A8-A08P-01APCCBchr3

136048826

-DLG1chr3

196921460

-
ChimerDB4BRCATCGA-A8-A08P-01APCCBchr3

136048826

+DLG1chr3

196921460

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000471595PCCBchr3136048826+ENST00000357674DLG1chr3196921460-602315961839591313
ENST00000471595PCCBchr3136048826+ENST00000314062DLG1chr3196921460-590315961838391273
ENST00000471595PCCBchr3136048826+ENST00000346964DLG1chr3196921460-612215961840581346
ENST00000471595PCCBchr3136048826+ENST00000419354DLG1chr3196921460-498515961839921324
ENST00000469217PCCBchr3136048826+ENST00000357674DLG1chr3196921460-6188176118424124760
ENST00000469217PCCBchr3136048826+ENST00000314062DLG1chr3196921460-6068176118424004720
ENST00000469217PCCBchr3136048826+ENST00000346964DLG1chr3196921460-6287176118424223793
ENST00000469217PCCBchr3136048826+ENST00000419354DLG1chr3196921460-5150176118424157771

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000471595ENST00000357674PCCBchr3136048826+DLG1chr3196921460-0.0001320970.9998679
ENST00000471595ENST00000314062PCCBchr3136048826+DLG1chr3196921460-0.0001553060.9998447
ENST00000471595ENST00000346964PCCBchr3136048826+DLG1chr3196921460-0.0001293670.99987066
ENST00000471595ENST00000419354PCCBchr3136048826+DLG1chr3196921460-0.000296460.99970347
ENST00000469217ENST00000357674PCCBchr3136048826+DLG1chr3196921460-0.0002022260.99979776
ENST00000469217ENST00000314062PCCBchr3136048826+DLG1chr3196921460-0.0002167120.99978334
ENST00000469217ENST00000346964PCCBchr3136048826+DLG1chr3196921460-0.0001984090.9998016
ENST00000469217ENST00000419354PCCBchr3136048826+DLG1chr3196921460-0.0003355080.99966455

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63168_63168_1_PCCB-DLG1_PCCB_chr3_136048826_ENST00000469217_DLG1_chr3_196921460_ENST00000314062_length(amino acids)=720AA_BP=
MVHVSEKNLSEIENVHGFVSHSHISPIKVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVND
CILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGK
LQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAV
LGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQ
YRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGE
SDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMK
DRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNA
IKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL

--------------------------------------------------------------

>63168_63168_2_PCCB-DLG1_PCCB_chr3_136048826_ENST00000469217_DLG1_chr3_196921460_ENST00000346964_length(amino acids)=793AA_BP=
MVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYE
EITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPV
SEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVA
KPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISF
ILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRS
LYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGQSFND
KRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGS
CVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIK

--------------------------------------------------------------

>63168_63168_3_PCCB-DLG1_PCCB_chr3_136048826_ENST00000469217_DLG1_chr3_196921460_ENST00000357674_length(amino acids)=760AA_BP=
MVHVSEKNLSEIENVHGFVSHSHISPIKANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFIT
KIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDN
SIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSF
LGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHE
QAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVI
NASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTS
NASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQ
EHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEF

--------------------------------------------------------------

>63168_63168_4_PCCB-DLG1_PCCB_chr3_136048826_ENST00000469217_DLG1_chr3_196921460_ENST00000419354_length(amino acids)=771AA_BP=
MVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYE
EITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPV
SEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVA
KPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISF
ILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRS
LYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDD
MGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFV
TSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKT

--------------------------------------------------------------

>63168_63168_5_PCCB-DLG1_PCCB_chr3_136048826_ENST00000471595_DLG1_chr3_196921460_ENST00000314062_length(amino acids)=1273AA_BP=521
MAAALRVAAVGARLSVLASGLRAAVRSLCSQATSVNERIENKRRTALLGGGQRRIDAQHKRGKLTARERISLLLDPGSFVESDMFVEHRC
ADFGMAADKNKFPGDSVVTGRGRINGRLVYVFSQDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGLNDSGGARIQEGVESLAGYADIF
LRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKDTSYLFITGPDVVKSVTNEDVTQEELGGAKTHTTMSGVAHRAFENDVDALCN
LRDFFNYLPLSSQDPAPVRECHDPSDRLVPELDTIVPLESTKAYNMVDIIHSVVDEREFFEIMPNYAKNIIVGFARMNGRTVGIVGNQPK
VASGCLDINSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKVTVITRKAYGGAYDVMSSKHLCGD
TNYAWPTAEIAVMGAKGAVEIIFKGHENVEAAQAEYIEKFANPFPAAVRGFVDDIIQPSSTRARICCDLDVLASKKKYRYQDEDTPPQEH
ISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITG
GAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVT
KIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTP
ASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAA
LKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDD
EWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEV
NYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAE
KGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQ

--------------------------------------------------------------

>63168_63168_6_PCCB-DLG1_PCCB_chr3_136048826_ENST00000471595_DLG1_chr3_196921460_ENST00000346964_length(amino acids)=1346AA_BP=521
MAAALRVAAVGARLSVLASGLRAAVRSLCSQATSVNERIENKRRTALLGGGQRRIDAQHKRGKLTARERISLLLDPGSFVESDMFVEHRC
ADFGMAADKNKFPGDSVVTGRGRINGRLVYVFSQDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGLNDSGGARIQEGVESLAGYADIF
LRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKDTSYLFITGPDVVKSVTNEDVTQEELGGAKTHTTMSGVAHRAFENDVDALCN
LRDFFNYLPLSSQDPAPVRECHDPSDRLVPELDTIVPLESTKAYNMVDIIHSVVDEREFFEIMPNYAKNIIVGFARMNGRTVGIVGNQPK
VASGCLDINSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKVTVITRKAYGGAYDVMSSKHLCGD
TNYAWPTAEIAVMGAKGAVEIIFKGHENVEAAQAEYIEKFANPFPAAVRGFVDDIIQPSSTRARICCDLDVLASKKKYRYQDEDTPPQEH
ISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETP
TYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAG
SIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTA
LKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNI
VGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSIS
SGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKF
NSKTRDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRIN
DDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRL

--------------------------------------------------------------

>63168_63168_7_PCCB-DLG1_PCCB_chr3_136048826_ENST00000471595_DLG1_chr3_196921460_ENST00000357674_length(amino acids)=1313AA_BP=521
MAAALRVAAVGARLSVLASGLRAAVRSLCSQATSVNERIENKRRTALLGGGQRRIDAQHKRGKLTARERISLLLDPGSFVESDMFVEHRC
ADFGMAADKNKFPGDSVVTGRGRINGRLVYVFSQDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGLNDSGGARIQEGVESLAGYADIF
LRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKDTSYLFITGPDVVKSVTNEDVTQEELGGAKTHTTMSGVAHRAFENDVDALCN
LRDFFNYLPLSSQDPAPVRECHDPSDRLVPELDTIVPLESTKAYNMVDIIHSVVDEREFFEIMPNYAKNIIVGFARMNGRTVGIVGNQPK
VASGCLDINSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKVTVITRKAYGGAYDVMSSKHLCGD
TNYAWPTAEIAVMGAKGAVEIIFKGHENVEAAQAEYIEKFANPFPAAVRGFVDDIIQPSSTRARICCDLDVLASKKKYRYQDEDTPPQEH
ISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTD
NPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSI
AGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSS
SQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRII
SVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQ
GLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPFYKNKDQS
EQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYH
FVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQAR

--------------------------------------------------------------

>63168_63168_8_PCCB-DLG1_PCCB_chr3_136048826_ENST00000471595_DLG1_chr3_196921460_ENST00000419354_length(amino acids)=1324AA_BP=521
MAAALRVAAVGARLSVLASGLRAAVRSLCSQATSVNERIENKRRTALLGGGQRRIDAQHKRGKLTARERISLLLDPGSFVESDMFVEHRC
ADFGMAADKNKFPGDSVVTGRGRINGRLVYVFSQDFTVFGGSLSGAHAQKICKIMDQAITVGAPVIGLNDSGGARIQEGVESLAGYADIF
LRNVTASGVIPQISLIMGPCAGGAVYSPALTDFTFMVKDTSYLFITGPDVVKSVTNEDVTQEELGGAKTHTTMSGVAHRAFENDVDALCN
LRDFFNYLPLSSQDPAPVRECHDPSDRLVPELDTIVPLESTKAYNMVDIIHSVVDEREFFEIMPNYAKNIIVGFARMNGRTVGIVGNQPK
VASGCLDINSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKVTVITRKAYGGAYDVMSSKHLCGD
TNYAWPTAEIAVMGAKGAVEIIFKGHENVEAAQAEYIEKFANPFPAAVRGFVDDIIQPSSTRARICCDLDVLASKKKYRYQDEDTPPQEH
ISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETP
TYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAG
SIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTA
LKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNI
VGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSIS
SGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKF
NSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPK
RDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIME

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:136048826/chr3:196921460)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DLG1

Q12959

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDLG1chr3:136048826chr3:196921460ENST00000314062324224_310106.0854.0DomainPDZ 1
TgeneDLG1chr3:136048826chr3:196921460ENST00000314062324319_405106.0854.0DomainPDZ 2
TgeneDLG1chr3:136048826chr3:196921460ENST00000314062324466_546106.0854.0DomainPDZ 3
TgeneDLG1chr3:136048826chr3:196921460ENST00000314062324581_651106.0854.0DomainSH3
TgeneDLG1chr3:136048826chr3:196921460ENST00000314062324714_889106.0854.0DomainGuanylate kinase-like
TgeneDLG1chr3:136048826chr3:196921460ENST00000346964326224_310106.0927.0DomainPDZ 1
TgeneDLG1chr3:136048826chr3:196921460ENST00000346964326319_405106.0927.0DomainPDZ 2
TgeneDLG1chr3:136048826chr3:196921460ENST00000346964326466_546106.0927.0DomainPDZ 3
TgeneDLG1chr3:136048826chr3:196921460ENST00000346964326581_651106.0927.0DomainSH3
TgeneDLG1chr3:136048826chr3:196921460ENST00000346964326714_889106.0927.0DomainGuanylate kinase-like
TgeneDLG1chr3:136048826chr3:196921460ENST00000357674325224_310106.0894.0DomainPDZ 1
TgeneDLG1chr3:136048826chr3:196921460ENST00000357674325319_405106.0894.0DomainPDZ 2
TgeneDLG1chr3:136048826chr3:196921460ENST00000357674325466_546106.0894.0DomainPDZ 3
TgeneDLG1chr3:136048826chr3:196921460ENST00000357674325581_651106.0894.0DomainSH3
TgeneDLG1chr3:136048826chr3:196921460ENST00000357674325714_889106.0894.0DomainGuanylate kinase-like
TgeneDLG1chr3:136048826chr3:196921460ENST00000392382325224_310106.0872.0DomainPDZ 1
TgeneDLG1chr3:136048826chr3:196921460ENST00000392382325319_405106.0872.0DomainPDZ 2
TgeneDLG1chr3:136048826chr3:196921460ENST00000392382325466_546106.0872.0DomainPDZ 3
TgeneDLG1chr3:136048826chr3:196921460ENST00000392382325581_651106.0872.0DomainSH3
TgeneDLG1chr3:136048826chr3:196921460ENST00000392382325714_889106.0872.0DomainGuanylate kinase-like
TgeneDLG1chr3:136048826chr3:196921460ENST00000419354326224_310106.0905.0DomainPDZ 1
TgeneDLG1chr3:136048826chr3:196921460ENST00000419354326319_405106.0905.0DomainPDZ 2
TgeneDLG1chr3:136048826chr3:196921460ENST00000419354326466_546106.0905.0DomainPDZ 3
TgeneDLG1chr3:136048826chr3:196921460ENST00000419354326581_651106.0905.0DomainSH3
TgeneDLG1chr3:136048826chr3:196921460ENST00000419354326714_889106.0905.0DomainGuanylate kinase-like
TgeneDLG1chr3:136048826chr3:196921460ENST00000422288223224_310106.0854.0DomainPDZ 1
TgeneDLG1chr3:136048826chr3:196921460ENST00000422288223319_405106.0854.0DomainPDZ 2
TgeneDLG1chr3:136048826chr3:196921460ENST00000422288223466_546106.0854.0DomainPDZ 3
TgeneDLG1chr3:136048826chr3:196921460ENST00000422288223581_651106.0854.0DomainSH3
TgeneDLG1chr3:136048826chr3:196921460ENST00000422288223714_889106.0854.0DomainGuanylate kinase-like
TgeneDLG1chr3:136048826chr3:196921460ENST00000443183022224_3100801.0DomainPDZ 1
TgeneDLG1chr3:136048826chr3:196921460ENST00000443183022319_4050801.0DomainPDZ 2
TgeneDLG1chr3:136048826chr3:196921460ENST00000443183022466_5460801.0DomainPDZ 3
TgeneDLG1chr3:136048826chr3:196921460ENST000004431830224_640801.0DomainL27
TgeneDLG1chr3:136048826chr3:196921460ENST00000443183022581_6510801.0DomainSH3
TgeneDLG1chr3:136048826chr3:196921460ENST00000443183022714_8890801.0DomainGuanylate kinase-like
TgeneDLG1chr3:136048826chr3:196921460ENST00000448528326224_310106.0905.0DomainPDZ 1
TgeneDLG1chr3:136048826chr3:196921460ENST00000448528326319_405106.0905.0DomainPDZ 2
TgeneDLG1chr3:136048826chr3:196921460ENST00000448528326466_546106.0905.0DomainPDZ 3
TgeneDLG1chr3:136048826chr3:196921460ENST00000448528326581_651106.0905.0DomainSH3
TgeneDLG1chr3:136048826chr3:196921460ENST00000448528326714_889106.0905.0DomainGuanylate kinase-like
TgeneDLG1chr3:136048826chr3:196921460ENST00000450955224224_310106.0894.0DomainPDZ 1
TgeneDLG1chr3:136048826chr3:196921460ENST00000450955224319_405106.0894.0DomainPDZ 2
TgeneDLG1chr3:136048826chr3:196921460ENST00000450955224466_546106.0894.0DomainPDZ 3
TgeneDLG1chr3:136048826chr3:196921460ENST00000450955224581_651106.0894.0DomainSH3
TgeneDLG1chr3:136048826chr3:196921460ENST00000450955224714_889106.0894.0DomainGuanylate kinase-like
TgeneDLG1chr3:136048826chr3:196921460ENST00000452595021224_3100789.0DomainPDZ 1
TgeneDLG1chr3:136048826chr3:196921460ENST00000452595021319_4050789.0DomainPDZ 2
TgeneDLG1chr3:136048826chr3:196921460ENST00000452595021466_5460789.0DomainPDZ 3
TgeneDLG1chr3:136048826chr3:196921460ENST000004525950214_640789.0DomainL27
TgeneDLG1chr3:136048826chr3:196921460ENST00000452595021581_6510789.0DomainSH3
TgeneDLG1chr3:136048826chr3:196921460ENST00000452595021714_8890789.0DomainGuanylate kinase-like

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCCBchr3:136048826chr3:196921460ENST00000251654+115294_5330540.0DomainCoA carboxyltransferase C-terminal
HgenePCCBchr3:136048826chr3:196921460ENST00000251654+11532_2900540.0DomainCoA carboxyltransferase N-terminal
HgenePCCBchr3:136048826chr3:196921460ENST00000469217+116294_5330560.0DomainCoA carboxyltransferase C-terminal
HgenePCCBchr3:136048826chr3:196921460ENST00000469217+11632_2900560.0DomainCoA carboxyltransferase N-terminal
HgenePCCBchr3:136048826chr3:196921460ENST00000251654+115325_3580540.0RegionAcyl-CoA binding
HgenePCCBchr3:136048826chr3:196921460ENST00000251654+11532_5330540.0RegionCarboxyltransferase
HgenePCCBchr3:136048826chr3:196921460ENST00000469217+116325_3580560.0RegionAcyl-CoA binding
HgenePCCBchr3:136048826chr3:196921460ENST00000469217+11632_5330560.0RegionCarboxyltransferase
TgeneDLG1chr3:136048826chr3:196921460ENST000003140623244_64106.0854.0DomainL27
TgeneDLG1chr3:136048826chr3:196921460ENST000003469643264_64106.0927.0DomainL27
TgeneDLG1chr3:136048826chr3:196921460ENST000003576743254_64106.0894.0DomainL27
TgeneDLG1chr3:136048826chr3:196921460ENST000003923823254_64106.0872.0DomainL27
TgeneDLG1chr3:136048826chr3:196921460ENST000004193543264_64106.0905.0DomainL27
TgeneDLG1chr3:136048826chr3:196921460ENST000004222882234_64106.0854.0DomainL27
TgeneDLG1chr3:136048826chr3:196921460ENST000004485283264_64106.0905.0DomainL27
TgeneDLG1chr3:136048826chr3:196921460ENST000004509552244_64106.0894.0DomainL27


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PCCB
DLG1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PCCB-DLG1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PCCB-DLG1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource