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Fusion Protein:PCDHGC3-QKI |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: PCDHGC3-QKI | FusionPDB ID: 63260 | FusionGDB2.0 ID: 63260 | Hgene | Tgene | Gene symbol | PCDHGC3 | QKI | Gene ID | 5098 | 9444 |
| Gene name | protocadherin gamma subfamily C, 3 | QKI, KH domain containing RNA binding | |
| Synonyms | PC43|PCDH-GAMMA-C3|PCDH2 | Hqk|QK|QK1|QK3|hqkI | |
| Cytomap | 5q31.3 | 6q26 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protocadherin gamma-C3cadherin-like 2protocadherin 43protocadherin-2 | protein quakingQKI/LOC100132735 fusionRNA binding protein HQKhomolog of mouse quaking QKI (KH domain RNA binding protein)quaking homolog, KH domain RNA binding | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | . | Q96PU8 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000308177, | ENST00000275262, ENST00000361195, ENST00000361752, ENST00000392127, ENST00000424802, ENST00000453779, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 1 X 1 X 1=1 | 23 X 23 X 9=4761 |
| # samples | 2 | 27 | |
| ** MAII score | log2(2/1*10)=4.32192809488736 | log2(27/4761*10)=-4.14023331650551 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: PCDHGC3 [Title/Abstract] AND QKI [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | PCDHGC3(140858113)-QKI(163956014), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | PCDHGC3-QKI seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PCDHGC3-QKI seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PCDHGC3-QKI seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PCDHGC3-QKI seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across PCDHGC3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across QKI (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | GBM | TCGA-06-0129-01A | PCDHGC3 | chr5 | 140858113 | - | QKI | chr6 | 163956014 | + |
| ChimerDB4 | GBM | TCGA-06-0129-01A | PCDHGC3 | chr5 | 140858113 | + | QKI | chr6 | 163956014 | + |
| ChimerDB4 | GBM | TCGA-06-0129 | PCDHGC3 | chr5 | 140858113 | + | QKI | chr6 | 163956013 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000308177 | PCDHGC3 | chr5 | 140858113 | + | ENST00000275262 | QKI | chr6 | 163956013 | + | 8545 | 2534 | 89 | 3109 | 1006 |
| ENST00000308177 | PCDHGC3 | chr5 | 140858113 | + | ENST00000392127 | QKI | chr6 | 163956013 | + | 9492 | 2534 | 89 | 3091 | 1000 |
| ENST00000308177 | PCDHGC3 | chr5 | 140858113 | + | ENST00000453779 | QKI | chr6 | 163956013 | + | 7266 | 2534 | 89 | 3091 | 1000 |
| ENST00000308177 | PCDHGC3 | chr5 | 140858113 | + | ENST00000361752 | QKI | chr6 | 163956013 | + | 11044 | 2534 | 89 | 3157 | 1022 |
| ENST00000308177 | PCDHGC3 | chr5 | 140858113 | + | ENST00000361195 | QKI | chr6 | 163956013 | + | 3171 | 2534 | 89 | 3133 | 1014 |
| ENST00000308177 | PCDHGC3 | chr5 | 140858113 | + | ENST00000424802 | QKI | chr6 | 163956013 | + | 3086 | 2534 | 89 | 3085 | 999 |
| ENST00000308177 | PCDHGC3 | chr5 | 140858113 | + | ENST00000275262 | QKI | chr6 | 163956014 | + | 8545 | 2534 | 89 | 3109 | 1006 |
| ENST00000308177 | PCDHGC3 | chr5 | 140858113 | + | ENST00000392127 | QKI | chr6 | 163956014 | + | 9492 | 2534 | 89 | 3091 | 1000 |
| ENST00000308177 | PCDHGC3 | chr5 | 140858113 | + | ENST00000453779 | QKI | chr6 | 163956014 | + | 7266 | 2534 | 89 | 3091 | 1000 |
| ENST00000308177 | PCDHGC3 | chr5 | 140858113 | + | ENST00000361752 | QKI | chr6 | 163956014 | + | 11044 | 2534 | 89 | 3157 | 1022 |
| ENST00000308177 | PCDHGC3 | chr5 | 140858113 | + | ENST00000361195 | QKI | chr6 | 163956014 | + | 3171 | 2534 | 89 | 3133 | 1014 |
| ENST00000308177 | PCDHGC3 | chr5 | 140858113 | + | ENST00000424802 | QKI | chr6 | 163956014 | + | 3086 | 2534 | 89 | 3085 | 999 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000308177 | ENST00000275262 | PCDHGC3 | chr5 | 140858113 | + | QKI | chr6 | 163956013 | + | 8.12E-05 | 0.9999187 |
| ENST00000308177 | ENST00000392127 | PCDHGC3 | chr5 | 140858113 | + | QKI | chr6 | 163956013 | + | 4.57E-05 | 0.9999542 |
| ENST00000308177 | ENST00000453779 | PCDHGC3 | chr5 | 140858113 | + | QKI | chr6 | 163956013 | + | 5.70E-05 | 0.999943 |
| ENST00000308177 | ENST00000361752 | PCDHGC3 | chr5 | 140858113 | + | QKI | chr6 | 163956013 | + | 0.000107736 | 0.99989223 |
| ENST00000308177 | ENST00000361195 | PCDHGC3 | chr5 | 140858113 | + | QKI | chr6 | 163956013 | + | 0.000714053 | 0.999286 |
| ENST00000308177 | ENST00000424802 | PCDHGC3 | chr5 | 140858113 | + | QKI | chr6 | 163956013 | + | 0.000598673 | 0.99940133 |
| ENST00000308177 | ENST00000275262 | PCDHGC3 | chr5 | 140858113 | + | QKI | chr6 | 163956014 | + | 8.12E-05 | 0.9999187 |
| ENST00000308177 | ENST00000392127 | PCDHGC3 | chr5 | 140858113 | + | QKI | chr6 | 163956014 | + | 4.57E-05 | 0.9999542 |
| ENST00000308177 | ENST00000453779 | PCDHGC3 | chr5 | 140858113 | + | QKI | chr6 | 163956014 | + | 5.70E-05 | 0.999943 |
| ENST00000308177 | ENST00000361752 | PCDHGC3 | chr5 | 140858113 | + | QKI | chr6 | 163956014 | + | 0.000107736 | 0.99989223 |
| ENST00000308177 | ENST00000361195 | PCDHGC3 | chr5 | 140858113 | + | QKI | chr6 | 163956014 | + | 0.000714053 | 0.999286 |
| ENST00000308177 | ENST00000424802 | PCDHGC3 | chr5 | 140858113 | + | QKI | chr6 | 163956014 | + | 0.000598673 | 0.99940133 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >63260_63260_1_PCDHGC3-QKI_PCDHGC3_chr5_140858113_ENST00000308177_QKI_chr6_163956013_ENST00000275262_length(amino acids)=1006AA_BP=815 MLLSEMVPEAWRSGLVSTGRVVGVLLLLGALNKASTVIHYEIPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGE MFVNDRLDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELS RNEYFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQ VLATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVT SVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLTSSLKNYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRV QVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYEDRREFEL TAHISDGGTPVLATNISVNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSLLGSPNQSLFAIGLHT GQISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVTEDSPEARAEFPSGSAPREQKKNLTFYLLLSLILVSVGFVVTVFGVIIF KVYKWKQSRDLYRAPVSSLYRTPGPSLHADAVRGGLMSPHLYHQVYLTTDSRRSDPLLKKPGAASPLASRQNTLRSCDPVFYRQVLGAES APPGQEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLA ATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSG -------------------------------------------------------------- >63260_63260_2_PCDHGC3-QKI_PCDHGC3_chr5_140858113_ENST00000308177_QKI_chr6_163956013_ENST00000361195_length(amino acids)=1014AA_BP=815 MLLSEMVPEAWRSGLVSTGRVVGVLLLLGALNKASTVIHYEIPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGE MFVNDRLDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELS RNEYFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQ VLATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVT SVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLTSSLKNYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRV QVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYEDRREFEL TAHISDGGTPVLATNISVNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSLLGSPNQSLFAIGLHT GQISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVTEDSPEARAEFPSGSAPREQKKNLTFYLLLSLILVSVGFVVTVFGVIIF KVYKWKQSRDLYRAPVSSLYRTPGPSLHADAVRGGLMSPHLYHQVYLTTDSRRSDPLLKKPGAASPLASRQNTLRSCDPVFYRQVLGAES APPGQEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPTAQAAPR IITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGVLGAVATK -------------------------------------------------------------- >63260_63260_3_PCDHGC3-QKI_PCDHGC3_chr5_140858113_ENST00000308177_QKI_chr6_163956013_ENST00000361752_length(amino acids)=1022AA_BP=815 MLLSEMVPEAWRSGLVSTGRVVGVLLLLGALNKASTVIHYEIPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGE MFVNDRLDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELS RNEYFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQ VLATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVT SVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLTSSLKNYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRV QVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYEDRREFEL TAHISDGGTPVLATNISVNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSLLGSPNQSLFAIGLHT GQISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVTEDSPEARAEFPSGSAPREQKKNLTFYLLLSLILVSVGFVVTVFGVIIF KVYKWKQSRDLYRAPVSSLYRTPGPSLHADAVRGGLMSPHLYHQVYLTTDSRRSDPLLKKPGAASPLASRQNTLRSCDPVFYRQVLGAES APPGQEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLA ATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSG -------------------------------------------------------------- >63260_63260_4_PCDHGC3-QKI_PCDHGC3_chr5_140858113_ENST00000308177_QKI_chr6_163956013_ENST00000392127_length(amino acids)=1000AA_BP=815 MLLSEMVPEAWRSGLVSTGRVVGVLLLLGALNKASTVIHYEIPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGE MFVNDRLDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELS RNEYFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQ VLATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVT SVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLTSSLKNYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRV QVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYEDRREFEL TAHISDGGTPVLATNISVNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSLLGSPNQSLFAIGLHT GQISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVTEDSPEARAEFPSGSAPREQKKNLTFYLLLSLILVSVGFVVTVFGVIIF KVYKWKQSRDLYRAPVSSLYRTPGPSLHADAVRGGLMSPHLYHQVYLTTDSRRSDPLLKKPGAASPLASRQNTLRSCDPVFYRQVLGAES APPGQEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLA ATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSG -------------------------------------------------------------- >63260_63260_5_PCDHGC3-QKI_PCDHGC3_chr5_140858113_ENST00000308177_QKI_chr6_163956013_ENST00000424802_length(amino acids)=999AA_BP=815 MLLSEMVPEAWRSGLVSTGRVVGVLLLLGALNKASTVIHYEIPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGE MFVNDRLDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELS RNEYFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQ VLATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVT SVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLTSSLKNYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRV QVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYEDRREFEL TAHISDGGTPVLATNISVNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSLLGSPNQSLFAIGLHT GQISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVTEDSPEARAEFPSGSAPREQKKNLTFYLLLSLILVSVGFVVTVFGVIIF KVYKWKQSRDLYRAPVSSLYRTPGPSLHADAVRGGLMSPHLYHQVYLTTDSRRSDPLLKKPGAASPLASRQNTLRSCDPVFYRQVLGAES APPGQEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPTAQAAPR IITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGVLEWIEMP -------------------------------------------------------------- >63260_63260_6_PCDHGC3-QKI_PCDHGC3_chr5_140858113_ENST00000308177_QKI_chr6_163956013_ENST00000453779_length(amino acids)=1000AA_BP=815 MLLSEMVPEAWRSGLVSTGRVVGVLLLLGALNKASTVIHYEIPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGE MFVNDRLDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELS RNEYFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQ VLATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVT SVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLTSSLKNYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRV QVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYEDRREFEL TAHISDGGTPVLATNISVNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSLLGSPNQSLFAIGLHT GQISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVTEDSPEARAEFPSGSAPREQKKNLTFYLLLSLILVSVGFVVTVFGVIIF KVYKWKQSRDLYRAPVSSLYRTPGPSLHADAVRGGLMSPHLYHQVYLTTDSRRSDPLLKKPGAASPLASRQNTLRSCDPVFYRQVLGAES APPGQEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLA ATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSG -------------------------------------------------------------- >63260_63260_7_PCDHGC3-QKI_PCDHGC3_chr5_140858113_ENST00000308177_QKI_chr6_163956014_ENST00000275262_length(amino acids)=1006AA_BP=815 MLLSEMVPEAWRSGLVSTGRVVGVLLLLGALNKASTVIHYEIPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGE MFVNDRLDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELS RNEYFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQ VLATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVT SVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLTSSLKNYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRV QVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYEDRREFEL TAHISDGGTPVLATNISVNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSLLGSPNQSLFAIGLHT GQISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVTEDSPEARAEFPSGSAPREQKKNLTFYLLLSLILVSVGFVVTVFGVIIF KVYKWKQSRDLYRAPVSSLYRTPGPSLHADAVRGGLMSPHLYHQVYLTTDSRRSDPLLKKPGAASPLASRQNTLRSCDPVFYRQVLGAES APPGQEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLA ATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSG -------------------------------------------------------------- >63260_63260_8_PCDHGC3-QKI_PCDHGC3_chr5_140858113_ENST00000308177_QKI_chr6_163956014_ENST00000361195_length(amino acids)=1014AA_BP=815 MLLSEMVPEAWRSGLVSTGRVVGVLLLLGALNKASTVIHYEIPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGE MFVNDRLDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELS RNEYFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQ VLATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVT SVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLTSSLKNYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRV QVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYEDRREFEL TAHISDGGTPVLATNISVNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSLLGSPNQSLFAIGLHT GQISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVTEDSPEARAEFPSGSAPREQKKNLTFYLLLSLILVSVGFVVTVFGVIIF KVYKWKQSRDLYRAPVSSLYRTPGPSLHADAVRGGLMSPHLYHQVYLTTDSRRSDPLLKKPGAASPLASRQNTLRSCDPVFYRQVLGAES APPGQEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPTAQAAPR IITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGVLGAVATK -------------------------------------------------------------- >63260_63260_9_PCDHGC3-QKI_PCDHGC3_chr5_140858113_ENST00000308177_QKI_chr6_163956014_ENST00000361752_length(amino acids)=1022AA_BP=815 MLLSEMVPEAWRSGLVSTGRVVGVLLLLGALNKASTVIHYEIPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGE MFVNDRLDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELS RNEYFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQ VLATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVT SVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLTSSLKNYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRV QVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYEDRREFEL TAHISDGGTPVLATNISVNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSLLGSPNQSLFAIGLHT GQISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVTEDSPEARAEFPSGSAPREQKKNLTFYLLLSLILVSVGFVVTVFGVIIF KVYKWKQSRDLYRAPVSSLYRTPGPSLHADAVRGGLMSPHLYHQVYLTTDSRRSDPLLKKPGAASPLASRQNTLRSCDPVFYRQVLGAES APPGQEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLA ATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSG -------------------------------------------------------------- >63260_63260_10_PCDHGC3-QKI_PCDHGC3_chr5_140858113_ENST00000308177_QKI_chr6_163956014_ENST00000392127_length(amino acids)=1000AA_BP=815 MLLSEMVPEAWRSGLVSTGRVVGVLLLLGALNKASTVIHYEIPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGE MFVNDRLDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELS RNEYFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQ VLATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVT SVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLTSSLKNYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRV QVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYEDRREFEL TAHISDGGTPVLATNISVNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSLLGSPNQSLFAIGLHT GQISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVTEDSPEARAEFPSGSAPREQKKNLTFYLLLSLILVSVGFVVTVFGVIIF KVYKWKQSRDLYRAPVSSLYRTPGPSLHADAVRGGLMSPHLYHQVYLTTDSRRSDPLLKKPGAASPLASRQNTLRSCDPVFYRQVLGAES APPGQEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLA ATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSG -------------------------------------------------------------- >63260_63260_11_PCDHGC3-QKI_PCDHGC3_chr5_140858113_ENST00000308177_QKI_chr6_163956014_ENST00000424802_length(amino acids)=999AA_BP=815 MLLSEMVPEAWRSGLVSTGRVVGVLLLLGALNKASTVIHYEIPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGE MFVNDRLDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELS RNEYFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQ VLATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVT SVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLTSSLKNYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRV QVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYEDRREFEL TAHISDGGTPVLATNISVNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSLLGSPNQSLFAIGLHT GQISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVTEDSPEARAEFPSGSAPREQKKNLTFYLLLSLILVSVGFVVTVFGVIIF KVYKWKQSRDLYRAPVSSLYRTPGPSLHADAVRGGLMSPHLYHQVYLTTDSRRSDPLLKKPGAASPLASRQNTLRSCDPVFYRQVLGAES APPGQEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPTAQAAPR IITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGVLEWIEMP -------------------------------------------------------------- >63260_63260_12_PCDHGC3-QKI_PCDHGC3_chr5_140858113_ENST00000308177_QKI_chr6_163956014_ENST00000453779_length(amino acids)=1000AA_BP=815 MLLSEMVPEAWRSGLVSTGRVVGVLLLLGALNKASTVIHYEIPEEREKGFAVGNVVANLGLDLGSLSARRFRVVSGASRRFFEVNRETGE MFVNDRLDREELCGTLPSCTVTLELVVENPLELFSVEVVIQDINDNNPAFPTQEMKLEISEAVAPGTRFPLESAHDPDVGSNSLQTYELS RNEYFALRVQTREDSTKYAELVLERALDREREPSLQLVLTALDGGTPALSASLPIHIKVLDANDNAPVFNQSLYRARVLEDAPSGTRVVQ VLATDLDEGPNGEIIYSFGSHNRAGVRQLFALDLVTGMLTIKGRLDFEDTKLHEIYIQAKDKGANPEGAHCKVLVEVVDVNDNAPEITVT SVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVPPGLPFSLTSSLKNYFTLKTSADLDRETVPEYNLSITARDAGTPSLSALTIVRV QVSDINDNPPQSSQSSYDVYIEENNLPGAPILNLSVWDPDAPQNARLSFFLLEQGAETGLVGRYFTINRDNGIVSSLVPLDYEDRREFEL TAHISDGGTPVLATNISVNIFVTDRNDNAPQVLYPRPGGSSVEMLPRGTSAGHLVSRVVGWDADAGHNAWLSYSLLGSPNQSLFAIGLHT GQISTARPVQDTDSPRQTLTVLIKDNGEPSLSTTATLTVSVTEDSPEARAEFPSGSAPREQKKNLTFYLLLSLILVSVGFVVTVFGVIIF KVYKWKQSRDLYRAPVSSLYRTPGPSLHADAVRGGLMSPHLYHQVYLTTDSRRSDPLLKKPGAASPLASRQNTLRSCDPVFYRQVLGAES APPGQEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLA ATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSG -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:140858113/chr6:163956014) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | QKI |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:16641098, ECO:0000269|PubMed:23630077}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PCDHGC3 | chr5:140858113 | chr6:163956013 | ENST00000308177 | + | 1 | 4 | 136_244 | 810.0 | 935.0 | Domain | Cadherin 2 |
| Hgene | PCDHGC3 | chr5:140858113 | chr6:163956013 | ENST00000308177 | + | 1 | 4 | 245_352 | 810.0 | 935.0 | Domain | Cadherin 3 |
| Hgene | PCDHGC3 | chr5:140858113 | chr6:163956013 | ENST00000308177 | + | 1 | 4 | 32_135 | 810.0 | 935.0 | Domain | Cadherin 1 |
| Hgene | PCDHGC3 | chr5:140858113 | chr6:163956013 | ENST00000308177 | + | 1 | 4 | 353_457 | 810.0 | 935.0 | Domain | Cadherin 4 |
| Hgene | PCDHGC3 | chr5:140858113 | chr6:163956013 | ENST00000308177 | + | 1 | 4 | 458_567 | 810.0 | 935.0 | Domain | Cadherin 5 |
| Hgene | PCDHGC3 | chr5:140858113 | chr6:163956013 | ENST00000308177 | + | 1 | 4 | 572_685 | 810.0 | 935.0 | Domain | Cadherin 6 |
| Hgene | PCDHGC3 | chr5:140858113 | chr6:163956014 | ENST00000308177 | + | 1 | 4 | 136_244 | 810.0 | 935.0 | Domain | Cadherin 2 |
| Hgene | PCDHGC3 | chr5:140858113 | chr6:163956014 | ENST00000308177 | + | 1 | 4 | 245_352 | 810.0 | 935.0 | Domain | Cadherin 3 |
| Hgene | PCDHGC3 | chr5:140858113 | chr6:163956014 | ENST00000308177 | + | 1 | 4 | 32_135 | 810.0 | 935.0 | Domain | Cadherin 1 |
| Hgene | PCDHGC3 | chr5:140858113 | chr6:163956014 | ENST00000308177 | + | 1 | 4 | 353_457 | 810.0 | 935.0 | Domain | Cadherin 4 |
| Hgene | PCDHGC3 | chr5:140858113 | chr6:163956014 | ENST00000308177 | + | 1 | 4 | 458_567 | 810.0 | 935.0 | Domain | Cadherin 5 |
| Hgene | PCDHGC3 | chr5:140858113 | chr6:163956014 | ENST00000308177 | + | 1 | 4 | 572_685 | 810.0 | 935.0 | Domain | Cadherin 6 |
| Hgene | PCDHGC3 | chr5:140858113 | chr6:163956013 | ENST00000308177 | + | 1 | 4 | 32_693 | 810.0 | 935.0 | Topological domain | Extracellular |
| Hgene | PCDHGC3 | chr5:140858113 | chr6:163956014 | ENST00000308177 | + | 1 | 4 | 32_693 | 810.0 | 935.0 | Topological domain | Extracellular |
| Hgene | PCDHGC3 | chr5:140858113 | chr6:163956013 | ENST00000308177 | + | 1 | 4 | 694_714 | 810.0 | 935.0 | Transmembrane | Helical |
| Hgene | PCDHGC3 | chr5:140858113 | chr6:163956014 | ENST00000308177 | + | 1 | 4 | 694_714 | 810.0 | 935.0 | Transmembrane | Helical |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000275262 | 2 | 7 | 276_279 | 134.0 | 326.0 | Motif | Note=SH3-binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000275262 | 2 | 7 | 324_330 | 134.0 | 326.0 | Motif | Nuclear localization signal | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000361195 | 2 | 8 | 276_279 | 134.0 | 334.0 | Motif | Note=SH3-binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000361195 | 2 | 8 | 324_330 | 134.0 | 334.0 | Motif | Nuclear localization signal | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000361752 | 2 | 8 | 276_279 | 134.0 | 342.0 | Motif | Note=SH3-binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000361752 | 2 | 8 | 324_330 | 134.0 | 342.0 | Motif | Nuclear localization signal | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000392127 | 2 | 6 | 276_279 | 134.0 | 320.0 | Motif | Note=SH3-binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000392127 | 2 | 6 | 324_330 | 134.0 | 320.0 | Motif | Nuclear localization signal | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000424802 | 2 | 7 | 276_279 | 134.0 | 318.0 | Motif | Note=SH3-binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000424802 | 2 | 7 | 324_330 | 134.0 | 318.0 | Motif | Nuclear localization signal | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000453779 | 2 | 7 | 276_279 | 134.0 | 320.0 | Motif | Note=SH3-binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000453779 | 2 | 7 | 324_330 | 134.0 | 320.0 | Motif | Nuclear localization signal | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000275262 | 2 | 7 | 276_279 | 134.0 | 326.0 | Motif | Note=SH3-binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000275262 | 2 | 7 | 324_330 | 134.0 | 326.0 | Motif | Nuclear localization signal | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000361195 | 2 | 8 | 276_279 | 134.0 | 334.0 | Motif | Note=SH3-binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000361195 | 2 | 8 | 324_330 | 134.0 | 334.0 | Motif | Nuclear localization signal | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000361752 | 2 | 8 | 276_279 | 134.0 | 342.0 | Motif | Note=SH3-binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000361752 | 2 | 8 | 324_330 | 134.0 | 342.0 | Motif | Nuclear localization signal | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000392127 | 2 | 6 | 276_279 | 134.0 | 320.0 | Motif | Note=SH3-binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000392127 | 2 | 6 | 324_330 | 134.0 | 320.0 | Motif | Nuclear localization signal | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000424802 | 2 | 7 | 276_279 | 134.0 | 318.0 | Motif | Note=SH3-binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000424802 | 2 | 7 | 324_330 | 134.0 | 318.0 | Motif | Nuclear localization signal | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000453779 | 2 | 7 | 276_279 | 134.0 | 320.0 | Motif | Note=SH3-binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000453779 | 2 | 7 | 324_330 | 134.0 | 320.0 | Motif | Nuclear localization signal | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000275262 | 2 | 7 | 182_213 | 134.0 | 326.0 | Region | Qua2 domain%3B involved in RNA binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000361195 | 2 | 8 | 182_213 | 134.0 | 334.0 | Region | Qua2 domain%3B involved in RNA binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000361752 | 2 | 8 | 182_213 | 134.0 | 342.0 | Region | Qua2 domain%3B involved in RNA binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000392127 | 2 | 6 | 182_213 | 134.0 | 320.0 | Region | Qua2 domain%3B involved in RNA binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000424802 | 2 | 7 | 182_213 | 134.0 | 318.0 | Region | Qua2 domain%3B involved in RNA binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000453779 | 2 | 7 | 182_213 | 134.0 | 320.0 | Region | Qua2 domain%3B involved in RNA binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000275262 | 2 | 7 | 182_213 | 134.0 | 326.0 | Region | Qua2 domain%3B involved in RNA binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000361195 | 2 | 8 | 182_213 | 134.0 | 334.0 | Region | Qua2 domain%3B involved in RNA binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000361752 | 2 | 8 | 182_213 | 134.0 | 342.0 | Region | Qua2 domain%3B involved in RNA binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000392127 | 2 | 6 | 182_213 | 134.0 | 320.0 | Region | Qua2 domain%3B involved in RNA binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000424802 | 2 | 7 | 182_213 | 134.0 | 318.0 | Region | Qua2 domain%3B involved in RNA binding | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000453779 | 2 | 7 | 182_213 | 134.0 | 320.0 | Region | Qua2 domain%3B involved in RNA binding |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PCDHGC3 | chr5:140858113 | chr6:163956013 | ENST00000308177 | + | 1 | 4 | 715_934 | 810.0 | 935.0 | Topological domain | Cytoplasmic |
| Hgene | PCDHGC3 | chr5:140858113 | chr6:163956014 | ENST00000308177 | + | 1 | 4 | 715_934 | 810.0 | 935.0 | Topological domain | Cytoplasmic |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000275262 | 2 | 7 | 87_153 | 134.0 | 326.0 | Domain | Note=KH | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000361195 | 2 | 8 | 87_153 | 134.0 | 334.0 | Domain | Note=KH | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000361752 | 2 | 8 | 87_153 | 134.0 | 342.0 | Domain | Note=KH | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000392127 | 2 | 6 | 87_153 | 134.0 | 320.0 | Domain | Note=KH | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000424802 | 2 | 7 | 87_153 | 134.0 | 318.0 | Domain | Note=KH | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000453779 | 2 | 7 | 87_153 | 134.0 | 320.0 | Domain | Note=KH | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000275262 | 2 | 7 | 87_153 | 134.0 | 326.0 | Domain | Note=KH | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000361195 | 2 | 8 | 87_153 | 134.0 | 334.0 | Domain | Note=KH | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000361752 | 2 | 8 | 87_153 | 134.0 | 342.0 | Domain | Note=KH | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000392127 | 2 | 6 | 87_153 | 134.0 | 320.0 | Domain | Note=KH | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000424802 | 2 | 7 | 87_153 | 134.0 | 318.0 | Domain | Note=KH | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000453779 | 2 | 7 | 87_153 | 134.0 | 320.0 | Domain | Note=KH | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000275262 | 2 | 7 | 11_82 | 134.0 | 326.0 | Region | Qua1 domain%3B involved in homodimerization | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000361195 | 2 | 8 | 11_82 | 134.0 | 334.0 | Region | Qua1 domain%3B involved in homodimerization | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000361752 | 2 | 8 | 11_82 | 134.0 | 342.0 | Region | Qua1 domain%3B involved in homodimerization | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000392127 | 2 | 6 | 11_82 | 134.0 | 320.0 | Region | Qua1 domain%3B involved in homodimerization | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000424802 | 2 | 7 | 11_82 | 134.0 | 318.0 | Region | Qua1 domain%3B involved in homodimerization | |
| Tgene | QKI | chr5:140858113 | chr6:163956013 | ENST00000453779 | 2 | 7 | 11_82 | 134.0 | 320.0 | Region | Qua1 domain%3B involved in homodimerization | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000275262 | 2 | 7 | 11_82 | 134.0 | 326.0 | Region | Qua1 domain%3B involved in homodimerization | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000361195 | 2 | 8 | 11_82 | 134.0 | 334.0 | Region | Qua1 domain%3B involved in homodimerization | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000361752 | 2 | 8 | 11_82 | 134.0 | 342.0 | Region | Qua1 domain%3B involved in homodimerization | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000392127 | 2 | 6 | 11_82 | 134.0 | 320.0 | Region | Qua1 domain%3B involved in homodimerization | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000424802 | 2 | 7 | 11_82 | 134.0 | 318.0 | Region | Qua1 domain%3B involved in homodimerization | |
| Tgene | QKI | chr5:140858113 | chr6:163956014 | ENST00000453779 | 2 | 7 | 11_82 | 134.0 | 320.0 | Region | Qua1 domain%3B involved in homodimerization |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| QKI | HNRNPK, USP30, MED12, MED13, MED25, MED16, MED17, MED1, MED24, MED23, MED4, MED29, MED31, MED15, MED14, MED26, MED10, POLR2A, MED27, ELAVL1, PSMF1, C10orf10, FUBP3, HCLS1, PCBP2, PTBP1, PTBP2, RBM14, RBFOX2, RBPMS, RNF138, SERF2, THAP1, USH1C, RBFOX1, PCBP1, PCBP4, APP, NDUFA7, CDV3, ATXN1, FN1, U2AF2, RBM23, RALY, WDR77, HNRNPH2, QKI, DAZ1, IL7R, CARM1, SNRPA, RBM11, NABP1, HNRNPLL, OIP5, RBMX, ZACN, CYP1A1, NTRK1, EWSR1, HYPK, DUSP22, DUSP4, ATE1, RBM42, FBXW11, SLC39A12, VAC14, TRIM11, SYNCRIP, SNRNP27, TAE1, PBP2, FBXO7, DMRTB1, CDKN2D, CCND3, TSG101, LSM3, TEX11, PIAS1, FHL3, ESR2, RAF1, APEX1, SNRNP70, DUSP14, LMBR1L, PRKAB2, TIAL1, E7, MIR7-1, MIR19B2, MIR34B, MIR34C, MIR141, MIR200A, CELF1, RBM47, RBMS1, C8orf82, RBM45, UFL1, DDRGK1, HNRNPA1, FZR1, HSPA2, HSPA1A, RBMS2, CYB5B, PRR3, CENPM, HNRNPUL2, FAM120A, HNRNPC, BAG1, IL7, TGM1, ELAVL2, BAG2, HSPA8, HNRNPCL2, HNRNPCL1, EIF4ENIF1, MBNL1, PCBP3, ALG13, YTHDF1, SNRPC, UNKL, BAG4, PRRC2B, MSI2, TNRC6A, ANKHD1, TXNL4A, CALD1, RBM7, ZMAT5, CCDC59, BCAS2, NXF1, TRNAU1AP, YTHDF3, NIP7, ZC3H10, CPSF7, SLAIN1, SECISBP2, RPL9, PRPF6, PRPF39, MBNL2, PCGF5, KIF21B, MRPL44, LSM5, UTP6, Pcbp1, Hnrnpk, Rbm38, Rbm47, Dusp14, Mrpl13, Ywhag, Pum2, Pef1, Hsp90aa1, GATA3, PAX9, SP7, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| PCDHGC3 | |
| QKI |  |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to PCDHGC3-QKI |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to PCDHGC3-QKI |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | QKI | C0036341 | Schizophrenia | 5 | PSYGENET |
| Tgene | QKI | C0017638 | Glioma | 1 | CTD_human |
| Tgene | QKI | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | QKI | C0259783 | mixed gliomas | 1 | CTD_human |
| Tgene | QKI | C0555198 | Malignant Glioma | 1 | CTD_human |
| Tgene | QKI | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Tgene | QKI | C2363903 | Angiocentric glioma | 1 | ORPHANET |
| Tgene | QKI | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
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