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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PCDHGC4-QKI

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PCDHGC4-QKI
FusionPDB ID: 63261
FusionGDB2.0 ID: 63261
HgeneTgene
Gene symbol

PCDHGC4

QKI

Gene ID

56098

9444

Gene nameprotocadherin gamma subfamily C, 4QKI, KH domain containing RNA binding
SynonymsPCDH-GAMMA-C4Hqk|QK|QK1|QK3|hqkI
Cytomap

5q31.3

6q26

Type of geneprotein-codingprotein-coding
Descriptionprotocadherin gamma-C4protein quakingQKI/LOC100132735 fusionRNA binding protein HQKhomolog of mouse quaking QKI (KH domain RNA binding protein)quaking homolog, KH domain RNA binding
Modification date2020031320200327
UniProtAcc.

Q96PU8

Ensembl transtripts involved in fusion geneENST idsENST00000306593, ENST00000275262, 
ENST00000361195, ENST00000361752, 
ENST00000392127, ENST00000424802, 
ENST00000453779, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score1 X 1 X 1=123 X 23 X 9=4761
# samples 127
** MAII scorelog2(1/1*10)=3.32192809488736log2(27/4761*10)=-4.14023331650551
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PCDHGC4 [Title/Abstract] AND QKI [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PCDHGC4(140867182)-QKI(163956014), # samples:1
Anticipated loss of major functional domain due to fusion event.PCDHGC4-QKI seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PCDHGC4-QKI seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PCDHGC4-QKI seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PCDHGC4-QKI seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PCDHGC4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across QKI (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0129-01APCDHGC4chr5

140867182

+QKIchr6

163956014

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000306593PCDHGC4chr5140867182+ENST00000275262QKIchr6163956014+84532442030171005
ENST00000306593PCDHGC4chr5140867182+ENST00000392127QKIchr6163956014+9400244202999999
ENST00000306593PCDHGC4chr5140867182+ENST00000453779QKIchr6163956014+7174244202999999
ENST00000306593PCDHGC4chr5140867182+ENST00000361752QKIchr6163956014+109522442030651021
ENST00000306593PCDHGC4chr5140867182+ENST00000361195QKIchr6163956014+30792442030411013
ENST00000306593PCDHGC4chr5140867182+ENST00000424802QKIchr6163956014+2994244202993997

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000306593ENST00000275262PCDHGC4chr5140867182+QKIchr6163956014+3.40E-050.9999659
ENST00000306593ENST00000392127PCDHGC4chr5140867182+QKIchr6163956014+6.46E-050.9999354
ENST00000306593ENST00000453779PCDHGC4chr5140867182+QKIchr6163956014+7.39E-050.9999261
ENST00000306593ENST00000361752PCDHGC4chr5140867182+QKIchr6163956014+0.0001034740.9998965
ENST00000306593ENST00000361195PCDHGC4chr5140867182+QKIchr6163956014+0.0007491610.9992508
ENST00000306593ENST00000424802PCDHGC4chr5140867182+QKIchr6163956014+0.0008235320.99917644

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63261_63261_1_PCDHGC4-QKI_PCDHGC4_chr5_140867182_ENST00000306593_QKI_chr6_163956014_ENST00000275262_length(amino acids)=1005AA_BP=814
MLRKVRSWTEIWRWATLLFLFYHLGYVCGQIRYPVPEESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNPI
DREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFAL
DVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPD
LGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLP
ESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVND
NPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDR
GNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRT
AVPIPADLPPQKLVIVVKDSGSPPLSTSVTLLVSLEEDTHPVVPDLRESSAPREGESRLTLYLAVSLVAICFVSFGSFVALLSKCLRGAA
CGVTCFPAGTCACLTRSRRREGLPPSNGILRIQLGSDDPIKFVDVGGHSHGCTPLASAPTRSDSFMMVKSPSAPMAGEPVRPSCPPSDLL
YGLEEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLAA
TAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGV

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>63261_63261_2_PCDHGC4-QKI_PCDHGC4_chr5_140867182_ENST00000306593_QKI_chr6_163956014_ENST00000361195_length(amino acids)=1013AA_BP=814
MLRKVRSWTEIWRWATLLFLFYHLGYVCGQIRYPVPEESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNPI
DREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFAL
DVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPD
LGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLP
ESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVND
NPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDR
GNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRT
AVPIPADLPPQKLVIVVKDSGSPPLSTSVTLLVSLEEDTHPVVPDLRESSAPREGESRLTLYLAVSLVAICFVSFGSFVALLSKCLRGAA
CGVTCFPAGTCACLTRSRRREGLPPSNGILRIQLGSDDPIKFVDVGGHSHGCTPLASAPTRSDSFMMVKSPSAPMAGEPVRPSCPPSDLL
YGLEEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPTAQAAPRI
ITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGVLGAVATKV

--------------------------------------------------------------

>63261_63261_3_PCDHGC4-QKI_PCDHGC4_chr5_140867182_ENST00000306593_QKI_chr6_163956014_ENST00000361752_length(amino acids)=1021AA_BP=814
MLRKVRSWTEIWRWATLLFLFYHLGYVCGQIRYPVPEESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNPI
DREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFAL
DVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPD
LGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLP
ESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVND
NPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDR
GNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRT
AVPIPADLPPQKLVIVVKDSGSPPLSTSVTLLVSLEEDTHPVVPDLRESSAPREGESRLTLYLAVSLVAICFVSFGSFVALLSKCLRGAA
CGVTCFPAGTCACLTRSRRREGLPPSNGILRIQLGSDDPIKFVDVGGHSHGCTPLASAPTRSDSFMMVKSPSAPMAGEPVRPSCPPSDLL
YGLEEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLAA
TAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGV

--------------------------------------------------------------

>63261_63261_4_PCDHGC4-QKI_PCDHGC4_chr5_140867182_ENST00000306593_QKI_chr6_163956014_ENST00000392127_length(amino acids)=999AA_BP=814
MLRKVRSWTEIWRWATLLFLFYHLGYVCGQIRYPVPEESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNPI
DREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFAL
DVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPD
LGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLP
ESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVND
NPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDR
GNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRT
AVPIPADLPPQKLVIVVKDSGSPPLSTSVTLLVSLEEDTHPVVPDLRESSAPREGESRLTLYLAVSLVAICFVSFGSFVALLSKCLRGAA
CGVTCFPAGTCACLTRSRRREGLPPSNGILRIQLGSDDPIKFVDVGGHSHGCTPLASAPTRSDSFMMVKSPSAPMAGEPVRPSCPPSDLL
YGLEEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLAA
TAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGV

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>63261_63261_5_PCDHGC4-QKI_PCDHGC4_chr5_140867182_ENST00000306593_QKI_chr6_163956014_ENST00000424802_length(amino acids)=997AA_BP=814
MLRKVRSWTEIWRWATLLFLFYHLGYVCGQIRYPVPEESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNPI
DREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFAL
DVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPD
LGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLP
ESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVND
NPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDR
GNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRT
AVPIPADLPPQKLVIVVKDSGSPPLSTSVTLLVSLEEDTHPVVPDLRESSAPREGESRLTLYLAVSLVAICFVSFGSFVALLSKCLRGAA
CGVTCFPAGTCACLTRSRRREGLPPSNGILRIQLGSDDPIKFVDVGGHSHGCTPLASAPTRSDSFMMVKSPSAPMAGEPVRPSCPPSDLL
YGLEEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPTAQAAPRI
ITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGVLEWIEMPV

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>63261_63261_6_PCDHGC4-QKI_PCDHGC4_chr5_140867182_ENST00000306593_QKI_chr6_163956014_ENST00000453779_length(amino acids)=999AA_BP=814
MLRKVRSWTEIWRWATLLFLFYHLGYVCGQIRYPVPEESQEGTFVGNVAQDFLLDTDSLSARRLQVAGEVNQRHFRVDLDSGALLIKNPI
DREALCGLSASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSSNEHFAL
DVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPD
LGPSGNVTFYFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTLP
ESAEPGTVVALISVQDPDSGSNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTIFLNISDVND
NPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSASSFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDR
GNPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPPSVGAGHLITKVTAVDLDSGYNAWVSYQLLEAPDPSLFAVSRYAGEVRT
AVPIPADLPPQKLVIVVKDSGSPPLSTSVTLLVSLEEDTHPVVPDLRESSAPREGESRLTLYLAVSLVAICFVSFGSFVALLSKCLRGAA
CGVTCFPAGTCACLTRSRRREGLPPSNGILRIQLGSDDPIKFVDVGGHSHGCTPLASAPTRSDSFMMVKSPSAPMAGEPVRPSCPPSDLL
YGLEEEQNRGKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLAA
TAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGV

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:140867182/chr6:163956014)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.QKI

Q96PU8

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). {ECO:0000250|UniProtKB:Q9QYS9, ECO:0000269|PubMed:16641098, ECO:0000269|PubMed:23630077}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCDHGC4chr5:140867182chr6:163956014ENST00000306593+14134_242814.0939.0DomainCadherin 2
HgenePCDHGC4chr5:140867182chr6:163956014ENST00000306593+14243_350814.0939.0DomainCadherin 3
HgenePCDHGC4chr5:140867182chr6:163956014ENST00000306593+1430_133814.0939.0DomainCadherin 1
HgenePCDHGC4chr5:140867182chr6:163956014ENST00000306593+14351_455814.0939.0DomainCadherin 4
HgenePCDHGC4chr5:140867182chr6:163956014ENST00000306593+14456_565814.0939.0DomainCadherin 5
HgenePCDHGC4chr5:140867182chr6:163956014ENST00000306593+14572_676814.0939.0DomainCadherin 6
HgenePCDHGC4chr5:140867182chr6:163956014ENST00000306593+1430_692814.0939.0Topological domainExtracellular
HgenePCDHGC4chr5:140867182chr6:163956014ENST00000306593+14693_713814.0939.0TransmembraneHelical
TgeneQKIchr5:140867182chr6:163956014ENST0000027526227276_279134.0326.0MotifNote=SH3-binding
TgeneQKIchr5:140867182chr6:163956014ENST0000027526227324_330134.0326.0MotifNuclear localization signal
TgeneQKIchr5:140867182chr6:163956014ENST0000036119528276_279134.0334.0MotifNote=SH3-binding
TgeneQKIchr5:140867182chr6:163956014ENST0000036119528324_330134.0334.0MotifNuclear localization signal
TgeneQKIchr5:140867182chr6:163956014ENST0000036175228276_279134.0342.0MotifNote=SH3-binding
TgeneQKIchr5:140867182chr6:163956014ENST0000036175228324_330134.0342.0MotifNuclear localization signal
TgeneQKIchr5:140867182chr6:163956014ENST0000039212726276_279134.0320.0MotifNote=SH3-binding
TgeneQKIchr5:140867182chr6:163956014ENST0000039212726324_330134.0320.0MotifNuclear localization signal
TgeneQKIchr5:140867182chr6:163956014ENST0000042480227276_279134.0318.0MotifNote=SH3-binding
TgeneQKIchr5:140867182chr6:163956014ENST0000042480227324_330134.0318.0MotifNuclear localization signal
TgeneQKIchr5:140867182chr6:163956014ENST0000045377927276_279134.0320.0MotifNote=SH3-binding
TgeneQKIchr5:140867182chr6:163956014ENST0000045377927324_330134.0320.0MotifNuclear localization signal
TgeneQKIchr5:140867182chr6:163956014ENST0000027526227182_213134.0326.0RegionQua2 domain%3B involved in RNA binding
TgeneQKIchr5:140867182chr6:163956014ENST0000036119528182_213134.0334.0RegionQua2 domain%3B involved in RNA binding
TgeneQKIchr5:140867182chr6:163956014ENST0000036175228182_213134.0342.0RegionQua2 domain%3B involved in RNA binding
TgeneQKIchr5:140867182chr6:163956014ENST0000039212726182_213134.0320.0RegionQua2 domain%3B involved in RNA binding
TgeneQKIchr5:140867182chr6:163956014ENST0000042480227182_213134.0318.0RegionQua2 domain%3B involved in RNA binding
TgeneQKIchr5:140867182chr6:163956014ENST0000045377927182_213134.0320.0RegionQua2 domain%3B involved in RNA binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCDHGC4chr5:140867182chr6:163956014ENST00000306593+14714_938814.0939.0Topological domainCytoplasmic
TgeneQKIchr5:140867182chr6:163956014ENST000002752622787_153134.0326.0DomainNote=KH
TgeneQKIchr5:140867182chr6:163956014ENST000003611952887_153134.0334.0DomainNote=KH
TgeneQKIchr5:140867182chr6:163956014ENST000003617522887_153134.0342.0DomainNote=KH
TgeneQKIchr5:140867182chr6:163956014ENST000003921272687_153134.0320.0DomainNote=KH
TgeneQKIchr5:140867182chr6:163956014ENST000004248022787_153134.0318.0DomainNote=KH
TgeneQKIchr5:140867182chr6:163956014ENST000004537792787_153134.0320.0DomainNote=KH
TgeneQKIchr5:140867182chr6:163956014ENST000002752622711_82134.0326.0RegionQua1 domain%3B involved in homodimerization
TgeneQKIchr5:140867182chr6:163956014ENST000003611952811_82134.0334.0RegionQua1 domain%3B involved in homodimerization
TgeneQKIchr5:140867182chr6:163956014ENST000003617522811_82134.0342.0RegionQua1 domain%3B involved in homodimerization
TgeneQKIchr5:140867182chr6:163956014ENST000003921272611_82134.0320.0RegionQua1 domain%3B involved in homodimerization
TgeneQKIchr5:140867182chr6:163956014ENST000004248022711_82134.0318.0RegionQua1 domain%3B involved in homodimerization
TgeneQKIchr5:140867182chr6:163956014ENST000004537792711_82134.0320.0RegionQua1 domain%3B involved in homodimerization


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
QKIHNRNPK, USP30, MED12, MED13, MED25, MED16, MED17, MED1, MED24, MED23, MED4, MED29, MED31, MED15, MED14, MED26, MED10, POLR2A, MED27, ELAVL1, PSMF1, C10orf10, FUBP3, HCLS1, PCBP2, PTBP1, PTBP2, RBM14, RBFOX2, RBPMS, RNF138, SERF2, THAP1, USH1C, RBFOX1, PCBP1, PCBP4, APP, NDUFA7, CDV3, ATXN1, FN1, U2AF2, RBM23, RALY, WDR77, HNRNPH2, QKI, DAZ1, IL7R, CARM1, SNRPA, RBM11, NABP1, HNRNPLL, OIP5, RBMX, ZACN, CYP1A1, NTRK1, EWSR1, HYPK, DUSP22, DUSP4, ATE1, RBM42, FBXW11, SLC39A12, VAC14, TRIM11, SYNCRIP, SNRNP27, TAE1, PBP2, FBXO7, DMRTB1, CDKN2D, CCND3, TSG101, LSM3, TEX11, PIAS1, FHL3, ESR2, RAF1, APEX1, SNRNP70, DUSP14, LMBR1L, PRKAB2, TIAL1, E7, MIR7-1, MIR19B2, MIR34B, MIR34C, MIR141, MIR200A, CELF1, RBM47, RBMS1, C8orf82, RBM45, UFL1, DDRGK1, HNRNPA1, FZR1, HSPA2, HSPA1A, RBMS2, CYB5B, PRR3, CENPM, HNRNPUL2, FAM120A, HNRNPC, BAG1, IL7, TGM1, ELAVL2, BAG2, HSPA8, HNRNPCL2, HNRNPCL1, EIF4ENIF1, MBNL1, PCBP3, ALG13, YTHDF1, SNRPC, UNKL, BAG4, PRRC2B, MSI2, TNRC6A, ANKHD1, TXNL4A, CALD1, RBM7, ZMAT5, CCDC59, BCAS2, NXF1, TRNAU1AP, YTHDF3, NIP7, ZC3H10, CPSF7, SLAIN1, SECISBP2, RPL9, PRPF6, PRPF39, MBNL2, PCGF5, KIF21B, MRPL44, LSM5, UTP6, Pcbp1, Hnrnpk, Rbm38, Rbm47, Dusp14, Mrpl13, Ywhag, Pum2, Pef1, Hsp90aa1, GATA3, PAX9, SP7,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PCDHGC4
QKIall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PCDHGC4-QKI


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PCDHGC4-QKI


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneQKIC0036341Schizophrenia5PSYGENET
TgeneQKIC0017638Glioma1CTD_human
TgeneQKIC0041696Unipolar Depression1PSYGENET
TgeneQKIC0259783mixed gliomas1CTD_human
TgeneQKIC0555198Malignant Glioma1CTD_human
TgeneQKIC1269683Major Depressive Disorder1PSYGENET
TgeneQKIC2363903Angiocentric glioma1ORPHANET
TgeneQKIC3714756Intellectual Disability1GENOMICS_ENGLAND