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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ARHGEF7-ING1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ARHGEF7-ING1
FusionPDB ID: 6347
FusionGDB2.0 ID: 6347
HgeneTgene
Gene symbol

ARHGEF7

ING1

Gene ID

8874

3621

Gene nameRho guanine nucleotide exchange factor 7inhibitor of growth family member 1
SynonymsBETA-PIX|COOL-1|COOL1|Nbla10314|P50|P50BP|P85|P85COOL1|P85SPR|PAK3|PIXBp24ING1c|p33|p33ING1|p33ING1b|p47|p47ING1a
Cytomap

13q34

13q34

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 7PAK-interacting exchange factor betaRho guanine nucleotide exchange factor (GEF) 7SH3 domain-containing proline-rich proteininhibitor of growth protein 1growth inhibitor ING1growth inhibitory protein ING1tumor suppressor ING1
Modification date2020032720200313
UniProtAcc

Q14155

Q9UK53

Ensembl transtripts involved in fusion geneENST idsENST00000317133, ENST00000370623, 
ENST00000375741, ENST00000218789, 
ENST00000375736, ENST00000544132, 
ENST00000375723, ENST00000375737, 
ENST00000375739, ENST00000426073, 
ENST00000478679, ENST00000483189, 
ENST00000464141, ENST00000375774, 
ENST00000375775, ENST00000333219, 
ENST00000338450, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score25 X 17 X 12=51007 X 5 X 4=140
# samples 267
** MAII scorelog2(26/5100*10)=-4.29391371871777
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ARHGEF7 [Title/Abstract] AND ING1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ARHGEF7(111806338)-ING1(111371576), # samples:1
Anticipated loss of major functional domain due to fusion event.ARHGEF7-ING1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF7-ING1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF7-ING1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF7-ING1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF7-ING1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ARHGEF7-ING1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ARHGEF7-ING1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGEF7

GO:0043547

positive regulation of GTPase activity

21048939


check buttonFusion gene breakpoints across ARHGEF7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ING1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-A01K-01AARHGEF7chr13

111806338

+ING1chr13

111371576

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000317133ARHGEF7chr13111806338+ENST00000338450ING1chr13111371576+2107116010301863277
ENST00000375741ARHGEF7chr13111806338+ENST00000338450ING1chr13111371576+14495023721205277
ENST00000370623ARHGEF7chr13111806338+ENST00000338450ING1chr13111371576+1199252122955277

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000317133ENST00000338450ARHGEF7chr13111806338+ING1chr13111371576+0.0110984340.9889016
ENST00000375741ENST00000338450ARHGEF7chr13111806338+ING1chr13111371576+0.0117363860.9882636
ENST00000370623ENST00000338450ARHGEF7chr13111806338+ING1chr13111371576+0.0240032780.97599673

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>6347_6347_1_ARHGEF7-ING1_ARHGEF7_chr13_111806338_ENST00000317133_ING1_chr13_111371576_ENST00000338450_length(amino acids)=277AA_BP=43
MQAAGAPAPRDHRESLPRAPERERVPEQHPRVPARLRGFPAAGEILKELDECYERFSRETDGAQKRRMLHCVQRALIRSQELGDEKIQIV
SQMVELVENRTRQVDSHVELFEAQQELGDTAGNSGKAGADRPKGEAAAQADKPNSKRSRRQRNNENRENASSNHDHDDGASGTPKEKKAK
TSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCRGENEKTMDKALEKSK

--------------------------------------------------------------

>6347_6347_2_ARHGEF7-ING1_ARHGEF7_chr13_111806338_ENST00000370623_ING1_chr13_111371576_ENST00000338450_length(amino acids)=277AA_BP=43
MQAAGAPAPRDHRESLPRAPERERVPEQHPRVPARLRGFPAAGEILKELDECYERFSRETDGAQKRRMLHCVQRALIRSQELGDEKIQIV
SQMVELVENRTRQVDSHVELFEAQQELGDTAGNSGKAGADRPKGEAAAQADKPNSKRSRRQRNNENRENASSNHDHDDGASGTPKEKKAK
TSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCRGENEKTMDKALEKSK

--------------------------------------------------------------

>6347_6347_3_ARHGEF7-ING1_ARHGEF7_chr13_111806338_ENST00000375741_ING1_chr13_111371576_ENST00000338450_length(amino acids)=277AA_BP=43
MQAAGAPAPRDHRESLPRAPERERVPEQHPRVPARLRGFPAAGEILKELDECYERFSRETDGAQKRRMLHCVQRALIRSQELGDEKIQIV
SQMVELVENRTRQVDSHVELFEAQQELGDTAGNSGKAGADRPKGEAAAQADKPNSKRSRRQRNNENRENASSNHDHDDGASGTPKEKKAK
TSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCRGENEKTMDKALEKSK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:111806338/chr13:111371576)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGEF7

Q14155

ING1

Q9UK53

FUNCTION: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}.FUNCTION: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene. {ECO:0000269|PubMed:9440695}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneING1chr13:111806338chr13:111371576ENST0000033321902405_42245.333333333333336280.0RegionPBR
TgeneING1chr13:111806338chr13:111371576ENST0000033845002405_4221.3333333333333333236.0RegionPBR
TgeneING1chr13:111806338chr13:111371576ENST0000037577402405_422188.33333333333334423.0RegionPBR
TgeneING1chr13:111806338chr13:111371576ENST0000037577502405_4220211.0RegionPBR
TgeneING1chr13:111806338chr13:111371576ENST0000033321902353_40245.333333333333336280.0Zinc fingerPHD-type
TgeneING1chr13:111806338chr13:111371576ENST0000033845002353_4021.3333333333333333236.0Zinc fingerPHD-type
TgeneING1chr13:111806338chr13:111371576ENST0000037577402353_402188.33333333333334423.0Zinc fingerPHD-type
TgeneING1chr13:111806338chr13:111371576ENST0000037577502353_4020211.0Zinc fingerPHD-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000317133+219184_24384.0783.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000317133+2191_13384.0783.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000317133+219271_45184.0783.0DomainDH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000317133+219473_57884.0783.0DomainPH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000370623+219184_24384.0732.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000370623+2191_13384.0732.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000370623+219271_45184.0732.0DomainDH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000370623+219473_57884.0732.0DomainPH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375723+117184_2430626.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375723+1171_1330626.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375723+117271_4510626.0DomainDH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375723+117473_5780626.0DomainPH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375736+120184_2430647.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375736+1201_1330647.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375736+120271_4510647.0DomainDH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375736+120473_5780647.0DomainPH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375739+118184_2430754.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375739+1181_1330754.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375739+118271_4510754.0DomainDH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375739+118473_5780754.0DomainPH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375741+220184_24384.0804.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375741+2201_13384.0804.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375741+220271_45184.0804.0DomainDH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000375741+220473_57884.0804.0DomainPH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000426073+120184_2430647.0DomainSH3
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000426073+1201_1330647.0DomainCalponin-homology (CH)
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000426073+120271_4510647.0DomainDH
HgeneARHGEF7chr13:111806338chr13:111371576ENST00000426073+120473_5780647.0DomainPH


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ARHGEF7
ING1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ARHGEF7-ING1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ARHGEF7-ING1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource