UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:PCNX-RAD51B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PCNX-RAD51B
FusionPDB ID: 63476
FusionGDB2.0 ID: 63476
HgeneTgene
Gene symbol

PCNX

RAD51B

Gene ID

22990

5890

Gene namepecanex 1RAD51 paralog B
SynonymsPCNX|PCNXL1|pecanexR51H2|RAD51L1|REC2
Cytomap

14q24.2

14q24.1

Type of geneprotein-codingprotein-coding
Descriptionpecanex-like protein 1pecanex homolog 1DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein
Modification date2020031320200313
UniProtAcc.

O15315

Ensembl transtripts involved in fusion geneENST idsENST00000238570, ENST00000304743, 
ENST00000439984, ENST00000556272, 
ENST00000469165, ENST00000390683, 
ENST00000471583, ENST00000487270, 
ENST00000487861, ENST00000488612, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 3 X 5=7541 X 23 X 12=11316
# samples 556
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(56/11316*10)=-4.33679344445129
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PCNX [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PCNX(71374720)-RAD51B(68758601), # samples:2
Anticipated loss of major functional domain due to fusion event.PCNX-RAD51B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PCNX-RAD51B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PCNX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAD51B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-8506-01APCNXchr14

71374720

-RAD51Bchr14

68758601

+
ChimerDB4LUADTCGA-55-8506-01APCNXchr14

71374720

+RAD51Bchr14

68758601

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000238570PCNXchr1471374720+ENST00000487861RAD51Bchr1468758601+14395993591120253
ENST00000238570PCNXchr1471374720+ENST00000471583RAD51Bchr1468758601+1331599359895178
ENST00000238570PCNXchr1471374720+ENST00000487270RAD51Bchr1468758601+2391599359997212
ENST00000238570PCNXchr1471374720+ENST00000488612RAD51Bchr1468758601+1366599359943194
ENST00000238570PCNXchr1471374720+ENST00000390683RAD51Bchr1468758601+944599359943195
ENST00000304743PCNXchr1471374720+ENST00000487861RAD51Bchr1468758601+14395993591120253
ENST00000304743PCNXchr1471374720+ENST00000471583RAD51Bchr1468758601+1331599359895178
ENST00000304743PCNXchr1471374720+ENST00000487270RAD51Bchr1468758601+2391599359997212
ENST00000304743PCNXchr1471374720+ENST00000488612RAD51Bchr1468758601+1366599359943194
ENST00000304743PCNXchr1471374720+ENST00000390683RAD51Bchr1468758601+944599359943195
ENST00000439984PCNXchr1471374720+ENST00000487861RAD51Bchr1468758601+110526525786253
ENST00000439984PCNXchr1471374720+ENST00000471583RAD51Bchr1468758601+99726525561178
ENST00000439984PCNXchr1471374720+ENST00000487270RAD51Bchr1468758601+205726525663212
ENST00000439984PCNXchr1471374720+ENST00000488612RAD51Bchr1468758601+103226525609194
ENST00000439984PCNXchr1471374720+ENST00000390683RAD51Bchr1468758601+61026525609195

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000238570ENST00000487861PCNXchr1471374720+RAD51Bchr1468758601+0.0271348660.9728651
ENST00000238570ENST00000471583PCNXchr1471374720+RAD51Bchr1468758601+0.01616840.98383164
ENST00000238570ENST00000487270PCNXchr1471374720+RAD51Bchr1468758601+0.0563168230.94368315
ENST00000238570ENST00000488612PCNXchr1471374720+RAD51Bchr1468758601+0.0091552070.9908448
ENST00000238570ENST00000390683PCNXchr1471374720+RAD51Bchr1468758601+0.0067888060.9932112
ENST00000304743ENST00000487861PCNXchr1471374720+RAD51Bchr1468758601+0.0271348660.9728651
ENST00000304743ENST00000471583PCNXchr1471374720+RAD51Bchr1468758601+0.01616840.98383164
ENST00000304743ENST00000487270PCNXchr1471374720+RAD51Bchr1468758601+0.0563168230.94368315
ENST00000304743ENST00000488612PCNXchr1471374720+RAD51Bchr1468758601+0.0091552070.9908448
ENST00000304743ENST00000390683PCNXchr1471374720+RAD51Bchr1468758601+0.0067888060.9932112
ENST00000439984ENST00000487861PCNXchr1471374720+RAD51Bchr1468758601+0.108534590.8914655
ENST00000439984ENST00000471583PCNXchr1471374720+RAD51Bchr1468758601+0.037817020.96218306
ENST00000439984ENST00000487270PCNXchr1471374720+RAD51Bchr1468758601+0.0582335440.9417665
ENST00000439984ENST00000488612PCNXchr1471374720+RAD51Bchr1468758601+0.0367705450.9632294
ENST00000439984ENST00000390683PCNXchr1471374720+RAD51Bchr1468758601+0.0429331320.9570669

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63476_63476_1_PCNX-RAD51B_PCNX_chr14_71374720_ENST00000238570_RAD51B_chr14_68758601_ENST00000390683_length(amino acids)=195AA_BP=80
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMVILTNQITTH
LSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICI

--------------------------------------------------------------

>63476_63476_2_PCNX-RAD51B_PCNX_chr14_71374720_ENST00000238570_RAD51B_chr14_68758601_ENST00000471583_length(amino acids)=178AA_BP=80
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMVILTNQITTH

--------------------------------------------------------------

>63476_63476_3_PCNX-RAD51B_PCNX_chr14_71374720_ENST00000238570_RAD51B_chr14_68758601_ENST00000487270_length(amino acids)=212AA_BP=80
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMVILTNQITTH
LSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSV

--------------------------------------------------------------

>63476_63476_4_PCNX-RAD51B_PCNX_chr14_71374720_ENST00000238570_RAD51B_chr14_68758601_ENST00000487861_length(amino acids)=253AA_BP=80
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMVILTNQITTH
LSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVAR

--------------------------------------------------------------

>63476_63476_5_PCNX-RAD51B_PCNX_chr14_71374720_ENST00000238570_RAD51B_chr14_68758601_ENST00000488612_length(amino acids)=194AA_BP=80
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMVILTNQITTH
LSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICI

--------------------------------------------------------------

>63476_63476_6_PCNX-RAD51B_PCNX_chr14_71374720_ENST00000304743_RAD51B_chr14_68758601_ENST00000390683_length(amino acids)=195AA_BP=80
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMVILTNQITTH
LSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICI

--------------------------------------------------------------

>63476_63476_7_PCNX-RAD51B_PCNX_chr14_71374720_ENST00000304743_RAD51B_chr14_68758601_ENST00000471583_length(amino acids)=178AA_BP=80
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMVILTNQITTH

--------------------------------------------------------------

>63476_63476_8_PCNX-RAD51B_PCNX_chr14_71374720_ENST00000304743_RAD51B_chr14_68758601_ENST00000487270_length(amino acids)=212AA_BP=80
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMVILTNQITTH
LSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSV

--------------------------------------------------------------

>63476_63476_9_PCNX-RAD51B_PCNX_chr14_71374720_ENST00000304743_RAD51B_chr14_68758601_ENST00000487861_length(amino acids)=253AA_BP=80
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMVILTNQITTH
LSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVAR

--------------------------------------------------------------

>63476_63476_10_PCNX-RAD51B_PCNX_chr14_71374720_ENST00000304743_RAD51B_chr14_68758601_ENST00000488612_length(amino acids)=194AA_BP=80
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMVILTNQITTH
LSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICI

--------------------------------------------------------------

>63476_63476_11_PCNX-RAD51B_PCNX_chr14_71374720_ENST00000439984_RAD51B_chr14_68758601_ENST00000390683_length(amino acids)=195AA_BP=80
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMVILTNQITTH
LSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICI

--------------------------------------------------------------

>63476_63476_12_PCNX-RAD51B_PCNX_chr14_71374720_ENST00000439984_RAD51B_chr14_68758601_ENST00000471583_length(amino acids)=178AA_BP=80
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMVILTNQITTH

--------------------------------------------------------------

>63476_63476_13_PCNX-RAD51B_PCNX_chr14_71374720_ENST00000439984_RAD51B_chr14_68758601_ENST00000487270_length(amino acids)=212AA_BP=80
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMVILTNQITTH
LSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSV

--------------------------------------------------------------

>63476_63476_14_PCNX-RAD51B_PCNX_chr14_71374720_ENST00000439984_RAD51B_chr14_68758601_ENST00000487861_length(amino acids)=253AA_BP=80
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMVILTNQITTH
LSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVAR

--------------------------------------------------------------

>63476_63476_15_PCNX-RAD51B_PCNX_chr14_71374720_ENST00000439984_RAD51B_chr14_68758601_ENST00000488612_length(amino acids)=194AA_BP=80
MQAPATEAELGPGRGRRRRRRRRRRRRVGMGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMVILTNQITTH
LSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICI

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:71374720/chr14:68758601)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RAD51B

O15315

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:11751636, ECO:0000269|PubMed:11842113, ECO:0000269|PubMed:12441335, ECO:0000269|PubMed:23108668, ECO:0000269|PubMed:23149936}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCNXchr14:71374720chr14:68758601ENST00000238570+13528_5051.02270.0TransmembraneHelical
HgenePCNXchr14:71374720chr14:68758601ENST00000304743+13628_5051.02342.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCNXchr14:71374720chr14:68758601ENST00000238570+1352103_219951.02270.0Compositional biasNote=Ser-rich
HgenePCNXchr14:71374720chr14:68758601ENST00000238570+135245_25051.02270.0Compositional biasNote=Poly-His
HgenePCNXchr14:71374720chr14:68758601ENST00000238570+135602_63551.02270.0Compositional biasNote=Ser-rich
HgenePCNXchr14:71374720chr14:68758601ENST00000304743+1362103_219951.02342.0Compositional biasNote=Ser-rich
HgenePCNXchr14:71374720chr14:68758601ENST00000304743+136245_25051.02342.0Compositional biasNote=Poly-His
HgenePCNXchr14:71374720chr14:68758601ENST00000304743+136602_63551.02342.0Compositional biasNote=Ser-rich
HgenePCNXchr14:71374720chr14:68758601ENST00000238570+1351003_102551.02270.0TransmembraneHelical
HgenePCNXchr14:71374720chr14:68758601ENST00000238570+1351032_104951.02270.0TransmembraneHelical
HgenePCNXchr14:71374720chr14:68758601ENST00000238570+1351067_108951.02270.0TransmembraneHelical
HgenePCNXchr14:71374720chr14:68758601ENST00000238570+1351110_113251.02270.0TransmembraneHelical
HgenePCNXchr14:71374720chr14:68758601ENST00000238570+1351160_118251.02270.0TransmembraneHelical
HgenePCNXchr14:71374720chr14:68758601ENST00000238570+1351194_121351.02270.0TransmembraneHelical
HgenePCNXchr14:71374720chr14:68758601ENST00000238570+1351266_128851.02270.0TransmembraneHelical
HgenePCNXchr14:71374720chr14:68758601ENST00000238570+1351295_131251.02270.0TransmembraneHelical
HgenePCNXchr14:71374720chr14:68758601ENST00000238570+13557_7451.02270.0TransmembraneHelical
HgenePCNXchr14:71374720chr14:68758601ENST00000304743+1361003_102551.02342.0TransmembraneHelical
HgenePCNXchr14:71374720chr14:68758601ENST00000304743+1361032_104951.02342.0TransmembraneHelical
HgenePCNXchr14:71374720chr14:68758601ENST00000304743+1361067_108951.02342.0TransmembraneHelical
HgenePCNXchr14:71374720chr14:68758601ENST00000304743+1361110_113251.02342.0TransmembraneHelical
HgenePCNXchr14:71374720chr14:68758601ENST00000304743+1361160_118251.02342.0TransmembraneHelical
HgenePCNXchr14:71374720chr14:68758601ENST00000304743+1361194_121351.02342.0TransmembraneHelical
HgenePCNXchr14:71374720chr14:68758601ENST00000304743+1361266_128851.02342.0TransmembraneHelical
HgenePCNXchr14:71374720chr14:68758601ENST00000304743+1361295_131251.02342.0TransmembraneHelical
HgenePCNXchr14:71374720chr14:68758601ENST00000304743+13657_7451.02342.0TransmembraneHelical
TgeneRAD51Bchr14:71374720chr14:68758601ENST00000390683510108_115252.0367.0Nucleotide bindingATP
TgeneRAD51Bchr14:71374720chr14:68758601ENST00000471583611108_115252.0351.0Nucleotide bindingATP
TgeneRAD51Bchr14:71374720chr14:68758601ENST00000487270611108_115252.0385.0Nucleotide bindingATP
TgeneRAD51Bchr14:71374720chr14:68758601ENST00000488612612108_115252.0495.6666666666667Nucleotide bindingATP


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
RAD51BRAD51, RAD51C, RAD51D, XRCC2, SWSAP1, FAM9B, DKKL1, ARL4C, MUC20, ADAMTS4, HELQ, HNRNPL, SPDL1, BRCA1, TPT1, ABL1, MEOX2, RPAIN, ANAPC5, BAGE2, C15orf39, PRPF6, C5orf34, N4BP2L2, BANP, ANKHD1-EIF4EBP3, KLRC2, DSCC1, SATB2, ZNHIT6, PMS1, NUF2, APAF1, PRKACB, MAPRE2, CD300LB, PRKACG, TBC1D2B, MTR,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PCNX
RAD51Ball structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneRAD51Bchr14:71374720chr14:68758601ENST000003906835101_75252.0367.0RAD51C
TgeneRAD51Bchr14:71374720chr14:68758601ENST000004715836111_75252.0351.0RAD51C
TgeneRAD51Bchr14:71374720chr14:68758601ENST000004872706111_75252.0385.0RAD51C
TgeneRAD51Bchr14:71374720chr14:68758601ENST000004886126121_75252.0495.6666666666667RAD51C


Top

Related Drugs to PCNX-RAD51B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to PCNX-RAD51B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRAD51BC0006142Malignant neoplasm of breast1CTD_human
TgeneRAD51BC0013146Drug abuse1CTD_human
TgeneRAD51BC0013170Drug habituation1CTD_human
TgeneRAD51BC0013222Drug Use Disorders1CTD_human
TgeneRAD51BC0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneRAD51BC0038580Substance Dependence1CTD_human
TgeneRAD51BC0038586Substance Use Disorders1CTD_human
TgeneRAD51BC0236969Substance-Related Disorders1CTD_human
TgeneRAD51BC0238033Carcinoma of Male Breast1CTD_human
TgeneRAD51BC0242788Breast Neoplasms, Male1CTD_human
TgeneRAD51BC0678222Breast Carcinoma1CTD_human
TgeneRAD51BC0740858Substance abuse problem1CTD_human
TgeneRAD51BC1257931Mammary Neoplasms, Human1CTD_human
TgeneRAD51BC1458155Mammary Neoplasms1CTD_human
TgeneRAD51BC1510472Drug Dependence1CTD_human
TgeneRAD51BC4316881Prescription Drug Abuse1CTD_human
TgeneRAD51BC4704874Mammary Carcinoma, Human1CTD_human