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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PDCD6-TERT

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PDCD6-TERT
	FusionPDB ID: 63623
	FusionGDB2.0 ID: 63623
		Hgene	Tgene
	Gene symbol	PDCD6	TERT
	Gene ID	10016	7015
	Gene name	programmed cell death 6	telomerase reverse transcriptase
	Synonyms	ALG-2\|ALG2\|PEF1B	CMM9\|DKCA2\|DKCB4\|EST2\|PFBMFT1\|TCS1\|TP2\|TRT\|hEST2\|hTRT
	Cytomap	5p15.33	5p15.33
	Type of gene	protein-coding	protein-coding
	Description	programmed cell death protein 6apoptosis-linked gene 2 proteinapoptosis-linked gene 2 protein homologprobable calcium-binding protein ALG-2	telomerase reverse transcriptasetelomerase catalytic subunittelomerase-associated protein 2
	Modification date	20200313	20200329
	UniProtAcc	O75340	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000264933, ENST00000505221, ENST00000507528, ENST00000509581, ENST00000511482,	ENST00000522877, ENST00000296820, ENST00000310581, ENST00000334602, ENST00000508104,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	3 X 2 X 4=24	22 X 7 X 15=2310
	# samples	4	31
	** MAII score	log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(31/2310*10)=-2.89755273102918 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PDCD6 [Title/Abstract] AND TERT [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PDCD6(272887)-TERT(1282739), # samples:4
Anticipated loss of major functional domain due to fusion event.	PDCD6-TERT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PDCD6-TERT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PDCD6-TERT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PDCD6-TERT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PDCD6-TERT seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PDCD6	GO:0001938	positive regulation of endothelial cell proliferation	21893193
Hgene	PDCD6	GO:0006886	intracellular protein transport	21122810
Hgene	PDCD6	GO:0010595	positive regulation of endothelial cell migration	21893193
Hgene	PDCD6	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	21893193
Hgene	PDCD6	GO:0032007	negative regulation of TOR signaling	21893193
Hgene	PDCD6	GO:0034605	cellular response to heat	21122810
Hgene	PDCD6	GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway	21893193
Hgene	PDCD6	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	16132846
Hgene	PDCD6	GO:0045766	positive regulation of angiogenesis	21893193
Hgene	PDCD6	GO:0051898	negative regulation of protein kinase B signaling	21893193
Tgene	TERT	GO:0001172	transcription, RNA-templated	19701182
Tgene	TERT	GO:0006278	RNA-dependent DNA biosynthetic process	9398860
Tgene	TERT	GO:0007004	telomere maintenance via telomerase	9443919\|16043710\|17940095\|19701182\|21531765\|29695869
Tgene	TERT	GO:0007005	mitochondrion organization	21937513
Tgene	TERT	GO:0010629	negative regulation of gene expression	11927518
Tgene	TERT	GO:0022616	DNA strand elongation	16043710
Tgene	TERT	GO:0030422	production of siRNA involved in RNA interference	19701182
Tgene	TERT	GO:0031647	regulation of protein stability	24415760\|26194824
Tgene	TERT	GO:0032092	positive regulation of protein binding	24415760
Tgene	TERT	GO:0051000	positive regulation of nitric-oxide synthase activity	11927518
Tgene	TERT	GO:0070200	establishment of protein localization to telomere	25589350
Tgene	TERT	GO:0071897	DNA biosynthetic process	9398860\|19701182
Tgene	TERT	GO:1903704	negative regulation of production of siRNA involved in RNA interference	19701182
Tgene	TERT	GO:1904751	positive regulation of protein localization to nucleolus	24415760
Tgene	TERT	GO:2000773	negative regulation of cellular senescence	11927518

Fusion gene breakpoints across PDCD6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TERT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KICH	TCGA-KN-8435-01A	PDCD6	chr5	271936	+	TERT	chr5	1282739	-
ChimerDB4	KICH	TCGA-KN-8435-01A	PDCD6	chr5	271936	-	TERT	chr5	1294781	-
ChimerDB4	KIRC	TCGA-BP-4991-01A	PDCD6	chr5	272887	-	TERT	chr5	1282739	-
ChimerDB4	KIRC	TCGA-BP-4991-01A	PDCD6	chr5	272887	+	TERT	chr5	1282739	-
ChimerDB4	KIRC	TCGA-BP-4991	PDCD6	chr5	272887	+	TERT	chr5	1282739	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264933	PDCD6	chr5	272887	+	ENST00000310581	TERT	chr5	1282739	-	2650	263	4	2088	694
ENST00000264933	PDCD6	chr5	272887	+	ENST00000334602	TERT	chr5	1282739	-	1900	263	4	1899	632
ENST00000264933	PDCD6	chr5	272887	+	ENST00000508104	TERT	chr5	1282739	-	1176	263	4	1113	369
ENST00000505221	PDCD6	chr5	272887	+	ENST00000310581	TERT	chr5	1282739	-	2624	237	20	2062	680
ENST00000505221	PDCD6	chr5	272887	+	ENST00000334602	TERT	chr5	1282739	-	1874	237	20	1873	618
ENST00000505221	PDCD6	chr5	272887	+	ENST00000508104	TERT	chr5	1282739	-	1150	237	20	1087	355
ENST00000509581	PDCD6	chr5	272887	+	ENST00000310581	TERT	chr5	1282739	-	2614	227	10	2052	680
ENST00000509581	PDCD6	chr5	272887	+	ENST00000334602	TERT	chr5	1282739	-	1864	227	10	1863	618
ENST00000509581	PDCD6	chr5	272887	+	ENST00000508104	TERT	chr5	1282739	-	1140	227	10	1077	355
ENST00000507528	PDCD6	chr5	272887	+	ENST00000310581	TERT	chr5	1282739	-	2614	227	10	2052	680
ENST00000507528	PDCD6	chr5	272887	+	ENST00000334602	TERT	chr5	1282739	-	1864	227	10	1863	618
ENST00000507528	PDCD6	chr5	272887	+	ENST00000508104	TERT	chr5	1282739	-	1140	227	10	1077	355

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264933	ENST00000310581	PDCD6	chr5	272887	+	TERT	chr5	1282739	-	0.02507733	0.97492266
ENST00000264933	ENST00000334602	PDCD6	chr5	272887	+	TERT	chr5	1282739	-	0.045585845	0.9544142
ENST00000264933	ENST00000508104	PDCD6	chr5	272887	+	TERT	chr5	1282739	-	0.088767715	0.91123235
ENST00000505221	ENST00000310581	PDCD6	chr5	272887	+	TERT	chr5	1282739	-	0.030087616	0.96991235
ENST00000505221	ENST00000334602	PDCD6	chr5	272887	+	TERT	chr5	1282739	-	0.047874704	0.9521254
ENST00000505221	ENST00000508104	PDCD6	chr5	272887	+	TERT	chr5	1282739	-	0.05288159	0.9471184
ENST00000509581	ENST00000310581	PDCD6	chr5	272887	+	TERT	chr5	1282739	-	0.02978985	0.9702102
ENST00000509581	ENST00000334602	PDCD6	chr5	272887	+	TERT	chr5	1282739	-	0.04885103	0.951149
ENST00000509581	ENST00000508104	PDCD6	chr5	272887	+	TERT	chr5	1282739	-	0.05373235	0.94626766
ENST00000507528	ENST00000310581	PDCD6	chr5	272887	+	TERT	chr5	1282739	-	0.02978985	0.9702102
ENST00000507528	ENST00000334602	PDCD6	chr5	272887	+	TERT	chr5	1282739	-	0.04885103	0.951149
ENST00000507528	ENST00000508104	PDCD6	chr5	272887	+	TERT	chr5	1282739	-	0.05373235	0.94626766

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63623_63623_1_PDCD6-TERT_PDCD6_chr5_272887_ENST00000264933_TERT_chr5_1282739_ENST00000310581_length(amino acids)=694AA_BP=1
MPGPAPGRGGSGVGLRGLSSLQAPQPSRVPWPMAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGVGC
VPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLT
SRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYF
VKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSL
NEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLV
RGVPEYGCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVL
RLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSE

--------------------------------------------------------------

>63623_63623_2_PDCD6-TERT_PDCD6_chr5_272887_ENST00000264933_TERT_chr5_1282739_ENST00000334602_length(amino acids)=632AA_BP=1
MPGPAPGRGGSGVGLRGLSSLQAPQPSRVPWPMAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGVGC
VPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLT
SRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYF
VKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSL
NEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLSYAR
TSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTAS
LCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTIL

--------------------------------------------------------------

>63623_63623_3_PDCD6-TERT_PDCD6_chr5_272887_ENST00000264933_TERT_chr5_1282739_ENST00000508104_length(amino acids)=369AA_BP=1
MPGPAPGRGGSGVGLRGLSSLQAPQPSRVPWPMAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGVGC
VPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLT
SRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYF
VKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVLRPVPGDPAGLHPLHAALQPVLRRHGEQAVCGDSA

--------------------------------------------------------------

>63623_63623_4_PDCD6-TERT_PDCD6_chr5_272887_ENST00000505221_TERT_chr5_1282739_ENST00000310581_length(amino acids)=680AA_BP=1
MRGLSSLQAPQPSRVPWPMAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGVGCVPAAEHRLREEILA
KFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRP
IVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQ
DRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRF
MCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRK
TVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVN
SLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKL

--------------------------------------------------------------

>63623_63623_5_PDCD6-TERT_PDCD6_chr5_272887_ENST00000505221_TERT_chr5_1282739_ENST00000334602_length(amino acids)=618AA_BP=1
MRGLSSLQAPQPSRVPWPMAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGVGCVPAAEHRLREEILA
KFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRP
IVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQ
DRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRF
MCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLSYARTSIRASLTFNRGFK
AGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMS

--------------------------------------------------------------

>63623_63623_6_PDCD6-TERT_PDCD6_chr5_272887_ENST00000505221_TERT_chr5_1282739_ENST00000508104_length(amino acids)=355AA_BP=1
MRGLSSLQAPQPSRVPWPMAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGVGCVPAAEHRLREEILA
KFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRP
IVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQ

--------------------------------------------------------------

>63623_63623_7_PDCD6-TERT_PDCD6_chr5_272887_ENST00000507528_TERT_chr5_1282739_ENST00000310581_length(amino acids)=680AA_BP=1
MRGLSSLQAPQPSRVPWPMAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGVGCVPAAEHRLREEILA
KFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRP
IVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQ
DRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRF
MCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRK
TVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVN
SLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKL

--------------------------------------------------------------

>63623_63623_8_PDCD6-TERT_PDCD6_chr5_272887_ENST00000507528_TERT_chr5_1282739_ENST00000334602_length(amino acids)=618AA_BP=1
MRGLSSLQAPQPSRVPWPMAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGVGCVPAAEHRLREEILA
KFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRP
IVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQ
DRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRF
MCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLSYARTSIRASLTFNRGFK
AGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMS

--------------------------------------------------------------

>63623_63623_9_PDCD6-TERT_PDCD6_chr5_272887_ENST00000507528_TERT_chr5_1282739_ENST00000508104_length(amino acids)=355AA_BP=1
MRGLSSLQAPQPSRVPWPMAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGVGCVPAAEHRLREEILA
KFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRP
IVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQ

--------------------------------------------------------------

>63623_63623_10_PDCD6-TERT_PDCD6_chr5_272887_ENST00000509581_TERT_chr5_1282739_ENST00000310581_length(amino acids)=680AA_BP=1
MRGLSSLQAPQPSRVPWPMAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGVGCVPAAEHRLREEILA
KFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRP
IVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQ
DRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRF
MCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRK
TVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVN
SLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKL

--------------------------------------------------------------

>63623_63623_11_PDCD6-TERT_PDCD6_chr5_272887_ENST00000509581_TERT_chr5_1282739_ENST00000334602_length(amino acids)=618AA_BP=1
MRGLSSLQAPQPSRVPWPMAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGVGCVPAAEHRLREEILA
KFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRP
IVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQ
DRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRF
MCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLSYARTSIRASLTFNRGFK
AGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMS

--------------------------------------------------------------

>63623_63623_12_PDCD6-TERT_PDCD6_chr5_272887_ENST00000509581_TERT_chr5_1282739_ENST00000508104_length(amino acids)=355AA_BP=1
MRGLSSLQAPQPSRVPWPMAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGVGCVPAAEHRLREEILA
KFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRP
IVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQ

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:272887/chr5:1282739)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PDCD6 O75340	.
FUNCTION: Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:20691033, PubMed:25667979). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:19520058). Together with PEF1, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (PubMed:19864416). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (By similarity). May mediate Ca(2+)-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (PubMed:16132846). Its role in apoptosis may however be indirect, as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (PubMed:21893193). In case of infection by HIV-1 virus, indirectly inhibits HIV-1 production by affecting viral Gag expression and distribution (PubMed:27784779). {ECO:0000250\|UniProtKB:P12815, ECO:0000269\|PubMed:16132846, ECO:0000269\|PubMed:19520058, ECO:0000269\|PubMed:19864416, ECO:0000269\|PubMed:20691033, ECO:0000269\|PubMed:21893193, ECO:0000269\|PubMed:25667979, ECO:0000269\|PubMed:27716508, ECO:0000269\|PubMed:27784779, ECO:0000269\|PubMed:27813252}.; FUNCTION: [Isoform 2]: Has a lower Ca(2+) affinity than isoform 1 (By similarity). {ECO:0000250\|UniProtKB:P12815}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000264933

36_47

54.333333333333336

192.0

Calcium binding

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000505221

36_47

54.333333333333336

70.0

Calcium binding

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000507528

36_47

54.333333333333336

190.0

Calcium binding

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000296820

605_935

524.3333333333334

445.6666666666667

Domain

Reverse transcriptase

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000310581

605_935

524.3333333333334

1133.0

Domain

Reverse transcriptase

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000334602

605_935

524.3333333333334

1070.0

Domain

Reverse transcriptase

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000508104

605_935

524.3333333333334

808.0

Domain

Reverse transcriptase

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000296820

914_928

524.3333333333334

445.6666666666667

Region

Note=Required for oligomerization

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000296820

936_1132

524.3333333333334

445.6666666666667

Region

Note=CTE

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000310581

914_928

524.3333333333334

1133.0

Region

Note=Required for oligomerization

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000310581

936_1132

524.3333333333334

1133.0

Region

Note=CTE

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000334602

914_928

524.3333333333334

1070.0

Region

Note=Required for oligomerization

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000334602

936_1132

524.3333333333334

1070.0

Region

Note=CTE

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000508104

914_928

524.3333333333334

808.0

Region

Note=Required for oligomerization

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000508104

936_1132

524.3333333333334

808.0

Region

Note=CTE

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000264933

103_114

54.333333333333336

192.0

Calcium binding

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000264933

73_84

54.333333333333336

192.0

Calcium binding

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000505221

103_114

54.333333333333336

70.0

Calcium binding

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000505221

73_84

54.333333333333336

70.0

Calcium binding

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000507528

103_114

54.333333333333336

190.0

Calcium binding

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000507528

73_84

54.333333333333336

190.0

Calcium binding

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000264933

126_161

54.333333333333336

192.0

Domain

EF-hand 4

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000264933

162_191

54.333333333333336

192.0

Domain

EF-hand 5

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000264933

23_58

54.333333333333336

192.0

Domain

EF-hand 1

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000264933

59_89

54.333333333333336

192.0

Domain

EF-hand 2

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000264933

90_125

54.333333333333336

192.0

Domain

EF-hand 3

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000505221

126_161

54.333333333333336

70.0

Domain

EF-hand 4

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000505221

162_191

54.333333333333336

70.0

Domain

EF-hand 5

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000505221

23_58

54.333333333333336

70.0

Domain

EF-hand 1

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000505221

59_89

54.333333333333336

70.0

Domain

EF-hand 2

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000505221

90_125

54.333333333333336

70.0

Domain

EF-hand 3

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000507528

126_161

54.333333333333336

190.0

Domain

EF-hand 4

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000507528

162_191

54.333333333333336

190.0

Domain

EF-hand 5

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000507528

23_58

54.333333333333336

190.0

Domain

EF-hand 1

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000507528

59_89

54.333333333333336

190.0

Domain

EF-hand 2

Hgene

PDCD6

chr5:272887

chr5:1282739

ENST00000507528

90_125

54.333333333333336

190.0

Domain

EF-hand 3

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000296820

222_240

524.3333333333334

445.6666666666667

Motif

Note=Bipartite nuclear localization signal

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000296820

328_333

524.3333333333334

445.6666666666667

Motif

TFLY%3B involved in RNA binding

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000310581

222_240

524.3333333333334

1133.0

Motif

Note=Bipartite nuclear localization signal

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000310581

328_333

524.3333333333334

1133.0

Motif

TFLY%3B involved in RNA binding

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000334602

222_240

524.3333333333334

1070.0

Motif

Note=Bipartite nuclear localization signal

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000334602

328_333

524.3333333333334

1070.0

Motif

TFLY%3B involved in RNA binding

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000508104

222_240

524.3333333333334

808.0

Motif

Note=Bipartite nuclear localization signal

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000508104

328_333

524.3333333333334

808.0

Motif

TFLY%3B involved in RNA binding

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000296820

1_230

524.3333333333334

445.6666666666667

Region

Note=RNA-interacting domain 1

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000296820

231_324

524.3333333333334

445.6666666666667

Region

Note=Linker

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000296820

301_538

524.3333333333334

445.6666666666667

Region

Note=Required for oligomerization

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000296820

325_550

524.3333333333334

445.6666666666667

Region

Note=RNA-interacting domain 2

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000296820

376_521

524.3333333333334

445.6666666666667

Region

Note=QFP motif

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000296820

397_417

524.3333333333334

445.6666666666667

Region

Note=CP motif

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000296820

58_197

524.3333333333334

445.6666666666667

Region

Note=GQ motif

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000310581

1_230

524.3333333333334

1133.0

Region

Note=RNA-interacting domain 1

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000310581

231_324

524.3333333333334

1133.0

Region

Note=Linker

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000310581

301_538

524.3333333333334

1133.0

Region

Note=Required for oligomerization

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000310581

325_550

524.3333333333334

1133.0

Region

Note=RNA-interacting domain 2

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000310581

376_521

524.3333333333334

1133.0

Region

Note=QFP motif

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000310581

397_417

524.3333333333334

1133.0

Region

Note=CP motif

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000310581

58_197

524.3333333333334

1133.0

Region

Note=GQ motif

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000334602

1_230

524.3333333333334

1070.0

Region

Note=RNA-interacting domain 1

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000334602

231_324

524.3333333333334

1070.0

Region

Note=Linker

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000334602

301_538

524.3333333333334

1070.0

Region

Note=Required for oligomerization

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000334602

325_550

524.3333333333334

1070.0

Region

Note=RNA-interacting domain 2

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000334602

376_521

524.3333333333334

1070.0

Region

Note=QFP motif

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000334602

397_417

524.3333333333334

1070.0

Region

Note=CP motif

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000334602

58_197

524.3333333333334

1070.0

Region

Note=GQ motif

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000508104

1_230

524.3333333333334

808.0

Region

Note=RNA-interacting domain 1

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000508104

231_324

524.3333333333334

808.0

Region

Note=Linker

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000508104

301_538

524.3333333333334

808.0

Region

Note=Required for oligomerization

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000508104

325_550

524.3333333333334

808.0

Region

Note=RNA-interacting domain 2

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000508104

376_521

524.3333333333334

808.0

Region

Note=QFP motif

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000508104

397_417

524.3333333333334

808.0

Region

Note=CP motif

Tgene

TERT

chr5:272887

chr5:1282739

ENST00000508104

58_197

524.3333333333334

808.0

Region

Note=GQ motif

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1423_PDCD6_272887_TERT_1282739_ranked_0.pdb	PDCD6	272887	272887	ENST00000508104	TERT	chr5	1282739	-	MPGPAPGRGGSGVGLRGLSSLQAPQPSRVPWPMAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGVGC VPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLT SRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYF VKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSL NEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLV RGVPEYGCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVL RLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSE	694

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PDCD6_pLDDT.png

TERT_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PDCD6
TERT

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to PDCD6-TERT

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PDCD6-TERT

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source