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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PDE4DIP-C1orf186

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PDE4DIP-C1orf186
FusionPDB ID: 63729
FusionGDB2.0 ID: 63729
HgeneTgene
Gene symbol

PDE4DIP

C1orf186

Gene ID

9659

440712

Gene namephosphodiesterase 4D interacting proteinregulator of hemoglobinization and erythroid cell expansion
SynonymsCMYA2|MMGLC1orf186
Cytomap

1q21.2

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionmyomegalincardiomyopathy-associated protein 2myomegalin/phosphodiesterase 4D interacting protein variant 8regulator of hemoglobinization and erythroid cell expansion proteinregulator of human erythroid cell expansionregulator of human erythroid cell expansion proteinuncharacterized protein C1orf186
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000313382, ENST00000313431, 
ENST00000369349, ENST00000369351, 
ENST00000369354, ENST00000369356, 
ENST00000369359, ENST00000479408, 
ENST00000529945, ENST00000530740, 
ENST00000369345, ENST00000369347, 
ENST00000369348, ENST00000478649, 
ENST00000493130, ENST00000524974, 
ENST00000469540, ENST00000331555, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 9 X 7=5674 X 4 X 4=64
# samples 94
** MAII scorelog2(9/567*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PDE4DIP [Title/Abstract] AND C1orf186 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PDE4DIP(144915445)-C1orf186(206239579), # samples:3
Anticipated loss of major functional domain due to fusion event.PDE4DIP-C1orf186 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PDE4DIP-C1orf186 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PDE4DIP-C1orf186 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PDE4DIP-C1orf186 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDE4DIP

GO:1903358

regulation of Golgi organization

27666745


check buttonFusion gene breakpoints across PDE4DIP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C1orf186 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A203-01APDE4DIPchr1

144915445

-C1orf186chr1

206239579

-
ChimerDB4BRCATCGA-BH-A203-01APDE4DIPchr1

144915445

+C1orf186chr1

206239579

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000313382PDE4DIPchr1144915445+ENST00000331555C1orf186chr1206239579+327925712972771824
ENST00000369354PDE4DIPchr1144915445+ENST00000331555C1orf186chr1206239579+287821701062370754
ENST00000369356PDE4DIPchr1144915445+ENST00000331555C1orf186chr1206239579+297922712072471754
ENST00000530740PDE4DIPchr1144915445+ENST00000331555C1orf186chr1206239579+31382430392630863
ENST00000369359PDE4DIPchr1144915445+ENST00000331555C1orf186chr1206239579+31382430392630863
ENST00000369351PDE4DIPchr1144915445+ENST00000331555C1orf186chr1206239579+27972089252289754
ENST00000369349PDE4DIPchr1144915445+ENST00000331555C1orf186chr1206239579+28332125612325754
ENST00000313431PDE4DIPchr1144915445+ENST00000331555C1orf186chr1206239579+383431266573326889
ENST00000529945PDE4DIPchr1144915445+ENST00000331555C1orf186chr1206239579+361729094403109889

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000313382ENST00000331555PDE4DIPchr1144915445+C1orf186chr1206239579+0.0220704970.97792953
ENST00000369354ENST00000331555PDE4DIPchr1144915445+C1orf186chr1206239579+0.0152983860.98470163
ENST00000369356ENST00000331555PDE4DIPchr1144915445+C1orf186chr1206239579+0.0134586060.9865414
ENST00000530740ENST00000331555PDE4DIPchr1144915445+C1orf186chr1206239579+0.0103153380.9896847
ENST00000369359ENST00000331555PDE4DIPchr1144915445+C1orf186chr1206239579+0.0103153380.9896847
ENST00000369351ENST00000331555PDE4DIPchr1144915445+C1orf186chr1206239579+0.016610820.9833892
ENST00000369349ENST00000331555PDE4DIPchr1144915445+C1orf186chr1206239579+0.0149817940.9850182
ENST00000313431ENST00000331555PDE4DIPchr1144915445+C1orf186chr1206239579+0.0037234560.99627656
ENST00000529945ENST00000331555PDE4DIPchr1144915445+C1orf186chr1206239579+0.0034803050.9965197

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63729_63729_1_PDE4DIP-C1orf186_PDE4DIP_chr1_144915445_ENST00000313382_C1orf186_chr1_206239579_ENST00000331555_length(amino acids)=824AA_BP=758
MRWRFVGKASHFPRLLPLPGEERPETKERAWKMEQTWTRDYFAEDDGEMVPRTSHTAAFLSDTKDRGPPVQSQIWRSGEKVPFVQTYSLR
AFEKPPQVQTQALRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQ
NEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRD
KRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKL
NEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQ
LEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHS
LSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEA
TMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQR
KERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQATEDVDYTQVVFSDPGELKNDSPLDYENIKEITDYVNVNPERHKPSFWYFVN

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>63729_63729_2_PDE4DIP-C1orf186_PDE4DIP_chr1_144915445_ENST00000313431_C1orf186_chr1_206239579_ENST00000331555_length(amino acids)=889AA_BP=823
MKEICRICARELCGNQRRWIFHTASKLNLQVLLSHVLGKDVPRDGKAEFACSKCAFMLDRIYRFDTVIARIEALSIERLQKLLLEKDRLK
FCIASMYRKNNDDSGAEIKAGNGTVDMSVLPDARYSALLQEDFAYSGFECWVENEDQIQEPHSCHGSEGPGNRPRRCRGCAALRVADSDY
EAICKVPRKVARSISCGPSSRWSTSICTEEPALSEVGPPDLASTKVPPDGESMEEETPGSSVESLDASVQASPPQQKDEETERSAKELGK
CDCCSDDQAPQHGCNHKLELALSMIKGLDYKPIQSPRGSRLPIPVKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKTPVSYPLELSDLQE
LWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLK
ETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ
FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTL
EANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQN
LQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQG

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>63729_63729_3_PDE4DIP-C1orf186_PDE4DIP_chr1_144915445_ENST00000369349_C1orf186_chr1_206239579_ENST00000331555_length(amino acids)=754AA_BP=688
MASCCGAAAPCSWVEGAIGHAPPHGLPIMSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKREL
QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWE
DVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA
ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGT
SPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWE
AEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLA
VRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLL
CKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQATEDVDYTQVVFSDPGELKNDSPLDYENIKEI

--------------------------------------------------------------

>63729_63729_4_PDE4DIP-C1orf186_PDE4DIP_chr1_144915445_ENST00000369351_C1orf186_chr1_206239579_ENST00000331555_length(amino acids)=754AA_BP=688
MASCCGAAAPCSWVEGAIGHAPPHGLPIMSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKREL
QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWE
DVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA
ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGT
SPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWE
AEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLA
VRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLL
CKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQATEDVDYTQVVFSDPGELKNDSPLDYENIKEI

--------------------------------------------------------------

>63729_63729_5_PDE4DIP-C1orf186_PDE4DIP_chr1_144915445_ENST00000369354_C1orf186_chr1_206239579_ENST00000331555_length(amino acids)=754AA_BP=688
MASCCGAAAPCSWVEGAIGHAPPHGLPIMSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKREL
QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWE
DVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA
ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGT
SPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWE
AEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLA
VRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLL
CKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQATEDVDYTQVVFSDPGELKNDSPLDYENIKEI

--------------------------------------------------------------

>63729_63729_6_PDE4DIP-C1orf186_PDE4DIP_chr1_144915445_ENST00000369356_C1orf186_chr1_206239579_ENST00000331555_length(amino acids)=754AA_BP=688
MASCCGAAAPCSWVEGAIGHAPPHGLPIMSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRNIELKVEVESLKREL
QDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAEKECNLELSEKLKGVTKNWE
DVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQKLNSHETTITQQSVSDSHLA
ELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGT
SPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWE
AEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLA
VRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLL
CKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQATEDVDYTQVVFSDPGELKNDSPLDYENIKEI

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>63729_63729_7_PDE4DIP-C1orf186_PDE4DIP_chr1_144915445_ENST00000369359_C1orf186_chr1_206239579_ENST00000331555_length(amino acids)=863AA_BP=797
MKGTDSGSCCRRRCDFGCCCRASRRAHYTPYRSGDATRTPQSPRQTPSRERRRPEPAGSWAAAAEEEEAAAAATPWMRDYFAEDDGEMVP
RTSHTAAFLSDTKDRGPPVQSQIWRSGEKVPFVQTYSLRAFEKPPQVQTQALRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASRED
IYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAE
KECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQK
LNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAK
LREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKA
LQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAID
EKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQL
QTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQATEDVDYTQVVFS

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>63729_63729_8_PDE4DIP-C1orf186_PDE4DIP_chr1_144915445_ENST00000529945_C1orf186_chr1_206239579_ENST00000331555_length(amino acids)=889AA_BP=823
MKEICRICARELCGNQRRWIFHTASKLNLQVLLSHVLGKDVPRDGKAEFACSKCAFMLDRIYRFDTVIARIEALSIERLQKLLLEKDRLK
FCIASMYRKNNDDSGAEIKAGNGTVDMSVLPDARYSALLQEDFAYSGFECWVENEDQIQEPHSCHGSEGPGNRPRRCRGCAALRVADSDY
EAICKVPRKVARSISCGPSSRWSTSICTEEPALSEVGPPDLASTKVPPDGESMEEETPGSSVESLDASVQASPPQQKDEETERSAKELGK
CDCCSDDQAPQHGCNHKLELALSMIKGLDYKPIQSPRGSRLPIPVKSSLPGAKPGPSMTDGVSSGFLNRSLKPLYKTPVSYPLELSDLQE
LWDDLCEDYLPLRVQPMTEELLKQQKLNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLK
ETLKSRERETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQ
FVEAAAHESEQQKEASWKHNQELRKALQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTL
EANEMLLEKLRQRIHDKAVALERAIDEKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQN
LQWLKEEMETKFSRWQKEQESIIQQLQTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQG

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>63729_63729_9_PDE4DIP-C1orf186_PDE4DIP_chr1_144915445_ENST00000530740_C1orf186_chr1_206239579_ENST00000331555_length(amino acids)=863AA_BP=797
MKGTDSGSCCRRRCDFGCCCRASRRAHYTPYRSGDATRTPQSPRQTPSRERRRPEPAGSWAAAAEEEEAAAAATPWMRDYFAEDDGEMVP
RTSHTAAFLSDTKDRGPPVQSQIWRSGEKVPFVQTYSLRAFEKPPQVQTQALRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASRED
IYKRNIELKVEVESLKRELQDKKQHLDKTWADVENLNSQNEAELRRQFEERQQETEHVYELLENKIQLLQEESRLAKNEAARMAALVEAE
KECNLELSEKLKGVTKNWEDVPGDQVKPDQYTEALAQRDKRIEELNQSLAAQERLVEQLSREKQQLLHLLEEPTSMEVQPMTEELLKQQK
LNSHETTITQQSVSDSHLAELQEKIQQTEATNKILQEKLNEMSYELKCAQESSQKQDGTIQNLKETLKSRERETEELYQVIEGQNDTMAK
LREMLHQSQLGQLHSSEGTSPAQQQVALLDLQSALFCSQLEIQKLQRVVRQKERQLADAKQCVQFVEAAAHESEQQKEASWKHNQELRKA
LQQLQEELQNKSQQLRAWEAEKYNEIRTQEQNIQHLNHSLSHKEQLLQEFRELLQYRDNSDKTLEANEMLLEKLRQRIHDKAVALERAID
EKFSALEEKEKELRQLRLAVRERDHDLERLRDVLSSNEATMQSMESLLRAKGLEVEQLSTTCQNLQWLKEEMETKFSRWQKEQESIIQQL
QTSLHDRNKEVEDLSATLLCKLGPGQSEIAEELCQRLQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQATEDVDYTQVVFS

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:144915445/chr1:206239579)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313382+1746162_205726.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313382+1746238_318726.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313382+1746350_684726.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313382+174641_132726.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313431+1019162_205823.01133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313431+1019238_318823.01133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313431+1019350_684823.01133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313431+101941_132823.01133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369349+1423162_205660.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369349+1423238_318660.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369349+142341_132660.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369351+1422162_205660.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369351+1422238_318660.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369351+142241_132660.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369354+1444162_205660.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369354+1444238_318660.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369354+144441_132660.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369356+1444162_205660.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369356+1444238_318660.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369356+144441_132660.02363.0Coiled coilOntology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313382+17461002_1043726.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313382+17461096_1124726.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313382+17461212_1240726.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313382+17461346_1385726.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313382+17461431_1455726.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313382+17461736_1760726.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313382+17461840_2077726.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313382+17462273_2312726.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313382+1746743_936726.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313431+10191002_1043823.01133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313431+10191096_1124823.01133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313431+10191212_1240823.01133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313431+10191346_1385823.01133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313431+10191431_1455823.01133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313431+10191736_1760823.01133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313431+10191840_2077823.01133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313431+10192273_2312823.01133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313431+1019743_936823.01133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369347+141002_10430174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369347+141096_11240174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369347+141212_12400174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369347+141346_13850174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369347+141431_14550174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369347+14162_2050174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369347+141736_17600174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369347+141840_20770174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369347+142273_23120174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369347+14238_3180174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369347+14350_6840174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369347+1441_1320174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369347+14743_9360174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369348+171002_10430311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369348+171096_11240311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369348+171212_12400311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369348+171346_13850311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369348+171431_14550311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369348+17162_2050311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369348+171736_17600311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369348+171840_20770311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369348+172273_23120311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369348+17238_3180311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369348+17350_6840311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369348+1741_1320311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369348+17743_9360311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369349+14231002_1043660.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369349+14231096_1124660.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369349+14231212_1240660.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369349+14231346_1385660.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369349+14231431_1455660.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369349+14231736_1760660.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369349+14231840_2077660.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369349+14232273_2312660.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369349+1423350_684660.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369349+1423743_936660.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369351+14221002_1043660.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369351+14221096_1124660.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369351+14221212_1240660.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369351+14221346_1385660.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369351+14221431_1455660.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369351+14221736_1760660.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369351+14221840_2077660.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369351+14222273_2312660.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369351+1422350_684660.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369351+1422743_936660.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369354+14441002_1043660.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369354+14441096_1124660.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369354+14441212_1240660.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369354+14441346_1385660.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369354+14441431_1455660.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369354+14441736_1760660.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369354+14441840_2077660.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369354+14442273_2312660.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369354+1444350_684660.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369354+1444743_936660.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369356+14441002_1043660.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369356+14441096_1124660.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369356+14441212_1240660.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369356+14441346_1385660.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369356+14441431_1455660.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369356+14441736_1760660.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369356+14441840_2077660.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369356+14442273_2312660.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369356+1444350_684660.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369356+1444743_936660.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313382+17461551_1642726.02241.0DomainOlduvai
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000313431+10191551_1642823.01133.0DomainOlduvai
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369347+141551_16420174.0DomainOlduvai
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369348+171551_16420311.0DomainOlduvai
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369349+14231551_1642660.0970.0DomainOlduvai
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369351+14221551_1642660.0989.0DomainOlduvai
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369354+14441551_1642660.02347.0DomainOlduvai
HgenePDE4DIPchr1:144915445chr1:206239579ENST00000369356+14441551_1642660.02363.0DomainOlduvai
TgeneC1orf186chr1:144915445chr1:206239579ENST00000331555469_29106.0173.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PDE4DIP
C1orf186


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PDE4DIP-C1orf186


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PDE4DIP-C1orf186


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource