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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PDE4DIP-ELMOD2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PDE4DIP-ELMOD2
FusionPDB ID: 63732
FusionGDB2.0 ID: 63732
HgeneTgene
Gene symbol

PDE4DIP

ELMOD2

Gene ID

9659

255520

Gene namephosphodiesterase 4D interacting proteinELMO domain containing 2
SynonymsCMYA2|MMGL9830169G11Rik
Cytomap

1q21.2

4q31.1

Type of geneprotein-codingprotein-coding
Descriptionmyomegalincardiomyopathy-associated protein 2myomegalin/phosphodiesterase 4D interacting protein variant 8ELMO domain-containing protein 2ELMO/CED-12 domain containing 2
Modification date2020031320200313
UniProtAcc.

Q8IZ81

Ensembl transtripts involved in fusion geneENST idsENST00000313382, ENST00000369347, 
ENST00000369348, ENST00000369349, 
ENST00000369351, ENST00000369354, 
ENST00000369356, ENST00000369359, 
ENST00000530740, ENST00000313431, 
ENST00000369345, ENST00000478649, 
ENST00000479408, ENST00000493130, 
ENST00000524974, ENST00000529945, 
ENST00000511887, ENST00000323570, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 9 X 7=5672 X 2 X 2=8
# samples 92
** MAII scorelog2(9/567*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: PDE4DIP [Title/Abstract] AND ELMOD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PDE4DIP(144994591)-ELMOD2(141456887), # samples:1
Anticipated loss of major functional domain due to fusion event.PDE4DIP-ELMOD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PDE4DIP-ELMOD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PDE4DIP-ELMOD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PDE4DIP-ELMOD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePDE4DIP

GO:1903358

regulation of Golgi organization

27666745

TgeneELMOD2

GO:0050688

regulation of defense response to virus

17452337


check buttonFusion gene breakpoints across PDE4DIP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ELMOD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0178-01APDE4DIPchr1

144994591

-ELMOD2chr4

141456887

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000313382PDE4DIPchr1144994591-ENST00000323570ELMOD2chr4141456887+48387322971442381
ENST00000369354PDE4DIPchr1144994591-ENST00000323570ELMOD2chr4141456887+44373311061041311
ENST00000369356PDE4DIPchr1144994591-ENST00000323570ELMOD2chr4141456887+45384322071142311
ENST00000530740PDE4DIPchr1144994591-ENST00000323570ELMOD2chr4141456887+4697591391301420
ENST00000369359PDE4DIPchr1144994591-ENST00000323570ELMOD2chr4141456887+4697591391301420
ENST00000369351PDE4DIPchr1144994591-ENST00000323570ELMOD2chr4141456887+435625025960311
ENST00000369349PDE4DIPchr1144994591-ENST00000323570ELMOD2chr4141456887+439228661996311
ENST00000369347PDE4DIPchr1144994591-ENST00000323570ELMOD2chr4141456887+4425319941029311
ENST00000369348PDE4DIPchr1144994591-ENST00000323570ELMOD2chr4141456887+49828763241586420

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000313382ENST00000323570PDE4DIPchr1144994591-ELMOD2chr4141456887+0.0002003410.99979967
ENST00000369354ENST00000323570PDE4DIPchr1144994591-ELMOD2chr4141456887+0.0001667710.9998332
ENST00000369356ENST00000323570PDE4DIPchr1144994591-ELMOD2chr4141456887+0.0001651850.9998348
ENST00000530740ENST00000323570PDE4DIPchr1144994591-ELMOD2chr4141456887+8.69E-050.9999131
ENST00000369359ENST00000323570PDE4DIPchr1144994591-ELMOD2chr4141456887+8.69E-050.9999131
ENST00000369351ENST00000323570PDE4DIPchr1144994591-ELMOD2chr4141456887+0.0001634520.99983656
ENST00000369349ENST00000323570PDE4DIPchr1144994591-ELMOD2chr4141456887+0.0001615770.99983835
ENST00000369347ENST00000323570PDE4DIPchr1144994591-ELMOD2chr4141456887+0.0001645440.9998354
ENST00000369348ENST00000323570PDE4DIPchr1144994591-ELMOD2chr4141456887+0.0001088150.99989116

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63732_63732_1_PDE4DIP-ELMOD2_PDE4DIP_chr1_144994591_ENST00000313382_ELMOD2_chr4_141456887_ENST00000323570_length(amino acids)=381AA_BP=143
MRWRFVGKASHFPRLLPLPGEERPETKERAWKMEQTWTRDYFAEDDGEMVPRTSHTAAFLSDTKDRGPPVQSQIWRSGEKVPFVQTYSLR
AFEKPPQVQTQALRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRVLQKATHVVQSEVDKYVDDIMKEKNINPEKDASFK
ICMKMCLLQITGYKQLYLDVESVRKRPYDSDNLQHEELLMKLWNLLMPTKKLNARISKQWAEIGFQGDDPKTDFRGMGILGLINLVYFSE
NYTSEAHQILSRSNHPKLGYSYAIVGINLTEMAYSLLKSEALKFHLYNLVPGIPTMEHFHQFYCYLVYEFDKFWFEEEPESIMYFNLYRE

--------------------------------------------------------------

>63732_63732_2_PDE4DIP-ELMOD2_PDE4DIP_chr1_144994591_ENST00000369347_ELMOD2_chr4_141456887_ENST00000323570_length(amino acids)=311AA_BP=73
MASCCGAAAPCSWVEGAIGHAPPHGLPIMSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRVLQKATHVVQSEVDK
YVDDIMKEKNINPEKDASFKICMKMCLLQITGYKQLYLDVESVRKRPYDSDNLQHEELLMKLWNLLMPTKKLNARISKQWAEIGFQGDDP
KTDFRGMGILGLINLVYFSENYTSEAHQILSRSNHPKLGYSYAIVGINLTEMAYSLLKSEALKFHLYNLVPGIPTMEHFHQFYCYLVYEF

--------------------------------------------------------------

>63732_63732_3_PDE4DIP-ELMOD2_PDE4DIP_chr1_144994591_ENST00000369348_ELMOD2_chr4_141456887_ENST00000323570_length(amino acids)=420AA_BP=182
MKGTDSGSCCRRRCDFGCCCRASRRAHYTPYRSGDATRTPQSPRQTPSRERRRPEPAGSWAAAAEEEEAAAAATPWMRDYFAEDDGEMVP
RTSHTAAFLSDTKDRGPPVQSQIWRSGEKVPFVQTYSLRAFEKPPQVQTQALRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASRED
IYKRVLQKATHVVQSEVDKYVDDIMKEKNINPEKDASFKICMKMCLLQITGYKQLYLDVESVRKRPYDSDNLQHEELLMKLWNLLMPTKK
LNARISKQWAEIGFQGDDPKTDFRGMGILGLINLVYFSENYTSEAHQILSRSNHPKLGYSYAIVGINLTEMAYSLLKSEALKFHLYNLVP

--------------------------------------------------------------

>63732_63732_4_PDE4DIP-ELMOD2_PDE4DIP_chr1_144994591_ENST00000369349_ELMOD2_chr4_141456887_ENST00000323570_length(amino acids)=311AA_BP=73
MASCCGAAAPCSWVEGAIGHAPPHGLPIMSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRVLQKATHVVQSEVDK
YVDDIMKEKNINPEKDASFKICMKMCLLQITGYKQLYLDVESVRKRPYDSDNLQHEELLMKLWNLLMPTKKLNARISKQWAEIGFQGDDP
KTDFRGMGILGLINLVYFSENYTSEAHQILSRSNHPKLGYSYAIVGINLTEMAYSLLKSEALKFHLYNLVPGIPTMEHFHQFYCYLVYEF

--------------------------------------------------------------

>63732_63732_5_PDE4DIP-ELMOD2_PDE4DIP_chr1_144994591_ENST00000369351_ELMOD2_chr4_141456887_ENST00000323570_length(amino acids)=311AA_BP=73
MASCCGAAAPCSWVEGAIGHAPPHGLPIMSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRVLQKATHVVQSEVDK
YVDDIMKEKNINPEKDASFKICMKMCLLQITGYKQLYLDVESVRKRPYDSDNLQHEELLMKLWNLLMPTKKLNARISKQWAEIGFQGDDP
KTDFRGMGILGLINLVYFSENYTSEAHQILSRSNHPKLGYSYAIVGINLTEMAYSLLKSEALKFHLYNLVPGIPTMEHFHQFYCYLVYEF

--------------------------------------------------------------

>63732_63732_6_PDE4DIP-ELMOD2_PDE4DIP_chr1_144994591_ENST00000369354_ELMOD2_chr4_141456887_ENST00000323570_length(amino acids)=311AA_BP=73
MASCCGAAAPCSWVEGAIGHAPPHGLPIMSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRVLQKATHVVQSEVDK
YVDDIMKEKNINPEKDASFKICMKMCLLQITGYKQLYLDVESVRKRPYDSDNLQHEELLMKLWNLLMPTKKLNARISKQWAEIGFQGDDP
KTDFRGMGILGLINLVYFSENYTSEAHQILSRSNHPKLGYSYAIVGINLTEMAYSLLKSEALKFHLYNLVPGIPTMEHFHQFYCYLVYEF

--------------------------------------------------------------

>63732_63732_7_PDE4DIP-ELMOD2_PDE4DIP_chr1_144994591_ENST00000369356_ELMOD2_chr4_141456887_ENST00000323570_length(amino acids)=311AA_BP=73
MASCCGAAAPCSWVEGAIGHAPPHGLPIMSNGYRTLSQHLNDLKKENFSLKLRIYFLEERMQQKYEASREDIYKRVLQKATHVVQSEVDK
YVDDIMKEKNINPEKDASFKICMKMCLLQITGYKQLYLDVESVRKRPYDSDNLQHEELLMKLWNLLMPTKKLNARISKQWAEIGFQGDDP
KTDFRGMGILGLINLVYFSENYTSEAHQILSRSNHPKLGYSYAIVGINLTEMAYSLLKSEALKFHLYNLVPGIPTMEHFHQFYCYLVYEF

--------------------------------------------------------------

>63732_63732_8_PDE4DIP-ELMOD2_PDE4DIP_chr1_144994591_ENST00000369359_ELMOD2_chr4_141456887_ENST00000323570_length(amino acids)=420AA_BP=182
MKGTDSGSCCRRRCDFGCCCRASRRAHYTPYRSGDATRTPQSPRQTPSRERRRPEPAGSWAAAAEEEEAAAAATPWMRDYFAEDDGEMVP
RTSHTAAFLSDTKDRGPPVQSQIWRSGEKVPFVQTYSLRAFEKPPQVQTQALRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASRED
IYKRVLQKATHVVQSEVDKYVDDIMKEKNINPEKDASFKICMKMCLLQITGYKQLYLDVESVRKRPYDSDNLQHEELLMKLWNLLMPTKK
LNARISKQWAEIGFQGDDPKTDFRGMGILGLINLVYFSENYTSEAHQILSRSNHPKLGYSYAIVGINLTEMAYSLLKSEALKFHLYNLVP

--------------------------------------------------------------

>63732_63732_9_PDE4DIP-ELMOD2_PDE4DIP_chr1_144994591_ENST00000530740_ELMOD2_chr4_141456887_ENST00000323570_length(amino acids)=420AA_BP=182
MKGTDSGSCCRRRCDFGCCCRASRRAHYTPYRSGDATRTPQSPRQTPSRERRRPEPAGSWAAAAEEEEAAAAATPWMRDYFAEDDGEMVP
RTSHTAAFLSDTKDRGPPVQSQIWRSGEKVPFVQTYSLRAFEKPPQVQTQALRDFEKHLNDLKKENFSLKLRIYFLEERMQQKYEASRED
IYKRVLQKATHVVQSEVDKYVDDIMKEKNINPEKDASFKICMKMCLLQITGYKQLYLDVESVRKRPYDSDNLQHEELLMKLWNLLMPTKK
LNARISKQWAEIGFQGDDPKTDFRGMGILGLINLVYFSENYTSEAHQILSRSNHPKLGYSYAIVGINLTEMAYSLLKSEALKFHLYNLVP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:144994591/chr4:141456887)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ELMOD2

Q8IZ81

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses. {ECO:0000269|PubMed:17452337, ECO:0000269|PubMed:19966137}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369348-4741_132184.0311.0Coiled coilOntology_term=ECO:0000255
TgeneELMOD2chr1:144994591chr4:141456887ENST0000032357029126_28257.0294.0DomainELMO

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313382-4461002_1043113.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313382-4461096_1124113.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313382-4461212_1240113.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313382-4461346_1385113.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313382-4461431_1455113.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313382-446162_205113.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313382-4461736_1760113.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313382-4461840_2077113.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313382-4462273_2312113.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313382-446238_318113.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313382-446350_684113.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313382-44641_132113.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313382-446743_936113.02241.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313431-1191002_104301133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313431-1191096_112401133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313431-1191212_124001133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313431-1191346_138501133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313431-1191431_145501133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313431-119162_20501133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313431-1191736_176001133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313431-1191840_207701133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313431-1192273_231201133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313431-119238_31801133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313431-119350_68401133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313431-11941_13201133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313431-119743_93601133.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369347-141002_104347.0174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369347-141096_112447.0174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369347-141212_124047.0174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369347-141346_138547.0174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369347-141431_145547.0174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369347-14162_20547.0174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369347-141736_176047.0174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369347-141840_207747.0174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369347-142273_231247.0174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369347-14238_31847.0174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369347-14350_68447.0174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369347-1441_13247.0174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369347-14743_93647.0174.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369348-471002_1043184.0311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369348-471096_1124184.0311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369348-471212_1240184.0311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369348-471346_1385184.0311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369348-471431_1455184.0311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369348-47162_205184.0311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369348-471736_1760184.0311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369348-471840_2077184.0311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369348-472273_2312184.0311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369348-47238_318184.0311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369348-47350_684184.0311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369348-47743_936184.0311.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369349-1231002_104347.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369349-1231096_112447.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369349-1231212_124047.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369349-1231346_138547.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369349-1231431_145547.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369349-123162_20547.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369349-1231736_176047.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369349-1231840_207747.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369349-1232273_231247.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369349-123238_31847.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369349-123350_68447.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369349-12341_13247.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369349-123743_93647.0970.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369351-1221002_104347.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369351-1221096_112447.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369351-1221212_124047.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369351-1221346_138547.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369351-1221431_145547.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369351-122162_20547.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369351-1221736_176047.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369351-1221840_207747.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369351-1222273_231247.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369351-122238_31847.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369351-122350_68447.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369351-12241_13247.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369351-122743_93647.0989.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369354-1441002_104347.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369354-1441096_112447.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369354-1441212_124047.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369354-1441346_138547.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369354-1441431_145547.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369354-144162_20547.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369354-1441736_176047.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369354-1441840_207747.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369354-1442273_231247.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369354-144238_31847.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369354-144350_68447.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369354-14441_13247.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369354-144743_93647.02347.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369356-1441002_104347.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369356-1441096_112447.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369356-1441212_124047.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369356-1441346_138547.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369356-1441431_145547.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369356-144162_20547.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369356-1441736_176047.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369356-1441840_207747.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369356-1442273_231247.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369356-144238_31847.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369356-144350_68447.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369356-14441_13247.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369356-144743_93647.02363.0Coiled coilOntology_term=ECO:0000255
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313382-4461551_1642113.02241.0DomainOlduvai
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000313431-1191551_164201133.0DomainOlduvai
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369347-141551_164247.0174.0DomainOlduvai
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369348-471551_1642184.0311.0DomainOlduvai
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369349-1231551_164247.0970.0DomainOlduvai
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369351-1221551_164247.0989.0DomainOlduvai
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369354-1441551_164247.02347.0DomainOlduvai
HgenePDE4DIPchr1:144994591chr4:141456887ENST00000369356-1441551_164247.02363.0DomainOlduvai


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PDE4DIP
ELMOD2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PDE4DIP-ELMOD2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PDE4DIP-ELMOD2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource