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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PDE4D-PLK2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PDE4D-PLK2
FusionPDB ID: 63754
FusionGDB2.0 ID: 63754
HgeneTgene
Gene symbol

PDE4D

PLK2

Gene ID

5144

10769

Gene namephosphodiesterase 4Dpolo like kinase 2
SynonymsACRDYS2|DPDE3|HSPDE4D|PDE43|PDE4DN2|STRK1SNK|hPlk2|hSNK
Cytomap

5q11.2-q12.1

5q11.2

Type of geneprotein-codingprotein-coding
DescriptioncAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific phosphodiesterase PDE4D6phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)testicular tissue protein Li 136serine/threonine-protein kinase PLK2PLK-2serine/threonine-protein kinase SNKserum-inducible kinase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000340635, ENST00000358923, 
ENST00000360047, ENST00000405755, 
ENST00000502484, ENST00000503258, 
ENST00000507116, ENST00000546160, 
ENST00000317118, ENST00000502575, 
ENST00000503947, 		ENST00000502671, 
ENST00000274289, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score40 X 32 X 12=153603 X 3 X 2=18
# samples 563
** MAII scorelog2(56/15360*10)=-4.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PDE4D [Title/Abstract] AND PLK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PDE4D(58334686)-PLK2(57754919), # samples:1
Anticipated loss of major functional domain due to fusion event.PDE4D-PLK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PDE4D-PLK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PDE4D-PLK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PDE4D-PLK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PDE4D-PLK2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PDE4D-PLK2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PDE4D-PLK2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PDE4D-PLK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PDE4D-PLK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
PDE4D-PLK2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLK2

GO:0006468

protein phosphorylation

20352051

TgenePLK2

GO:0007052

mitotic spindle organization

19001868

TgenePLK2

GO:0010508

positive regulation of autophagy

23983262

TgenePLK2

GO:0018105

peptidyl-serine phosphorylation

23983262

TgenePLK2

GO:0045732

positive regulation of protein catabolic process

23983262

TgenePLK2

GO:0046599

regulation of centriole replication

19001868|20352051|20531387


check buttonFusion gene breakpoints across PDE4D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PLK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4MESOTCGA-TS-A7OY-01APDE4Dchr5

58334686

-PLK2chr5

57754919

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000340635PDE4Dchr558334686-ENST00000274289PLK2chr557754919-348610971762884902
ENST00000360047PDE4Dchr558334686-ENST00000274289PLK2chr557754919-3026637312424797
ENST00000507116PDE4Dchr558334686-ENST00000274289PLK2chr557754919-325486572652881
ENST00000546160PDE4Dchr558334686-ENST00000274289PLK2chr557754919-312773802525841
ENST00000503258PDE4Dchr558334686-ENST00000274289PLK2chr557754919-363712487173035772
ENST00000405755PDE4Dchr558334686-ENST00000274289PLK2chr557754919-30736841022471789

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000340635ENST00000274289PDE4Dchr558334686-PLK2chr557754919-0.0045289540.9954711
ENST00000360047ENST00000274289PDE4Dchr558334686-PLK2chr557754919-0.0011429680.998857
ENST00000507116ENST00000274289PDE4Dchr558334686-PLK2chr557754919-0.0027431050.99725693
ENST00000546160ENST00000274289PDE4Dchr558334686-PLK2chr557754919-0.0012699010.9987301
ENST00000503258ENST00000274289PDE4Dchr558334686-PLK2chr557754919-0.0017381160.99826187
ENST00000405755ENST00000274289PDE4Dchr558334686-PLK2chr557754919-0.0009600760.99903995

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63754_63754_1_PDE4D-PLK2_PDE4D_chr5_58334686_ENST00000340635_PLK2_chr5_57754919_ENST00000274289_length(amino acids)=902AA_BP=0
MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPSPQPQPQCPLQPPPPPPLPPPPPPPGA
ARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQA
NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITE
EAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVV
QFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPL
EHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRP
SLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSK
HRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQW
VTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVT
DIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTLLMSGCSSELKNRMEYALNMLLQR

--------------------------------------------------------------

>63754_63754_2_PDE4D-PLK2_PDE4D_chr5_58334686_ENST00000360047_PLK2_chr5_57754919_ENST00000274289_length(amino acids)=797AA_BP=1
MLKQESWNSSVKITTCNVGDKKNINDRRSANMMHVNNFPFRRHSWICFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRS
DSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELD
WCLDQLETLQTRHSVSEMASNKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYIL
LEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLS
PEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGF
TPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVA
RSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGY
QLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKS

--------------------------------------------------------------

>63754_63754_3_PDE4D-PLK2_PDE4D_chr5_58334686_ENST00000405755_PLK2_chr5_57754919_ENST00000274289_length(amino acids)=789AA_BP=1
MGILASSLKMAFVWDPLGATVPGPSTRAKSRLRFSKSYSFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSP
KSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLET
LQTRHSVSEMASNKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRS
MAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQG
HGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSS
CCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVE
NKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVG
VLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLF

--------------------------------------------------------------

>63754_63754_4_PDE4D-PLK2_PDE4D_chr5_58334686_ENST00000503258_PLK2_chr5_57754919_ENST00000274289_length(amino acids)=772AA_BP=0
MSIIMKPRSRSTSSLRTAEAVCFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDD
LIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKGGF
AKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVR
YYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTM
LLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNF
FKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTL
GSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKT
VHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKII

--------------------------------------------------------------

>63754_63754_5_PDE4D-PLK2_PDE4D_chr5_58334686_ENST00000507116_PLK2_chr5_57754919_ENST00000274289_length(amino acids)=881AA_BP=1
MRQATECTNSSRLRPASLDISGTVSEGTTLPWILASCTKLTRKMAQQTSPDTLTVPEVDNPHCPNPWLNEDLVKSLRENLLQHEKSKTAR
KSVSPKLSPVISPRNSPRLLRRMLLSSNIPKQRRFTVAHTCFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDL
SPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQL
ETLQTRHSVSEMASNKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSR
RSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNK
QGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLS
SSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPA
VENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHT
VGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMM

--------------------------------------------------------------

>63754_63754_6_PDE4D-PLK2_PDE4D_chr5_58334686_ENST00000546160_PLK2_chr5_57754919_ENST00000274289_length(amino acids)=841AA_BP=0
MKRNTCDLLSRSKSASEETLHSSNEEEDPFRGMEPYLVRRLSCRNIQLPPLAFRQLEQADLKSESENIQRPTSLPLKILPLIAITSAESS
GFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFA
ALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKGGFAKCYEMTDLTNNKVYAAKIIP
HSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHR
DLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIRE
ARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDT
HNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADT
VARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQ
FISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTT

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:58334686/chr5:57754919)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE4Dchr5:58334686chr5:57754919ENST00000340635-61542_88307.0810.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr5:57754919ENST00000360047-61542_88171.0674.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr5:57754919ENST00000405755-61542_88185.0688.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr5:57754919ENST00000502484-81742_88246.0749.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr5:57754919ENST00000503258-61542_88177.0680.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr5:57754919ENST00000507116-61542_88243.0746.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr5:57754919ENST00000546160-71642_88246.0749.0Compositional biasNote=Pro-rich
TgenePLK2chr5:58334686chr5:57754919ENST00000274289014510_57390.0686.0DomainPOLO box 1
TgenePLK2chr5:58334686chr5:57754919ENST00000274289014606_67790.0686.0DomainPOLO box 2
TgenePLK2chr5:58334686chr5:57754919ENST0000027428901488_9690.0686.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePDE4Dchr5:58334686chr5:57754919ENST00000317118-11042_880519.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr5:57754919ENST00000358923-21142_885.0508.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr5:57754919ENST00000502575-1642_880220.0Compositional biasNote=Pro-rich
HgenePDE4Dchr5:58334686chr5:57754919ENST00000317118-110386_7150519.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000340635-615386_715307.0810.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000358923-211386_7155.0508.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000360047-615386_715171.0674.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000405755-615386_715185.0688.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000502484-817386_715246.0749.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000502575-16386_7150220.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000503258-615386_715177.0680.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000507116-615386_715243.0746.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000546160-716386_715246.0749.0DomainPDEase
HgenePDE4Dchr5:58334686chr5:57754919ENST00000317118-110462_4660519.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr5:57754919ENST00000340635-615462_466307.0810.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr5:57754919ENST00000358923-211462_4665.0508.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr5:57754919ENST00000360047-615462_466171.0674.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr5:57754919ENST00000405755-615462_466185.0688.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr5:57754919ENST00000502484-817462_466246.0749.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr5:57754919ENST00000502575-16462_4660220.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr5:57754919ENST00000503258-615462_466177.0680.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr5:57754919ENST00000507116-615462_466243.0746.0Nucleotide bindingcAMP
HgenePDE4Dchr5:58334686chr5:57754919ENST00000546160-716462_466246.0749.0Nucleotide bindingcAMP
TgenePLK2chr5:58334686chr5:57754919ENST0000027428901457_6490.0686.0Compositional biasNote=Poly-His
TgenePLK2chr5:58334686chr5:57754919ENST0000027428901482_33490.0686.0DomainProtein kinase


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PDE4D
PLK2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PDE4D-PLK2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PDE4D-PLK2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource