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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ARID1B-EZR

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ARID1B-EZR
FusionPDB ID: 6406
FusionGDB2.0 ID: 6406
HgeneTgene
Gene symbol

ARID1B

EZR

Gene ID

57492

7430

Gene nameAT-rich interaction domain 1Bezrin
Synonyms6A3-5|BAF250B|BRIGHT|CSS1|DAN15|ELD/OSA1|MRD12|OSA2|P250RCVIL|CVL|HEL-S-105|VIL2
Cytomap

6q25.3

6q25.3

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 1BARID domain-containing protein 1BAT rich interactive domain 1B (SWI1-like)BRG1-associated factor 250bBRG1-binding protein ELD/OSA1ELD (eyelid)/OSA proteinezrincytovillin 2epididymis secretory protein Li 105p81villin 2 (ezrin)
Modification date2020032020200322
UniProtAcc

Q8NFD5

P15311

Ensembl transtripts involved in fusion geneENST idsENST00000275248, ENST00000346085, 
ENST00000350026, ENST00000367148, 
ENST00000478761, 		ENST00000476189, 
ENST00000337147, ENST00000367075, 
ENST00000392177, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score27 X 18 X 14=680425 X 24 X 6=3600
# samples 3127
** MAII scorelog2(31/6804*10)=-4.45604302038915
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/3600*10)=-3.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ARID1B [Title/Abstract] AND EZR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ARID1B(157256710)-EZR(159210403), # samples:4
Anticipated loss of major functional domain due to fusion event.ARID1B-EZR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID1B-EZR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID1B-EZR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARID1B-EZR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEZR

GO:0048015

phosphatidylinositol-mediated signaling

25591774

TgeneEZR

GO:0051017

actin filament bundle assembly

10793131


check buttonFusion gene breakpoints across ARID1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EZR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-EY-A4KR-01AARID1Bchr6

157256710

-EZRchr6

159210403

-
ChimerDB4UCECTCGA-EY-A4KR-01AARID1Bchr6

157256710

+EZRchr6

159210403

-
ChimerDB4UCECTCGA-EY-A4KRARID1Bchr6

157256710

+EZRchr6

159210403

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000350026ARID1Bchr6157256710+ENST00000337147EZRchr6159210403-49211999137471248
ENST00000350026ARID1Bchr6157256710+ENST00000367075EZRchr6159210403-49141999137471248
ENST00000350026ARID1Bchr6157256710+ENST00000392177EZRchr6159210403-36701999136511216
ENST00000346085ARID1Bchr6157256710+ENST00000337147EZRchr6159210403-49602038137861261
ENST00000346085ARID1Bchr6157256710+ENST00000367075EZRchr6159210403-49532038137861261
ENST00000346085ARID1Bchr6157256710+ENST00000392177EZRchr6159210403-37092038136901229
ENST00000367148ARID1Bchr6157256710+ENST00000337147EZRchr6159210403-49201998037461248
ENST00000367148ARID1Bchr6157256710+ENST00000367075EZRchr6159210403-49131998037461248
ENST00000367148ARID1Bchr6157256710+ENST00000392177EZRchr6159210403-36691998036501216
ENST00000275248ARID1Bchr6157256710+ENST00000337147EZRchr6159210403-489819767737241215
ENST00000275248ARID1Bchr6157256710+ENST00000367075EZRchr6159210403-489119767737241215
ENST00000275248ARID1Bchr6157256710+ENST00000392177EZRchr6159210403-364719767736281183

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000350026ENST00000337147ARID1Bchr6157256710+EZRchr6159210403-0.0075202090.9924798
ENST00000350026ENST00000367075ARID1Bchr6157256710+EZRchr6159210403-0.0074221420.99257785
ENST00000350026ENST00000392177ARID1Bchr6157256710+EZRchr6159210403-0.0139757970.9860242
ENST00000346085ENST00000337147ARID1Bchr6157256710+EZRchr6159210403-0.0063215130.9936785
ENST00000346085ENST00000367075ARID1Bchr6157256710+EZRchr6159210403-0.0062184050.9937816
ENST00000346085ENST00000392177ARID1Bchr6157256710+EZRchr6159210403-0.0131928730.98680717
ENST00000367148ENST00000337147ARID1Bchr6157256710+EZRchr6159210403-0.0075012530.9924987
ENST00000367148ENST00000367075ARID1Bchr6157256710+EZRchr6159210403-0.0074034410.9925965
ENST00000367148ENST00000392177ARID1Bchr6157256710+EZRchr6159210403-0.0139915240.98600847
ENST00000275248ENST00000337147ARID1Bchr6157256710+EZRchr6159210403-0.0088394140.9911606
ENST00000275248ENST00000367075ARID1Bchr6157256710+EZRchr6159210403-0.0087341230.99126583
ENST00000275248ENST00000392177ARID1Bchr6157256710+EZRchr6159210403-0.0151189230.98488104

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>6406_6406_1_ARID1B-EZR_ARID1B_chr6_157256710_ENST00000275248_EZR_chr6_159210403_ENST00000337147_length(amino acids)=1215AA_BP=47
MSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQ
QQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQP
PVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSR
PGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKA
AAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQY
AAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGM
QYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPS
SLPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAE
ELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG
MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYA
PRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKA
ERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKE
AQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQA

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>6406_6406_2_ARID1B-EZR_ARID1B_chr6_157256710_ENST00000275248_EZR_chr6_159210403_ENST00000367075_length(amino acids)=1215AA_BP=47
MSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQ
QQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQP
PVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSR
PGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKA
AAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQY
AAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGM
QYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPS
SLPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAE
ELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG
MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYA
PRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKA
ERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKE
AQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQA

--------------------------------------------------------------

>6406_6406_3_ARID1B-EZR_ARID1B_chr6_157256710_ENST00000275248_EZR_chr6_159210403_ENST00000392177_length(amino acids)=1183AA_BP=47
MSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHAHHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQ
QQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLSKPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQP
PVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSR
PGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKA
AAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQY
AAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQQSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGM
QYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPS
SLPINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAV
LLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKG
TDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQ
QMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADR
MAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSY
HVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQ

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>6406_6406_4_ARID1B-EZR_ARID1B_chr6_157256710_ENST00000346085_EZR_chr6_159210403_ENST00000337147_length(amino acids)=1261AA_BP=80
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYL
PSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYF
GLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFG
DYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGL
NIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQ
KQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELER
QAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAE
PTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEA

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>6406_6406_5_ARID1B-EZR_ARID1B_chr6_157256710_ENST00000346085_EZR_chr6_159210403_ENST00000367075_length(amino acids)=1261AA_BP=80
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYL
PSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYF
GLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFG
DYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGL
NIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQ
KQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELER
QAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAE
PTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEA

--------------------------------------------------------------

>6406_6406_6_ARID1B-EZR_ARID1B_chr6_157256710_ENST00000346085_EZR_chr6_159210403_ENST00000392177_length(amino acids)=1229AA_BP=80
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQDSGDATWKETFWLMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYL
PSQSQQRYQPQQDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQ
FKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQ
WEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVI
KPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEEL
MLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRR
KEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERV

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>6406_6406_7_ARID1B-EZR_ARID1B_chr6_157256710_ENST00000350026_EZR_chr6_159210403_ENST00000337147_length(amino acids)=1248AA_BP=80
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQD
MSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTW
LKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLS
SERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKI
GFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKK
RRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLA
AELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGI

--------------------------------------------------------------

>6406_6406_8_ARID1B-EZR_ARID1B_chr6_157256710_ENST00000350026_EZR_chr6_159210403_ENST00000367075_length(amino acids)=1248AA_BP=80
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQD
MSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTW
LKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLS
SERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKI
GFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKK
RRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLA
AELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGI

--------------------------------------------------------------

>6406_6406_9_ARID1B-EZR_ARID1B_chr6_157256710_ENST00000350026_EZR_chr6_159210403_ENST00000392177_length(amino acids)=1216AA_BP=80
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQD
MSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVA
EELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR
GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFY
APRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK
AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAK
EAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQ

--------------------------------------------------------------

>6406_6406_10_ARID1B-EZR_ARID1B_chr6_157256710_ENST00000367148_EZR_chr6_159210403_ENST00000337147_length(amino acids)=1248AA_BP=80
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQD
MSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTW
LKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLS
SERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKI
GFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKK
RRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLA
AELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGI

--------------------------------------------------------------

>6406_6406_11_ARID1B-EZR_ARID1B_chr6_157256710_ENST00000367148_EZR_chr6_159210403_ENST00000367075_length(amino acids)=1248AA_BP=80
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQD
MSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTW
LKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLS
SERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKI
GFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKK
RRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLA
AELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGI

--------------------------------------------------------------

>6406_6406_12_ARID1B-EZR_ARID1B_chr6_157256710_ENST00000367148_EZR_chr6_159210403_ENST00000392177_length(amino acids)=1216AA_BP=80
MAHNAGAAAAAGTHSAKSGGSEAALKEGGSAAALSSSSSSSAAAAAASSSSSSGPGSAMETGLLPNHKLKTVGEAPAAPPHQQHHHHHHA
HHHHHHAHHLHHHHALQQQLNQFQQQQQQQQQQQQQQQQQQHPISNNNSLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPGPPLLS
KPGDEDDAPPKMGEPAGGRYEHPGLGALGTQQPPVAVPGGGGGPAAVPEFNNYYGSAAPASGGPGGRAGPCFDQHGGQQSPGMGMMHSAS
AAAAGAPGSMDPLQNSHEGYPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG
SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPP
SQPQSQAAAAGAAAGGQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKRPQLYGMGSNPHSQPQ
QSSPYPGGSYGPPGPQRYPIGIQGRTPGAMAGMQYPQQQMPPQYGQQGVSGYCQQGQQPYYSQQPQPPHLPPQAQYLPSQSQQRYQPQQD
MSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVA
EELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR
GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFY
APRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK
AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAK
EAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQ

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:157256710/chr6:159210403)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARID1B

Q8NFD5

EZR

P15311

FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388). {ECO:0000250|UniProtKB:E9Q4N7, ECO:0000269|PubMed:14982958, ECO:0000269|PubMed:15170388, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID1Bchr6:157256710chr6:159210403ENST00000346085+520107_131679.02250.0Compositional biasNote=Gln-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000346085+520114_131679.02250.0Compositional biasNote=Poly-Gln
HgeneARID1Bchr6:157256710chr6:159210403ENST00000346085+520141_401679.02250.0Compositional biasNote=Gly-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000346085+5202_47679.02250.0Compositional biasNote=Ala-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000346085+520329_493679.02250.0Compositional biasNote=Ala-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000346085+52035_57679.02250.0Compositional biasNote=Ser-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000346085+520574_633679.02250.0Compositional biasNote=Gln-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000346085+52081_104679.02250.0Compositional biasNote=His-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000350026+419107_131666.02237.0Compositional biasNote=Gln-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000350026+419114_131666.02237.0Compositional biasNote=Poly-Gln
HgeneARID1Bchr6:157256710chr6:159210403ENST00000350026+419141_401666.02237.0Compositional biasNote=Gly-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000350026+4192_47666.02237.0Compositional biasNote=Ala-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000350026+419329_493666.02237.0Compositional biasNote=Ala-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000350026+41935_57666.02237.0Compositional biasNote=Ser-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000350026+419574_633666.02237.0Compositional biasNote=Gln-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000350026+41981_104666.02237.0Compositional biasNote=His-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000367148+420107_131666.02290.0Compositional biasNote=Gln-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000367148+420114_131666.02290.0Compositional biasNote=Poly-Gln
HgeneARID1Bchr6:157256710chr6:159210403ENST00000367148+420141_401666.02290.0Compositional biasNote=Gly-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000367148+4202_47666.02290.0Compositional biasNote=Ala-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000367148+420329_493666.02290.0Compositional biasNote=Ala-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000367148+42035_57666.02290.0Compositional biasNote=Ser-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000367148+420574_633666.02290.0Compositional biasNote=Gln-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000367148+42081_104666.02290.0Compositional biasNote=His-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000346085+520419_423679.02250.0MotifNote=LXXLL
HgeneARID1Bchr6:157256710chr6:159210403ENST00000350026+419419_423666.02237.0MotifNote=LXXLL
HgeneARID1Bchr6:157256710chr6:159210403ENST00000367148+420419_423666.02290.0MotifNote=LXXLL
TgeneEZRchr6:157256710chr6:159210403ENST000003371470132_2954.0587.0DomainFERM
TgeneEZRchr6:157256710chr6:159210403ENST000003670751142_2954.0587.0DomainFERM
TgeneEZRchr6:157256710chr6:159210403ENST00000337147013115_1204.0587.0Motif[IL]-x-C-x-x-[DE] motif
TgeneEZRchr6:157256710chr6:159210403ENST00000367075114115_1204.0587.0Motif[IL]-x-C-x-x-[DE] motif

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID1Bchr6:157256710chr6:159210403ENST00000346085+5201034_1037679.02250.0Compositional biasNote=Poly-Ser
HgeneARID1Bchr6:157256710chr6:159210403ENST00000346085+5201441_1444679.02250.0Compositional biasNote=Poly-Ser
HgeneARID1Bchr6:157256710chr6:159210403ENST00000346085+5201459_1597679.02250.0Compositional biasNote=Pro-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000346085+5201833_1836679.02250.0Compositional biasNote=Poly-Pro
HgeneARID1Bchr6:157256710chr6:159210403ENST00000346085+520684_771679.02250.0Compositional biasNote=Ser-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000346085+520932_935679.02250.0Compositional biasNote=Poly-Ala
HgeneARID1Bchr6:157256710chr6:159210403ENST00000350026+4191034_1037666.02237.0Compositional biasNote=Poly-Ser
HgeneARID1Bchr6:157256710chr6:159210403ENST00000350026+4191441_1444666.02237.0Compositional biasNote=Poly-Ser
HgeneARID1Bchr6:157256710chr6:159210403ENST00000350026+4191459_1597666.02237.0Compositional biasNote=Pro-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000350026+4191833_1836666.02237.0Compositional biasNote=Poly-Pro
HgeneARID1Bchr6:157256710chr6:159210403ENST00000350026+419684_771666.02237.0Compositional biasNote=Ser-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000350026+419932_935666.02237.0Compositional biasNote=Poly-Ala
HgeneARID1Bchr6:157256710chr6:159210403ENST00000367148+4201034_1037666.02290.0Compositional biasNote=Poly-Ser
HgeneARID1Bchr6:157256710chr6:159210403ENST00000367148+4201441_1444666.02290.0Compositional biasNote=Poly-Ser
HgeneARID1Bchr6:157256710chr6:159210403ENST00000367148+4201459_1597666.02290.0Compositional biasNote=Pro-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000367148+4201833_1836666.02290.0Compositional biasNote=Poly-Pro
HgeneARID1Bchr6:157256710chr6:159210403ENST00000367148+420684_771666.02290.0Compositional biasNote=Ser-rich
HgeneARID1Bchr6:157256710chr6:159210403ENST00000367148+420932_935666.02290.0Compositional biasNote=Poly-Ala
HgeneARID1Bchr6:157256710chr6:159210403ENST00000346085+5201053_1144679.02250.0DomainARID
HgeneARID1Bchr6:157256710chr6:159210403ENST00000350026+4191053_1144666.02237.0DomainARID
HgeneARID1Bchr6:157256710chr6:159210403ENST00000367148+4201053_1144666.02290.0DomainARID
HgeneARID1Bchr6:157256710chr6:159210403ENST00000346085+5201358_1377679.02250.0MotifNuclear localization signal
HgeneARID1Bchr6:157256710chr6:159210403ENST00000346085+5202036_2040679.02250.0MotifNote=LXXLL
HgeneARID1Bchr6:157256710chr6:159210403ENST00000350026+4191358_1377666.02237.0MotifNuclear localization signal
HgeneARID1Bchr6:157256710chr6:159210403ENST00000350026+4192036_2040666.02237.0MotifNote=LXXLL
HgeneARID1Bchr6:157256710chr6:159210403ENST00000367148+4201358_1377666.02290.0MotifNuclear localization signal
HgeneARID1Bchr6:157256710chr6:159210403ENST00000367148+4202036_2040666.02290.0MotifNote=LXXLL


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ARID1B_pLDDT.png
all structure
all structure
EZR_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
EZRPRKAB1, HLA-B, GABARAPL2, MCC, BID, TNFRSF10B, FAS, MSN, RHOA, ARHGDIA, FADD, FASLG, MAPK8, CASP10, CASP8, TNFRSF1A, AHNAK, PPL, SPTA1, PRX, S100P, SCYL3, SLC9A3R2, NF2, EZR, PTK2, L1CAM, TSC1, PIK3R1, ICAM1, ICAM2, ICAM3, Tsc1, VCAM1, ADORA2B, IQGAP1, CLIC5, CD44, PALLD, SLC9A3R1, PRKCA, SELP, DLG1, CFTR, SELL, SDC2, SPN, CTNNB1, CDH1, PHLPP2, DCC, Cdk1, ELAVL1, WWP1, ISG15, BRCA1, RDX, ACTN1, DGKQ, ARPC3, FN1, GZMM, BAG3, MPP3, WFDC1, MDM2, MAPK10, FBXO6, ASB6, CROCC, FH, FKBP9, GNPDA1, GTF3C4, H2AFZ, HEXA, HEXB, PDCD10, PDCD6IP, UBA1, IPO5, MC1R, OGFOD1, PYGL, RIC8A, TRNT1, UBE2R2, XPNPEP1, CUL7, OBSL1, VPS11, ACAA2, AKR1B1, CALR, CLIC4, ECE2, EIF5A2, EIF5AL1, ENO1, ENO2, AURKA, GDI2, TPD52, FABP5, GPX4, HSD17B10, HSPA4, HSPA4L, HSPE1, HSPH1, ISYNA1, LCP1, OAT, P4HB, PDXK, PGD, PLS1, PLS3, PPA2, RCN1, SHMT2, STIP1, TAGLN2, TKT, TPD52L2, TXNRD2, UCHL3, WDR1, NTRK1, SCARNA22, PTTG1, PPME1, NOLC1, B4GALT7, TIMM13, Msn, EGFR, MCM2, Mdm2, U2AF2, ERBB2, MRPL12, MISP, TSPAN33, PTPRQ, SLC9A1, LASP1, DNM1L, FOXA1, TRIM25, HEY1, PRPF8, AAR2, PIH1D1, EFTUD2, SOCS2, ESR2, RUNX1, AGR2, MME, ZFP36L2, EEF2K, LSM1, MAP3K7, MGEA5, SRGAP2, COBL, IKBKAP, SVIL, MAPT, BCR, CAST, SHC1, NMT1, UTRN, ANK2, ANK3, ABR, GAB1, MTMR1, SNTB1, SEPT6, TAB1, PKN2, COBLL1, C6orf132, MPRIP, KIAA1211, CYFIP1, GPRIN1, R3HCC1L, PARG, SIRT2, PALM2, PHACTR4, ARFGAP1, ENAH, ZC3H15, SEPT8, USP47, DOCK7, ERBB2IP, PPP1R9B, EFHD1, SORBS1, EIF2A, TNKS1BP1, C1orf198, EPB41L1, SH2D4A, LZTFL1, CYLD, SH3GLB2, ARHGAP35, FARSB, PRMT7, ACTR10, DIP2B, ABCF2, SRP68, TRMT112, ASAP1, LIMCH1, AKAP2, WDR45, WASF2, RPA3, RPL32, POLDIP3, MACROD2, CASK, HGS, SEC16A, TIMM44, MYO1B, KIF5C, CTNND1, SRP72, AP2A1, ECD, PAK4, SLC25A5, HSPA1A, DDX6, EPHA2, TIE1, TRAPPC10, NUMB, NUP107, RPS13, OCRL, AKAP12, DST, NOTCH2, TCHH, FCHO2, KIAA0196, HDAC1, SCRIB, GOLGB1, KARS, RABEP1, PCBP2, TBR1, SEL1L2, FAM21A, FTSJ3, ABI1, EHBP1, NDRG1, SYAP1, FERMT2, CCDC124, CYFIP2, AHCYL2, PGAM5, TRAPPC9, FAM129B, TRIOBP, PEAK1, ELP3, PALMD, FAM207A, KLC4, LIN7C, DDX18, LYAR, ABI2, ITSN2, RAI14, FAM135A, ADD3, SWAP70, BAIAP2L1, TNIK, MYH13, MYO6, ICAM5, PACSIN2, SNX6, NCKAP1, TRAPPC1, NUMBL, DSG2, SKA2, EGLN1, PDLIM1, EIF4G3, EPB41, LRBA, AFD1, SNTB2, ITSN1, WDR44, HAUS6, FAM101B, DVL3, BCL11A, PLEKHA1, KIAA1429, ATG16L1, ACTC1, PHB, NEDD4, PODXL, GBF1, KRAS, HADHB, VDAC1, VDAC2, ABCC6, BIRC3, PARK2, PINK1, FANCD2, ORF3a, DUSP6, PTPN12, RAC1, SH2D3C, ERBB3, LRRC6, ZSWIM2, WDR37, S, USP1, CIT, ANLN, AURKB, CHMP4B, KIF14, PRNP, Arhgap28, ARHGEF15, HNRNPH1, SUMO2, NDN, NUPR1, RBM39, LGALS9, PMAIP1, CD274, DDRGK1, TP53, ACTB, SEPT9, ABLIM1, ACTN4, ATP2B1, BASP1, BSG, CCDC18, CDCA3, CORO1C, CTNNAL1, DEPDC1B, DLG5, DTNA, EFNB2, EPB41L5, FLOT2, FRS2, HNRNPA1L2, ITGB1, KIAA1549, KIAA1671, KIDINS220, LIMA1, LMO7, LSR, MARK2, MARK3, MB21D2, MYO5C, NEBL, OCLN, PALM2-AKAP2, PPFIBP1, PPP1R18, PPP1R9A, PPP6R1, PROSER2, PTPN14, RAP1GDS1, RASAL2, SH3D19, SLC12A2, SLC1A5, SLC29A1, SLC38A2, SLC39A14, SLC39A6, SLC3A2, SLC4A7, SLC6A8, SLC7A5, SNAP23, SPTAN1, STK10, VANGL1, VANGL2, YES1, YKT6, ZDHHC5, ANKRD26, ANKRD28, APBB1, APC, ARHGAP21, ARHGEF12, ATP1A1, CALD1, CDC42BPA, CTNNA1, DBN1, DIAPH3, DYNC1I2, DYNC1LI1, EFNB1, GOLGA3, H3F3A, HLA-A, IFT74, INA, IRS2, JMY, KANK2, KIF15, LPP, LUZP1, MACF1, MINK1, NBEA, PI4KA, PLEKHA5, RAPH1, REPS1, RTN1, SDCCAG3, SLAIN2, SLC6A15, STAU2, SYNJ1, TANC1, TDRD3, TJP1, nsp3, E, nsp3ab, SLC26A4-AS1, GOT1, ZNF622, TREML1, nsp11, nsp12, nsp13, nsp14, nsp16, nsp8, PER2,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ARID1B
EZRall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ARID1B-EZR


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ARID1B-EZR


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneEZRC0033578Prostatic Neoplasms3CTD_human
TgeneEZRC0376358Malignant neoplasm of prostate3CTD_human
TgeneEZRC0007097Carcinoma1CTD_human
TgeneEZRC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneEZRC0024667Animal Mammary Neoplasms1CTD_human
TgeneEZRC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneEZRC0027627Neoplasm Metastasis1CTD_human
TgeneEZRC0029408Degenerative polyarthritis1CTD_human
TgeneEZRC0086743Osteoarthrosis Deformans1CTD_human
TgeneEZRC0205696Anaplastic carcinoma1CTD_human
TgeneEZRC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneEZRC0205698Undifferentiated carcinoma1CTD_human
TgeneEZRC0205699Carcinomatosis1CTD_human
TgeneEZRC1257925Mammary Carcinoma, Animal1CTD_human