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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PELI2-KTN1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PELI2-KTN1
	FusionPDB ID: 64255
	FusionGDB2.0 ID: 64255
		Hgene	Tgene
	Gene symbol	PELI2	KTN1
	Gene ID	57161	3895
	Gene name	pellino E3 ubiquitin protein ligase family member 2	kinectin 1
	Synonyms	-	CG1\|KNT\|MU-RMS-40.19
	Cytomap	14q22.3	14q22.3
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase pellino homolog 2RING-type E3 ubiquitin transferase pellino homolog 2pellino homolog 2pellino-2protein pellino homolog 2	kinectinCG-1 antigenkinesin receptor
	Modification date	20200313	20200313
	UniProtAcc	.	Q86SY8
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000267460,	ENST00000555573, ENST00000395308, ENST00000395309, ENST00000395311, ENST00000395314, ENST00000413890, ENST00000416613, ENST00000438792, ENST00000554507,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 5 X 6=270	18 X 20 X 7=2520
	# samples	10	22
	** MAII score	log2(10/270*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(22/2520*10)=-3.51784830486262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PELI2 [Title/Abstract] AND KTN1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PELI2(56585455)-KTN1(56122760), # samples:2 KTN1(56146403)-PELI2(56763318), # samples:1
Anticipated loss of major functional domain due to fusion event.	PELI2-KTN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PELI2-KTN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KTN1-PELI2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. KTN1-PELI2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. PELI2-KTN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PELI2-KTN1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PELI2	GO:0001934	positive regulation of protein phosphorylation	12804775
Hgene	PELI2	GO:0043410	positive regulation of MAPK cascade	12804775

Fusion gene breakpoints across PELI2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KTN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-AX-A2H4-01A	PELI2	chr14	56585455	-	KTN1	chr14	56122760	+
ChimerDB4	UCEC	TCGA-AX-A2H4-01A	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+
ChimerDB4	UCEC	TCGA-DI-A1NO-01A	PELI2	chr14	56645182	+	KTN1	chr14	56119568	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000267460	PELI2	chr14	56585455	+	ENST00000395309	KTN1	chr14	56122760	+	1636	363	286	1635	450
ENST00000267460	PELI2	chr14	56585455	+	ENST00000413890	KTN1	chr14	56122760	+	2032	363	286	1551	421
ENST00000267460	PELI2	chr14	56585455	+	ENST00000438792	KTN1	chr14	56122760	+	1941	363	286	1464	392
ENST00000267460	PELI2	chr14	56585455	+	ENST00000395314	KTN1	chr14	56122760	+	2112	363	286	1635	449
ENST00000267460	PELI2	chr14	56585455	+	ENST00000395308	KTN1	chr14	56122760	+	1580	363	286	1551	421
ENST00000267460	PELI2	chr14	56585455	+	ENST00000395311	KTN1	chr14	56122760	+	2028	363	286	1551	421
ENST00000267460	PELI2	chr14	56585455	+	ENST00000416613	KTN1	chr14	56122760	+	2172	363	286	1635	449
ENST00000267460	PELI2	chr14	56585455	+	ENST00000554507	KTN1	chr14	56122760	+	1622	363	286	1464	392

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000267460	ENST00000395309	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+	0.003410162	0.9965899
ENST00000267460	ENST00000413890	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+	0.00079478	0.9992053
ENST00000267460	ENST00000438792	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+	0.000819098	0.99918085
ENST00000267460	ENST00000395314	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+	0.000862006	0.999138
ENST00000267460	ENST00000395308	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+	0.002982181	0.99701786
ENST00000267460	ENST00000395311	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+	0.000805297	0.9991947
ENST00000267460	ENST00000416613	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+	0.000868705	0.99913126
ENST00000267460	ENST00000554507	PELI2	chr14	56585455	+	KTN1	chr14	56122760	+	0.001610784	0.99838924

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>64255_64255_1_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000395308_length(amino acids)=421AA_BP=26
MFSPGQEEHCAPNKEPVKYGELVVLGLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL
KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSN
LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM
QSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSK

--------------------------------------------------------------

>64255_64255_2_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000395309_length(amino acids)=450AA_BP=26
MFSPGQEEHCAPNKEPVKYGELVVLGLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL
KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSN
LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM
QSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTK
LRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLEX

--------------------------------------------------------------

>64255_64255_3_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000395311_length(amino acids)=421AA_BP=26
MFSPGQEEHCAPNKEPVKYGELVVLGLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL
KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSN
LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM
QSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSK

--------------------------------------------------------------

>64255_64255_4_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000395314_length(amino acids)=449AA_BP=26
MFSPGQEEHCAPNKEPVKYGELVVLGLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL
KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSN
LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM
QSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTK

--------------------------------------------------------------

>64255_64255_5_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000413890_length(amino acids)=421AA_BP=26
MFSPGQEEHCAPNKEPVKYGELVVLGLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL
KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSN
LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM
QSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSK

--------------------------------------------------------------

>64255_64255_6_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000416613_length(amino acids)=449AA_BP=26
MFSPGQEEHCAPNKEPVKYGELVVLGLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL
KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSN
LSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM
QSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTK

--------------------------------------------------------------

>64255_64255_7_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000438792_length(amino acids)=392AA_BP=26
MFSPGQEEHCAPNKEPVKYGELVVLGLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL
KVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKV
LEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRERE
HLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMS

--------------------------------------------------------------

>64255_64255_8_PELI2-KTN1_PELI2_chr14_56585455_ENST00000267460_KTN1_chr14_56122760_ENST00000554507_length(amino acids)=392AA_BP=26
MFSPGQEEHCAPNKEPVKYGELVVLGLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL
KVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKV
LEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRERE
HLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:56585455/chr14:56122760)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	KTN1 Q86SY8
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PELI2

chr14:56585455

chr14:56122760

ENST00000267460

15_202

25.666666666666668

421.0

Domain

Note=FHA%3B atypical

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395308

330_1356

910.6666666666666

1307.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395309

330_1356

933.6666666666666

1358.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395311

330_1356

910.6666666666666

1307.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395314

330_1356

933.6666666666666

1358.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000413890

330_1356

910.6666666666666

1307.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000416613

330_1356

933.6666666666666

1321.3333333333333

Coiled coil

Ontology_term=ECO:0000255

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000438792

330_1356

933.6666666666666

1301.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395308

1_6

910.6666666666666

1307.0

Topological domain

Cytoplasmic

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395308

30_1357

910.6666666666666

1307.0

Topological domain

Lumenal

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395309

1_6

933.6666666666666

1358.0

Topological domain

Cytoplasmic

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395309

30_1357

933.6666666666666

1358.0

Topological domain

Lumenal

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395311

1_6

910.6666666666666

1307.0

Topological domain

Cytoplasmic

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395311

30_1357

910.6666666666666

1307.0

Topological domain

Lumenal

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395314

1_6

933.6666666666666

1358.0

Topological domain

Cytoplasmic

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395314

30_1357

933.6666666666666

1358.0

Topological domain

Lumenal

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000413890

1_6

910.6666666666666

1307.0

Topological domain

Cytoplasmic

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000413890

30_1357

910.6666666666666

1307.0

Topological domain

Lumenal

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000416613

1_6

933.6666666666666

1321.3333333333333

Topological domain

Cytoplasmic

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000416613

30_1357

933.6666666666666

1321.3333333333333

Topological domain

Lumenal

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000438792

1_6

933.6666666666666

1301.0

Topological domain

Cytoplasmic

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000438792

30_1357

933.6666666666666

1301.0

Topological domain

Lumenal

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395308

7_29

910.6666666666666

1307.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395309

7_29

933.6666666666666

1358.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395311

7_29

910.6666666666666

1307.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000395314

7_29

933.6666666666666

1358.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000413890

7_29

910.6666666666666

1307.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000416613

7_29

933.6666666666666

1321.3333333333333

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

KTN1

chr14:56585455

chr14:56122760

ENST00000438792

7_29

933.6666666666666

1301.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

KTN1

EEF1D, IKBKE, RHOA, RHOG, RAC1, PSMD7, PLEKHA5, ARRB1, HERC2, NEURL4, CDH2, NPM1, CTPS2, EHD1, HEXA, WARS, BNIP3, MEOX2, SGTA, CLEC7A, SYNE4, BMI1, DTNBP1, RTN4, PTGER3, EEF1G, C17orf59, LPAR1, FAM134C, SPC25, NTRK1, TMEM237, TMEM17, TMEM216, PKN2, XRCC3, RAB7A, EMC2, ATP6AP2, GOLT1B, MMGT1, Eef1a1, Kcnk1, Rab5c, Tmed2, Chmp4b, FOXN1, CDH1, CDR2, SPPL2B, YIPF3, NDEL1, CAPN1, SSX3, VTN, IPPK, ADAM32, FAM167A, TRIM25, ZNF598, PPIE, EFTUD2, TNIP2, SOCS6, RNF4, RNF123, AGR2, MB21D1, MYC, CANX, LAMP1, METTL14, SIRPA, ATG16L1, PHB, NRAS, KRAS, CSK, ARMCX3, ARMCX2, PGAM5, HIST1H4A, APEX1, TCF7L2, SCARB2, VAMP5, CYLD, RHBDD1, RHBDF2, IFT20, BIRC3, STAU1, LMBR1L, NFX1, WWP2, FAM105A, M6PR, FFAR2, CD68, HIATL1, STOM, SUSD3, CD3G, SYNPR, TMEM179B, PDCD1LG2, LHFPL5, CLEC4C, KIR2DL3, PLEKHA4, HCVgp1, ATF4, SPATA9, PHRF1, SLC16A7, EIF2S2, BCAP31, AKAP17A, FAM184A, TTN, MYO9A, DCLRE1A, FRA10AC1, CENPE, AKAP1, NEUROD6, HNRNPA1L2, E, M, nsp4, nsp6, ORF7a, ORF7b, ESR1, S, ORF8, ORF6, ABI1, UBE2I, SNAPIN, CAPRIN1, ST7, CIT, KIF20A, PRC1, FIS1, FKBP8, PTPN1, SLC25A46, LRRC59, Apc2, LGALS9, IFI16, NR3C1, DNAJC14, DNAJC16, DNAJC1, DNAJC25, SEC63, DDX58, ATP2A1, B3GAT1, CKAP4, CYP2C9, DERL1, DHFRL1, ELOVL5, EMD, ERGIC2, FBL, GJA1, GJD3, HSD17B11, HSD3B7, KRT19, LAMP2, LAMP3, LMAN1, KIAA1715, METTL7A, NUP155, PANX1, PFN1, PTK2, PXMP2, RAB11A, RAB3B, RAB4A, RAB5A, RAB5C, RAB9A, REEP5, RPN1, RPN2, SEC61B, SEC62, SERBP1, SSR1, STIM1, STX4, STX6, STX7, TMPO, WDR5, NAA40, IGSF3, TACR3, DYNLL1, SFT2D1, NUF2, CDR2L, EEF1A2, FBXW7, TMPRSS2, TOP3B, TFRC, ANPEP, DPP4, TMPRSS11B, CLEC4D, ACE2, CLEC4E, RB1CC1,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PELI2
KTN1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to PELI2-KTN1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PELI2-KTN1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	KTN1	C0023893	Liver Cirrhosis, Experimental	1	CTD_human