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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PGAP1-HSPD1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PGAP1-HSPD1
	FusionPDB ID: 64537
	FusionGDB2.0 ID: 64537
		Hgene	Tgene
	Gene symbol	PGAP1	HSPD1
	Gene ID	80055	3329
	Gene name	post-GPI attachment to proteins inositol deacylase 1	heat shock protein family D (Hsp60) member 1
	Synonyms	Bst1\|ISPD3024\|MRT42\|SPG67	CPN60\|GROEL\|HLD4\|HSP-60\|HSP60\|HSP65\|HuCHA60\|SPG13
	Cytomap	2q33.1	2q33.1
	Type of gene	protein-coding	protein-coding
	Description	GPI inositol-deacylasepost-GPI attachment to proteins 1post-GPI attachment to proteins factor 1	60 kDa heat shock protein, mitochondrial60 kDa chaperoninP60 lymphocyte proteinchaperonin 60epididymis secretory sperm binding proteinheat shock 60kDa protein 1 (chaperonin)heat shock protein 65mitochondrial matrix protein P1short heat shock prote
	Modification date	20200313	20200315
	UniProtAcc	.	P10809
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000354764, ENST00000409475, ENST00000409188, ENST00000485830,	ENST00000544407, ENST00000345042, ENST00000388968,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 12 X 7=756	14 X 10 X 6=840
	# samples	10	16
	** MAII score	log2(10/756*10)=-2.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/840*10)=-2.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PGAP1 [Title/Abstract] AND HSPD1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PGAP1(197750148)-HSPD1(198362116), # samples:2
Anticipated loss of major functional domain due to fusion event.	PGAP1-HSPD1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PGAP1-HSPD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PGAP1-HSPD1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PGAP1-HSPD1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. PGAP1-HSPD1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	HSPD1	GO:0002368	B cell cytokine production	16148103
Tgene	HSPD1	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	16148103
Tgene	HSPD1	GO:0002842	positive regulation of T cell mediated immune response to tumor cell	10663613
Tgene	HSPD1	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	17823127
Tgene	HSPD1	GO:0006986	response to unfolded protein	11050098
Tgene	HSPD1	GO:0032727	positive regulation of interferon-alpha production	17164250
Tgene	HSPD1	GO:0032729	positive regulation of interferon-gamma production	17164250
Tgene	HSPD1	GO:0032733	positive regulation of interleukin-10 production	16148103
Tgene	HSPD1	GO:0032735	positive regulation of interleukin-12 production	17164250
Tgene	HSPD1	GO:0032755	positive regulation of interleukin-6 production	16148103
Tgene	HSPD1	GO:0042026	protein refolding	11050098
Tgene	HSPD1	GO:0042100	B cell proliferation	16148103
Tgene	HSPD1	GO:0042110	T cell activation	15371451\|17164250\|18256040
Tgene	HSPD1	GO:0042113	B cell activation	16148103
Tgene	HSPD1	GO:0043032	positive regulation of macrophage activation	17164250
Tgene	HSPD1	GO:0044406	adhesion of symbiont to host	20633027
Tgene	HSPD1	GO:0048291	isotype switching to IgG isotypes	16148103
Tgene	HSPD1	GO:0050870	positive regulation of T cell activation	16148103\|17164250

Fusion gene breakpoints across PGAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HSPD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ACC	TCGA-OR-A5J7-01A	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000354764	PGAP1	chr2	197750148	-	ENST00000388968	HSPD1	chr2	198362116	-	3400	1387	49	2934	961
ENST00000354764	PGAP1	chr2	197750148	-	ENST00000345042	HSPD1	chr2	198362116	-	3395	1387	49	2934	961
ENST00000409475	PGAP1	chr2	197750148	-	ENST00000388968	HSPD1	chr2	198362116	-	3399	1386	48	2933	961
ENST00000409475	PGAP1	chr2	197750148	-	ENST00000345042	HSPD1	chr2	198362116	-	3394	1386	48	2933	961

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000354764	ENST00000388968	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-	0.000263253	0.9997367
ENST00000354764	ENST00000345042	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-	0.00027177	0.99972826
ENST00000409475	ENST00000388968	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-	0.000263254	0.9997367
ENST00000409475	ENST00000345042	PGAP1	chr2	197750148	-	HSPD1	chr2	198362116	-	0.000271356	0.9997286

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>64537_64537_1_PGAP1-HSPD1_PGAP1_chr2_197750148_ENST00000354764_HSPD1_chr2_198362116_ENST00000345042_length(amino acids)=961AA_BP=446
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYL
YGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY
KGQEFAPKSVAIIGHSMGGLVARALLTLKNFKHDLINLLITQATPHVAPVMPLDRFITDFYTTVNNYWILNARHINLTTLSVAGGFRDYQ
VRSGLTFLPKLSHHTSALSVVSSAVPKTWVSTDHLSIVWCKQLQLTTVRAFFDLIDADTKQITQNSKKKLSVLYHHFIRHPSKHFEENPA
IISDLTGTSMWVLVKVSKWTYVAYNESEKIYFTFPLENHRKIYTHVYCQSTMLDTNSWIFACINSTSMCLQGVDLSWKAELLPTIKGRTV
IIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVI
AELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDA
YVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTL
NLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVT
DALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVN

--------------------------------------------------------------

>64537_64537_2_PGAP1-HSPD1_PGAP1_chr2_197750148_ENST00000354764_HSPD1_chr2_198362116_ENST00000388968_length(amino acids)=961AA_BP=446
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYL
YGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY
KGQEFAPKSVAIIGHSMGGLVARALLTLKNFKHDLINLLITQATPHVAPVMPLDRFITDFYTTVNNYWILNARHINLTTLSVAGGFRDYQ
VRSGLTFLPKLSHHTSALSVVSSAVPKTWVSTDHLSIVWCKQLQLTTVRAFFDLIDADTKQITQNSKKKLSVLYHHFIRHPSKHFEENPA
IISDLTGTSMWVLVKVSKWTYVAYNESEKIYFTFPLENHRKIYTHVYCQSTMLDTNSWIFACINSTSMCLQGVDLSWKAELLPTIKGRTV
IIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVI
AELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDA
YVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTL
NLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVT
DALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVN

--------------------------------------------------------------

>64537_64537_3_PGAP1-HSPD1_PGAP1_chr2_197750148_ENST00000409475_HSPD1_chr2_198362116_ENST00000345042_length(amino acids)=961AA_BP=446
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYL
YGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY
KGQEFAPKSVAIIGHSMGGLVARALLTLKNFKHDLINLLITQATPHVAPVMPLDRFITDFYTTVNNYWILNARHINLTTLSVAGGFRDYQ
VRSGLTFLPKLSHHTSALSVVSSAVPKTWVSTDHLSIVWCKQLQLTTVRAFFDLIDADTKQITQNSKKKLSVLYHHFIRHPSKHFEENPA
IISDLTGTSMWVLVKVSKWTYVAYNESEKIYFTFPLENHRKIYTHVYCQSTMLDTNSWIFACINSTSMCLQGVDLSWKAELLPTIKGRTV
IIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVI
AELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDA
YVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTL
NLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVT
DALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVN

--------------------------------------------------------------

>64537_64537_4_PGAP1-HSPD1_PGAP1_chr2_197750148_ENST00000409475_HSPD1_chr2_198362116_ENST00000388968_length(amino acids)=961AA_BP=446
MGPRGGEGGRGGGGGGGGGGGTMFLHSVNLWNLAFYVFMVFLATLGLWDVFFGFEENKCSMSYMFEYPEYQKIELPKKLAKRYPAYELYL
YGEGSYAEEHKILPLTGIPVLFLPGNAGSYKQVRSIGSIALRKAEDIDFKYHFDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY
KGQEFAPKSVAIIGHSMGGLVARALLTLKNFKHDLINLLITQATPHVAPVMPLDRFITDFYTTVNNYWILNARHINLTTLSVAGGFRDYQ
VRSGLTFLPKLSHHTSALSVVSSAVPKTWVSTDHLSIVWCKQLQLTTVRAFFDLIDADTKQITQNSKKKLSVLYHHFIRHPSKHFEENPA
IISDLTGTSMWVLVKVSKWTYVAYNESEKIYFTFPLENHRKIYTHVYCQSTMLDTNSWIFACINSTSMCLQGVDLSWKAELLPTIKGRTV
IIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVI
AELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDA
YVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTL
NLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVT
DALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVN

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:197750148/chr2:198362116)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	HSPD1 P10809
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269\|PubMed:11422376, ECO:0000269\|PubMed:1346131, ECO:0000305\|PubMed:25918392}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

1_11

424.0

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

1_11

424.0

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

12_32

424.0

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

12_32

424.0

593.0

Transmembrane

Helical

Tgene

HSPD1

chr2:197750148

chr2:198362116

ENST00000345042

111_115

58.0

574.0

Nucleotide binding

ATP

Tgene

HSPD1

chr2:197750148

chr2:198362116

ENST00000388968

111_115

58.0

574.0

Nucleotide binding

ATP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

33_641

424.0

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

663_668

424.0

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

690_733

424.0

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

755_817

424.0

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

839_853

424.0

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

875_893

424.0

923.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

915_922

424.0

923.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

33_641

424.0

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

663_668

424.0

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

690_733

424.0

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

755_817

424.0

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

839_853

424.0

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

875_893

424.0

593.0

Topological domain

Cytoplasmic

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

915_922

424.0

593.0

Topological domain

Lumenal

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

642_662

424.0

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

669_689

424.0

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

734_754

424.0

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

818_838

424.0

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

854_874

424.0

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000354764

894_914

424.0

923.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

642_662

424.0

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

669_689

424.0

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

734_754

424.0

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

818_838

424.0

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

854_874

424.0

593.0

Transmembrane

Helical

Hgene

PGAP1

chr2:197750148

chr2:198362116

ENST00000409475

894_914

424.0

593.0

Transmembrane

Helical

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PGAP1
HSPD1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to PGAP1-HSPD1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to PGAP1-HSPD1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source