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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PHC3-PLD1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PHC3-PLD1
FusionPDB ID: 64750
FusionGDB2.0 ID: 64750
HgeneTgene
Gene symbol

PHC3

PLD1

Gene ID

80012

5589

Gene namepolyhomeotic homolog 3protein kinase C substrate 80K-H
SynonymsEDR3|HPH3AGE-R2|G19P1|GIIB|PCLD|PCLD1|PKCSH|PLD1|VASAP-60
Cytomap

3q26.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionpolyhomeotic-like protein 3early development regulator 3early development regulatory protein 3homolog of polyhomeotic 3polyhomeotic like 3glucosidase 2 subunit betaAGE-binding receptor 2advanced glycation end-product receptor 2glucosidase II subunit betahepatocystinprotein kinase C substrate 60.1 kDa protein heavy chainprotein kinase C substrate, 80 Kda protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000467570, ENST00000474275, 
ENST00000494943, ENST00000495893, 
ENST00000481639, ENST00000497658, 
ENST00000497307, ENST00000340989, 
ENST00000342215, ENST00000351298, 
ENST00000356327, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 15 X 11=24758 X 6 X 4=192
# samples 209
** MAII scorelog2(20/2475*10)=-3.62935662007961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PHC3 [Title/Abstract] AND PLD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PHC3(169889160)-PLD1(171443866), # samples:1
Anticipated loss of major functional domain due to fusion event.PHC3-PLD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PHC3-PLD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PHC3-PLD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PHC3-PLD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLD1

GO:0006491

N-glycan processing

10929008


check buttonFusion gene breakpoints across PHC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PLD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer5373NPHC3chr3

169889160

-PLD1chr3

171443866

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000495893PHC3chr3169889160-ENST00000356327PLD1chr3171443866-5624446322950972
ENST00000495893PHC3chr3169889160-ENST00000351298PLD1chr3171443866-53174463230641010
ENST00000495893PHC3chr3169889160-ENST00000342215PLD1chr3171443866-4985446321633533
ENST00000495893PHC3chr3169889160-ENST00000340989PLD1chr3171443866-2756446322755908
ENST00000494943PHC3chr3169889160-ENST00000356327PLD1chr3171443866-5625447692951960
ENST00000494943PHC3chr3169889160-ENST00000351298PLD1chr3171443866-5318447693065998
ENST00000494943PHC3chr3169889160-ENST00000342215PLD1chr3171443866-4986447691634521
ENST00000494943PHC3chr3169889160-ENST00000340989PLD1chr3171443866-2757447692756895
ENST00000467570PHC3chr3169889160-ENST00000356327PLD1chr3171443866-5626448342952972
ENST00000467570PHC3chr3169889160-ENST00000351298PLD1chr3171443866-53194483430661010
ENST00000467570PHC3chr3169889160-ENST00000342215PLD1chr3171443866-4987448341635533
ENST00000467570PHC3chr3169889160-ENST00000340989PLD1chr3171443866-2758448342757908
ENST00000474275PHC3chr3169889160-ENST00000356327PLD1chr3171443866-5608430642934956
ENST00000474275PHC3chr3169889160-ENST00000351298PLD1chr3171443866-5301430643048994
ENST00000474275PHC3chr3169889160-ENST00000342215PLD1chr3171443866-4969430641617517
ENST00000474275PHC3chr3169889160-ENST00000340989PLD1chr3171443866-2740430642739892

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000495893ENST00000356327PHC3chr3169889160-PLD1chr3171443866-0.0003578330.99964213
ENST00000495893ENST00000351298PHC3chr3169889160-PLD1chr3171443866-0.0001624010.9998375
ENST00000495893ENST00000342215PHC3chr3169889160-PLD1chr3171443866-0.0078210710.9921789
ENST00000495893ENST00000340989PHC3chr3169889160-PLD1chr3171443866-0.0015391020.9984609
ENST00000494943ENST00000356327PHC3chr3169889160-PLD1chr3171443866-0.0002927990.99970716
ENST00000494943ENST00000351298PHC3chr3169889160-PLD1chr3171443866-0.000271090.99972886
ENST00000494943ENST00000342215PHC3chr3169889160-PLD1chr3171443866-0.0059699980.99403
ENST00000494943ENST00000340989PHC3chr3169889160-PLD1chr3171443866-0.0013526070.9986474
ENST00000467570ENST00000356327PHC3chr3169889160-PLD1chr3171443866-0.000361280.9996387
ENST00000467570ENST00000351298PHC3chr3169889160-PLD1chr3171443866-0.0001646560.9998354
ENST00000467570ENST00000342215PHC3chr3169889160-PLD1chr3171443866-0.0078983050.9921017
ENST00000467570ENST00000340989PHC3chr3169889160-PLD1chr3171443866-0.001572650.9984274
ENST00000474275ENST00000356327PHC3chr3169889160-PLD1chr3171443866-0.0002931780.9997068
ENST00000474275ENST00000351298PHC3chr3169889160-PLD1chr3171443866-0.0002365920.9997634
ENST00000474275ENST00000342215PHC3chr3169889160-PLD1chr3171443866-0.0061648390.9938352
ENST00000474275ENST00000340989PHC3chr3169889160-PLD1chr3171443866-0.0013547470.99864525

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>64750_64750_1_PHC3-PLD1_PHC3_chr3_169889160_ENST00000467570_PLD1_chr3_171443866_ENST00000340989_length(amino acids)=908AA_BP=138
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQG
RACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNF
LKDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVE
LALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPP
AAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGLKPHF
KLFHPSSESEQGLTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVA
RHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFF
ISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYIS
FCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRSKM

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>64750_64750_2_PHC3-PLD1_PHC3_chr3_169889160_ENST00000467570_PLD1_chr3_171443866_ENST00000342215_length(amino acids)=533AA_BP=138
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQG
RACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNF
LKDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVE
LALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPI

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>64750_64750_3_PHC3-PLD1_PHC3_chr3_169889160_ENST00000467570_PLD1_chr3_171443866_ENST00000351298_length(amino acids)=1010AA_BP=138
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQG
RACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNF
LKDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVE
LALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPP
AAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGLKPHF
KLFHPSSESEQGLTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVA
RHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFF
ISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYIS
FCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRVVL
GYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFINKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSE

--------------------------------------------------------------

>64750_64750_4_PHC3-PLD1_PHC3_chr3_169889160_ENST00000467570_PLD1_chr3_171443866_ENST00000356327_length(amino acids)=972AA_BP=138
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQG
RACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNF
LKDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVE
LALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPP
AAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSNTGSIRSLQTGVGELHGETR
FWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTAHELRY
QVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIP
LLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSA
NINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVF

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>64750_64750_5_PHC3-PLD1_PHC3_chr3_169889160_ENST00000474275_PLD1_chr3_171443866_ENST00000340989_length(amino acids)=892AA_BP=122
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQ
SLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQGRACYRWSKRWLIVKDS
FLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENA
LAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMR
LHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLKDKNE
PVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGLKPHFKLFHPSSESEQGLTRP
HADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSK
YRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVVFNKIGDA
IAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVT

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>64750_64750_6_PHC3-PLD1_PHC3_chr3_169889160_ENST00000474275_PLD1_chr3_171443866_ENST00000342215_length(amino acids)=517AA_BP=122
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQ
SLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQGRACYRWSKRWLIVKDS
FLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENA
LAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMR
LHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPIPGPSVVYRQVWESCMG

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>64750_64750_7_PHC3-PLD1_PHC3_chr3_169889160_ENST00000474275_PLD1_chr3_171443866_ENST00000351298_length(amino acids)=994AA_BP=122
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQ
SLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQGRACYRWSKRWLIVKDS
FLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENA
LAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMR
LHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLKDKNE
PVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGLKPHFKLFHPSSESEQGLTRP
HADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSK
YRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVVFNKIGDA
IAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVT
ELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRVVLGYLDDPSEDIQDPVSD
KFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFINKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLLPSVGTKEAIVPM

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>64750_64750_8_PHC3-PLD1_PHC3_chr3_169889160_ENST00000474275_PLD1_chr3_171443866_ENST00000356327_length(amino acids)=956AA_BP=122
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQ
SLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQGRACYRWSKRWLIVKDS
FLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENA
LAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMR
LHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLKDKNE
PVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSNTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWV
QLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQLLRSA
ADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNA
LQAIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMA
VIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRD

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>64750_64750_9_PHC3-PLD1_PHC3_chr3_169889160_ENST00000494943_PLD1_chr3_171443866_ENST00000340989_length(amino acids)=895AA_BP=126
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSS
SQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQGRACYRWSKRWLI
VKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAI
QENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKR
TLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLK
DKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGLKPHFKLFHPSSESEQG
LTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKI
MKSKYRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVVFNK
IGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEG

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>64750_64750_10_PHC3-PLD1_PHC3_chr3_169889160_ENST00000494943_PLD1_chr3_171443866_ENST00000342215_length(amino acids)=521AA_BP=126
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSS
SQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQGRACYRWSKRWLI
VKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAI
QENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKR
TLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPIPGPSVVYRQVWE

--------------------------------------------------------------

>64750_64750_11_PHC3-PLD1_PHC3_chr3_169889160_ENST00000494943_PLD1_chr3_171443866_ENST00000351298_length(amino acids)=998AA_BP=126
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSS
SQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQGRACYRWSKRWLI
VKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAI
QENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKR
TLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLK
DKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGLKPHFKLFHPSSESEQG
LTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKI
MKSKYRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVVFNK
IGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEG
NLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRVVLGYLDDPSEDIQD
PVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFINKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLLPSVGTKEA

--------------------------------------------------------------

>64750_64750_12_PHC3-PLD1_PHC3_chr3_169889160_ENST00000494943_PLD1_chr3_171443866_ENST00000356327_length(amino acids)=960AA_BP=126
MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSS
SQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQGRACYRWSKRWLI
VKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAI
QENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKR
TLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLK
DKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSNTGSIRSLQTGVGELHGETRFWHGKDYCNFVF
KDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQL
LRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTG
GGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRD
SEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLI

--------------------------------------------------------------

>64750_64750_13_PHC3-PLD1_PHC3_chr3_169889160_ENST00000495893_PLD1_chr3_171443866_ENST00000340989_length(amino acids)=908AA_BP=138
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQG
RACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNF
LKDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVE
LALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPP
AAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGLKPHF
KLFHPSSESEQGLTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVA
RHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFF
ISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYIS
FCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRSKM

--------------------------------------------------------------

>64750_64750_14_PHC3-PLD1_PHC3_chr3_169889160_ENST00000495893_PLD1_chr3_171443866_ENST00000342215_length(amino acids)=533AA_BP=138
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQG
RACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNF
LKDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVE
LALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPI

--------------------------------------------------------------

>64750_64750_15_PHC3-PLD1_PHC3_chr3_169889160_ENST00000495893_PLD1_chr3_171443866_ENST00000351298_length(amino acids)=1010AA_BP=138
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQG
RACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNF
LKDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVE
LALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPP
AAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGLKPHF
KLFHPSSESEQGLTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVA
RHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFF
ISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYIS
FCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRVVL
GYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFINKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSE

--------------------------------------------------------------

>64750_64750_16_PHC3-PLD1_PHC3_chr3_169889160_ENST00000495893_PLD1_chr3_171443866_ENST00000356327_length(amino acids)=972AA_BP=138
MAEAEFKDHSTAMDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLML
HTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQG
RACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNF
LKDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVE
LALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPP
AAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSNTGSIRSLQTGVGELHGETR
FWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTAHELRY
QVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIP
LLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSA
NINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVF

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:169889160/chr3:171443866)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHC3chr3:169889160chr3:171443866ENST00000474275-4519_26122.0187.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169889160chr3:171443866ENST00000494943-41519_26126.0984.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169889160chr3:171443866ENST00000495893-41519_26138.0996.0Compositional biasNote=Poly-Thr
TgenePLD1chr3:169889160chr3:171443866ENST00000340989526219_328202.0972.0DomainNote=PH
TgenePLD1chr3:169889160chr3:171443866ENST00000340989526459_486202.0972.0DomainPLD phosphodiesterase 1
TgenePLD1chr3:169889160chr3:171443866ENST00000340989526891_918202.0972.0DomainPLD phosphodiesterase 2
TgenePLD1chr3:169889160chr3:171443866ENST00000342215525219_328202.01375.0DomainNote=PH
TgenePLD1chr3:169889160chr3:171443866ENST00000342215525459_486202.01375.0DomainPLD phosphodiesterase 1
TgenePLD1chr3:169889160chr3:171443866ENST00000342215525891_918202.01375.0DomainPLD phosphodiesterase 2
TgenePLD1chr3:169889160chr3:171443866ENST00000351298527219_328202.01075.0DomainNote=PH
TgenePLD1chr3:169889160chr3:171443866ENST00000351298527459_486202.01075.0DomainPLD phosphodiesterase 1
TgenePLD1chr3:169889160chr3:171443866ENST00000351298527891_918202.01075.0DomainPLD phosphodiesterase 2
TgenePLD1chr3:169889160chr3:171443866ENST00000356327526219_328202.01037.0DomainNote=PH
TgenePLD1chr3:169889160chr3:171443866ENST00000356327526459_486202.01037.0DomainPLD phosphodiesterase 1
TgenePLD1chr3:169889160chr3:171443866ENST00000356327526891_918202.01037.0DomainPLD phosphodiesterase 2
TgenePLD1chr3:169889160chr3:171443866ENST00000340989526463_928202.0972.0RegionNote=Catalytic
TgenePLD1chr3:169889160chr3:171443866ENST00000342215525463_928202.01375.0RegionNote=Catalytic
TgenePLD1chr3:169889160chr3:171443866ENST00000351298527463_928202.01075.0RegionNote=Catalytic
TgenePLD1chr3:169889160chr3:171443866ENST00000356327526463_928202.01037.0RegionNote=Catalytic

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePHC3chr3:169889160chr3:171443866ENST00000474275-45324_539122.0187.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169889160chr3:171443866ENST00000474275-45346_670122.0187.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169889160chr3:171443866ENST00000474275-4589_287122.0187.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169889160chr3:171443866ENST00000494943-415324_539126.0984.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169889160chr3:171443866ENST00000494943-415346_670126.0984.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169889160chr3:171443866ENST00000494943-41589_287126.0984.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169889160chr3:171443866ENST00000495893-415324_539138.0996.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169889160chr3:171443866ENST00000495893-415346_670138.0996.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169889160chr3:171443866ENST00000495893-41589_287138.0996.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169889160chr3:171443866ENST00000497658-1419_260152.0Compositional biasNote=Poly-Thr
HgenePHC3chr3:169889160chr3:171443866ENST00000497658-14324_5390152.0Compositional biasNote=Gln-rich
HgenePHC3chr3:169889160chr3:171443866ENST00000497658-14346_6700152.0Compositional biasNote=Pro-rich
HgenePHC3chr3:169889160chr3:171443866ENST00000497658-1489_2870152.0Compositional biasNote=Ser-rich
HgenePHC3chr3:169889160chr3:171443866ENST00000474275-45919_983122.0187.0DomainSAM
HgenePHC3chr3:169889160chr3:171443866ENST00000494943-415919_983126.0984.0DomainSAM
HgenePHC3chr3:169889160chr3:171443866ENST00000495893-415919_983138.0996.0DomainSAM
HgenePHC3chr3:169889160chr3:171443866ENST00000497658-14919_9830152.0DomainSAM
HgenePHC3chr3:169889160chr3:171443866ENST00000474275-45691_720122.0187.0MotifNote=HD1
HgenePHC3chr3:169889160chr3:171443866ENST00000494943-415691_720126.0984.0MotifNote=HD1
HgenePHC3chr3:169889160chr3:171443866ENST00000495893-415691_720138.0996.0MotifNote=HD1
HgenePHC3chr3:169889160chr3:171443866ENST00000497658-14691_7200152.0MotifNote=HD1
HgenePHC3chr3:169889160chr3:171443866ENST00000474275-45776_810122.0187.0Zinc fingerFCS-type
HgenePHC3chr3:169889160chr3:171443866ENST00000494943-415776_810126.0984.0Zinc fingerFCS-type
HgenePHC3chr3:169889160chr3:171443866ENST00000495893-415776_810138.0996.0Zinc fingerFCS-type
HgenePHC3chr3:169889160chr3:171443866ENST00000497658-14776_8100152.0Zinc fingerFCS-type
TgenePLD1chr3:169889160chr3:171443866ENST0000034098952681_212202.0972.0DomainPX
TgenePLD1chr3:169889160chr3:171443866ENST0000034221552581_212202.01375.0DomainPX
TgenePLD1chr3:169889160chr3:171443866ENST0000035129852781_212202.01075.0DomainPX
TgenePLD1chr3:169889160chr3:171443866ENST0000035632752681_212202.01037.0DomainPX


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PHC3
PLD1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PHC3-PLD1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PHC3-PLD1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource