UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PIAS2-ST8SIA5

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PIAS2-ST8SIA5
	FusionPDB ID: 65117
	FusionGDB2.0 ID: 65117
		Hgene	Tgene
	Gene symbol	PIAS2	ST8SIA5
	Gene ID	9063	29906
	Gene name	protein inhibitor of activated STAT 2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
	Synonyms	ARIP3\|DIP\|MIZ1\|PIASX\|SIZ2\|ZMIZ4	SIAT8-E\|SIAT8E\|ST8SiaV
	Cytomap	18q21.1	18q21.1
	Type of gene	protein-coding	protein-coding
	Description	E3 SUMO-protein ligase PIAS2DAB2-interacting proteinE3 SUMO-protein transferase PIAS2androgen receptor-interacting protein 3msx-interacting zinc finger proteinprotein inhibitor of activated STAT Xzinc finger, MIZ-type containing 4	alpha-2,8-sialyltransferase 8EST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 5sialyltransferase 8E (alpha-2, 8-polysialytransferase)sialyltransferase St8Sia V
	Modification date	20200320	20200320
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000324794, ENST00000545673, ENST00000585916, ENST00000590944,	ENST00000536490, ENST00000538168, ENST00000590497, ENST00000315087,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 13 X 6=780	4 X 4 X 6=96
	# samples	15	8
	** MAII score	log2(15/780*10)=-2.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/96*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PIAS2 [Title/Abstract] AND ST8SIA5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PIAS2(44407922)-ST8SIA5(44284627), # samples:3 PIAS2(44407922)-ST8SIA5(44272218), # samples:3
Anticipated loss of major functional domain due to fusion event.	PIAS2-ST8SIA5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PIAS2-ST8SIA5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PIAS2-ST8SIA5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PIAS2-ST8SIA5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PIAS2-ST8SIA5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PIAS2	GO:0016925	protein sumoylation	22406621
Hgene	PIAS2	GO:0060766	negative regulation of androgen receptor signaling pathway	11477070

Fusion gene breakpoints across PIAS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ST8SIA5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AC-A2FM-01A	PIAS2	chr18	44407922	-	ST8SIA5	chr18	44284627	-
ChimerDB4	COAD	TCGA-D5-6531	PIAS2	chr18	44407921	-	ST8SIA5	chr18	44284627	-
ChimerDB4	GBM	TCGA-06-0744-01A	PIAS2	chr18	44407922	-	ST8SIA5	chr18	44272218	-
ChimerDB4	GBM	TCGA-06-5408-01A	PIAS2	chr18	44407922	-	ST8SIA5	chr18	44272218	-
ChimerDB4	GBM	TCGA-27-2521-01A	PIAS2	chr18	44407922	-	ST8SIA5	chr18	44284627	-
ChimerDB4	GBM	TCGA-28-5209-01A	PIAS2	chr18	44407922	-	ST8SIA5	chr18	44284627	-
ChimerDB4	LUSC	TCGA-58-8390	PIAS2	chr18	44407921	-	ST8SIA5	chr18	44272218	-
ChimerDB4	PCPG	TCGA-PR-A5PF-01A	PIAS2	chr18	44407922	-	ST8SIA5	chr18	44272218	-
ChimerDB4	SKCM	TCGA-ER-A19T-06A	PIAS2	chr18	44395275	-	ST8SIA5	chr18	44272218	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000585916	PIAS2	chr18	44407921	-	ENST00000315087	ST8SIA5	chr18	44284627	-	3432	1508	0	2507	835
ENST00000545673	PIAS2	chr18	44407921	-	ENST00000315087	ST8SIA5	chr18	44284627	-	3117	1193	231	2192	653
ENST00000324794	PIAS2	chr18	44407921	-	ENST00000315087	ST8SIA5	chr18	44284627	-	3590	1666	158	2665	835
ENST00000585916	PIAS2	chr18	44407921	-	ENST00000315087	ST8SIA5	chr18	44272218	-	3339	1508	0	2414	804
ENST00000545673	PIAS2	chr18	44407921	-	ENST00000315087	ST8SIA5	chr18	44272218	-	3024	1193	231	2099	622
ENST00000324794	PIAS2	chr18	44407921	-	ENST00000315087	ST8SIA5	chr18	44272218	-	3497	1666	158	2572	804
ENST00000585916	PIAS2	chr18	44407922	-	ENST00000315087	ST8SIA5	chr18	44284627	-	3432	1508	0	2507	835
ENST00000545673	PIAS2	chr18	44407922	-	ENST00000315087	ST8SIA5	chr18	44284627	-	3117	1193	231	2192	653
ENST00000324794	PIAS2	chr18	44407922	-	ENST00000315087	ST8SIA5	chr18	44284627	-	3590	1666	158	2665	835
ENST00000585916	PIAS2	chr18	44407922	-	ENST00000315087	ST8SIA5	chr18	44272218	-	3339	1508	0	2414	804
ENST00000545673	PIAS2	chr18	44407922	-	ENST00000315087	ST8SIA5	chr18	44272218	-	3024	1193	231	2099	622
ENST00000324794	PIAS2	chr18	44407922	-	ENST00000315087	ST8SIA5	chr18	44272218	-	3497	1666	158	2572	804

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000585916	ENST00000315087	PIAS2	chr18	44407921	-	ST8SIA5	chr18	44284627	-	0.002173876	0.99782604
ENST00000545673	ENST00000315087	PIAS2	chr18	44407921	-	ST8SIA5	chr18	44284627	-	0.004950555	0.9950494
ENST00000324794	ENST00000315087	PIAS2	chr18	44407921	-	ST8SIA5	chr18	44284627	-	0.002198805	0.9978011
ENST00000585916	ENST00000315087	PIAS2	chr18	44407921	-	ST8SIA5	chr18	44272218	-	0.002699008	0.99730104
ENST00000545673	ENST00000315087	PIAS2	chr18	44407921	-	ST8SIA5	chr18	44272218	-	0.00479663	0.9952034
ENST00000324794	ENST00000315087	PIAS2	chr18	44407921	-	ST8SIA5	chr18	44272218	-	0.00271766	0.99728227
ENST00000585916	ENST00000315087	PIAS2	chr18	44407922	-	ST8SIA5	chr18	44284627	-	0.002173876	0.99782604
ENST00000545673	ENST00000315087	PIAS2	chr18	44407922	-	ST8SIA5	chr18	44284627	-	0.004950555	0.9950494
ENST00000324794	ENST00000315087	PIAS2	chr18	44407922	-	ST8SIA5	chr18	44284627	-	0.002198805	0.9978011
ENST00000585916	ENST00000315087	PIAS2	chr18	44407922	-	ST8SIA5	chr18	44272218	-	0.002699008	0.99730104
ENST00000545673	ENST00000315087	PIAS2	chr18	44407922	-	ST8SIA5	chr18	44272218	-	0.00479663	0.9952034
ENST00000324794	ENST00000315087	PIAS2	chr18	44407922	-	ST8SIA5	chr18	44272218	-	0.00271766	0.99728227

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>65117_65117_1_PIAS2-ST8SIA5_PIAS2_chr18_44407921_ENST00000324794_ST8SIA5_chr18_44272218_ENST00000315087_length(amino acids)=804AA_BP=0
MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSTIKSSVFSLDGGSS
PVEPDLAVAGIHSLPSTSVTPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFI
FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLS
SAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAV
TCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVL
SKPCSVTVASEASKKKVDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCN
APAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTM
DVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSL

--------------------------------------------------------------

>65117_65117_2_PIAS2-ST8SIA5_PIAS2_chr18_44407921_ENST00000324794_ST8SIA5_chr18_44284627_ENST00000315087_length(amino acids)=835AA_BP=0
MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSTIKSSVFSLDGGSS
PVEPDLAVAGIHSLPSTSVTPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFI
FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLS
SAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAV
TCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVL
SKPCSVTVASEASKKKVDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGYFEFYEGPFEYNSTRCLELRHEILEVKVLSMVKQSEL
FDRWKSLQMCKWAMNISEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGG
ILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRV
KYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMP

--------------------------------------------------------------

>65117_65117_3_PIAS2-ST8SIA5_PIAS2_chr18_44407921_ENST00000545673_ST8SIA5_chr18_44272218_ENST00000315087_length(amino acids)=622AA_BP=1
MTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSA
VPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTC
THLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVLSK
PCSVTVASEASKKKVDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCNAP
AFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDV
GVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGV

--------------------------------------------------------------

>65117_65117_4_PIAS2-ST8SIA5_PIAS2_chr18_44407921_ENST00000545673_ST8SIA5_chr18_44284627_ENST00000315087_length(amino acids)=653AA_BP=1
MTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSA
VPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTC
THLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVLSK
PCSVTVASEASKKKVDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGYFEFYEGPFEYNSTRCLELRHEILEVKVLSMVKQSELFD
RWKSLQMCKWAMNISEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGIL
KNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKY
VLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMPSE

--------------------------------------------------------------

>65117_65117_5_PIAS2-ST8SIA5_PIAS2_chr18_44407921_ENST00000585916_ST8SIA5_chr18_44272218_ENST00000315087_length(amino acids)=804AA_BP=0
MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSTIKSSVFSLDGGSS
PVEPDLAVAGIHSLPSTSVTPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFI
FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLS
SAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAV
TCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVL
SKPCSVTVASEASKKKVDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCN
APAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTM
DVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSL

--------------------------------------------------------------

>65117_65117_6_PIAS2-ST8SIA5_PIAS2_chr18_44407921_ENST00000585916_ST8SIA5_chr18_44284627_ENST00000315087_length(amino acids)=835AA_BP=0
MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSTIKSSVFSLDGGSS
PVEPDLAVAGIHSLPSTSVTPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFI
FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLS
SAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAV
TCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVL
SKPCSVTVASEASKKKVDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGYFEFYEGPFEYNSTRCLELRHEILEVKVLSMVKQSEL
FDRWKSLQMCKWAMNISEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGG
ILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRV
KYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMP

--------------------------------------------------------------

>65117_65117_7_PIAS2-ST8SIA5_PIAS2_chr18_44407922_ENST00000324794_ST8SIA5_chr18_44272218_ENST00000315087_length(amino acids)=804AA_BP=0
MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSTIKSSVFSLDGGSS
PVEPDLAVAGIHSLPSTSVTPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFI
FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLS
SAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAV
TCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVL
SKPCSVTVASEASKKKVDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCN
APAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTM
DVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSL

--------------------------------------------------------------

>65117_65117_8_PIAS2-ST8SIA5_PIAS2_chr18_44407922_ENST00000324794_ST8SIA5_chr18_44284627_ENST00000315087_length(amino acids)=835AA_BP=0
MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSTIKSSVFSLDGGSS
PVEPDLAVAGIHSLPSTSVTPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFI
FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLS
SAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAV
TCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVL
SKPCSVTVASEASKKKVDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGYFEFYEGPFEYNSTRCLELRHEILEVKVLSMVKQSEL
FDRWKSLQMCKWAMNISEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGG
ILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRV
KYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMP

--------------------------------------------------------------

>65117_65117_9_PIAS2-ST8SIA5_PIAS2_chr18_44407922_ENST00000545673_ST8SIA5_chr18_44272218_ENST00000315087_length(amino acids)=622AA_BP=1
MTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSA
VPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTC
THLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVLSK
PCSVTVASEASKKKVDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCNAP
AFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDV
GVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGV

--------------------------------------------------------------

>65117_65117_10_PIAS2-ST8SIA5_PIAS2_chr18_44407922_ENST00000545673_ST8SIA5_chr18_44284627_ENST00000315087_length(amino acids)=653AA_BP=1
MTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSA
VPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTC
THLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVLSK
PCSVTVASEASKKKVDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGYFEFYEGPFEYNSTRCLELRHEILEVKVLSMVKQSELFD
RWKSLQMCKWAMNISEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGIL
KNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKY
VLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMPSE

--------------------------------------------------------------

>65117_65117_11_PIAS2-ST8SIA5_PIAS2_chr18_44407922_ENST00000585916_ST8SIA5_chr18_44272218_ENST00000315087_length(amino acids)=804AA_BP=0
MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSTIKSSVFSLDGGSS
PVEPDLAVAGIHSLPSTSVTPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFI
FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLS
SAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAV
TCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVL
SKPCSVTVASEASKKKVDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCN
APAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTM
DVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSL

--------------------------------------------------------------

>65117_65117_12_PIAS2-ST8SIA5_PIAS2_chr18_44407922_ENST00000585916_ST8SIA5_chr18_44284627_ENST00000315087_length(amino acids)=835AA_BP=0
MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSTIKSSVFSLDGGSS
PVEPDLAVAGIHSLPSTSVTPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFI
FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLS
SAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAV
TCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVL
SKPCSVTVASEASKKKVDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGYFEFYEGPFEYNSTRCLELRHEILEVKVLSMVKQSEL
FDRWKSLQMCKWAMNISEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGG
ILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRV
KYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMP

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:44407922/chr18:44284627)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PIAS2

chr18:44407921

chr18:44272218

ENST00000324794

11_45

502.6666666666667

573.0

Domain

SAP

Hgene

PIAS2

chr18:44407921

chr18:44272218

ENST00000324794

134_299

502.6666666666667

573.0

Domain

PINIT

Hgene

PIAS2

chr18:44407921

chr18:44272218

ENST00000585916

11_45

502.6666666666667

622.0

Domain

SAP

Hgene

PIAS2

chr18:44407921

chr18:44272218

ENST00000585916

134_299

502.6666666666667

622.0

Domain

PINIT

Hgene

PIAS2

chr18:44407921

chr18:44284627

ENST00000324794

11_45

502.6666666666667

573.0

Domain

SAP

Hgene

PIAS2

chr18:44407921

chr18:44284627

ENST00000324794

134_299

502.6666666666667

573.0

Domain

PINIT

Hgene

PIAS2

chr18:44407921

chr18:44284627

ENST00000585916

11_45

502.6666666666667

622.0

Domain

SAP

Hgene

PIAS2

chr18:44407921

chr18:44284627

ENST00000585916

134_299

502.6666666666667

622.0

Domain

PINIT

Hgene

PIAS2

chr18:44407922

chr18:44272218

ENST00000324794

11_45

502.6666666666667

573.0

Domain

SAP

Hgene

PIAS2

chr18:44407922

chr18:44272218

ENST00000324794

134_299

502.6666666666667

573.0

Domain

PINIT

Hgene

PIAS2

chr18:44407922

chr18:44272218

ENST00000585916

11_45

502.6666666666667

622.0

Domain

SAP

Hgene

PIAS2

chr18:44407922

chr18:44272218

ENST00000585916

134_299

502.6666666666667

622.0

Domain

PINIT

Hgene

PIAS2

chr18:44407922

chr18:44284627

ENST00000324794

11_45

502.6666666666667

573.0

Domain

SAP

Hgene

PIAS2

chr18:44407922

chr18:44284627

ENST00000324794

134_299

502.6666666666667

573.0

Domain

PINIT

Hgene

PIAS2

chr18:44407922

chr18:44284627

ENST00000585916

11_45

502.6666666666667

622.0

Domain

SAP

Hgene

PIAS2

chr18:44407922

chr18:44284627

ENST00000585916

134_299

502.6666666666667

622.0

Domain

PINIT

Hgene

PIAS2

chr18:44407921

chr18:44272218

ENST00000324794

19_23

502.6666666666667

573.0

Motif

Note=LXXLL motif

Hgene

PIAS2

chr18:44407921

chr18:44272218

ENST00000324794

484_492

502.6666666666667

573.0

Motif

Nuclear localization signal

Hgene

PIAS2

chr18:44407921

chr18:44272218

ENST00000585916

19_23

502.6666666666667

622.0

Motif

Note=LXXLL motif

Hgene

PIAS2

chr18:44407921

chr18:44272218

ENST00000585916

484_492

502.6666666666667

622.0

Motif

Nuclear localization signal

Hgene

PIAS2

chr18:44407921

chr18:44284627

ENST00000324794

19_23

502.6666666666667

573.0

Motif

Note=LXXLL motif

Hgene

PIAS2

chr18:44407921

chr18:44284627

ENST00000324794

484_492

502.6666666666667

573.0

Motif

Nuclear localization signal

Hgene

PIAS2

chr18:44407921

chr18:44284627

ENST00000585916

19_23

502.6666666666667

622.0

Motif

Note=LXXLL motif

Hgene

PIAS2

chr18:44407921

chr18:44284627

ENST00000585916

484_492

502.6666666666667

622.0

Motif

Nuclear localization signal

Hgene

PIAS2

chr18:44407922

chr18:44272218

ENST00000324794

19_23

502.6666666666667

573.0

Motif

Note=LXXLL motif

Hgene

PIAS2

chr18:44407922

chr18:44272218

ENST00000324794

484_492

502.6666666666667

573.0

Motif

Nuclear localization signal

Hgene

PIAS2

chr18:44407922

chr18:44272218

ENST00000585916

19_23

502.6666666666667

622.0

Motif

Note=LXXLL motif

Hgene

PIAS2

chr18:44407922

chr18:44272218

ENST00000585916

484_492

502.6666666666667

622.0

Motif

Nuclear localization signal

Hgene

PIAS2

chr18:44407922

chr18:44284627

ENST00000324794

19_23

502.6666666666667

573.0

Motif

Note=LXXLL motif

Hgene

PIAS2

chr18:44407922

chr18:44284627

ENST00000324794

484_492

502.6666666666667

573.0

Motif

Nuclear localization signal

Hgene

PIAS2

chr18:44407922

chr18:44284627

ENST00000585916

19_23

502.6666666666667

622.0

Motif

Note=LXXLL motif

Hgene

PIAS2

chr18:44407922

chr18:44284627

ENST00000585916

484_492

502.6666666666667

622.0

Motif

Nuclear localization signal

Hgene

PIAS2

chr18:44407921

chr18:44272218

ENST00000324794

467_473

502.6666666666667

573.0

Region

Note=SUMO1-binding

Hgene

PIAS2

chr18:44407921

chr18:44272218

ENST00000585916

467_473

502.6666666666667

622.0

Region

Note=SUMO1-binding

Hgene

PIAS2

chr18:44407921

chr18:44284627

ENST00000324794

467_473

502.6666666666667

573.0

Region

Note=SUMO1-binding

Hgene

PIAS2

chr18:44407921

chr18:44284627

ENST00000585916

467_473

502.6666666666667

622.0

Region

Note=SUMO1-binding

Hgene

PIAS2

chr18:44407922

chr18:44272218

ENST00000324794

467_473

502.6666666666667

573.0

Region

Note=SUMO1-binding

Hgene

PIAS2

chr18:44407922

chr18:44272218

ENST00000585916

467_473

502.6666666666667

622.0

Region

Note=SUMO1-binding

Hgene

PIAS2

chr18:44407922

chr18:44284627

ENST00000324794

467_473

502.6666666666667

573.0

Region

Note=SUMO1-binding

Hgene

PIAS2

chr18:44407922

chr18:44284627

ENST00000585916

467_473

502.6666666666667

622.0

Region

Note=SUMO1-binding

Hgene

PIAS2

chr18:44407921

chr18:44272218

ENST00000324794

331_408

502.6666666666667

573.0

Zinc finger

SP-RING-type

Hgene

PIAS2

chr18:44407921

chr18:44272218

ENST00000585916

331_408

502.6666666666667

622.0

Zinc finger

SP-RING-type

Hgene

PIAS2

chr18:44407921

chr18:44284627

ENST00000324794

331_408

502.6666666666667

573.0

Zinc finger

SP-RING-type

Hgene

PIAS2

chr18:44407921

chr18:44284627

ENST00000585916

331_408

502.6666666666667

622.0

Zinc finger

SP-RING-type

Hgene

PIAS2

chr18:44407922

chr18:44272218

ENST00000324794

331_408

502.6666666666667

573.0

Zinc finger

SP-RING-type

Hgene

PIAS2

chr18:44407922

chr18:44272218

ENST00000585916

331_408

502.6666666666667

622.0

Zinc finger

SP-RING-type

Hgene

PIAS2

chr18:44407922

chr18:44284627

ENST00000324794

331_408

502.6666666666667

573.0

Zinc finger

SP-RING-type

Hgene

PIAS2

chr18:44407922

chr18:44284627

ENST00000585916

331_408

502.6666666666667

622.0

Zinc finger

SP-RING-type

Tgene

ST8SIA5

chr18:44407921

chr18:44272218

ENST00000315087

214_216

74.66666666666667

377.0

Region

Substrate binding

Tgene

ST8SIA5

chr18:44407921

chr18:44272218

ENST00000315087

300_302

74.66666666666667

377.0

Region

Substrate binding

Tgene

ST8SIA5

chr18:44407921

chr18:44284627

ENST00000315087

214_216

43.666666666666664

377.0

Region

Substrate binding

Tgene

ST8SIA5

chr18:44407921

chr18:44284627

ENST00000315087

300_302

43.666666666666664

377.0

Region

Substrate binding

Tgene

ST8SIA5

chr18:44407922

chr18:44272218

ENST00000315087

214_216

74.66666666666667

377.0

Region

Substrate binding

Tgene

ST8SIA5

chr18:44407922

chr18:44272218

ENST00000315087

300_302

74.66666666666667

377.0

Region

Substrate binding

Tgene

ST8SIA5

chr18:44407922

chr18:44284627

ENST00000315087

214_216

43.666666666666664

377.0

Region

Substrate binding

Tgene

ST8SIA5

chr18:44407922

chr18:44284627

ENST00000315087

300_302

43.666666666666664

377.0

Region

Substrate binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PIAS2

chr18:44407921

chr18:44272218

ENST00000324794

571_612

502.6666666666667

573.0

Compositional bias

Note=Ser-rich

Hgene

PIAS2

chr18:44407921

chr18:44272218

ENST00000324794

596_602

502.6666666666667

573.0

Compositional bias

Note=Poly-Ser

Hgene

PIAS2

chr18:44407921

chr18:44272218

ENST00000585916

571_612

502.6666666666667

622.0

Compositional bias

Note=Ser-rich

Hgene

PIAS2

chr18:44407921

chr18:44272218

ENST00000585916

596_602

502.6666666666667

622.0

Compositional bias

Note=Poly-Ser

Hgene

PIAS2

chr18:44407921

chr18:44284627

ENST00000324794

571_612

502.6666666666667

573.0

Compositional bias

Note=Ser-rich

Hgene

PIAS2

chr18:44407921

chr18:44284627

ENST00000324794

596_602

502.6666666666667

573.0

Compositional bias

Note=Poly-Ser

Hgene

PIAS2

chr18:44407921

chr18:44284627

ENST00000585916

571_612

502.6666666666667

622.0

Compositional bias

Note=Ser-rich

Hgene

PIAS2

chr18:44407921

chr18:44284627

ENST00000585916

596_602

502.6666666666667

622.0

Compositional bias

Note=Poly-Ser

Hgene

PIAS2

chr18:44407922

chr18:44272218

ENST00000324794

571_612

502.6666666666667

573.0

Compositional bias

Note=Ser-rich

Hgene

PIAS2

chr18:44407922

chr18:44272218

ENST00000324794

596_602

502.6666666666667

573.0

Compositional bias

Note=Poly-Ser

Hgene

PIAS2

chr18:44407922

chr18:44272218

ENST00000585916

571_612

502.6666666666667

622.0

Compositional bias

Note=Ser-rich

Hgene

PIAS2

chr18:44407922

chr18:44272218

ENST00000585916

596_602

502.6666666666667

622.0

Compositional bias

Note=Poly-Ser

Hgene

PIAS2

chr18:44407922

chr18:44284627

ENST00000324794

571_612

502.6666666666667

573.0

Compositional bias

Note=Ser-rich

Hgene

PIAS2

chr18:44407922

chr18:44284627

ENST00000324794

596_602

502.6666666666667

573.0

Compositional bias

Note=Poly-Ser

Hgene

PIAS2

chr18:44407922

chr18:44284627

ENST00000585916

571_612

502.6666666666667

622.0

Compositional bias

Note=Ser-rich

Hgene

PIAS2

chr18:44407922

chr18:44284627

ENST00000585916

596_602

502.6666666666667

622.0

Compositional bias

Note=Poly-Ser

Tgene

ST8SIA5

chr18:44407921

chr18:44272218

ENST00000315087

1_17

74.66666666666667

377.0

Topological domain

Cytoplasmic

Tgene

ST8SIA5

chr18:44407921

chr18:44272218

ENST00000315087

39_376

74.66666666666667

377.0

Topological domain

Lumenal

Tgene

ST8SIA5

chr18:44407921

chr18:44284627

ENST00000315087

1_17

43.666666666666664

377.0

Topological domain

Cytoplasmic

Tgene

ST8SIA5

chr18:44407921

chr18:44284627

ENST00000315087

39_376

43.666666666666664

377.0

Topological domain

Lumenal

Tgene

ST8SIA5

chr18:44407922

chr18:44272218

ENST00000315087

1_17

74.66666666666667

377.0

Topological domain

Cytoplasmic

Tgene

ST8SIA5

chr18:44407922

chr18:44272218

ENST00000315087

39_376

74.66666666666667

377.0

Topological domain

Lumenal

Tgene

ST8SIA5

chr18:44407922

chr18:44284627

ENST00000315087

1_17

43.666666666666664

377.0

Topological domain

Cytoplasmic

Tgene

ST8SIA5

chr18:44407922

chr18:44284627

ENST00000315087

39_376

43.666666666666664

377.0

Topological domain

Lumenal

Tgene

ST8SIA5

chr18:44407921

chr18:44272218

ENST00000315087

18_38

74.66666666666667

377.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST8SIA5

chr18:44407921

chr18:44284627

ENST00000315087

18_38

43.666666666666664

377.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST8SIA5

chr18:44407922

chr18:44272218

ENST00000315087

18_38

74.66666666666667

377.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ST8SIA5

chr18:44407922

chr18:44284627

ENST00000315087

18_38

43.666666666666664

377.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1584_PIAS2_44407922_ST8SIA5_44272218_ranked_0.pdb	PIAS2	44407922	44407922	ENST00000315087	ST8SIA5	chr18	44272218	-	MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSTIKSSVFSLDGGSS PVEPDLAVAGIHSLPSTSVTPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFI FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLS SAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAV TCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVL SKPCSVTVASEASKKKVDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCN APAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTM DVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSL	804

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PIAS2_pLDDT.png

ST8SIA5_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PIAS2
ST8SIA5

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to PIAS2-ST8SIA5

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PIAS2-ST8SIA5

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source