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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PICALM-NFATC2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PICALM-NFATC2
	FusionPDB ID: 65156
	FusionGDB2.0 ID: 65156
		Hgene	Tgene
	Gene symbol	PICALM	NFATC2
	Gene ID	8301	4773
	Gene name	phosphatidylinositol binding clathrin assembly protein	nuclear factor of activated T cells 2
	Synonyms	CALM\|CLTH\|LAP	NFAT1\|NFATP
	Cytomap	11q14.2	20q13.2
	Type of gene	protein-coding	protein-coding
	Description	phosphatidylinositol-binding clathrin assembly proteinclathrin assembly lymphoid myeloid leukemia protein	nuclear factor of activated T-cells, cytoplasmic 2NF-ATc2NFAT pre-existing subunitNFAT transcription complex, preexisting componentT cell transcription factor NFAT1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2nuclear fact
	Modification date	20200322	20200329
	UniProtAcc	Q13492	Q8NCF5
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000528411, ENST00000356360, ENST00000393346, ENST00000526033, ENST00000532317, ENST00000528398,	ENST00000371564, ENST00000396009, ENST00000414705, ENST00000609507, ENST00000609943, ENST00000610033,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	24 X 29 X 9=6264	10 X 12 X 6=720
	# samples	39	12
	** MAII score	log2(39/6264*10)=-4.00553818354143 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/720*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PICALM [Title/Abstract] AND NFATC2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PICALM(85779692)-NFATC2(50092197), # samples:1
Anticipated loss of major functional domain due to fusion event.	PICALM-NFATC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PICALM-NFATC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PICALM-NFATC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PICALM-NFATC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PICALM	GO:0006897	endocytosis	22118466
Hgene	PICALM	GO:0006898	receptor-mediated endocytosis	10436022
Hgene	PICALM	GO:0032880	regulation of protein localization	10436022
Hgene	PICALM	GO:0045893	positive regulation of transcription, DNA-templated	11425879
Hgene	PICALM	GO:0048261	negative regulation of receptor-mediated endocytosis	10436022
Hgene	PICALM	GO:1905224	clathrin-coated pit assembly	16262731
Tgene	NFATC2	GO:0016477	cell migration	21871017
Tgene	NFATC2	GO:0045893	positive regulation of transcription, DNA-templated	15790681
Tgene	NFATC2	GO:1905064	negative regulation of vascular smooth muscle cell differentiation	23853098

Fusion gene breakpoints across PICALM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NFATC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4H2	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000532317	PICALM	chr11	85779692	-	ENST00000371564	NFATC2	chr20	50092197	-	6382	409	310	1842	510
ENST00000532317	PICALM	chr11	85779692	-	ENST00000396009	NFATC2	chr20	50092197	-	6294	409	310	1854	514
ENST00000532317	PICALM	chr11	85779692	-	ENST00000609943	NFATC2	chr20	50092197	-	4625	409	310	1854	514
ENST00000532317	PICALM	chr11	85779692	-	ENST00000610033	NFATC2	chr20	50092197	-	2111	409	310	1842	510
ENST00000532317	PICALM	chr11	85779692	-	ENST00000414705	NFATC2	chr20	50092197	-	2111	409	310	1842	510
ENST00000532317	PICALM	chr11	85779692	-	ENST00000609507	NFATC2	chr20	50092197	-	2111	409	310	1842	510
ENST00000526033	PICALM	chr11	85779692	-	ENST00000371564	NFATC2	chr20	50092197	-	6420	447	348	1880	510
ENST00000526033	PICALM	chr11	85779692	-	ENST00000396009	NFATC2	chr20	50092197	-	6332	447	348	1892	514
ENST00000526033	PICALM	chr11	85779692	-	ENST00000609943	NFATC2	chr20	50092197	-	4663	447	348	1892	514
ENST00000526033	PICALM	chr11	85779692	-	ENST00000610033	NFATC2	chr20	50092197	-	2149	447	348	1880	510
ENST00000526033	PICALM	chr11	85779692	-	ENST00000414705	NFATC2	chr20	50092197	-	2149	447	348	1880	510
ENST00000526033	PICALM	chr11	85779692	-	ENST00000609507	NFATC2	chr20	50092197	-	2149	447	348	1880	510
ENST00000393346	PICALM	chr11	85779692	-	ENST00000371564	NFATC2	chr20	50092197	-	6252	279	180	1712	510
ENST00000393346	PICALM	chr11	85779692	-	ENST00000396009	NFATC2	chr20	50092197	-	6164	279	180	1724	514
ENST00000393346	PICALM	chr11	85779692	-	ENST00000609943	NFATC2	chr20	50092197	-	4495	279	180	1724	514
ENST00000393346	PICALM	chr11	85779692	-	ENST00000610033	NFATC2	chr20	50092197	-	1981	279	180	1712	510
ENST00000393346	PICALM	chr11	85779692	-	ENST00000414705	NFATC2	chr20	50092197	-	1981	279	180	1712	510
ENST00000393346	PICALM	chr11	85779692	-	ENST00000609507	NFATC2	chr20	50092197	-	1981	279	180	1712	510
ENST00000356360	PICALM	chr11	85779692	-	ENST00000371564	NFATC2	chr20	50092197	-	6103	130	31	1563	510
ENST00000356360	PICALM	chr11	85779692	-	ENST00000396009	NFATC2	chr20	50092197	-	6015	130	31	1575	514
ENST00000356360	PICALM	chr11	85779692	-	ENST00000609943	NFATC2	chr20	50092197	-	4346	130	31	1575	514
ENST00000356360	PICALM	chr11	85779692	-	ENST00000610033	NFATC2	chr20	50092197	-	1832	130	31	1563	510
ENST00000356360	PICALM	chr11	85779692	-	ENST00000414705	NFATC2	chr20	50092197	-	1832	130	31	1563	510
ENST00000356360	PICALM	chr11	85779692	-	ENST00000609507	NFATC2	chr20	50092197	-	1832	130	31	1563	510

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000532317	ENST00000371564	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.001198956	0.998801
ENST00000532317	ENST00000396009	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.001224073	0.9987759
ENST00000532317	ENST00000609943	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.001761996	0.99823797
ENST00000532317	ENST00000610033	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.010084116	0.9899159
ENST00000532317	ENST00000414705	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.010084116	0.9899159
ENST00000532317	ENST00000609507	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.010084116	0.9899159
ENST00000526033	ENST00000371564	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.00125692	0.9987431
ENST00000526033	ENST00000396009	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.001280606	0.99871945
ENST00000526033	ENST00000609943	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.001846822	0.99815315
ENST00000526033	ENST00000610033	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.010689441	0.9893106
ENST00000526033	ENST00000414705	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.010689441	0.9893106
ENST00000526033	ENST00000609507	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.010689441	0.9893106
ENST00000393346	ENST00000371564	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.001170506	0.99882954
ENST00000393346	ENST00000396009	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.001194743	0.9988053
ENST00000393346	ENST00000609943	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.001733759	0.9982663
ENST00000393346	ENST00000610033	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.01083011	0.9891699
ENST00000393346	ENST00000414705	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.01083011	0.9891699
ENST00000393346	ENST00000609507	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.01083011	0.9891699
ENST00000356360	ENST00000371564	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.00120243	0.99879754
ENST00000356360	ENST00000396009	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.00122299	0.998777
ENST00000356360	ENST00000609943	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.001817236	0.9981828
ENST00000356360	ENST00000610033	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.012851504	0.98714846
ENST00000356360	ENST00000414705	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.012851504	0.98714846
ENST00000356360	ENST00000609507	PICALM	chr11	85779692	-	NFATC2	chr20	50092197	-	0.012851504	0.98714846

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>65156_65156_1_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000356360_NFATC2_chr20_50092197_ENST00000371564_length(amino acids)=510AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

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>65156_65156_2_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000356360_NFATC2_chr20_50092197_ENST00000396009_length(amino acids)=514AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

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>65156_65156_3_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000356360_NFATC2_chr20_50092197_ENST00000414705_length(amino acids)=510AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

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>65156_65156_4_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000356360_NFATC2_chr20_50092197_ENST00000609507_length(amino acids)=510AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

--------------------------------------------------------------

>65156_65156_5_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000356360_NFATC2_chr20_50092197_ENST00000609943_length(amino acids)=514AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

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>65156_65156_6_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000356360_NFATC2_chr20_50092197_ENST00000610033_length(amino acids)=510AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

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>65156_65156_7_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000393346_NFATC2_chr20_50092197_ENST00000371564_length(amino acids)=510AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

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>65156_65156_8_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000393346_NFATC2_chr20_50092197_ENST00000396009_length(amino acids)=514AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

--------------------------------------------------------------

>65156_65156_9_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000393346_NFATC2_chr20_50092197_ENST00000414705_length(amino acids)=510AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

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>65156_65156_10_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000393346_NFATC2_chr20_50092197_ENST00000609507_length(amino acids)=510AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

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>65156_65156_11_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000393346_NFATC2_chr20_50092197_ENST00000609943_length(amino acids)=514AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

--------------------------------------------------------------

>65156_65156_12_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000393346_NFATC2_chr20_50092197_ENST00000610033_length(amino acids)=510AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

--------------------------------------------------------------

>65156_65156_13_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000526033_NFATC2_chr20_50092197_ENST00000371564_length(amino acids)=510AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

--------------------------------------------------------------

>65156_65156_14_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000526033_NFATC2_chr20_50092197_ENST00000396009_length(amino acids)=514AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

--------------------------------------------------------------

>65156_65156_15_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000526033_NFATC2_chr20_50092197_ENST00000414705_length(amino acids)=510AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

--------------------------------------------------------------

>65156_65156_16_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000526033_NFATC2_chr20_50092197_ENST00000609507_length(amino acids)=510AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

--------------------------------------------------------------

>65156_65156_17_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000526033_NFATC2_chr20_50092197_ENST00000609943_length(amino acids)=514AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

--------------------------------------------------------------

>65156_65156_18_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000526033_NFATC2_chr20_50092197_ENST00000610033_length(amino acids)=510AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

--------------------------------------------------------------

>65156_65156_19_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000532317_NFATC2_chr20_50092197_ENST00000371564_length(amino acids)=510AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

--------------------------------------------------------------

>65156_65156_20_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000532317_NFATC2_chr20_50092197_ENST00000396009_length(amino acids)=514AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

--------------------------------------------------------------

>65156_65156_21_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000532317_NFATC2_chr20_50092197_ENST00000414705_length(amino acids)=510AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

--------------------------------------------------------------

>65156_65156_22_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000532317_NFATC2_chr20_50092197_ENST00000609507_length(amino acids)=510AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

--------------------------------------------------------------

>65156_65156_23_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000532317_NFATC2_chr20_50092197_ENST00000609943_length(amino acids)=514AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

--------------------------------------------------------------

>65156_65156_24_PICALM-NFATC2_PICALM_chr11_85779692_ENST00000532317_NFATC2_chr20_50092197_ENST00000610033_length(amino acids)=510AA_BP=33
MPPSTVSPALPYPRQYARPRPTRSWGPRKSTWTLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEI
PLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVY
GGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAI
KTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDARYQQQNPAAVLYQRSKSLSPSLLGYQQPALM
AAPLSLADAHRSVLVHAGSQGQSSALLHPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSYP

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:85779692/chr20:50092197)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PICALM Q13492	NFATC2 Q8NCF5
FUNCTION: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:22118466, PubMed:21808019, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:25241929, PubMed:24067654). {ECO:0000269\|PubMed:10436022, ECO:0000269\|PubMed:16262731, ECO:0000269\|PubMed:21808019, ECO:0000269\|PubMed:22118466, ECO:0000269\|PubMed:23741335, ECO:0000269\|PubMed:24067654, ECO:0000269\|PubMed:25241929, ECO:0000269\|PubMed:25898166, ECO:0000269\|PubMed:27574975}.	FUNCTION: In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000414705

421_428

424.0

639.3333333333334

DNA binding

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000371564

664_666

444.0

1989.6666666666667

Motif

Note=Nuclear localization signal

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000371564

904_913

444.0

1989.6666666666667

Motif

Note=Nuclear export signal

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000396009

664_666

444.0

926.0

Motif

Note=Nuclear localization signal

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000396009

904_913

444.0

926.0

Motif

Note=Nuclear export signal

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000414705

664_666

424.0

639.3333333333334

Motif

Note=Nuclear localization signal

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000414705

904_913

424.0

639.3333333333334

Motif

Note=Nuclear export signal

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PICALM

chr11:85779692

chr20:50092197

ENST00000356360

14_145

43.333333333333336

633.0

Domain

ENTH

Hgene

PICALM

chr11:85779692

chr20:50092197

ENST00000393346

14_145

43.333333333333336

653.0

Domain

ENTH

Hgene

PICALM

chr11:85779692

chr20:50092197

ENST00000526033

14_145

43.333333333333336

646.0

Domain

ENTH

Hgene

PICALM

chr11:85779692

chr20:50092197

ENST00000528398

14_145

552.0

Domain

ENTH

Hgene

PICALM

chr11:85779692

chr20:50092197

ENST00000532317

14_145

43.333333333333336

611.0

Domain

ENTH

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000371564

421_428

444.0

1989.6666666666667

DNA binding

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000396009

421_428

444.0

926.0

DNA binding

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000371564

392_574

444.0

1989.6666666666667

Domain

RHD

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000396009

392_574

444.0

926.0

Domain

RHD

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000414705

392_574

424.0

639.3333333333334

Domain

RHD

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000371564

251_253

444.0

1989.6666666666667

Motif

Note=Nuclear localization signal

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000371564

26_34

444.0

1989.6666666666667

Motif

Note=9aaTAD

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000396009

251_253

444.0

926.0

Motif

Note=Nuclear localization signal

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000396009

26_34

444.0

926.0

Motif

Note=9aaTAD

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000414705

251_253

424.0

639.3333333333334

Motif

Note=Nuclear localization signal

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000414705

26_34

424.0

639.3333333333334

Motif

Note=9aaTAD

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000371564

111_116

444.0

1989.6666666666667

Region

Calcineurin-binding

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000371564

119_199

444.0

1989.6666666666667

Region

Note=Trans-activation domain A (TAD-A)

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000371564

161_175

444.0

1989.6666666666667

Region

Required for cytoplasmic retention of the phosphorylated form

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000371564

184_286

444.0

1989.6666666666667

Region

Note=3 X approximate SP repeats

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000396009

111_116

444.0

926.0

Region

Calcineurin-binding

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000396009

119_199

444.0

926.0

Region

Note=Trans-activation domain A (TAD-A)

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000396009

161_175

444.0

926.0

Region

Required for cytoplasmic retention of the phosphorylated form

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000396009

184_286

444.0

926.0

Region

Note=3 X approximate SP repeats

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000414705

111_116

424.0

639.3333333333334

Region

Calcineurin-binding

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000414705

119_199

424.0

639.3333333333334

Region

Note=Trans-activation domain A (TAD-A)

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000414705

161_175

424.0

639.3333333333334

Region

Required for cytoplasmic retention of the phosphorylated form

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000414705

184_286

424.0

639.3333333333334

Region

Note=3 X approximate SP repeats

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000371564

184_200

444.0

1989.6666666666667

Repeat

Note=1

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000371564

213_229

444.0

1989.6666666666667

Repeat

Note=2

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000371564

272_286

444.0

1989.6666666666667

Repeat

Note=3%3B approximate

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000396009

184_200

444.0

926.0

Repeat

Note=1

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000396009

213_229

444.0

926.0

Repeat

Note=2

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000396009

272_286

444.0

926.0

Repeat

Note=3%3B approximate

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000414705

184_200

424.0

639.3333333333334

Repeat

Note=1

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000414705

213_229

424.0

639.3333333333334

Repeat

Note=2

Tgene

NFATC2

chr11:85779692

chr20:50092197

ENST00000414705

272_286

424.0

639.3333333333334

Repeat

Note=3%3B approximate

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
NFATC2	NFATC2, EP300, CREBBP, MED31, VIM, PRKCZ, PIN1, MEF2D, IRF4, FOXP3, MAPK9, MAPK8, SUV39H1, TUBA1A, KPNB1, TAF9, HNRNPA1, TFAP4, IRF2BP2, JUN, LRRK2, IQGAP1, CSE1L, TNPO1, PPP2R1A, USP22, GNB2, HCVgp1, CREB1, IKZF1, RPTOR, FOS, CHEK1, SCAI, IKZF2, GSK3B, RUNX1, SATB1, WDR48, NFATC1, ZNF384, ATF7, ZNF131, MAFK, XRCC5, PRKDC, CSNK1D, JUNB, NFYC, PLK1, LIG3, XRCC1, HSPA1A, HLTF, BTAF1, YWHAB, CHAF1B, LEF1, IRF2BP1, JUND, TFAM, MAFG, SSBP1, RANBP9, CHAMP1, RPA1, WDR26, ZNF148, FOXK1, ZNF217, DEK, RPA3, POLG, CACYBP, RPA2, NFYB, PARP1, ETV6, XRCC6, KIF4A, RFC4, RFC3, EGR1, CAD, RFC5, CTBP1, RFC2, BCL11B, YWHAG, KIF2C, RNGTT, PRDM15, ALDH18A1, MTHFD2, YWHAE, MRPL39, TUFM, IFI16, TP53BP1, ERAL1, SSRP1, TRRAP, YWHAQ, HIRA, ERCC3, UBE2S, SUPT6H, ARID1A, HSPA9, POGZ, UHRF1, SUCLA2, HSPA5, DPF2, YWHAZ, GATAD2A, LRRC47, ZMYM2, DNAJA1, IDH3A, SDHA, CBX5, CABIN1, VAPA, CBX3, MRE11A, SMARCA5, EEF2, RB1, MCRS1, EMD, GTF2H2C, GTF2H2, GTF2H2C_2, SUPT5H, RCOR1, VAPB, MRPL17, UQCRC2, TCF12, BEND3, SMARCA4, KDM1A, SMARCD2, AIFM1, MCM2, H2AFY, HSPA8, POLDIP2, RAD50, SMARCC1, POLR1C, TIMM50, MTA2, HADHA, TLK2, TLK1, RBBP4, GATAD2B, RANBP2, CEBPE, ADNP, SMARCE1, CNP, CBX1, SMARCC2, ZNF24, CHD4, SMARCD1, MBD3, NUDC, ACTL6A, MTA1, IDH3B, CSTF1, RPL23, PPP1CA, HSPH1, PMPCB, GTF3C5, TCP1, GTF3C4, DCAF7, HDAC1, NKX2-1, KIAA1429, ESR1, EGFR, CIC, SOCS3,
PICALM	PLCG1, CLTC, ITSN1, AP2A1, HIP1R, LAMTOR3, EEF1A1, SEC24D, DNM2, EGFR, FLOT1, SEC24C, ATP6V1E1, ILF3, HNRNPDL, SH3GLB2, ABCC2, ATP6V1F, CD55, SIRT1, FN1, VCAM1, ITGA4, PELI2, KLHL20, SLC25A41, ITLN1, ATF6B, SLC25A32, SOX2, FAM64A, CYP1A1, HNRNPA1, UNK, NTRK1, C14orf166, CARS, CPPED1, HNRNPD, ILVBL, ITGB1, LPP, PAPOLA, DDX1, EWSR1, FERMT2, FUS, ILK, NPLOC4, PFKM, PTPRF, VCL, PXN, STXBP1, TRIM25, UNC13D, XPO1, AP2B1, AP2M1, CLTA, CLTB, DAB2, EPS15, GAK, MYO6, PIK3C2A, SEC13, CLTCL1, CAPZA2, DBN1, MYH9, LIMA1, GTSE1, ANLN, MYO19, MYO18A, CLINT1, SEC16A, TNRC6A, BMP2K, MICAL3, DENND1A, WNK1, PRRC2B, STON2, FCHO2, Actb, Myh9, Myo1c, Tpm1, Lima1, Calml3, Sec24c, MCM2, SNW1, CDC5L, SMURF1, CDH1, STAMBPL1, RALBP1, SNRNP27, DLST, FCHO1, RBPMS, CRX, AGR2, CDK9, TGOLN2, ATG16L1, MAP1LC3A, DYRK1A, APEX1, SCARB2, VMP1, MTMR4, TENM1, ATXN1, ZC3H10, ATXN1L, PLEKHA4, ORF6, ORF3a, SMAP2, CIT, ECT2, KIF14, KIF20A, MKI67, HNRNPH1, CDC42, Rnf183, E, WDR76, GGA2, FAM20C, OGT, ISG15, ARF6, B3GAT1, C11orf52, DIRAS3, GJA1, KRAS, LAMP2, LAMP3, LAMTOR1, MARCKS, OCLN, RAB35, RHOB, STX6, STX7, SYNE3, ZFPL1, NAA40, PIP, SNAP91, MTSS1L, BAG2, DDX3Y, ZBTB2, DNAJB6, PINK1, WIF1, ZNF444, CCR1, CENPQ, DOK4, ST3GAL5, BBS1, RBM47, C10orf88, NTNG1, C11orf49, DNAJC6, MBNL1, RDH11, MED17, POGZ, SERBP1, RBM38, FSCN1, IFITM1, IFITM3, ACE2, M, nsp14, DDX3X,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PICALM
NFATC2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	PICALM	chr11:85779692	chr20:50092197	ENST00000356360	-	1	19	221_294	43.333333333333336	633.0	PIMREG
Hgene	PICALM	chr11:85779692	chr20:50092197	ENST00000393346	-	1	20	221_294	43.333333333333336	653.0	PIMREG
Hgene	PICALM	chr11:85779692	chr20:50092197	ENST00000526033	-	1	20	221_294	43.333333333333336	646.0	PIMREG
Hgene	PICALM	chr11:85779692	chr20:50092197	ENST00000528398	-	1	19	221_294	0	552.0	PIMREG
Hgene	PICALM	chr11:85779692	chr20:50092197	ENST00000532317	-	1	20	221_294	43.333333333333336	611.0	PIMREG

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Related Drugs to PICALM-NFATC2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to PICALM-NFATC2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PICALM	C0002395	Alzheimer's Disease	2	CTD_human
Hgene	PICALM	C0011265	Presenile dementia	2	CTD_human
Hgene	PICALM	C0276496	Familial Alzheimer Disease (FAD)	2	CTD_human
Hgene	PICALM	C0494463	Alzheimer Disease, Late Onset	2	CTD_human
Hgene	PICALM	C0546126	Acute Confusional Senile Dementia	2	CTD_human
Hgene	PICALM	C0750900	Alzheimer's Disease, Focal Onset	2	CTD_human
Hgene	PICALM	C0750901	Alzheimer Disease, Early Onset	2	CTD_human
Hgene	PICALM	C0234985	Mental deterioration	1	CTD_human
Hgene	PICALM	C0338656	Impaired cognition	1	CTD_human
Hgene	PICALM	C1270972	Mild cognitive disorder	1	CTD_human
Tgene	NFATC2	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human
Tgene	NFATC2	C0020542	Pulmonary Hypertension	1	CTD_human
Tgene	NFATC2	C0027765	nervous system disorder	1	CTD_human