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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PICALM-ZSCAN20

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PICALM-ZSCAN20
FusionPDB ID: 65167
FusionGDB2.0 ID: 65167
HgeneTgene
Gene symbol

PICALM

ZSCAN20

Gene ID

8301

7579

Gene namephosphatidylinositol binding clathrin assembly proteinzinc finger and SCAN domain containing 20
SynonymsCALM|CLTH|LAPKOX29|ZFP-31|ZNF31|ZNF360
Cytomap

11q14.2

1p35.1

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol-binding clathrin assembly proteinclathrin assembly lymphoid myeloid leukemia proteinzinc finger and SCAN domain-containing protein 20zinc finger protein 31zinc finger protein 360zinc finger protein KOX29
Modification date2020032220200313
UniProtAcc

Q13492

.
Ensembl transtripts involved in fusion geneENST idsENST00000356360, ENST00000393346, 
ENST00000526033, ENST00000528398, 
ENST00000532317, ENST00000528411, 
ENST00000480917, ENST00000361328, 
ENST00000373413, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score24 X 29 X 9=62642 X 2 X 2=8
# samples 392
** MAII scorelog2(39/6264*10)=-4.00553818354143
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: PICALM [Title/Abstract] AND ZSCAN20 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PICALM(85685750)-ZSCAN20(33954064), # samples:1
Anticipated loss of major functional domain due to fusion event.PICALM-ZSCAN20 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PICALM-ZSCAN20 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PICALM-ZSCAN20 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PICALM-ZSCAN20 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PICALM-ZSCAN20 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PICALM-ZSCAN20 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PICALM-ZSCAN20 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePICALM

GO:0006897

endocytosis

22118466

HgenePICALM

GO:0006898

receptor-mediated endocytosis

10436022

HgenePICALM

GO:0032880

regulation of protein localization

10436022

HgenePICALM

GO:0045893

positive regulation of transcription, DNA-templated

11425879

HgenePICALM

GO:0048261

negative regulation of receptor-mediated endocytosis

10436022

HgenePICALM

GO:1905224

clathrin-coated pit assembly

16262731


check buttonFusion gene breakpoints across PICALM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZSCAN20 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-A747PICALMchr11

85685750

-ZSCAN20chr1

33954064

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000532317PICALMchr1185685750-ENST00000361328ZSCAN20chr133954064+584320977848111577
ENST00000532317PICALMchr1185685750-ENST00000373413ZSCAN20chr133954064+38962097782981967
ENST00000526033PICALMchr1185685750-ENST00000361328ZSCAN20chr133954064+5986224011649541612
ENST00000526033PICALMchr1185685750-ENST00000373413ZSCAN20chr133954064+4039224011631241002
ENST00000393346PICALMchr1185685750-ENST00000361328ZSCAN20chr133954064+5839209311348071564
ENST00000393346PICALMchr1185685750-ENST00000373413ZSCAN20chr133954064+389220931132977954
ENST00000356360PICALMchr1185685750-ENST00000361328ZSCAN20chr133954064+56301884045981532
ENST00000356360PICALMchr1185685750-ENST00000373413ZSCAN20chr133954064+3683188402768922

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000532317ENST00000361328PICALMchr1185685750-ZSCAN20chr133954064+0.000565260.99943477
ENST00000532317ENST00000373413PICALMchr1185685750-ZSCAN20chr133954064+0.0013884560.99861157
ENST00000526033ENST00000361328PICALMchr1185685750-ZSCAN20chr133954064+0.000607880.99939215
ENST00000526033ENST00000373413PICALMchr1185685750-ZSCAN20chr133954064+0.000909090.9990909
ENST00000393346ENST00000361328PICALMchr1185685750-ZSCAN20chr133954064+0.0004821350.9995179
ENST00000393346ENST00000373413PICALMchr1185685750-ZSCAN20chr133954064+0.0007937920.99920624
ENST00000356360ENST00000361328PICALMchr1185685750-ZSCAN20chr133954064+0.0002831190.9997168
ENST00000356360ENST00000373413PICALMchr1185685750-ZSCAN20chr133954064+0.0010825950.99891746

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>65167_65167_1_PICALM-ZSCAN20_PICALM_chr11_85685750_ENST00000356360_ZSCAN20_chr1_33954064_ENST00000361328_length(amino acids)=1532AA_BP=628
MSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGN
ERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLD
FNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQA
PSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASP
VSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNPFLTKSSGDVHLS
ISSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDL
DSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQGL
ELHTEETRPLKTGEEAQSFQLQPVDPWPEGQSQKKGVKNTCPDLPNHLNAEVAPQPLKESAVLTPRVPTLPKMGSVGDWEVTAESQEALG
PGKHAEKELCKDPPGDDCGNSVCLGVPVSKPSNTSEKEQGPEFWGLSLINSGKRSTADYSLDNEPAQALTWRDSRAWEEQYQWDVEDMKV
SGVHWGYEETKTFLAILSESPFSEKLRTCHQNRQVYRAIAEQLRARGFLRTLEQCRYRVKNLLRNYRKAKSSHPPGTCPFYEELEALVRA
RTAIRATDGPGEAVALPRLGYSDAEMDEQEEGGWDPEEMAEDCNGAGLVNVESTQGPRIAGAPALFQSRIAGVHWGYEETKAFLAILSES
PFSEKLRTCHQNSQVYRAIAERLCALGFLRTLEQCRYRFKNLLRSYRKAKSSHPPGTCPFYEELDSLMRARAAVRAMGTVREAAGLPRCG
QSSAETDAQEAWGEVANEDAVKPSTLCPKAPDMGFEMRHEDEDQISEQDIFEGLPGALSKCPTEAVCQPLDWGEDSENENEDEGQWGNPS
QEQWQESSSEEDLEKLIDHQGLYLAEKPYKCDTCMKSFSRSSHFIAHQRIHTGEKPYKCLECGKNFSDRSNLNTHQRIHTGEKPYKCLEC
GKSFSDHSNLITHQRIHTGEKPYKCGECWKSFNQSSNLLKHQRIHLGGNPDQCSEPGGNFAQSPSFSAHWRNSTEETAPEQPQSISKDLN
SPGPHSTNSGEKLYECSECGRSFSKSSALISHQRIHTGEKPYECAECGKSFSKSSTLANHQRTHTGEKPYKCVDCGKCFSERSKLITHQR
VHTGEKPYKCLECGKFFRDRSNLITHQRIHTGEKPYKCRECGKCFNQSSSLIIHQRIHTGEKPYKCTECGKDFNNSSHFSAHRRTHAGGK

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>65167_65167_2_PICALM-ZSCAN20_PICALM_chr11_85685750_ENST00000356360_ZSCAN20_chr1_33954064_ENST00000373413_length(amino acids)=922AA_BP=628
MSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGN
ERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLD
FNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQA
PSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASP
VSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNPFLTKSSGDVHLS
ISSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDL
DSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQGL
ELHTEETRPLKTGEEAQSFQLQPVDPWPEGQSQKKGVKNTCPDLPNHLNAEVAPQPLKESGVPVSKPSNTSEKEQGPEFWGLSLINSGKR
STADYSLDNEPAQALTWRDSRAWEEQYQWDVEDMKVSGVHWGYEETKTFLAILSESPFSEKLRTCHQNRQVYRAIAEQLRARGFLRTLEQ
CRYRVKNLLRNYRKAKSSHPPGTCPFYEELEALVRARTAIRATDGPGEAVALPRLGYSDAEMDEQEEGGWDPEEMAEDCNGAGLVNVEST

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>65167_65167_3_PICALM-ZSCAN20_PICALM_chr11_85685750_ENST00000393346_ZSCAN20_chr1_33954064_ENST00000361328_length(amino acids)=1564AA_BP=660
MLSGWGGGGAAEMSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKS
LITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTV
PIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVG
IDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAK
KPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNP
FLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVA
KLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTGMIGYGIPPQMG
SVPVMTQPTLIYSQPVMRPPNPFGPVSGAQGLELHTEETRPLKTGEEAQSFQLQPVDPWPEGQSQKKGVKNTCPDLPNHLNAEVAPQPLK
ESAVLTPRVPTLPKMGSVGDWEVTAESQEALGPGKHAEKELCKDPPGDDCGNSVCLGVPVSKPSNTSEKEQGPEFWGLSLINSGKRSTAD
YSLDNEPAQALTWRDSRAWEEQYQWDVEDMKVSGVHWGYEETKTFLAILSESPFSEKLRTCHQNRQVYRAIAEQLRARGFLRTLEQCRYR
VKNLLRNYRKAKSSHPPGTCPFYEELEALVRARTAIRATDGPGEAVALPRLGYSDAEMDEQEEGGWDPEEMAEDCNGAGLVNVESTQGPR
IAGAPALFQSRIAGVHWGYEETKAFLAILSESPFSEKLRTCHQNSQVYRAIAERLCALGFLRTLEQCRYRFKNLLRSYRKAKSSHPPGTC
PFYEELDSLMRARAAVRAMGTVREAAGLPRCGQSSAETDAQEAWGEVANEDAVKPSTLCPKAPDMGFEMRHEDEDQISEQDIFEGLPGAL
SKCPTEAVCQPLDWGEDSENENEDEGQWGNPSQEQWQESSSEEDLEKLIDHQGLYLAEKPYKCDTCMKSFSRSSHFIAHQRIHTGEKPYK
CLECGKNFSDRSNLNTHQRIHTGEKPYKCLECGKSFSDHSNLITHQRIHTGEKPYKCGECWKSFNQSSNLLKHQRIHLGGNPDQCSEPGG
NFAQSPSFSAHWRNSTEETAPEQPQSISKDLNSPGPHSTNSGEKLYECSECGRSFSKSSALISHQRIHTGEKPYECAECGKSFSKSSTLA
NHQRTHTGEKPYKCVDCGKCFSERSKLITHQRVHTGEKPYKCLECGKFFRDRSNLITHQRIHTGEKPYKCRECGKCFNQSSSLIIHQRIH

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>65167_65167_4_PICALM-ZSCAN20_PICALM_chr11_85685750_ENST00000393346_ZSCAN20_chr1_33954064_ENST00000373413_length(amino acids)=954AA_BP=660
MLSGWGGGGAAEMSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKS
LITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTV
PIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVG
IDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAK
KPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNP
FLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVA
KLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTGMIGYGIPPQMG
SVPVMTQPTLIYSQPVMRPPNPFGPVSGAQGLELHTEETRPLKTGEEAQSFQLQPVDPWPEGQSQKKGVKNTCPDLPNHLNAEVAPQPLK
ESGVPVSKPSNTSEKEQGPEFWGLSLINSGKRSTADYSLDNEPAQALTWRDSRAWEEQYQWDVEDMKVSGVHWGYEETKTFLAILSESPF
SEKLRTCHQNRQVYRAIAEQLRARGFLRTLEQCRYRVKNLLRNYRKAKSSHPPGTCPFYEELEALVRARTAIRATDGPGEAVALPRLGYS

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>65167_65167_5_PICALM-ZSCAN20_PICALM_chr11_85685750_ENST00000526033_ZSCAN20_chr1_33954064_ENST00000361328_length(amino acids)=1612AA_BP=708
MSDSAGDTSRFSLDWWQRAAPNRAPGRQAGKEPVGVGGAVGGGDPPALGGPSPRRLLSGWGGGGAAEMSGQSLTDRITAAQHSVTGSAVS
KTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKS
GLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKD
AIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDS
TAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSS
NSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQPH
PSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEK
KLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQGLELHTEETRPL
KTGEEAQSFQLQPVDPWPEGQSQKKGVKNTCPDLPNHLNAEVAPQPLKESAVLTPRVPTLPKMGSVGDWEVTAESQEALGPGKHAEKELC
KDPPGDDCGNSVCLGVPVSKPSNTSEKEQGPEFWGLSLINSGKRSTADYSLDNEPAQALTWRDSRAWEEQYQWDVEDMKVSGVHWGYEET
KTFLAILSESPFSEKLRTCHQNRQVYRAIAEQLRARGFLRTLEQCRYRVKNLLRNYRKAKSSHPPGTCPFYEELEALVRARTAIRATDGP
GEAVALPRLGYSDAEMDEQEEGGWDPEEMAEDCNGAGLVNVESTQGPRIAGAPALFQSRIAGVHWGYEETKAFLAILSESPFSEKLRTCH
QNSQVYRAIAERLCALGFLRTLEQCRYRFKNLLRSYRKAKSSHPPGTCPFYEELDSLMRARAAVRAMGTVREAAGLPRCGQSSAETDAQE
AWGEVANEDAVKPSTLCPKAPDMGFEMRHEDEDQISEQDIFEGLPGALSKCPTEAVCQPLDWGEDSENENEDEGQWGNPSQEQWQESSSE
EDLEKLIDHQGLYLAEKPYKCDTCMKSFSRSSHFIAHQRIHTGEKPYKCLECGKNFSDRSNLNTHQRIHTGEKPYKCLECGKSFSDHSNL
ITHQRIHTGEKPYKCGECWKSFNQSSNLLKHQRIHLGGNPDQCSEPGGNFAQSPSFSAHWRNSTEETAPEQPQSISKDLNSPGPHSTNSG
EKLYECSECGRSFSKSSALISHQRIHTGEKPYECAECGKSFSKSSTLANHQRTHTGEKPYKCVDCGKCFSERSKLITHQRVHTGEKPYKC

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>65167_65167_6_PICALM-ZSCAN20_PICALM_chr11_85685750_ENST00000526033_ZSCAN20_chr1_33954064_ENST00000373413_length(amino acids)=1002AA_BP=708
MSDSAGDTSRFSLDWWQRAAPNRAPGRQAGKEPVGVGGAVGGGDPPALGGPSPRRLLSGWGGGGAAEMSGQSLTDRITAAQHSVTGSAVS
KTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKS
GLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKD
AIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDS
TAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSS
NSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQPH
PSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEK
KLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQGLELHTEETRPL
KTGEEAQSFQLQPVDPWPEGQSQKKGVKNTCPDLPNHLNAEVAPQPLKESGVPVSKPSNTSEKEQGPEFWGLSLINSGKRSTADYSLDNE
PAQALTWRDSRAWEEQYQWDVEDMKVSGVHWGYEETKTFLAILSESPFSEKLRTCHQNRQVYRAIAEQLRARGFLRTLEQCRYRVKNLLR
NYRKAKSSHPPGTCPFYEELEALVRARTAIRATDGPGEAVALPRLGYSDAEMDEQEEGGWDPEEMAEDCNGAGLVNVESTQGPRIAGAPA

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>65167_65167_7_PICALM-ZSCAN20_PICALM_chr11_85685750_ENST00000532317_ZSCAN20_chr1_33954064_ENST00000361328_length(amino acids)=1577AA_BP=673
MSDSAGDTSRFSLDWWQRAAPNRAPGRQAGKEPVGVGGAVGGGDPPALGGPSPRRLLSGWGGGGAAEMSGQSLTDRITAAQHSVTGSAVS
KTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKS
GLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKD
AIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDS
TAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSS
NSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQ
NLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMNGMHFPQYAPPVMAYPATTP
TGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQGLELHTEETRPLKTGEEAQSFQLQPVDPWPEGQSQKKGVKNTCPDLP
NHLNAEVAPQPLKESAVLTPRVPTLPKMGSVGDWEVTAESQEALGPGKHAEKELCKDPPGDDCGNSVCLGVPVSKPSNTSEKEQGPEFWG
LSLINSGKRSTADYSLDNEPAQALTWRDSRAWEEQYQWDVEDMKVSGVHWGYEETKTFLAILSESPFSEKLRTCHQNRQVYRAIAEQLRA
RGFLRTLEQCRYRVKNLLRNYRKAKSSHPPGTCPFYEELEALVRARTAIRATDGPGEAVALPRLGYSDAEMDEQEEGGWDPEEMAEDCNG
AGLVNVESTQGPRIAGAPALFQSRIAGVHWGYEETKAFLAILSESPFSEKLRTCHQNSQVYRAIAERLCALGFLRTLEQCRYRFKNLLRS
YRKAKSSHPPGTCPFYEELDSLMRARAAVRAMGTVREAAGLPRCGQSSAETDAQEAWGEVANEDAVKPSTLCPKAPDMGFEMRHEDEDQI
SEQDIFEGLPGALSKCPTEAVCQPLDWGEDSENENEDEGQWGNPSQEQWQESSSEEDLEKLIDHQGLYLAEKPYKCDTCMKSFSRSSHFI
AHQRIHTGEKPYKCLECGKNFSDRSNLNTHQRIHTGEKPYKCLECGKSFSDHSNLITHQRIHTGEKPYKCGECWKSFNQSSNLLKHQRIH
LGGNPDQCSEPGGNFAQSPSFSAHWRNSTEETAPEQPQSISKDLNSPGPHSTNSGEKLYECSECGRSFSKSSALISHQRIHTGEKPYECA
ECGKSFSKSSTLANHQRTHTGEKPYKCVDCGKCFSERSKLITHQRVHTGEKPYKCLECGKFFRDRSNLITHQRIHTGEKPYKCRECGKCF

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>65167_65167_8_PICALM-ZSCAN20_PICALM_chr11_85685750_ENST00000532317_ZSCAN20_chr1_33954064_ENST00000373413_length(amino acids)=967AA_BP=673
MSDSAGDTSRFSLDWWQRAAPNRAPGRQAGKEPVGVGGAVGGGDPPALGGPSPRRLLSGWGGGGAAEMSGQSLTDRITAAQHSVTGSAVS
KTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKS
GLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKD
AIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDS
TAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSS
NSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQ
NLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMNGMHFPQYAPPVMAYPATTP
TGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQGLELHTEETRPLKTGEEAQSFQLQPVDPWPEGQSQKKGVKNTCPDLP
NHLNAEVAPQPLKESGVPVSKPSNTSEKEQGPEFWGLSLINSGKRSTADYSLDNEPAQALTWRDSRAWEEQYQWDVEDMKVSGVHWGYEE
TKTFLAILSESPFSEKLRTCHQNRQVYRAIAEQLRARGFLRTLEQCRYRVKNLLRNYRKAKSSHPPGTCPFYEELEALVRARTAIRATDG

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:85685750/chr1:33954064)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PICALM

Q13492

.
FUNCTION: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:22118466, PubMed:21808019, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:25241929, PubMed:24067654). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePICALMchr11:85685750chr1:33954064ENST00000356360-181914_145628.0633.0DomainENTH
HgenePICALMchr11:85685750chr1:33954064ENST00000393346-192014_145648.0653.0DomainENTH
HgenePICALMchr11:85685750chr1:33954064ENST00000526033-192014_145641.0646.0DomainENTH
HgenePICALMchr11:85685750chr1:33954064ENST00000528398-181914_145547.0552.0DomainENTH
HgenePICALMchr11:85685750chr1:33954064ENST00000532317-192014_145606.0611.0DomainENTH
TgeneZSCAN20chr11:85685750chr1:33954064ENST00000361328181015_1037139.01044.0Zinc fingerC2H2-type 10
TgeneZSCAN20chr11:85685750chr1:33954064ENST0000036132818710_732139.01044.0Zinc fingerC2H2-type 1
TgeneZSCAN20chr11:85685750chr1:33954064ENST0000036132818738_760139.01044.0Zinc fingerC2H2-type 2
TgeneZSCAN20chr11:85685750chr1:33954064ENST0000036132818766_788139.01044.0Zinc fingerC2H2-type 3
TgeneZSCAN20chr11:85685750chr1:33954064ENST0000036132818794_816139.01044.0Zinc fingerC2H2-type 4
TgeneZSCAN20chr11:85685750chr1:33954064ENST0000036132818875_897139.01044.0Zinc fingerC2H2-type 5
TgeneZSCAN20chr11:85685750chr1:33954064ENST0000036132818903_925139.01044.0Zinc fingerC2H2-type 6
TgeneZSCAN20chr11:85685750chr1:33954064ENST0000036132818931_953139.01044.0Zinc fingerC2H2-type 7
TgeneZSCAN20chr11:85685750chr1:33954064ENST0000036132818959_981139.01044.0Zinc fingerC2H2-type 8
TgeneZSCAN20chr11:85685750chr1:33954064ENST0000036132818987_1009139.01044.0Zinc fingerC2H2-type 9
TgeneZSCAN20chr11:85685750chr1:33954064ENST00000373413141015_1037139.0434.0Zinc fingerC2H2-type 10
TgeneZSCAN20chr11:85685750chr1:33954064ENST0000037341314710_732139.0434.0Zinc fingerC2H2-type 1
TgeneZSCAN20chr11:85685750chr1:33954064ENST0000037341314738_760139.0434.0Zinc fingerC2H2-type 2
TgeneZSCAN20chr11:85685750chr1:33954064ENST0000037341314766_788139.0434.0Zinc fingerC2H2-type 3
TgeneZSCAN20chr11:85685750chr1:33954064ENST0000037341314794_816139.0434.0Zinc fingerC2H2-type 4
TgeneZSCAN20chr11:85685750chr1:33954064ENST0000037341314875_897139.0434.0Zinc fingerC2H2-type 5
TgeneZSCAN20chr11:85685750chr1:33954064ENST0000037341314903_925139.0434.0Zinc fingerC2H2-type 6
TgeneZSCAN20chr11:85685750chr1:33954064ENST0000037341314931_953139.0434.0Zinc fingerC2H2-type 7
TgeneZSCAN20chr11:85685750chr1:33954064ENST0000037341314959_981139.0434.0Zinc fingerC2H2-type 8
TgeneZSCAN20chr11:85685750chr1:33954064ENST0000037341314987_1009139.0434.0Zinc fingerC2H2-type 9

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZSCAN20chr11:85685750chr1:33954064ENST000003613281851_133139.01044.0DomainSCAN box
TgeneZSCAN20chr11:85685750chr1:33954064ENST000003734131451_133139.0434.0DomainSCAN box


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
PICALMPLCG1, CLTC, ITSN1, AP2A1, HIP1R, LAMTOR3, EEF1A1, SEC24D, DNM2, EGFR, FLOT1, SEC24C, ATP6V1E1, ILF3, HNRNPDL, SH3GLB2, ABCC2, ATP6V1F, CD55, SIRT1, FN1, VCAM1, ITGA4, PELI2, KLHL20, SLC25A41, ITLN1, ATF6B, SLC25A32, SOX2, FAM64A, CYP1A1, HNRNPA1, UNK, NTRK1, C14orf166, CARS, CPPED1, HNRNPD, ILVBL, ITGB1, LPP, PAPOLA, DDX1, EWSR1, FERMT2, FUS, ILK, NPLOC4, PFKM, PTPRF, VCL, PXN, STXBP1, TRIM25, UNC13D, XPO1, AP2B1, AP2M1, CLTA, CLTB, DAB2, EPS15, GAK, MYO6, PIK3C2A, SEC13, CLTCL1, CAPZA2, DBN1, MYH9, LIMA1, GTSE1, ANLN, MYO19, MYO18A, CLINT1, SEC16A, TNRC6A, BMP2K, MICAL3, DENND1A, WNK1, PRRC2B, STON2, FCHO2, Actb, Myh9, Myo1c, Tpm1, Lima1, Calml3, Sec24c, MCM2, SNW1, CDC5L, SMURF1, CDH1, STAMBPL1, RALBP1, SNRNP27, DLST, FCHO1, RBPMS, CRX, AGR2, CDK9, TGOLN2, ATG16L1, MAP1LC3A, DYRK1A, APEX1, SCARB2, VMP1, MTMR4, TENM1, ATXN1, ZC3H10, ATXN1L, PLEKHA4, ORF6, ORF3a, SMAP2, CIT, ECT2, KIF14, KIF20A, MKI67, HNRNPH1, CDC42, Rnf183, E, WDR76, GGA2, FAM20C, OGT, ISG15, ARF6, B3GAT1, C11orf52, DIRAS3, GJA1, KRAS, LAMP2, LAMP3, LAMTOR1, MARCKS, OCLN, RAB35, RHOB, STX6, STX7, SYNE3, ZFPL1, NAA40, PIP, SNAP91, MTSS1L, BAG2, DDX3Y, ZBTB2, DNAJB6, PINK1, WIF1, ZNF444, CCR1, CENPQ, DOK4, ST3GAL5, BBS1, RBM47, C10orf88, NTNG1, C11orf49, DNAJC6, MBNL1, RDH11, MED17, POGZ, SERBP1, RBM38, FSCN1, IFITM1, IFITM3, ACE2, M, nsp14, DDX3X,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PICALMall structure
ZSCAN20


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PICALM-ZSCAN20


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PICALM-ZSCAN20


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePICALMC0002395Alzheimer's Disease2CTD_human
HgenePICALMC0011265Presenile dementia2CTD_human
HgenePICALMC0276496Familial Alzheimer Disease (FAD)2CTD_human
HgenePICALMC0494463Alzheimer Disease, Late Onset2CTD_human
HgenePICALMC0546126Acute Confusional Senile Dementia2CTD_human
HgenePICALMC0750900Alzheimer's Disease, Focal Onset2CTD_human
HgenePICALMC0750901Alzheimer Disease, Early Onset2CTD_human
HgenePICALMC0234985Mental deterioration1CTD_human
HgenePICALMC0338656Impaired cognition1CTD_human
HgenePICALMC1270972Mild cognitive disorder1CTD_human