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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PIGN-CTNNA2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PIGN-CTNNA2
FusionPDB ID: 65254
FusionGDB2.0 ID: 65254
HgeneTgene
Gene symbol

PIGN

CTNNA2

Gene ID

23556

1496

Gene namephosphatidylinositol glycan anchor biosynthesis class Ncatenin alpha 2
SynonymsMCAHS|MCAHS1|MCD4|MDC4|PIG-NCAP-R|CAPR|CDCBM9|CT114|CTNR
Cytomap

18q21.33

2p12

Type of geneprotein-codingprotein-coding
DescriptionGPI ethanolamine phosphate transferase 1MCD4 homologphosphatidylinositol-glycan biosynthesis class N proteincatenin alpha-2alpha-N-cateninalpha-catenin-related proteincadherin-associated protein, relatedcancer/testis antigen 114catenin (cadherin-associated protein), alpha 2
Modification date2020031320200313
UniProtAcc.

P26232

Ensembl transtripts involved in fusion geneENST idsENST00000357637, ENST00000400334, 
ENST00000593225, 		ENST00000409266, 
ENST00000496251, ENST00000343114, 
ENST00000361291, ENST00000402739, 
ENST00000466387, ENST00000496558, 
ENST00000540488, ENST00000541047, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 12 X 4=52826 X 24 X 10=6240
# samples 1228
** MAII scorelog2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/6240*10)=-4.47804729680464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PIGN [Title/Abstract] AND CTNNA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PIGN(59763081)-CTNNA2(80874710), # samples:2
PIGN(59768308)-CTNNA2(80874710), # samples:2
Anticipated loss of major functional domain due to fusion event.PIGN-CTNNA2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PIGN-CTNNA2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
PIGN-CTNNA2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PIGN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CTNNA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1N9-01APIGNchr18

59763081

-CTNNA2chr2

80874710

+
ChimerDB4BRCATCGA-E9-A1N9-01APIGNchr18

59768308

-CTNNA2chr2

80874710

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357637PIGNchr1859763081-ENST00000496558CTNNA2chr280874710+379225964102638742
ENST00000357637PIGNchr1859763081-ENST00000343114CTNNA2chr280874710+379225964102638742
ENST00000400334PIGNchr1859763081-ENST00000466387CTNNA2chr280874710+372825333472575742
ENST00000400334PIGNchr1859763081-ENST00000402739CTNNA2chr280874710+363825333472575742
ENST00000400334PIGNchr1859763081-ENST00000541047CTNNA2chr280874710+372825333472575742
ENST00000357637PIGNchr1859768308-ENST00000361291CTNNA2chr280874710+278124934102527705
ENST00000357637PIGNchr1859768308-ENST00000540488CTNNA2chr280874710+278124934102527705
ENST00000400334PIGNchr1859768308-ENST00000496558CTNNA2chr280874710+362624303472464705
ENST00000400334PIGNchr1859768308-ENST00000343114CTNNA2chr280874710+362624303472464705

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357637ENST00000496558PIGNchr1859763081-CTNNA2chr280874710+0.0005658010.9994342
ENST00000357637ENST00000343114PIGNchr1859763081-CTNNA2chr280874710+0.0005658010.9994342
ENST00000400334ENST00000466387PIGNchr1859763081-CTNNA2chr280874710+0.0006396270.9993604
ENST00000400334ENST00000402739PIGNchr1859763081-CTNNA2chr280874710+0.0006716070.9993284
ENST00000400334ENST00000541047PIGNchr1859763081-CTNNA2chr280874710+0.0006396270.9993604
ENST00000357637ENST00000361291PIGNchr1859768308-CTNNA2chr280874710+0.0006427610.9993573
ENST00000357637ENST00000540488PIGNchr1859768308-CTNNA2chr280874710+0.0006427610.9993573
ENST00000400334ENST00000496558PIGNchr1859768308-CTNNA2chr280874710+0.0005628480.99943715
ENST00000400334ENST00000343114PIGNchr1859768308-CTNNA2chr280874710+0.0005628480.99943715

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>65254_65254_1_PIGN-CTNNA2_PIGN_chr18_59763081_ENST00000357637_CTNNA2_chr2_80874710_ENST00000343114_length(amino acids)=742AA_BP=
MDMLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHT
RVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWV
FDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDW
GSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAE
SMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVV
IGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLT
YPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVL
LLSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWATLASSLVVPLLSSPVLFQRLFSILLSLM

--------------------------------------------------------------

>65254_65254_2_PIGN-CTNNA2_PIGN_chr18_59763081_ENST00000357637_CTNNA2_chr2_80874710_ENST00000496558_length(amino acids)=742AA_BP=
MDMLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHT
RVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWV
FDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDW
GSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAE
SMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVV
IGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLT
YPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVL
LLSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWATLASSLVVPLLSSPVLFQRLFSILLSLM

--------------------------------------------------------------

>65254_65254_3_PIGN-CTNNA2_PIGN_chr18_59763081_ENST00000400334_CTNNA2_chr2_80874710_ENST00000402739_length(amino acids)=742AA_BP=
MDMLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHT
RVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWV
FDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDW
GSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAE
SMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVV
IGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLT
YPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVL
LLSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWATLASSLVVPLLSSPVLFQRLFSILLSLM

--------------------------------------------------------------

>65254_65254_4_PIGN-CTNNA2_PIGN_chr18_59763081_ENST00000400334_CTNNA2_chr2_80874710_ENST00000466387_length(amino acids)=742AA_BP=
MDMLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHT
RVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWV
FDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDW
GSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAE
SMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVV
IGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLT
YPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVL
LLSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWATLASSLVVPLLSSPVLFQRLFSILLSLM

--------------------------------------------------------------

>65254_65254_5_PIGN-CTNNA2_PIGN_chr18_59763081_ENST00000400334_CTNNA2_chr2_80874710_ENST00000541047_length(amino acids)=742AA_BP=
MDMLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHT
RVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWV
FDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDW
GSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAE
SMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVV
IGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLT
YPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVL
LLSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWATLASSLVVPLLSSPVLFQRLFSILLSLM

--------------------------------------------------------------

>65254_65254_6_PIGN-CTNNA2_PIGN_chr18_59768308_ENST00000357637_CTNNA2_chr2_80874710_ENST00000361291_length(amino acids)=705AA_BP=
MDMLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHT
RVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWV
FDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDW
GSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAE
SMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVV
IGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLT
YPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVL

--------------------------------------------------------------

>65254_65254_7_PIGN-CTNNA2_PIGN_chr18_59768308_ENST00000357637_CTNNA2_chr2_80874710_ENST00000540488_length(amino acids)=705AA_BP=
MDMLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHT
RVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWV
FDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDW
GSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAE
SMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVV
IGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLT
YPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVL

--------------------------------------------------------------

>65254_65254_8_PIGN-CTNNA2_PIGN_chr18_59768308_ENST00000400334_CTNNA2_chr2_80874710_ENST00000343114_length(amino acids)=705AA_BP=
MDMLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHT
RVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWV
FDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDW
GSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAE
SMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVV
IGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLT
YPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVL

--------------------------------------------------------------

>65254_65254_9_PIGN-CTNNA2_PIGN_chr18_59768308_ENST00000400334_CTNNA2_chr2_80874710_ENST00000496558_length(amino acids)=705AA_BP=
MDMLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHT
RVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWV
FDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDW
GSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAE
SMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVV
IGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLT
YPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:59763081/chr2:80874710)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CTNNA2

P26232

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-23311_1726.6666666666666932.0Topological domainCytoplasmic
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-233125_442726.6666666666666932.0Topological domainLumenal
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331464_482726.6666666666666932.0Topological domainCytoplasmic
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331504_508726.6666666666666932.0Topological domainLumenal
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331530_543726.6666666666666932.0Topological domainCytoplasmic
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331565_565726.6666666666666932.0Topological domainLumenal
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331587_591726.6666666666666932.0Topological domainCytoplasmic
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331613_618726.6666666666666932.0Topological domainLumenal
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331640_649726.6666666666666932.0Topological domainCytoplasmic
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331671_685726.6666666666666932.0Topological domainLumenal
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331707_723726.6666666666666932.0Topological domainCytoplasmic
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-22301_1726.6666666666666932.0Topological domainCytoplasmic
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-223025_442726.6666666666666932.0Topological domainLumenal
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230464_482726.6666666666666932.0Topological domainCytoplasmic
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230504_508726.6666666666666932.0Topological domainLumenal
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230530_543726.6666666666666932.0Topological domainCytoplasmic
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230565_565726.6666666666666932.0Topological domainLumenal
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230587_591726.6666666666666932.0Topological domainCytoplasmic
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230613_618726.6666666666666932.0Topological domainLumenal
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230640_649726.6666666666666932.0Topological domainCytoplasmic
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230671_685726.6666666666666932.0Topological domainLumenal
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230707_723726.6666666666666932.0Topological domainCytoplasmic
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-22311_1692.3333333333334932.0Topological domainCytoplasmic
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-223125_442692.3333333333334932.0Topological domainLumenal
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231464_482692.3333333333334932.0Topological domainCytoplasmic
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231504_508692.3333333333334932.0Topological domainLumenal
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231530_543692.3333333333334932.0Topological domainCytoplasmic
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231565_565692.3333333333334932.0Topological domainLumenal
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231587_591692.3333333333334932.0Topological domainCytoplasmic
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231613_618692.3333333333334932.0Topological domainLumenal
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231640_649692.3333333333334932.0Topological domainCytoplasmic
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231671_685692.3333333333334932.0Topological domainLumenal
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-21301_1692.3333333333334932.0Topological domainCytoplasmic
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-213025_442692.3333333333334932.0Topological domainLumenal
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130464_482692.3333333333334932.0Topological domainCytoplasmic
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130504_508692.3333333333334932.0Topological domainLumenal
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130530_543692.3333333333334932.0Topological domainCytoplasmic
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130565_565692.3333333333334932.0Topological domainLumenal
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130587_591692.3333333333334932.0Topological domainCytoplasmic
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130613_618692.3333333333334932.0Topological domainLumenal
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130640_649692.3333333333334932.0Topological domainCytoplasmic
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130671_685692.3333333333334932.0Topological domainLumenal
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-23312_24726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331443_463726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331483_503726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331509_529726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331544_564726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331566_586726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331592_612726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331619_639726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331650_670726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331686_706726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-22302_24726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230443_463726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230483_503726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230509_529726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230544_564726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230566_586726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230592_612726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230619_639726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230650_670726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230686_706726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-22312_24692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231443_463692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231483_503692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231509_529692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231544_564692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231566_586692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231592_612692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231619_639692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231650_670692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-21302_24692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130443_463692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130483_503692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130509_529692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130544_564692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130566_586692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130592_612692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130619_639692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130650_670692.3333333333334932.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331745_786726.6666666666666932.0Topological domainLumenal
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331808_824726.6666666666666932.0Topological domainCytoplasmic
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331846_858726.6666666666666932.0Topological domainLumenal
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331880_894726.6666666666666932.0Topological domainCytoplasmic
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331916_931726.6666666666666932.0Topological domainLumenal
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230745_786726.6666666666666932.0Topological domainLumenal
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230808_824726.6666666666666932.0Topological domainCytoplasmic
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230846_858726.6666666666666932.0Topological domainLumenal
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230880_894726.6666666666666932.0Topological domainCytoplasmic
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230916_931726.6666666666666932.0Topological domainLumenal
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231707_723692.3333333333334932.0Topological domainCytoplasmic
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231745_786692.3333333333334932.0Topological domainLumenal
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231808_824692.3333333333334932.0Topological domainCytoplasmic
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231846_858692.3333333333334932.0Topological domainLumenal
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231880_894692.3333333333334932.0Topological domainCytoplasmic
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231916_931692.3333333333334932.0Topological domainLumenal
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130707_723692.3333333333334932.0Topological domainCytoplasmic
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130745_786692.3333333333334932.0Topological domainLumenal
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130808_824692.3333333333334932.0Topological domainCytoplasmic
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130846_858692.3333333333334932.0Topological domainLumenal
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130880_894692.3333333333334932.0Topological domainCytoplasmic
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130916_931692.3333333333334932.0Topological domainLumenal
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331724_744726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331787_807726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331825_845726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331859_879726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000357637-2331895_915726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230724_744726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230787_807726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230825_845726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230859_879726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59763081chr2:80874710ENST00000400334-2230895_915726.6666666666666932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231686_706692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231724_744692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231787_807692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231825_845692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231859_879692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000357637-2231895_915692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130686_706692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130724_744692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130787_807692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130825_845692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130859_879692.3333333333334932.0TransmembraneHelical
HgenePIGNchr18:59768308chr2:80874710ENST00000400334-2130895_915692.3333333333334932.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PIGN
CTNNA2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PIGN-CTNNA2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PIGN-CTNNA2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource