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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PLA2G6-TPTE2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PLA2G6-TPTE2
FusionPDB ID: 65881
FusionGDB2.0 ID: 65881
HgeneTgene
Gene symbol

PLA2G6

TPTE2

Gene ID

8398

93492

Gene namephospholipase A2 group VItransmembrane phosphoinositide 3-phosphatase and tensin homolog 2
SynonymsCaI-PLA2|GVI|INAD1|IPLA2-VIA|NBIA2|NBIA2A|NBIA2B|PARK14|PLA2|PNPLA9|iPLA2|iPLA2betaTPIP
Cytomap

22q13.1

13q12.11

Type of geneprotein-codingprotein-coding
Description85/88 kDa calcium-independent phospholipase A285 kDa calcium-independent phospholipase A2GVI PLA2iPLA2-betaintracellular membrane-associated calcium-independent phospholipase A2 betaneurodegeneration with brain iron accumulation 2patatin-like phosphphosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2PTEN-like inositol lipid phosphataseTPIP lipid phosphataseTPTE and PTEN homologous inositol lipid phosphataselipid phosphatase TPIPtransmembrane phosphoinositide 3-phosphatase and tensin 2-l
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000332509, ENST00000335539, 
ENST00000402064, ENST00000436218, 
ENST00000417303, ENST00000435484, 
ENST00000447598, ENST00000490473, 
ENST00000255310, ENST00000382975, 
ENST00000382977, ENST00000382978, 
ENST00000390680, ENST00000400103, 
ENST00000400230, ENST00000457266, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 12 X 6=6485 X 5 X 4=100
# samples 136
** MAII scorelog2(13/648*10)=-2.31748218985617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PLA2G6 [Title/Abstract] AND TPTE2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PLA2G6(38541444)-TPTE2(20067641), # samples:2
Anticipated loss of major functional domain due to fusion event.PLA2G6-TPTE2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PLA2G6-TPTE2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PLA2G6-TPTE2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PLA2G6-TPTE2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePLA2G6

GO:0019731

antibacterial humoral response

18714013


check buttonFusion gene breakpoints across PLA2G6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TPTE2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A8NIPLA2G6chr22

38541444

-TPTE2chr13

20067641

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000332509PLA2G6chr2238541444-ENST00000382978TPTE2chr1320067641-2232609462046666
ENST00000332509PLA2G6chr2238541444-ENST00000400230TPTE2chr1320067641-2346609462166706
ENST00000332509PLA2G6chr2238541444-ENST00000255310TPTE2chr1320067641-2115609461935629
ENST00000332509PLA2G6chr2238541444-ENST00000400103TPTE2chr1320067641-2013609461833595
ENST00000332509PLA2G6chr2238541444-ENST00000390680TPTE2chr1320067641-1946609461935629
ENST00000332509PLA2G6chr2238541444-ENST00000382975TPTE2chr1320067641-2057609462046666
ENST00000332509PLA2G6chr2238541444-ENST00000457266TPTE2chr1320067641-1844609461833595
ENST00000332509PLA2G6chr2238541444-ENST00000382977TPTE2chr1320067641-2177609462166706
ENST00000335539PLA2G6chr2238541444-ENST00000382978TPTE2chr1320067641-2184561611998645
ENST00000335539PLA2G6chr2238541444-ENST00000400230TPTE2chr1320067641-2298561612118685
ENST00000335539PLA2G6chr2238541444-ENST00000255310TPTE2chr1320067641-2067561611887608
ENST00000335539PLA2G6chr2238541444-ENST00000400103TPTE2chr1320067641-1965561611785574
ENST00000335539PLA2G6chr2238541444-ENST00000390680TPTE2chr1320067641-1898561611887608
ENST00000335539PLA2G6chr2238541444-ENST00000382975TPTE2chr1320067641-2009561611998645
ENST00000335539PLA2G6chr2238541444-ENST00000457266TPTE2chr1320067641-1796561611785574
ENST00000335539PLA2G6chr2238541444-ENST00000382977TPTE2chr1320067641-2129561612118685
ENST00000402064PLA2G6chr2238541444-ENST00000382978TPTE2chr1320067641-2139516911953620
ENST00000402064PLA2G6chr2238541444-ENST00000400230TPTE2chr1320067641-2253516912073660
ENST00000402064PLA2G6chr2238541444-ENST00000255310TPTE2chr1320067641-2022516911842583
ENST00000402064PLA2G6chr2238541444-ENST00000400103TPTE2chr1320067641-1920516911740549
ENST00000402064PLA2G6chr2238541444-ENST00000390680TPTE2chr1320067641-1853516911842583
ENST00000402064PLA2G6chr2238541444-ENST00000382975TPTE2chr1320067641-1964516911953620
ENST00000402064PLA2G6chr2238541444-ENST00000457266TPTE2chr1320067641-1751516911740549
ENST00000402064PLA2G6chr2238541444-ENST00000382977TPTE2chr1320067641-2084516912073660
ENST00000436218PLA2G6chr2238541444-ENST00000382978TPTE2chr1320067641-2140517921954620
ENST00000436218PLA2G6chr2238541444-ENST00000400230TPTE2chr1320067641-2254517922074660
ENST00000436218PLA2G6chr2238541444-ENST00000255310TPTE2chr1320067641-2023517921843583
ENST00000436218PLA2G6chr2238541444-ENST00000400103TPTE2chr1320067641-1921517921741549
ENST00000436218PLA2G6chr2238541444-ENST00000390680TPTE2chr1320067641-1854517921843583
ENST00000436218PLA2G6chr2238541444-ENST00000382975TPTE2chr1320067641-1965517921954620
ENST00000436218PLA2G6chr2238541444-ENST00000457266TPTE2chr1320067641-1752517921741549
ENST00000436218PLA2G6chr2238541444-ENST00000382977TPTE2chr1320067641-2085517922074660

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000332509ENST00000382978PLA2G6chr2238541444-TPTE2chr1320067641-0.00249850.99750155
ENST00000332509ENST00000400230PLA2G6chr2238541444-TPTE2chr1320067641-0.0020257570.9979742
ENST00000332509ENST00000255310PLA2G6chr2238541444-TPTE2chr1320067641-0.0031183320.9968817
ENST00000332509ENST00000400103PLA2G6chr2238541444-TPTE2chr1320067641-0.0022386340.99776137
ENST00000332509ENST00000390680PLA2G6chr2238541444-TPTE2chr1320067641-0.0038659910.99613404
ENST00000332509ENST00000382975PLA2G6chr2238541444-TPTE2chr1320067641-0.003127290.9968727
ENST00000332509ENST00000457266PLA2G6chr2238541444-TPTE2chr1320067641-0.0029083010.99709165
ENST00000332509ENST00000382977PLA2G6chr2238541444-TPTE2chr1320067641-0.002375760.9976242
ENST00000335539ENST00000382978PLA2G6chr2238541444-TPTE2chr1320067641-0.0024316960.9975683
ENST00000335539ENST00000400230PLA2G6chr2238541444-TPTE2chr1320067641-0.0019942870.9980057
ENST00000335539ENST00000255310PLA2G6chr2238541444-TPTE2chr1320067641-0.002905010.997095
ENST00000335539ENST00000400103PLA2G6chr2238541444-TPTE2chr1320067641-0.0020684840.9979315
ENST00000335539ENST00000390680PLA2G6chr2238541444-TPTE2chr1320067641-0.0036150050.996385
ENST00000335539ENST00000382975PLA2G6chr2238541444-TPTE2chr1320067641-0.0030993860.9969007
ENST00000335539ENST00000457266PLA2G6chr2238541444-TPTE2chr1320067641-0.002828860.9971711
ENST00000335539ENST00000382977PLA2G6chr2238541444-TPTE2chr1320067641-0.0023301730.99766976
ENST00000402064ENST00000382978PLA2G6chr2238541444-TPTE2chr1320067641-0.0026404470.9973596
ENST00000402064ENST00000400230PLA2G6chr2238541444-TPTE2chr1320067641-0.0021538610.9978461
ENST00000402064ENST00000255310PLA2G6chr2238541444-TPTE2chr1320067641-0.0030841070.99691594
ENST00000402064ENST00000400103PLA2G6chr2238541444-TPTE2chr1320067641-0.0023121890.9976878
ENST00000402064ENST00000390680PLA2G6chr2238541444-TPTE2chr1320067641-0.0037760280.9962239
ENST00000402064ENST00000382975PLA2G6chr2238541444-TPTE2chr1320067641-0.0034441170.9965559
ENST00000402064ENST00000457266PLA2G6chr2238541444-TPTE2chr1320067641-0.0031526050.99684733
ENST00000402064ENST00000382977PLA2G6chr2238541444-TPTE2chr1320067641-0.0025996840.9974003
ENST00000436218ENST00000382978PLA2G6chr2238541444-TPTE2chr1320067641-0.0026300550.9973699
ENST00000436218ENST00000400230PLA2G6chr2238541444-TPTE2chr1320067641-0.0021402690.9978598
ENST00000436218ENST00000255310PLA2G6chr2238541444-TPTE2chr1320067641-0.0030669020.9969331
ENST00000436218ENST00000400103PLA2G6chr2238541444-TPTE2chr1320067641-0.002302320.99769765
ENST00000436218ENST00000390680PLA2G6chr2238541444-TPTE2chr1320067641-0.0037441340.9962559
ENST00000436218ENST00000382975PLA2G6chr2238541444-TPTE2chr1320067641-0.00341370.9965863
ENST00000436218ENST00000457266PLA2G6chr2238541444-TPTE2chr1320067641-0.0031081680.9968919
ENST00000436218ENST00000382977PLA2G6chr2238541444-TPTE2chr1320067641-0.002574970.9974251

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>65881_65881_1_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000332509_TPTE2_chr13_20067641_ENST00000255310_length(amino acids)=629AA_BP=187
MGVRSPTSSALRTPKSPPDPPLDIPRVSDSETEGEDGGASPPAPQKMQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQL
ILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIREC
FHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKRIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDV
LLRVFVEGWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFL
DKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLT
AEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNC

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>65881_65881_2_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000332509_TPTE2_chr13_20067641_ENST00000382975_length(amino acids)=666AA_BP=187
MGVRSPTSSALRTPKSPPDPPLDIPRVSDSETEGEDGGASPPAPQKMQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQL
ILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIREC
FHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLL
DVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDG
FDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNE
WMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRIL
FIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQ

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>65881_65881_3_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000332509_TPTE2_chr13_20067641_ENST00000382977_length(amino acids)=706AA_BP=187
MGVRSPTSSALRTPKSPPDPPLDIPRVSDSETEGEDGGASPPAPQKMQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQL
ILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIREC
FHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLL
DVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLV
RLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNL
CSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRT
NKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILI

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>65881_65881_4_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000332509_TPTE2_chr13_20067641_ENST00000382978_length(amino acids)=666AA_BP=187
MGVRSPTSSALRTPKSPPDPPLDIPRVSDSETEGEDGGASPPAPQKMQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQL
ILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIREC
FHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLL
DVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDG
FDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNE
WMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRIL
FIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQ

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>65881_65881_5_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000332509_TPTE2_chr13_20067641_ENST00000390680_length(amino acids)=629AA_BP=187
MGVRSPTSSALRTPKSPPDPPLDIPRVSDSETEGEDGGASPPAPQKMQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQL
ILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIREC
FHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKRIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDV
LLRVFVEGWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFL
DKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLT
AEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNC

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>65881_65881_6_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000332509_TPTE2_chr13_20067641_ENST00000400103_length(amino acids)=595AA_BP=187
MGVRSPTSSALRTPKSPPDPPLDIPRVSDSETEGEDGGASPPAPQKMQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQL
ILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIREC
FHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYEWTHLVRLLRLIILIRIFHLLHQKRQL
EKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMID
DHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVG
YFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNL

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>65881_65881_7_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000332509_TPTE2_chr13_20067641_ENST00000400230_length(amino acids)=706AA_BP=187
MGVRSPTSSALRTPKSPPDPPLDIPRVSDSETEGEDGGASPPAPQKMQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQL
ILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIREC
FHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLL
DVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLV
RLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNL
CSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRT
NKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILI

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>65881_65881_8_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000332509_TPTE2_chr13_20067641_ENST00000457266_length(amino acids)=595AA_BP=187
MGVRSPTSSALRTPKSPPDPPLDIPRVSDSETEGEDGGASPPAPQKMQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQL
ILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIREC
FHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYEWTHLVRLLRLIILIRIFHLLHQKRQL
EKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMID
DHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVG
YFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNL

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>65881_65881_9_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000335539_TPTE2_chr13_20067641_ENST00000255310_length(amino acids)=608AA_BP=166
MDIPRVSDSETEGEDGGASPPAPQKMQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNS
QSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEA
PAKESPHTSEFKGAALVSPISKRIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGWTHLVRLLRLIIL
IRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDP
KHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKF
QGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPL

--------------------------------------------------------------

>65881_65881_10_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000335539_TPTE2_chr13_20067641_ENST00000382975_length(amino acids)=645AA_BP=166
MDIPRVSDSETEGEDGGASPPAPQKMQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNS
QSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEA
PAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLE
YRSISLAIGLFFLMDVLLRVFVEGWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSG
RQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRT
GTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQV
VMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAWK

--------------------------------------------------------------

>65881_65881_11_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000335539_TPTE2_chr13_20067641_ENST00000382977_length(amino acids)=685AA_BP=166
MDIPRVSDSETEGEDGGASPPAPQKMQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNS
QSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEA
PAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLE
YRSISLAIGLFFLMDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLRLIILIRIFHLLHQKRQL
EKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMID
DHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVG
YFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNL

--------------------------------------------------------------

>65881_65881_12_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000335539_TPTE2_chr13_20067641_ENST00000382978_length(amino acids)=645AA_BP=166
MDIPRVSDSETEGEDGGASPPAPQKMQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNS
QSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEA
PAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLE
YRSISLAIGLFFLMDVLLRVFVEGWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSG
RQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRT
GTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQV
VMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAWK

--------------------------------------------------------------

>65881_65881_13_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000335539_TPTE2_chr13_20067641_ENST00000390680_length(amino acids)=608AA_BP=166
MDIPRVSDSETEGEDGGASPPAPQKMQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNS
QSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEA
PAKESPHTSEFKGAALVSPISKRIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGWTHLVRLLRLIIL
IRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDP
KHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKF
QGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPL

--------------------------------------------------------------

>65881_65881_14_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000335539_TPTE2_chr13_20067641_ENST00000400103_length(amino acids)=574AA_BP=166
MDIPRVSDSETEGEDGGASPPAPQKMQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNS
QSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEA
PAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYEWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFD
LDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWM
AQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFI
KRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNN

--------------------------------------------------------------

>65881_65881_15_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000335539_TPTE2_chr13_20067641_ENST00000400230_length(amino acids)=685AA_BP=166
MDIPRVSDSETEGEDGGASPPAPQKMQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNS
QSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEA
PAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLE
YRSISLAIGLFFLMDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLRLIILIRIFHLLHQKRQL
EKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMID
DHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVG
YFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNL

--------------------------------------------------------------

>65881_65881_16_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000335539_TPTE2_chr13_20067641_ENST00000457266_length(amino acids)=574AA_BP=166
MDIPRVSDSETEGEDGGASPPAPQKMQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNS
QSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEA
PAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYEWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFD
LDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWM
AQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFI
KRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNN

--------------------------------------------------------------

>65881_65881_17_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000402064_TPTE2_chr13_20067641_ENST00000255310_length(amino acids)=583AA_BP=141
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQ
LLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKRIF
GVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENK
RRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVV
FTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWN
LPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFW

--------------------------------------------------------------

>65881_65881_18_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000402064_TPTE2_chr13_20067641_ENST00000382975_length(amino acids)=620AA_BP=141
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQ
LLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSML
ERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGW
THLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYR
VYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFG
ERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETD

--------------------------------------------------------------

>65881_65881_19_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000402064_TPTE2_chr13_20067641_ENST00000382977_length(amino acids)=660AA_BP=141
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQ
LLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSML
ERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGR
QQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLT
YVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDL
ENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFI
IYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCL

--------------------------------------------------------------

>65881_65881_20_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000402064_TPTE2_chr13_20067641_ENST00000382978_length(amino acids)=620AA_BP=141
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQ
LLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSML
ERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGW
THLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYR
VYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFG
ERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETD

--------------------------------------------------------------

>65881_65881_21_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000402064_TPTE2_chr13_20067641_ENST00000390680_length(amino acids)=583AA_BP=141
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQ
LLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKRIF
GVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENK
RRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVV
FTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWN
LPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFW

--------------------------------------------------------------

>65881_65881_22_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000402064_TPTE2_chr13_20067641_ENST00000400103_length(amino acids)=549AA_BP=141
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQ
LLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSML
ERLSKFEVEDAENVASYEWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYR
NPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCA
LLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKV
VFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEF

--------------------------------------------------------------

>65881_65881_23_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000402064_TPTE2_chr13_20067641_ENST00000400230_length(amino acids)=660AA_BP=141
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQ
LLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSML
ERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGR
QQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLT
YVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDL
ENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFI
IYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCL

--------------------------------------------------------------

>65881_65881_24_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000402064_TPTE2_chr13_20067641_ENST00000457266_length(amino acids)=549AA_BP=141
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQ
LLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSML
ERLSKFEVEDAENVASYEWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYR
NPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCA
LLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKV
VFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEF

--------------------------------------------------------------

>65881_65881_25_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000436218_TPTE2_chr13_20067641_ENST00000255310_length(amino acids)=583AA_BP=141
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQ
LLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKRIF
GVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENK
RRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVV
FTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWN
LPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFW

--------------------------------------------------------------

>65881_65881_26_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000436218_TPTE2_chr13_20067641_ENST00000382975_length(amino acids)=620AA_BP=141
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQ
LLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSML
ERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGW
THLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYR
VYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFG
ERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETD

--------------------------------------------------------------

>65881_65881_27_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000436218_TPTE2_chr13_20067641_ENST00000382977_length(amino acids)=660AA_BP=141
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQ
LLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSML
ERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGR
QQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLT
YVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDL
ENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFI
IYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCL

--------------------------------------------------------------

>65881_65881_28_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000436218_TPTE2_chr13_20067641_ENST00000382978_length(amino acids)=620AA_BP=141
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQ
LLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSML
ERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGW
THLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYR
VYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFG
ERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETD

--------------------------------------------------------------

>65881_65881_29_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000436218_TPTE2_chr13_20067641_ENST00000390680_length(amino acids)=583AA_BP=141
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQ
LLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKRIF
GVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENK
RRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVV
FTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWN
LPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFW

--------------------------------------------------------------

>65881_65881_30_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000436218_TPTE2_chr13_20067641_ENST00000400103_length(amino acids)=549AA_BP=141
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQ
LLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSML
ERLSKFEVEDAENVASYEWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYR
NPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCA
LLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKV
VFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEF

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>65881_65881_31_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000436218_TPTE2_chr13_20067641_ENST00000400230_length(amino acids)=660AA_BP=141
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQ
LLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSML
ERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGR
QQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLT
YVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDL
ENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFI
IYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCL

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>65881_65881_32_PLA2G6-TPTE2_PLA2G6_chr22_38541444_ENST00000436218_TPTE2_chr13_20067641_ENST00000457266_length(amino acids)=549AA_BP=141
MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQ
LLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSML
ERLSKFEVEDAENVASYEWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYR
NPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCA
LLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKV
VFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEF

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:38541444/chr13:20067641)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTPTE2chr22:38541444chr13:20067641ENST00000255310017210_3863.6666666666666665446.0DomainPhosphatase tensin-type
TgeneTPTE2chr22:38541444chr13:20067641ENST00000255310017393_5223.6666666666666665446.0DomainC2 tensin-type
TgeneTPTE2chr22:38541444chr13:20067641ENST00000382975120210_3863.6666666666666665483.0DomainPhosphatase tensin-type
TgeneTPTE2chr22:38541444chr13:20067641ENST00000382975120393_5223.6666666666666665483.0DomainC2 tensin-type
TgeneTPTE2chr22:38541444chr13:20067641ENST00000382977121210_3863.6666666666666665523.0DomainPhosphatase tensin-type
TgeneTPTE2chr22:38541444chr13:20067641ENST00000382977121393_5223.6666666666666665523.0DomainC2 tensin-type
TgeneTPTE2chr22:38541444chr13:20067641ENST00000382978019210_3863.6666666666666665483.0DomainPhosphatase tensin-type
TgeneTPTE2chr22:38541444chr13:20067641ENST00000382978019393_5223.6666666666666665483.0DomainC2 tensin-type
TgeneTPTE2chr22:38541444chr13:20067641ENST00000390680118210_3863.6666666666666665446.0DomainPhosphatase tensin-type
TgeneTPTE2chr22:38541444chr13:20067641ENST00000390680118393_5223.6666666666666665446.0DomainC2 tensin-type
TgeneTPTE2chr22:38541444chr13:20067641ENST00000400103118210_3863.6666666666666665412.0DomainPhosphatase tensin-type
TgeneTPTE2chr22:38541444chr13:20067641ENST00000400103118393_5223.6666666666666665412.0DomainC2 tensin-type
TgeneTPTE2chr22:38541444chr13:20067641ENST00000400230020210_3863.6666666666666665523.0DomainPhosphatase tensin-type
TgeneTPTE2chr22:38541444chr13:20067641ENST00000400230020393_5223.6666666666666665523.0DomainC2 tensin-type
TgeneTPTE2chr22:38541444chr13:20067641ENST00000457266118210_3863.6666666666666665412.0DomainPhosphatase tensin-type
TgeneTPTE2chr22:38541444chr13:20067641ENST00000457266118393_5223.6666666666666665412.0DomainC2 tensin-type
TgeneTPTE2chr22:38541444chr13:20067641ENST00000255310017111_1313.6666666666666665446.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST00000255310017146_1663.6666666666666665446.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST0000025531001766_863.6666666666666665446.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST00000382975120111_1313.6666666666666665483.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST00000382975120146_1663.6666666666666665483.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST0000038297512066_863.6666666666666665483.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST00000382977121111_1313.6666666666666665523.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST00000382977121146_1663.6666666666666665523.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST0000038297712166_863.6666666666666665523.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST00000382978019111_1313.6666666666666665483.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST00000382978019146_1663.6666666666666665483.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST0000038297801966_863.6666666666666665483.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST00000390680118111_1313.6666666666666665446.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST00000390680118146_1663.6666666666666665446.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST0000039068011866_863.6666666666666665446.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST00000400103118111_1313.6666666666666665412.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST00000400103118146_1663.6666666666666665412.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST0000040010311866_863.6666666666666665412.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST00000400230020111_1313.6666666666666665523.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST00000400230020146_1663.6666666666666665523.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST0000040023002066_863.6666666666666665523.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST00000457266118111_1313.6666666666666665412.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST00000457266118146_1663.6666666666666665412.0TransmembraneHelical
TgeneTPTE2chr22:38541444chr13:20067641ENST0000045726611866_863.6666666666666665412.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLA2G6chr22:38541444chr13:20067641ENST00000332509-317481_665141.66666666666666807.0DomainPNPLA
HgenePLA2G6chr22:38541444chr13:20067641ENST00000335539-316481_665141.66666666666666753.0DomainPNPLA
HgenePLA2G6chr22:38541444chr13:20067641ENST00000402064-316481_665141.66666666666666753.0DomainPNPLA
HgenePLA2G6chr22:38541444chr13:20067641ENST00000332509-317485_490141.66666666666666807.0MotifGXGXXG
HgenePLA2G6chr22:38541444chr13:20067641ENST00000332509-317517_521141.66666666666666807.0MotifGXSXG
HgenePLA2G6chr22:38541444chr13:20067641ENST00000332509-317652_654141.66666666666666807.0MotifDGA/G
HgenePLA2G6chr22:38541444chr13:20067641ENST00000335539-316485_490141.66666666666666753.0MotifGXGXXG
HgenePLA2G6chr22:38541444chr13:20067641ENST00000335539-316517_521141.66666666666666753.0MotifGXSXG
HgenePLA2G6chr22:38541444chr13:20067641ENST00000335539-316652_654141.66666666666666753.0MotifDGA/G
HgenePLA2G6chr22:38541444chr13:20067641ENST00000402064-316485_490141.66666666666666753.0MotifGXGXXG
HgenePLA2G6chr22:38541444chr13:20067641ENST00000402064-316517_521141.66666666666666753.0MotifGXSXG
HgenePLA2G6chr22:38541444chr13:20067641ENST00000402064-316652_654141.66666666666666753.0MotifDGA/G
HgenePLA2G6chr22:38541444chr13:20067641ENST00000332509-317677_686141.66666666666666807.0RegionCalmodulin-binding (1-9-14 motif)
HgenePLA2G6chr22:38541444chr13:20067641ENST00000332509-317748_759141.66666666666666807.0RegionCalmodulin-binding (IQ motif)
HgenePLA2G6chr22:38541444chr13:20067641ENST00000335539-316677_686141.66666666666666753.0RegionCalmodulin-binding (1-9-14 motif)
HgenePLA2G6chr22:38541444chr13:20067641ENST00000335539-316748_759141.66666666666666753.0RegionCalmodulin-binding (IQ motif)
HgenePLA2G6chr22:38541444chr13:20067641ENST00000402064-316677_686141.66666666666666753.0RegionCalmodulin-binding (1-9-14 motif)
HgenePLA2G6chr22:38541444chr13:20067641ENST00000402064-316748_759141.66666666666666753.0RegionCalmodulin-binding (IQ motif)
HgenePLA2G6chr22:38541444chr13:20067641ENST00000332509-317120_147141.66666666666666807.0RepeatANK 1
HgenePLA2G6chr22:38541444chr13:20067641ENST00000332509-317151_181141.66666666666666807.0RepeatANK 1
HgenePLA2G6chr22:38541444chr13:20067641ENST00000332509-317185_215141.66666666666666807.0RepeatANK 2
HgenePLA2G6chr22:38541444chr13:20067641ENST00000332509-317219_248141.66666666666666807.0RepeatANK 3
HgenePLA2G6chr22:38541444chr13:20067641ENST00000332509-317251_281141.66666666666666807.0RepeatANK 4
HgenePLA2G6chr22:38541444chr13:20067641ENST00000332509-317286_312141.66666666666666807.0RepeatANK 5
HgenePLA2G6chr22:38541444chr13:20067641ENST00000332509-317316_345141.66666666666666807.0RepeatANK 6
HgenePLA2G6chr22:38541444chr13:20067641ENST00000332509-317349_378141.66666666666666807.0RepeatANK 7
HgenePLA2G6chr22:38541444chr13:20067641ENST00000332509-317382_403141.66666666666666807.0RepeatANK 9
HgenePLA2G6chr22:38541444chr13:20067641ENST00000335539-316120_147141.66666666666666753.0RepeatANK 1
HgenePLA2G6chr22:38541444chr13:20067641ENST00000335539-316151_181141.66666666666666753.0RepeatANK 1
HgenePLA2G6chr22:38541444chr13:20067641ENST00000335539-316185_215141.66666666666666753.0RepeatANK 2
HgenePLA2G6chr22:38541444chr13:20067641ENST00000335539-316219_248141.66666666666666753.0RepeatANK 3
HgenePLA2G6chr22:38541444chr13:20067641ENST00000335539-316251_281141.66666666666666753.0RepeatANK 4
HgenePLA2G6chr22:38541444chr13:20067641ENST00000335539-316286_312141.66666666666666753.0RepeatANK 5
HgenePLA2G6chr22:38541444chr13:20067641ENST00000335539-316316_345141.66666666666666753.0RepeatANK 6
HgenePLA2G6chr22:38541444chr13:20067641ENST00000335539-316349_378141.66666666666666753.0RepeatANK 7
HgenePLA2G6chr22:38541444chr13:20067641ENST00000335539-316382_403141.66666666666666753.0RepeatANK 9
HgenePLA2G6chr22:38541444chr13:20067641ENST00000402064-316120_147141.66666666666666753.0RepeatANK 1
HgenePLA2G6chr22:38541444chr13:20067641ENST00000402064-316151_181141.66666666666666753.0RepeatANK 1
HgenePLA2G6chr22:38541444chr13:20067641ENST00000402064-316185_215141.66666666666666753.0RepeatANK 2
HgenePLA2G6chr22:38541444chr13:20067641ENST00000402064-316219_248141.66666666666666753.0RepeatANK 3
HgenePLA2G6chr22:38541444chr13:20067641ENST00000402064-316251_281141.66666666666666753.0RepeatANK 4
HgenePLA2G6chr22:38541444chr13:20067641ENST00000402064-316286_312141.66666666666666753.0RepeatANK 5
HgenePLA2G6chr22:38541444chr13:20067641ENST00000402064-316316_345141.66666666666666753.0RepeatANK 6
HgenePLA2G6chr22:38541444chr13:20067641ENST00000402064-316349_378141.66666666666666753.0RepeatANK 7
HgenePLA2G6chr22:38541444chr13:20067641ENST00000402064-316382_403141.66666666666666753.0RepeatANK 9
HgenePLA2G6chr22:38541444chr13:20067641ENST00000332509-317480_500141.66666666666666807.0TransmembraneHelical
HgenePLA2G6chr22:38541444chr13:20067641ENST00000332509-317511_531141.66666666666666807.0TransmembraneHelical
HgenePLA2G6chr22:38541444chr13:20067641ENST00000335539-316480_500141.66666666666666753.0TransmembraneHelical
HgenePLA2G6chr22:38541444chr13:20067641ENST00000335539-316511_531141.66666666666666753.0TransmembraneHelical
HgenePLA2G6chr22:38541444chr13:20067641ENST00000402064-316480_500141.66666666666666753.0TransmembraneHelical
HgenePLA2G6chr22:38541444chr13:20067641ENST00000402064-316511_531141.66666666666666753.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PLA2G6
TPTE2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PLA2G6-TPTE2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PLA2G6-TPTE2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource