UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:PLCD4-VIL1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PLCD4-VIL1
FusionPDB ID: 66008
FusionGDB2.0 ID: 66008
HgeneTgene
Gene symbol

PLCD4

VIL1

Gene ID

84812

7429

Gene namephospholipase C delta 4villin 1
Synonyms-D2S1471|VIL
Cytomap

2q35

2q35

Type of geneprotein-codingprotein-coding
Description1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4PLC delta4phosphoinositide phospholipase C-delta-4villin-1
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000417849, ENST00000432688, 
ENST00000450993, 		ENST00000440053, 
ENST00000248444, ENST00000392114, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 3 X 2=183 X 4 X 3=36
# samples 44
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PLCD4 [Title/Abstract] AND VIL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PLCD4(219487601)-VIL1(219313946), # samples:3
Anticipated loss of major functional domain due to fusion event.PLCD4-VIL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PLCD4-VIL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PLCD4-VIL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PLCD4-VIL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneVIL1

GO:0007173

epidermal growth factor receptor signaling pathway

17229814

TgeneVIL1

GO:0008360

regulation of cell shape

16921170

TgeneVIL1

GO:0009617

response to bacterium

17182858

TgeneVIL1

GO:0010634

positive regulation of epithelial cell migration

17229814

TgeneVIL1

GO:0030041

actin filament polymerization

11500485

TgeneVIL1

GO:0030042

actin filament depolymerization

11500485

TgeneVIL1

GO:0030335

positive regulation of cell migration

16921170

TgeneVIL1

GO:0032233

positive regulation of actin filament bundle assembly

19808673

TgeneVIL1

GO:0051014

actin filament severing

16921170|17182858|19808673

TgeneVIL1

GO:0051125

regulation of actin nucleation

16921170|17182858|19808673

TgeneVIL1

GO:0051693

actin filament capping

16921170|17182858|19808673

TgeneVIL1

GO:0060327

cytoplasmic actin-based contraction involved in cell motility

15342783

TgeneVIL1

GO:0071364

cellular response to epidermal growth factor stimulus

17229814


check buttonFusion gene breakpoints across PLCD4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VIL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A1LE-01APLCD4chr2

219487601

-VIL1chr2

219313946

+
ChimerDB4BRCATCGA-E2-A1LE-01APLCD4chr2

219487601

+VIL1chr2

219313946

+
ChimerDB4BRCATCGA-E2-A1LEPLCD4chr2

219487601

+VIL1chr2

219313945

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000450993PLCD4chr2219487601+ENST00000248444VIL1chr2219313946+518411112971127276
ENST00000450993PLCD4chr2219487601+ENST00000392114VIL1chr2219313946+141311112971127276
ENST00000417849PLCD4chr2219487601+ENST00000248444VIL1chr2219313946+5030957143973276
ENST00000417849PLCD4chr2219487601+ENST00000392114VIL1chr2219313946+1259957143973276
ENST00000432688PLCD4chr2219487601+ENST00000248444VIL1chr2219313946+508710142241030268
ENST00000432688PLCD4chr2219487601+ENST00000392114VIL1chr2219313946+131610142241030268
ENST00000450993PLCD4chr2219487601+ENST00000248444VIL1chr2219313945+518411112971127276
ENST00000450993PLCD4chr2219487601+ENST00000392114VIL1chr2219313945+141311112971127276
ENST00000417849PLCD4chr2219487601+ENST00000248444VIL1chr2219313945+5030957143973276
ENST00000417849PLCD4chr2219487601+ENST00000392114VIL1chr2219313945+1259957143973276
ENST00000432688PLCD4chr2219487601+ENST00000248444VIL1chr2219313945+508710142241030268
ENST00000432688PLCD4chr2219487601+ENST00000392114VIL1chr2219313945+131610142241030268

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000450993ENST00000248444PLCD4chr2219487601+VIL1chr2219313946+0.0011623340.99883765
ENST00000450993ENST00000392114PLCD4chr2219487601+VIL1chr2219313946+0.0076218990.9923781
ENST00000417849ENST00000248444PLCD4chr2219487601+VIL1chr2219313946+0.0010976180.9989023
ENST00000417849ENST00000392114PLCD4chr2219487601+VIL1chr2219313946+0.0043250560.9956749
ENST00000432688ENST00000248444PLCD4chr2219487601+VIL1chr2219313946+0.0012116870.9987883
ENST00000432688ENST00000392114PLCD4chr2219487601+VIL1chr2219313946+0.005006040.994994
ENST00000450993ENST00000248444PLCD4chr2219487601+VIL1chr2219313945+0.0011623340.99883765
ENST00000450993ENST00000392114PLCD4chr2219487601+VIL1chr2219313945+0.0076218990.9923781
ENST00000417849ENST00000248444PLCD4chr2219487601+VIL1chr2219313945+0.0010976180.9989023
ENST00000417849ENST00000392114PLCD4chr2219487601+VIL1chr2219313945+0.0043250560.9956749
ENST00000432688ENST00000248444PLCD4chr2219487601+VIL1chr2219313945+0.0012116870.9987883
ENST00000432688ENST00000392114PLCD4chr2219487601+VIL1chr2219313945+0.005006040.994994

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>66008_66008_1_PLCD4-VIL1_PLCD4_chr2_219487601_ENST00000417849_VIL1_chr2_219313945_ENST00000248444_length(amino acids)=276AA_BP=
MPTVIWCQLVEQWVMASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSE
LLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLM
NVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSD

--------------------------------------------------------------

>66008_66008_2_PLCD4-VIL1_PLCD4_chr2_219487601_ENST00000417849_VIL1_chr2_219313945_ENST00000392114_length(amino acids)=276AA_BP=
MPTVIWCQLVEQWVMASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSE
LLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLM
NVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSD

--------------------------------------------------------------

>66008_66008_3_PLCD4-VIL1_PLCD4_chr2_219487601_ENST00000417849_VIL1_chr2_219313946_ENST00000248444_length(amino acids)=276AA_BP=
MPTVIWCQLVEQWVMASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSE
LLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLM
NVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSD

--------------------------------------------------------------

>66008_66008_4_PLCD4-VIL1_PLCD4_chr2_219487601_ENST00000417849_VIL1_chr2_219313946_ENST00000392114_length(amino acids)=276AA_BP=
MPTVIWCQLVEQWVMASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSE
LLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLM
NVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSD

--------------------------------------------------------------

>66008_66008_5_PLCD4-VIL1_PLCD4_chr2_219487601_ENST00000432688_VIL1_chr2_219313945_ENST00000248444_length(amino acids)=268AA_BP=
MVEQWVMASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSELLRSLAEE
LPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEY

--------------------------------------------------------------

>66008_66008_6_PLCD4-VIL1_PLCD4_chr2_219487601_ENST00000432688_VIL1_chr2_219313945_ENST00000392114_length(amino acids)=268AA_BP=
MVEQWVMASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSELLRSLAEE
LPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEY

--------------------------------------------------------------

>66008_66008_7_PLCD4-VIL1_PLCD4_chr2_219487601_ENST00000432688_VIL1_chr2_219313946_ENST00000248444_length(amino acids)=268AA_BP=
MVEQWVMASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSELLRSLAEE
LPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEY

--------------------------------------------------------------

>66008_66008_8_PLCD4-VIL1_PLCD4_chr2_219487601_ENST00000432688_VIL1_chr2_219313946_ENST00000392114_length(amino acids)=268AA_BP=
MVEQWVMASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSELLRSLAEE
LPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEY

--------------------------------------------------------------

>66008_66008_9_PLCD4-VIL1_PLCD4_chr2_219487601_ENST00000450993_VIL1_chr2_219313945_ENST00000248444_length(amino acids)=276AA_BP=
MPTVIWCQLVEQWVMASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSE
LLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLM
NVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSD

--------------------------------------------------------------

>66008_66008_10_PLCD4-VIL1_PLCD4_chr2_219487601_ENST00000450993_VIL1_chr2_219313945_ENST00000392114_length(amino acids)=276AA_BP=
MPTVIWCQLVEQWVMASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSE
LLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLM
NVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSD

--------------------------------------------------------------

>66008_66008_11_PLCD4-VIL1_PLCD4_chr2_219487601_ENST00000450993_VIL1_chr2_219313946_ENST00000248444_length(amino acids)=276AA_BP=
MPTVIWCQLVEQWVMASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSE
LLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLM
NVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSD

--------------------------------------------------------------

>66008_66008_12_PLCD4-VIL1_PLCD4_chr2_219487601_ENST00000450993_VIL1_chr2_219313946_ENST00000392114_length(amino acids)=276AA_BP=
MPTVIWCQLVEQWVMASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSE
LLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLM
NVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSD

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:219487601/chr2:219313946)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLCD4chr2:219487601chr2:219313945ENST00000417849+617147_158257.3333333333333800.0Calcium binding1
HgenePLCD4chr2:219487601chr2:219313945ENST00000417849+617183_194257.3333333333333800.0Calcium binding2
HgenePLCD4chr2:219487601chr2:219313945ENST00000450993+616147_158257.3333333333333763.0Calcium binding1
HgenePLCD4chr2:219487601chr2:219313945ENST00000450993+616183_194257.3333333333333763.0Calcium binding2
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617147_158257.3333333333333800.0Calcium binding1
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617183_194257.3333333333333800.0Calcium binding2
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616147_158257.3333333333333763.0Calcium binding1
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616183_194257.3333333333333763.0Calcium binding2
HgenePLCD4chr2:219487601chr2:219313945ENST00000417849+617134_169257.3333333333333800.0DomainEF-hand 1
HgenePLCD4chr2:219487601chr2:219313945ENST00000417849+61716_124257.3333333333333800.0DomainPH
HgenePLCD4chr2:219487601chr2:219313945ENST00000417849+617170_205257.3333333333333800.0DomainEF-hand 2
HgenePLCD4chr2:219487601chr2:219313945ENST00000417849+617203_237257.3333333333333800.0DomainEF-hand 3
HgenePLCD4chr2:219487601chr2:219313945ENST00000450993+616134_169257.3333333333333763.0DomainEF-hand 1
HgenePLCD4chr2:219487601chr2:219313945ENST00000450993+61616_124257.3333333333333763.0DomainPH
HgenePLCD4chr2:219487601chr2:219313945ENST00000450993+616170_205257.3333333333333763.0DomainEF-hand 2
HgenePLCD4chr2:219487601chr2:219313945ENST00000450993+616203_237257.3333333333333763.0DomainEF-hand 3
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617134_169257.3333333333333800.0DomainEF-hand 1
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+61716_124257.3333333333333800.0DomainPH
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617170_205257.3333333333333800.0DomainEF-hand 2
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617203_237257.3333333333333800.0DomainEF-hand 3
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616134_169257.3333333333333763.0DomainEF-hand 1
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+61616_124257.3333333333333763.0DomainPH
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616170_205257.3333333333333763.0DomainEF-hand 2
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616203_237257.3333333333333763.0DomainEF-hand 3
HgenePLCD4chr2:219487601chr2:219313945ENST00000417849+617213_243257.3333333333333800.0MotifGBA
HgenePLCD4chr2:219487601chr2:219313945ENST00000450993+616213_243257.3333333333333763.0MotifGBA
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617213_243257.3333333333333800.0MotifGBA
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616213_243257.3333333333333763.0MotifGBA
HgenePLCD4chr2:219487601chr2:219313945ENST00000417849+61726_53257.3333333333333800.0RegionSubstrate binding
HgenePLCD4chr2:219487601chr2:219313945ENST00000450993+61626_53257.3333333333333763.0RegionSubstrate binding
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+61726_53257.3333333333333800.0RegionSubstrate binding
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+61626_53257.3333333333333763.0RegionSubstrate binding
TgeneVIL1chr2:219487601chr2:219313945ENST000002484441820816_824790.0828.0RegionNote=LPA/PIP2-binding site 3
TgeneVIL1chr2:219487601chr2:219313946ENST000002484441820816_824790.0828.0RegionNote=LPA/PIP2-binding site 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLCD4chr2:219487601chr2:219313945ENST00000417849+617440_473257.3333333333333800.0Compositional biasNote=Glu-rich
HgenePLCD4chr2:219487601chr2:219313945ENST00000417849+617479_486257.3333333333333800.0Compositional biasNote=Poly-Lys
HgenePLCD4chr2:219487601chr2:219313945ENST00000450993+616440_473257.3333333333333763.0Compositional biasNote=Glu-rich
HgenePLCD4chr2:219487601chr2:219313945ENST00000450993+616479_486257.3333333333333763.0Compositional biasNote=Poly-Lys
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617440_473257.3333333333333800.0Compositional biasNote=Glu-rich
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617479_486257.3333333333333800.0Compositional biasNote=Poly-Lys
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616440_473257.3333333333333763.0Compositional biasNote=Glu-rich
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616479_486257.3333333333333763.0Compositional biasNote=Poly-Lys
HgenePLCD4chr2:219487601chr2:219313945ENST00000417849+617290_435257.3333333333333800.0DomainPI-PLC X-box
HgenePLCD4chr2:219487601chr2:219313945ENST00000417849+617493_609257.3333333333333800.0DomainPI-PLC Y-box
HgenePLCD4chr2:219487601chr2:219313945ENST00000417849+617609_736257.3333333333333800.0DomainC2
HgenePLCD4chr2:219487601chr2:219313945ENST00000450993+616290_435257.3333333333333763.0DomainPI-PLC X-box
HgenePLCD4chr2:219487601chr2:219313945ENST00000450993+616493_609257.3333333333333763.0DomainPI-PLC Y-box
HgenePLCD4chr2:219487601chr2:219313945ENST00000450993+616609_736257.3333333333333763.0DomainC2
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617290_435257.3333333333333800.0DomainPI-PLC X-box
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617493_609257.3333333333333800.0DomainPI-PLC Y-box
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617609_736257.3333333333333800.0DomainC2
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616290_435257.3333333333333763.0DomainPI-PLC X-box
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616493_609257.3333333333333763.0DomainPI-PLC Y-box
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616609_736257.3333333333333763.0DomainC2
HgenePLCD4chr2:219487601chr2:219313945ENST00000417849+617731_734257.3333333333333800.0MotifNote=PDZ-binding
HgenePLCD4chr2:219487601chr2:219313945ENST00000450993+616731_734257.3333333333333763.0MotifNote=PDZ-binding
HgenePLCD4chr2:219487601chr2:219313946ENST00000417849+617731_734257.3333333333333800.0MotifNote=PDZ-binding
HgenePLCD4chr2:219487601chr2:219313946ENST00000450993+616731_734257.3333333333333763.0MotifNote=PDZ-binding
TgeneVIL1chr2:219487601chr2:219313945ENST000002484441820761_827790.0828.0DomainHP
TgeneVIL1chr2:219487601chr2:219313946ENST000002484441820761_827790.0828.0DomainHP
TgeneVIL1chr2:219487601chr2:219313945ENST000002484441820112_119790.0828.0RegionNote=LPA/PIP2-binding site 1
TgeneVIL1chr2:219487601chr2:219313945ENST000002484441820138_146790.0828.0RegionNote=LPA/PIP2-binding site 2
TgeneVIL1chr2:219487601chr2:219313945ENST0000024844418202_126790.0828.0RegionNote=Necessary for homodimerization
TgeneVIL1chr2:219487601chr2:219313945ENST0000024844418202_734790.0828.0RegionNote=Core
TgeneVIL1chr2:219487601chr2:219313945ENST000002484441820735_827790.0828.0RegionNote=Headpiece
TgeneVIL1chr2:219487601chr2:219313946ENST000002484441820112_119790.0828.0RegionNote=LPA/PIP2-binding site 1
TgeneVIL1chr2:219487601chr2:219313946ENST000002484441820138_146790.0828.0RegionNote=LPA/PIP2-binding site 2
TgeneVIL1chr2:219487601chr2:219313946ENST0000024844418202_126790.0828.0RegionNote=Necessary for homodimerization
TgeneVIL1chr2:219487601chr2:219313946ENST0000024844418202_734790.0828.0RegionNote=Core
TgeneVIL1chr2:219487601chr2:219313946ENST000002484441820735_827790.0828.0RegionNote=Headpiece
TgeneVIL1chr2:219487601chr2:219313945ENST000002484441820148_188790.0828.0RepeatNote=Gelsolin-like 2
TgeneVIL1chr2:219487601chr2:219313945ENST000002484441820265_309790.0828.0RepeatNote=Gelsolin-like 3
TgeneVIL1chr2:219487601chr2:219313945ENST00000248444182027_76790.0828.0RepeatNote=Gelsolin-like 1
TgeneVIL1chr2:219487601chr2:219313945ENST000002484441820407_457790.0828.0RepeatNote=Gelsolin-like 4
TgeneVIL1chr2:219487601chr2:219313945ENST000002484441820528_568790.0828.0RepeatNote=Gelsolin-like 5
TgeneVIL1chr2:219487601chr2:219313945ENST000002484441820631_672790.0828.0RepeatNote=Gelsolin-like 6
TgeneVIL1chr2:219487601chr2:219313946ENST000002484441820148_188790.0828.0RepeatNote=Gelsolin-like 2
TgeneVIL1chr2:219487601chr2:219313946ENST000002484441820265_309790.0828.0RepeatNote=Gelsolin-like 3
TgeneVIL1chr2:219487601chr2:219313946ENST00000248444182027_76790.0828.0RepeatNote=Gelsolin-like 1
TgeneVIL1chr2:219487601chr2:219313946ENST000002484441820407_457790.0828.0RepeatNote=Gelsolin-like 4
TgeneVIL1chr2:219487601chr2:219313946ENST000002484441820528_568790.0828.0RepeatNote=Gelsolin-like 5
TgeneVIL1chr2:219487601chr2:219313946ENST000002484441820631_672790.0828.0RepeatNote=Gelsolin-like 6


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PLCD4
VIL1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to PLCD4-VIL1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to PLCD4-VIL1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource