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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PLIN1-ACSL6

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PLIN1-ACSL6
	FusionPDB ID: 66353
	FusionGDB2.0 ID: 66353
		Hgene	Tgene
	Gene symbol	PLIN1	ACSL6
	Gene ID	5346	23305
	Gene name	perilipin 1	acyl-CoA synthetase long chain family member 6
	Synonyms	FPLD4\|PERI\|PLIN	ACS2\|FACL6\|LACS 6\|LACS2\|LACS5
	Cytomap	15q26.1	5q31.1
	Type of gene	protein-coding	protein-coding
	Description	perilipin-1lipid droplet-associated protein	long-chain-fatty-acid--CoA ligase 6arachidonate--CoA ligasefatty-acid-Coenzyme A ligase, long-chain 6long fatty acyl-CoA synthetase 2
	Modification date	20200315	20200313
	UniProtAcc	.	Q9UKU0
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000300055, ENST00000430628,	ENST00000357096, ENST00000379240, ENST00000431707, ENST00000477640, ENST00000296869, ENST00000379244, ENST00000379246, ENST00000379249, ENST00000379255, ENST00000379264, ENST00000379272, ENST00000543479, ENST00000544770,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	2 X 2 X 2=8	6 X 8 X 8=384
	# samples	2	10
	** MAII score	log2(2/8*10)=1.32192809488736	log2(10/384*10)=-1.94110631094643 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PLIN1 [Title/Abstract] AND ACSL6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PLIN1(90212731)-ACSL6(131321151), # samples:3
Anticipated loss of major functional domain due to fusion event.	PLIN1-ACSL6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PLIN1-ACSL6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PLIN1-ACSL6 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PLIN1-ACSL6 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PLIN1-ACSL6 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PLIN1-ACSL6 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ACSL6	GO:0001676	long-chain fatty acid metabolic process	24269233

Fusion gene breakpoints across PLIN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACSL6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E9-A1RC-01A	PLIN1	chr15	90212731	-	ACSL6	chr5	131321151	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000430628	PLIN1	chr15	90212731	-	ENST00000379249	ACSL6	chr5	131321151	-	2106	891	120	2105	661
ENST00000430628	PLIN1	chr15	90212731	-	ENST00000379264	ACSL6	chr5	131321151	-	6457	891	120	2195	691
ENST00000430628	PLIN1	chr15	90212731	-	ENST00000379272	ACSL6	chr5	131321151	-	4826	891	120	2195	691
ENST00000430628	PLIN1	chr15	90212731	-	ENST00000379255	ACSL6	chr5	131321151	-	2412	891	120	2075	651
ENST00000430628	PLIN1	chr15	90212731	-	ENST00000296869	ACSL6	chr5	131321151	-	2528	891	120	2195	691
ENST00000430628	PLIN1	chr15	90212731	-	ENST00000379246	ACSL6	chr5	131321151	-	2525	891	120	2195	691
ENST00000430628	PLIN1	chr15	90212731	-	ENST00000379244	ACSL6	chr5	131321151	-	2523	891	120	2195	691
ENST00000430628	PLIN1	chr15	90212731	-	ENST00000544770	ACSL6	chr5	131321151	-	2518	891	120	2195	691
ENST00000430628	PLIN1	chr15	90212731	-	ENST00000543479	ACSL6	chr5	131321151	-	2196	891	120	2195	691

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000430628	ENST00000379249	PLIN1	chr15	90212731	-	ACSL6	chr5	131321151	-	0.007946049	0.992054
ENST00000430628	ENST00000379264	PLIN1	chr15	90212731	-	ACSL6	chr5	131321151	-	0.00049999	0.99950004
ENST00000430628	ENST00000379272	PLIN1	chr15	90212731	-	ACSL6	chr5	131321151	-	0.00091878	0.99908125
ENST00000430628	ENST00000379255	PLIN1	chr15	90212731	-	ACSL6	chr5	131321151	-	0.003565486	0.99643457
ENST00000430628	ENST00000296869	PLIN1	chr15	90212731	-	ACSL6	chr5	131321151	-	0.003871557	0.99612844
ENST00000430628	ENST00000379246	PLIN1	chr15	90212731	-	ACSL6	chr5	131321151	-	0.003509265	0.99649066
ENST00000430628	ENST00000379244	PLIN1	chr15	90212731	-	ACSL6	chr5	131321151	-	0.003929666	0.9960704
ENST00000430628	ENST00000544770	PLIN1	chr15	90212731	-	ACSL6	chr5	131321151	-	0.003602843	0.9963972
ENST00000430628	ENST00000543479	PLIN1	chr15	90212731	-	ACSL6	chr5	131321151	-	0.007831858	0.9921681

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>66353_66353_1_PLIN1-ACSL6_PLIN1_chr15_90212731_ENST00000430628_ACSL6_chr5_131321151_ENST00000296869_length(amino acids)=691AA_BP=257
MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANEL
ACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLA
LGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLPPQPDDLSIVCFT
SGTTGNPKGAMLTHGNVVADFSGFLKVTESQWAPTCADVHISYLPLAHMFERMVQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVV
PRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYE
GYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLP
AGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILE

--------------------------------------------------------------

>66353_66353_2_PLIN1-ACSL6_PLIN1_chr15_90212731_ENST00000430628_ACSL6_chr5_131321151_ENST00000379244_length(amino acids)=691AA_BP=257
MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANEL
ACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLA
LGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLPPQPDDLSIVCFT
SGTTGNPKGAMLTHGNVVADFSGFLKVTESQWAPTCADVHISYLPLAHMFERMVQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVV
PRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYE
GYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLP
AGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILE

--------------------------------------------------------------

>66353_66353_3_PLIN1-ACSL6_PLIN1_chr15_90212731_ENST00000430628_ACSL6_chr5_131321151_ENST00000379246_length(amino acids)=691AA_BP=257
MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANEL
ACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLA
LGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLPPQPDDLSIVCFT
SGTTGNPKGAMLTHGNVVADFSGFLKVTEKVIFPRQDDVLISFLPLAHMFERVIQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVV
PRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYE
GYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLP
AGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILE

--------------------------------------------------------------

>66353_66353_4_PLIN1-ACSL6_PLIN1_chr15_90212731_ENST00000430628_ACSL6_chr5_131321151_ENST00000379249_length(amino acids)=661AA_BP=257
MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANEL
ACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLA
LGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLPPQPDDLSIVCFT
SGTTGNPKGAMLTHGNVVADFSGFLKVTESQWAPTCADVHISYLPLAHMFERMVQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVV
PRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYE
GYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLP
AGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILE

--------------------------------------------------------------

>66353_66353_5_PLIN1-ACSL6_PLIN1_chr15_90212731_ENST00000430628_ACSL6_chr5_131321151_ENST00000379255_length(amino acids)=651AA_BP=257
MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANEL
ACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLA
LGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLPPQPDDLSIVCFT
SGTTGNPKGAMLTHGNVVADFSGFLKVTEGDIRLLSDDMKALCPTIFPVVPRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGII
RNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEE
LNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQI
YVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQVKAIHIHSDMFSVQNGLLTPTLKA

--------------------------------------------------------------

>66353_66353_6_PLIN1-ACSL6_PLIN1_chr15_90212731_ENST00000430628_ACSL6_chr5_131321151_ENST00000379264_length(amino acids)=691AA_BP=257
MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANEL
ACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLA
LGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLPPQPDDLSIVCFT
SGTTGNPKGAMLTHGNVVADFSGFLKVTEKVIFPRQDDVLISFLPLAHMFERVIQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVV
PRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYE
GYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLP
AGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILE

--------------------------------------------------------------

>66353_66353_7_PLIN1-ACSL6_PLIN1_chr15_90212731_ENST00000430628_ACSL6_chr5_131321151_ENST00000379272_length(amino acids)=691AA_BP=257
MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANEL
ACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLA
LGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLPPQPDDLSIVCFT
SGTTGNPKGAMLTHGNVVADFSGFLKVTEKVIFPRQDDVLISFLPLAHMFERVIQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVV
PRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYE
GYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLP
AGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILE

--------------------------------------------------------------

>66353_66353_8_PLIN1-ACSL6_PLIN1_chr15_90212731_ENST00000430628_ACSL6_chr5_131321151_ENST00000543479_length(amino acids)=691AA_BP=257
MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANEL
ACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLA
LGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLPPQPDDLSIVCFT
SGTTGNPKGAMLTHGNVVADFSGFLKVTESQWAPTCADVHISYLPLAHMFERMVQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVV
PRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYE
GYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLP
AGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILE

--------------------------------------------------------------

>66353_66353_9_PLIN1-ACSL6_PLIN1_chr15_90212731_ENST00000430628_ACSL6_chr5_131321151_ENST00000544770_length(amino acids)=691AA_BP=257
MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANEL
ACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLA
LGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLPPQPDDLSIVCFT
SGTTGNPKGAMLTHGNVVADFSGFLKVTEKVIFPRQDDVLISFLPLAHMFERVIQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVV
PRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYE
GYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLP
AGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:90212731/chr5:131321151)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ACSL6 Q9UKU0
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490, PubMed:24269233). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. {ECO:0000269\|PubMed:22633490, ECO:0000269\|PubMed:24269233}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PLIN1

chr15:90212731

chr5:131321151

ENST00000300055

307_316

257.0

523.0

Compositional bias

Note=Poly-Glu

Hgene

PLIN1

chr15:90212731

chr5:131321151

ENST00000430628

307_316

257.0

523.0

Compositional bias

Note=Poly-Glu

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000296869

46_697

288.0

723.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000357096

46_697

228.0

623.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000379240

46_697

263.0

698.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000379244

46_697

263.0

698.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000379246

46_697

274.0

709.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000379249

46_697

263.0

668.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000379255

46_697

228.0

623.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000379264

46_697

288.0

723.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000379272

46_697

278.0

713.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000543479

46_697

263.0

698.0

Topological domain

Cytoplasmic

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000296869

25_45

288.0

723.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000357096

25_45

228.0

623.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000379240

25_45

263.0

698.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000379244

25_45

263.0

698.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000379246

25_45

274.0

709.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000379249

25_45

263.0

668.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000379255

25_45

228.0

623.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000379264

25_45

288.0

723.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000379272

25_45

278.0

713.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

ACSL6

chr15:90212731

chr5:131321151

ENST00000543479

25_45

263.0

698.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PLIN1
ACSL6

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to PLIN1-ACSL6

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PLIN1-ACSL6

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source