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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PLXDC2-SYNE1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PLXDC2-SYNE1
FusionPDB ID: 66512
FusionGDB2.0 ID: 66512
HgeneTgene
Gene symbol

PLXDC2

SYNE1

Gene ID

84898

23345

Gene nameplexin domain containing 2spectrin repeat containing nuclear envelope protein 1
SynonymsTEM7R8B|AMCM|ARCA1|C6orf98|CPG2|EDMD4|KASH1|MYNE1|Nesp1|SCAR8|dJ45H2.2
Cytomap

10p12.31

6q25.2

Type of geneprotein-codingprotein-coding
Descriptionplexin domain-containing protein 21200007L24Riktumor endothelial marker 7-related proteinnesprin-1CPG2 full lengthKASH domain-containing protein 1enaptinmyocyte nuclear envelope protein 1nesprin 1spectrin repeat containing, nuclear envelope 1synaptic nuclear envelope protein 1synaptic nuclei expressed gene 1
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000377242, ENST00000377252, 
ENST00000377238, 		ENST00000265368, 
ENST00000341594, ENST00000347037, 
ENST00000354674, ENST00000356820, 
ENST00000367248, ENST00000367253, 
ENST00000413186, ENST00000423061, 
ENST00000448038, ENST00000466159, 
ENST00000495090, ENST00000539504, 
ENST00000367255, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score19 X 12 X 11=250816 X 18 X 9=2592
# samples 1918
** MAII scorelog2(19/2508*10)=-3.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/2592*10)=-3.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PLXDC2 [Title/Abstract] AND SYNE1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PLXDC2(20290915)-SYNE1(152793548), # samples:4
Anticipated loss of major functional domain due to fusion event.PLXDC2-SYNE1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PLXDC2-SYNE1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PLXDC2-SYNE1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PLXDC2-SYNE1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSYNE1

GO:0007030

Golgi organization

12808039

TgeneSYNE1

GO:0042692

muscle cell differentiation

11792814

TgeneSYNE1

GO:0090286

cytoskeletal anchoring at nuclear membrane

18396275

TgeneSYNE1

GO:0090292

nuclear matrix anchoring at nuclear membrane

11801724


check buttonFusion gene breakpoints across PLXDC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SYNE1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A07R-01APLXDC2chr10

20290915

-SYNE1chr6

152793548

-
ChimerDB4BRCATCGA-A8-A07R-01APLXDC2chr10

20290915

+SYNE1chr6

152793548

-
ChimerDB4BRCATCGA-A8-A07RPLXDC2chr10

20290915

+SYNE1chr6

152793548

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377242PLXDC2chr1020290915+ENST00000367255SYNE1chr6152793548-269611165841262088455
ENST00000377252PLXDC2chr1020290915+ENST00000367255SYNE1chr6152793548-269611165841262088455

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377242ENST00000367255PLXDC2chr1020290915+SYNE1chr6152793548-0.0088954120.99110454
ENST00000377252ENST00000367255PLXDC2chr1020290915+SYNE1chr6152793548-0.0088954120.99110454

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>66512_66512_1_PLXDC2-SYNE1_PLXDC2_chr10_20290915_ENST00000377242_SYNE1_chr6_152793548_ENST00000367255_length(amino acids)=8455AA_BP=108
MARFPKADLAAAGVMLLCHFFTDQFQFADGKPGDQILDWQYGVTQAFPHTEEEVEVDSHAYSHRWKRNLDFLKAVDTNRASVGQDSPEPR
SFTDLLLDDGQDNNTQIEDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESK
LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVI
SNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ
ADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKL
KEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKF
VTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQ
RVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHR
VFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKG
EAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVK
NSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQE
RRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKS
IKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQ
FVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQAL
ESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKV
EGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIK
LFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAE
FLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERI
QNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAF
APEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDL
DNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLR
AEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTK
VEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFS
ESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQ
CLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAG
QEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLN
MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVL
LDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEE
LHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMA
LSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG
LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLS
TLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEE
IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD
KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS
GWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVR
LHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAY
QHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVN
SRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHS
LLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEK
KAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMS
GRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLE
HELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKL
VQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEIN
HLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKM
IEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICS
ELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHI
CLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFD
KACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDK
FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKM
LHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDL
APHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQE
EVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNG
LDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREE
VIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQ
EKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPP
LMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQK
EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGC
NSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQL
REQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQ
ATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQEAVVQYEQ
YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLD
GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQ
EFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILM
LQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLST
KATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQG
TAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQEL
GMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGA
KRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLL
GRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQV
EQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMI
LTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLY
QHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT
QQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPS
RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKS
WQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNK
KEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEK
QERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNK
DIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLE
ALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQ
SFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSN
QWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLL
LSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVG
SWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIE
EMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA
HIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRL
KIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMV
HEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQ
LIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLA
QPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQT
ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKW
QQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWD
RVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN
AEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSV

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>66512_66512_2_PLXDC2-SYNE1_PLXDC2_chr10_20290915_ENST00000377252_SYNE1_chr6_152793548_ENST00000367255_length(amino acids)=8455AA_BP=108
MARFPKADLAAAGVMLLCHFFTDQFQFADGKPGDQILDWQYGVTQAFPHTEEEVEVDSHAYSHRWKRNLDFLKAVDTNRASVGQDSPEPR
SFTDLLLDDGQDNNTQIEDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESK
LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVI
SNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ
ADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKL
KEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKF
VTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQ
RVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHR
VFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKG
EAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVK
NSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQE
RRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKS
IKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQ
FVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQAL
ESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKV
EGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIK
LFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAE
FLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERI
QNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAF
APEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDL
DNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLR
AEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTK
VEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFS
ESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQ
CLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAG
QEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLN
MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVL
LDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEE
LHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMA
LSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG
LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLS
TLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEE
IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD
KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS
GWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVR
LHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAY
QHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVN
SRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHS
LLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEK
KAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMS
GRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLE
HELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKL
VQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEIN
HLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKM
IEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICS
ELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHI
CLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFD
KACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDK
FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKM
LHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDL
APHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQE
EVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNG
LDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREE
VIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQ
EKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPP
LMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQK
EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGC
NSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQL
REQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQ
ATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQEAVVQYEQ
YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLD
GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQ
EFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILM
LQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLST
KATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQG
TAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQEL
GMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGA
KRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLL
GRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQV
EQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMI
LTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLY
QHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT
QQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPS
RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKS
WQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNK
KEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEK
QERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNK
DIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLE
ALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQ
SFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSN
QWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLL
LSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVG
SWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIE
EMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA
HIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRL
KIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMV
HEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQ
LIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLA
QPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQT
ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKW
QQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWD
RVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN
AEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSV

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:20290915/chr6:152793548)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311368663_8729450.01726.0Compositional biasNote=Ser-rich
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131468663_8729450.08798.0Compositional biasNote=Ser-rich
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611318663_8729450.01444.0Compositional biasNote=Ser-rich
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131468663_8729457.08750.0Compositional biasNote=Ser-rich
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311368738_8797450.01726.0DomainKASH
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131468738_8797450.08798.0DomainKASH
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611318738_8797450.01444.0DomainKASH
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131468738_8797457.08750.0DomainKASH
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311361025_1122450.01726.0RepeatNote=Spectrin 8
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311361123_1246450.01726.0RepeatNote=Spectrin 9
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311361247_1335450.01726.0RepeatNote=Spectrin 10
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311361336_1444450.01726.0RepeatNote=Spectrin 11
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311361445_1550450.01726.0RepeatNote=Spectrin 12
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311361551_1653450.01726.0RepeatNote=Spectrin 13
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311361654_1763450.01726.0RepeatNote=Spectrin 14
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311361764_1879450.01726.0RepeatNote=Spectrin 15
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311361880_1976450.01726.0RepeatNote=Spectrin 16
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311361977_2081450.01726.0RepeatNote=Spectrin 17
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311362082_2195450.01726.0RepeatNote=Spectrin 18
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311362196_2303450.01726.0RepeatNote=Spectrin 19
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311362304_2401450.01726.0RepeatNote=Spectrin 20
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311362402_2513450.01726.0RepeatNote=Spectrin 21
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311362514_2619450.01726.0RepeatNote=Spectrin 22
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311362620_2731450.01726.0RepeatNote=Spectrin 23
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311362732_2838450.01726.0RepeatNote=Spectrin 24
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311362839_2962450.01726.0RepeatNote=Spectrin 25
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311362963_3062450.01726.0RepeatNote=Spectrin 26
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311363063_3171450.01726.0RepeatNote=Spectrin 27
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311363172_3275450.01726.0RepeatNote=Spectrin 28
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311363276_3387450.01726.0RepeatNote=Spectrin 29
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311363388_3490450.01726.0RepeatNote=Spectrin 30
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311363491_3593450.01726.0RepeatNote=Spectrin 31
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311363594_3720450.01726.0RepeatNote=Spectrin 32
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311363721_3814450.01726.0RepeatNote=Spectrin 33
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311363815_3920450.01726.0RepeatNote=Spectrin 34
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311363921_4028450.01726.0RepeatNote=Spectrin 35
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311364029_4139450.01726.0RepeatNote=Spectrin 36
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311364140_4235450.01726.0RepeatNote=Spectrin 37
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311364236_4339450.01726.0RepeatNote=Spectrin 38
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311364340_4451450.01726.0RepeatNote=Spectrin 39
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311364452_4560450.01726.0RepeatNote=Spectrin 40
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311364561_4669450.01726.0RepeatNote=Spectrin 41
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311364670_4776450.01726.0RepeatNote=Spectrin 42
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311364777_4882450.01726.0RepeatNote=Spectrin 43
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311364883_4991450.01726.0RepeatNote=Spectrin 44
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311364992_5099450.01726.0RepeatNote=Spectrin 45
TgeneSYNE1chr10:20290915chr6:152793548ENST000003672531136503_609450.01726.0RepeatNote=Spectrin 3
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311365100_5209450.01726.0RepeatNote=Spectrin 46
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311365210_5318450.01726.0RepeatNote=Spectrin 47
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311365319_5424450.01726.0RepeatNote=Spectrin 48
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311365425_5522450.01726.0RepeatNote=Spectrin 49
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311365523_5630450.01726.0RepeatNote=Spectrin 50
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311365631_5736450.01726.0RepeatNote=Spectrin 51
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311365737_5842450.01726.0RepeatNote=Spectrin 52
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311365962_6071450.01726.0RepeatNote=Spectrin 53
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311366072_6178450.01726.0RepeatNote=Spectrin 54
TgeneSYNE1chr10:20290915chr6:152793548ENST000003672531136610_703450.01726.0RepeatNote=Spectrin 4
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311366374_6485450.01726.0RepeatNote=Spectrin 55
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311366486_6581450.01726.0RepeatNote=Spectrin 56
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311366582_6691450.01726.0RepeatNote=Spectrin 57
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311366692_6795450.01726.0RepeatNote=Spectrin 58
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311366796_6902450.01726.0RepeatNote=Spectrin 59
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311366903_7020450.01726.0RepeatNote=Spectrin 60
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311367021_7128450.01726.0RepeatNote=Spectrin 61
TgeneSYNE1chr10:20290915chr6:152793548ENST000003672531136704_815450.01726.0RepeatNote=Spectrin 5
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311367129_7237450.01726.0RepeatNote=Spectrin 62
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311367238_7350450.01726.0RepeatNote=Spectrin 63
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311367351_7454450.01726.0RepeatNote=Spectrin 64
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311367455_7558450.01726.0RepeatNote=Spectrin 65
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311367559_7671450.01726.0RepeatNote=Spectrin 66
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311367672_7783450.01726.0RepeatNote=Spectrin 67
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311367784_7883450.01726.0RepeatNote=Spectrin 68
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311367884_7997450.01726.0RepeatNote=Spectrin 69
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311367998_8106450.01726.0RepeatNote=Spectrin 70
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311368107_8216450.01726.0RepeatNote=Spectrin 71
TgeneSYNE1chr10:20290915chr6:152793548ENST000003672531136816_923450.01726.0RepeatNote=Spectrin 6
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311368329_8438450.01726.0RepeatNote=Spectrin 72
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311368439_8548450.01726.0RepeatNote=Spectrin 73
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311368549_8666450.01726.0RepeatNote=Spectrin 74
TgeneSYNE1chr10:20290915chr6:152793548ENST000003672531136924_1024450.01726.0RepeatNote=Spectrin 7
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131461025_1122450.08798.0RepeatNote=Spectrin 8
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131461123_1246450.08798.0RepeatNote=Spectrin 9
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131461247_1335450.08798.0RepeatNote=Spectrin 10
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131461336_1444450.08798.0RepeatNote=Spectrin 11
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131461445_1550450.08798.0RepeatNote=Spectrin 12
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131461551_1653450.08798.0RepeatNote=Spectrin 13
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131461654_1763450.08798.0RepeatNote=Spectrin 14
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131461764_1879450.08798.0RepeatNote=Spectrin 15
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131461880_1976450.08798.0RepeatNote=Spectrin 16
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131461977_2081450.08798.0RepeatNote=Spectrin 17
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131462082_2195450.08798.0RepeatNote=Spectrin 18
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131462196_2303450.08798.0RepeatNote=Spectrin 19
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131462304_2401450.08798.0RepeatNote=Spectrin 20
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131462402_2513450.08798.0RepeatNote=Spectrin 21
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131462514_2619450.08798.0RepeatNote=Spectrin 22
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131462620_2731450.08798.0RepeatNote=Spectrin 23
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131462732_2838450.08798.0RepeatNote=Spectrin 24
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131462839_2962450.08798.0RepeatNote=Spectrin 25
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131462963_3062450.08798.0RepeatNote=Spectrin 26
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131463063_3171450.08798.0RepeatNote=Spectrin 27
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131463172_3275450.08798.0RepeatNote=Spectrin 28
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131463276_3387450.08798.0RepeatNote=Spectrin 29
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131463388_3490450.08798.0RepeatNote=Spectrin 30
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131463491_3593450.08798.0RepeatNote=Spectrin 31
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131463594_3720450.08798.0RepeatNote=Spectrin 32
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131463721_3814450.08798.0RepeatNote=Spectrin 33
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131463815_3920450.08798.0RepeatNote=Spectrin 34
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131463921_4028450.08798.0RepeatNote=Spectrin 35
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131464029_4139450.08798.0RepeatNote=Spectrin 36
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131464140_4235450.08798.0RepeatNote=Spectrin 37
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131464236_4339450.08798.0RepeatNote=Spectrin 38
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131464340_4451450.08798.0RepeatNote=Spectrin 39
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131464452_4560450.08798.0RepeatNote=Spectrin 40
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131464561_4669450.08798.0RepeatNote=Spectrin 41
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131464670_4776450.08798.0RepeatNote=Spectrin 42
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131464777_4882450.08798.0RepeatNote=Spectrin 43
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131464883_4991450.08798.0RepeatNote=Spectrin 44
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131464992_5099450.08798.0RepeatNote=Spectrin 45
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725513146503_609450.08798.0RepeatNote=Spectrin 3
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131465100_5209450.08798.0RepeatNote=Spectrin 46
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131465210_5318450.08798.0RepeatNote=Spectrin 47
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131465319_5424450.08798.0RepeatNote=Spectrin 48
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131465425_5522450.08798.0RepeatNote=Spectrin 49
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131465523_5630450.08798.0RepeatNote=Spectrin 50
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131465631_5736450.08798.0RepeatNote=Spectrin 51
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131465737_5842450.08798.0RepeatNote=Spectrin 52
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131465962_6071450.08798.0RepeatNote=Spectrin 53
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131466072_6178450.08798.0RepeatNote=Spectrin 54
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725513146610_703450.08798.0RepeatNote=Spectrin 4
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131466374_6485450.08798.0RepeatNote=Spectrin 55
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131466486_6581450.08798.0RepeatNote=Spectrin 56
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131466582_6691450.08798.0RepeatNote=Spectrin 57
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131466692_6795450.08798.0RepeatNote=Spectrin 58
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131466796_6902450.08798.0RepeatNote=Spectrin 59
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131466903_7020450.08798.0RepeatNote=Spectrin 60
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131467021_7128450.08798.0RepeatNote=Spectrin 61
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725513146704_815450.08798.0RepeatNote=Spectrin 5
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131467129_7237450.08798.0RepeatNote=Spectrin 62
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131467238_7350450.08798.0RepeatNote=Spectrin 63
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131467351_7454450.08798.0RepeatNote=Spectrin 64
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131467455_7558450.08798.0RepeatNote=Spectrin 65
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131467559_7671450.08798.0RepeatNote=Spectrin 66
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131467672_7783450.08798.0RepeatNote=Spectrin 67
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131467784_7883450.08798.0RepeatNote=Spectrin 68
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131467884_7997450.08798.0RepeatNote=Spectrin 69
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131467998_8106450.08798.0RepeatNote=Spectrin 70
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131468107_8216450.08798.0RepeatNote=Spectrin 71
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725513146816_923450.08798.0RepeatNote=Spectrin 6
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131468329_8438450.08798.0RepeatNote=Spectrin 72
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131468439_8548450.08798.0RepeatNote=Spectrin 73
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131468549_8666450.08798.0RepeatNote=Spectrin 74
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725513146924_1024450.08798.0RepeatNote=Spectrin 7
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611311025_1122450.01444.0RepeatNote=Spectrin 8
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611311123_1246450.01444.0RepeatNote=Spectrin 9
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611311247_1335450.01444.0RepeatNote=Spectrin 10
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611311336_1444450.01444.0RepeatNote=Spectrin 11
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611311445_1550450.01444.0RepeatNote=Spectrin 12
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611311551_1653450.01444.0RepeatNote=Spectrin 13
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611311654_1763450.01444.0RepeatNote=Spectrin 14
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611311764_1879450.01444.0RepeatNote=Spectrin 15
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611311880_1976450.01444.0RepeatNote=Spectrin 16
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611311977_2081450.01444.0RepeatNote=Spectrin 17
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611312082_2195450.01444.0RepeatNote=Spectrin 18
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611312196_2303450.01444.0RepeatNote=Spectrin 19
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611312304_2401450.01444.0RepeatNote=Spectrin 20
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611312402_2513450.01444.0RepeatNote=Spectrin 21
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611312514_2619450.01444.0RepeatNote=Spectrin 22
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611312620_2731450.01444.0RepeatNote=Spectrin 23
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611312732_2838450.01444.0RepeatNote=Spectrin 24
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611312839_2962450.01444.0RepeatNote=Spectrin 25
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611312963_3062450.01444.0RepeatNote=Spectrin 26
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611313063_3171450.01444.0RepeatNote=Spectrin 27
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611313172_3275450.01444.0RepeatNote=Spectrin 28
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611313276_3387450.01444.0RepeatNote=Spectrin 29
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611313388_3490450.01444.0RepeatNote=Spectrin 30
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611313491_3593450.01444.0RepeatNote=Spectrin 31
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611313594_3720450.01444.0RepeatNote=Spectrin 32
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611313721_3814450.01444.0RepeatNote=Spectrin 33
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611313815_3920450.01444.0RepeatNote=Spectrin 34
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611313921_4028450.01444.0RepeatNote=Spectrin 35
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611314029_4139450.01444.0RepeatNote=Spectrin 36
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611314140_4235450.01444.0RepeatNote=Spectrin 37
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611314236_4339450.01444.0RepeatNote=Spectrin 38
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611314340_4451450.01444.0RepeatNote=Spectrin 39
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611314452_4560450.01444.0RepeatNote=Spectrin 40
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611314561_4669450.01444.0RepeatNote=Spectrin 41
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611314670_4776450.01444.0RepeatNote=Spectrin 42
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611314777_4882450.01444.0RepeatNote=Spectrin 43
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611314883_4991450.01444.0RepeatNote=Spectrin 44
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611314992_5099450.01444.0RepeatNote=Spectrin 45
TgeneSYNE1chr10:20290915chr6:152793548ENST000004131861131503_609450.01444.0RepeatNote=Spectrin 3
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611315100_5209450.01444.0RepeatNote=Spectrin 46
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611315210_5318450.01444.0RepeatNote=Spectrin 47
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611315319_5424450.01444.0RepeatNote=Spectrin 48
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611315425_5522450.01444.0RepeatNote=Spectrin 49
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611315523_5630450.01444.0RepeatNote=Spectrin 50
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611315631_5736450.01444.0RepeatNote=Spectrin 51
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611315737_5842450.01444.0RepeatNote=Spectrin 52
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611315962_6071450.01444.0RepeatNote=Spectrin 53
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611316072_6178450.01444.0RepeatNote=Spectrin 54
TgeneSYNE1chr10:20290915chr6:152793548ENST000004131861131610_703450.01444.0RepeatNote=Spectrin 4
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611316374_6485450.01444.0RepeatNote=Spectrin 55
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611316486_6581450.01444.0RepeatNote=Spectrin 56
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611316582_6691450.01444.0RepeatNote=Spectrin 57
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611316692_6795450.01444.0RepeatNote=Spectrin 58
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611316796_6902450.01444.0RepeatNote=Spectrin 59
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611316903_7020450.01444.0RepeatNote=Spectrin 60
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611317021_7128450.01444.0RepeatNote=Spectrin 61
TgeneSYNE1chr10:20290915chr6:152793548ENST000004131861131704_815450.01444.0RepeatNote=Spectrin 5
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611317129_7237450.01444.0RepeatNote=Spectrin 62
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611317238_7350450.01444.0RepeatNote=Spectrin 63
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611317351_7454450.01444.0RepeatNote=Spectrin 64
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611317455_7558450.01444.0RepeatNote=Spectrin 65
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611317559_7671450.01444.0RepeatNote=Spectrin 66
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611317672_7783450.01444.0RepeatNote=Spectrin 67
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611317784_7883450.01444.0RepeatNote=Spectrin 68
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611317884_7997450.01444.0RepeatNote=Spectrin 69
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611317998_8106450.01444.0RepeatNote=Spectrin 70
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611318107_8216450.01444.0RepeatNote=Spectrin 71
TgeneSYNE1chr10:20290915chr6:152793548ENST000004131861131816_923450.01444.0RepeatNote=Spectrin 6
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611318329_8438450.01444.0RepeatNote=Spectrin 72
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611318439_8548450.01444.0RepeatNote=Spectrin 73
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611318549_8666450.01444.0RepeatNote=Spectrin 74
TgeneSYNE1chr10:20290915chr6:152793548ENST000004131861131924_1024450.01444.0RepeatNote=Spectrin 7
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131461025_1122457.08750.0RepeatNote=Spectrin 8
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131461123_1246457.08750.0RepeatNote=Spectrin 9
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131461247_1335457.08750.0RepeatNote=Spectrin 10
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131461336_1444457.08750.0RepeatNote=Spectrin 11
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131461445_1550457.08750.0RepeatNote=Spectrin 12
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131461551_1653457.08750.0RepeatNote=Spectrin 13
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131461654_1763457.08750.0RepeatNote=Spectrin 14
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131461764_1879457.08750.0RepeatNote=Spectrin 15
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131461880_1976457.08750.0RepeatNote=Spectrin 16
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131461977_2081457.08750.0RepeatNote=Spectrin 17
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131462082_2195457.08750.0RepeatNote=Spectrin 18
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131462196_2303457.08750.0RepeatNote=Spectrin 19
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131462304_2401457.08750.0RepeatNote=Spectrin 20
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131462402_2513457.08750.0RepeatNote=Spectrin 21
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131462514_2619457.08750.0RepeatNote=Spectrin 22
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131462620_2731457.08750.0RepeatNote=Spectrin 23
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131462732_2838457.08750.0RepeatNote=Spectrin 24
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131462839_2962457.08750.0RepeatNote=Spectrin 25
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131462963_3062457.08750.0RepeatNote=Spectrin 26
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131463063_3171457.08750.0RepeatNote=Spectrin 27
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131463172_3275457.08750.0RepeatNote=Spectrin 28
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131463276_3387457.08750.0RepeatNote=Spectrin 29
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131463388_3490457.08750.0RepeatNote=Spectrin 30
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131463491_3593457.08750.0RepeatNote=Spectrin 31
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131463594_3720457.08750.0RepeatNote=Spectrin 32
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131463721_3814457.08750.0RepeatNote=Spectrin 33
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131463815_3920457.08750.0RepeatNote=Spectrin 34
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131463921_4028457.08750.0RepeatNote=Spectrin 35
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131464029_4139457.08750.0RepeatNote=Spectrin 36
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131464140_4235457.08750.0RepeatNote=Spectrin 37
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131464236_4339457.08750.0RepeatNote=Spectrin 38
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131464340_4451457.08750.0RepeatNote=Spectrin 39
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131464452_4560457.08750.0RepeatNote=Spectrin 40
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131464561_4669457.08750.0RepeatNote=Spectrin 41
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131464670_4776457.08750.0RepeatNote=Spectrin 42
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131464777_4882457.08750.0RepeatNote=Spectrin 43
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131464883_4991457.08750.0RepeatNote=Spectrin 44
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131464992_5099457.08750.0RepeatNote=Spectrin 45
TgeneSYNE1chr10:20290915chr6:152793548ENST0000042306113146503_609457.08750.0RepeatNote=Spectrin 3
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131465100_5209457.08750.0RepeatNote=Spectrin 46
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131465210_5318457.08750.0RepeatNote=Spectrin 47
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131465319_5424457.08750.0RepeatNote=Spectrin 48
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131465425_5522457.08750.0RepeatNote=Spectrin 49
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131465523_5630457.08750.0RepeatNote=Spectrin 50
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131465631_5736457.08750.0RepeatNote=Spectrin 51
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131465737_5842457.08750.0RepeatNote=Spectrin 52
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131465962_6071457.08750.0RepeatNote=Spectrin 53
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131466072_6178457.08750.0RepeatNote=Spectrin 54
TgeneSYNE1chr10:20290915chr6:152793548ENST0000042306113146610_703457.08750.0RepeatNote=Spectrin 4
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131466374_6485457.08750.0RepeatNote=Spectrin 55
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131466486_6581457.08750.0RepeatNote=Spectrin 56
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131466582_6691457.08750.0RepeatNote=Spectrin 57
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131466692_6795457.08750.0RepeatNote=Spectrin 58
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131466796_6902457.08750.0RepeatNote=Spectrin 59
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131466903_7020457.08750.0RepeatNote=Spectrin 60
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131467021_7128457.08750.0RepeatNote=Spectrin 61
TgeneSYNE1chr10:20290915chr6:152793548ENST0000042306113146704_815457.08750.0RepeatNote=Spectrin 5
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131467129_7237457.08750.0RepeatNote=Spectrin 62
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131467238_7350457.08750.0RepeatNote=Spectrin 63
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131467351_7454457.08750.0RepeatNote=Spectrin 64
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131467455_7558457.08750.0RepeatNote=Spectrin 65
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131467559_7671457.08750.0RepeatNote=Spectrin 66
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131467672_7783457.08750.0RepeatNote=Spectrin 67
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131467784_7883457.08750.0RepeatNote=Spectrin 68
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131467884_7997457.08750.0RepeatNote=Spectrin 69
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131467998_8106457.08750.0RepeatNote=Spectrin 70
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131468107_8216457.08750.0RepeatNote=Spectrin 71
TgeneSYNE1chr10:20290915chr6:152793548ENST0000042306113146816_923457.08750.0RepeatNote=Spectrin 6
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131468329_8438457.08750.0RepeatNote=Spectrin 72
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131468439_8548457.08750.0RepeatNote=Spectrin 73
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131468549_8666457.08750.0RepeatNote=Spectrin 74
TgeneSYNE1chr10:20290915chr6:152793548ENST0000042306113146924_1024457.08750.0RepeatNote=Spectrin 7
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311368768_8797450.01726.0Topological domainPerinuclear space
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131468768_8797450.08798.0Topological domainPerinuclear space
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611318768_8797450.01444.0Topological domainPerinuclear space
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131468768_8797457.08750.0Topological domainPerinuclear space
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311368747_8767450.01726.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131468747_8767450.08798.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611318747_8767450.01444.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131468747_8767457.08750.0TransmembraneHelical%3B Anchor for type IV membrane protein

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePLXDC2chr10:20290915chr6:152793548ENST00000377242+213383_427108.0481.0Compositional biasNote=Thr-rich
HgenePLXDC2chr10:20290915chr6:152793548ENST00000377252+214383_427108.0530.0Compositional biasNote=Thr-rich
HgenePLXDC2chr10:20290915chr6:152793548ENST00000377242+213327_372108.0481.0DomainNote=PSI
HgenePLXDC2chr10:20290915chr6:152793548ENST00000377252+214327_372108.0530.0DomainNote=PSI
HgenePLXDC2chr10:20290915chr6:152793548ENST00000377242+21331_454108.0481.0Topological domainExtracellular
HgenePLXDC2chr10:20290915chr6:152793548ENST00000377242+213476_529108.0481.0Topological domainCytoplasmic
HgenePLXDC2chr10:20290915chr6:152793548ENST00000377252+21431_454108.0530.0Topological domainExtracellular
HgenePLXDC2chr10:20290915chr6:152793548ENST00000377252+214476_529108.0530.0Topological domainCytoplasmic
HgenePLXDC2chr10:20290915chr6:152793548ENST00000377242+213455_475108.0481.0TransmembraneHelical
HgenePLXDC2chr10:20290915chr6:152793548ENST00000377252+214455_475108.0530.0TransmembraneHelical
TgeneSYNE1chr10:20290915chr6:152793548ENST000003672531136314_8666450.01726.0Coiled coilOntology_term=ECO:0000255
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725513146314_8666450.08798.0Coiled coilOntology_term=ECO:0000255
TgeneSYNE1chr10:20290915chr6:152793548ENST000004131861131314_8666450.01444.0Coiled coilOntology_term=ECO:0000255
TgeneSYNE1chr10:20290915chr6:152793548ENST0000042306113146314_8666457.08750.0Coiled coilOntology_term=ECO:0000255
TgeneSYNE1chr10:20290915chr6:152793548ENST000003672531136178_283450.01726.0DomainCalponin-homology (CH) 2
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367253113627_134450.01726.0DomainCalponin-homology (CH) 1
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725513146178_283450.08798.0DomainCalponin-homology (CH) 2
TgeneSYNE1chr10:20290915chr6:152793548ENST000003672551314627_134450.08798.0DomainCalponin-homology (CH) 1
TgeneSYNE1chr10:20290915chr6:152793548ENST000004131861131178_283450.01444.0DomainCalponin-homology (CH) 2
TgeneSYNE1chr10:20290915chr6:152793548ENST00000413186113127_134450.01444.0DomainCalponin-homology (CH) 1
TgeneSYNE1chr10:20290915chr6:152793548ENST0000042306113146178_283457.08750.0DomainCalponin-homology (CH) 2
TgeneSYNE1chr10:20290915chr6:152793548ENST000004230611314627_134457.08750.0DomainCalponin-homology (CH) 1
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311361_289450.01726.0RegionNote=Actin-binding
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131461_289450.08798.0RegionNote=Actin-binding
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611311_289450.01444.0RegionNote=Actin-binding
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131461_289457.08750.0RegionNote=Actin-binding
TgeneSYNE1chr10:20290915chr6:152793548ENST000003672531136314_397450.01726.0RepeatNote=Spectrin 1
TgeneSYNE1chr10:20290915chr6:152793548ENST000003672531136398_502450.01726.0RepeatNote=Spectrin 2
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725513146314_397450.08798.0RepeatNote=Spectrin 1
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725513146398_502450.08798.0RepeatNote=Spectrin 2
TgeneSYNE1chr10:20290915chr6:152793548ENST000004131861131314_397450.01444.0RepeatNote=Spectrin 1
TgeneSYNE1chr10:20290915chr6:152793548ENST000004131861131398_502450.01444.0RepeatNote=Spectrin 2
TgeneSYNE1chr10:20290915chr6:152793548ENST0000042306113146314_397457.08750.0RepeatNote=Spectrin 1
TgeneSYNE1chr10:20290915chr6:152793548ENST0000042306113146398_502457.08750.0RepeatNote=Spectrin 2
TgeneSYNE1chr10:20290915chr6:152793548ENST0000036725311361_8746450.01726.0Topological domainCytoplasmic
TgeneSYNE1chr10:20290915chr6:152793548ENST00000367255131461_8746450.08798.0Topological domainCytoplasmic
TgeneSYNE1chr10:20290915chr6:152793548ENST0000041318611311_8746450.01444.0Topological domainCytoplasmic
TgeneSYNE1chr10:20290915chr6:152793548ENST00000423061131461_8746457.08750.0Topological domainCytoplasmic


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PLXDC2_pLDDT.png
all structure
all structure
SYNE1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PLXDC2
SYNE1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PLXDC2-SYNE1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PLXDC2-SYNE1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource