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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PLXNA1-TNK2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PLXNA1-TNK2
	FusionPDB ID: 66525
	FusionGDB2.0 ID: 66525
		Hgene	Tgene
	Gene symbol	PLXNA1	TNK2
	Gene ID	5361	10188
	Gene name	plexin A1	tyrosine kinase non receptor 2
	Synonyms	NOV\|NOVP\|PLEXIN-A1\|PLXN1	ACK\|ACK-1\|ACK1\|p21cdc42Hs
	Cytomap	3q21.3	3q29
	Type of gene	protein-coding	protein-coding
	Description	plexin-A1plexin 1semaphorin receptor NOV	activated CDC42 kinase 1activated Cdc42-associated kinase 1activated p21cdc42Hs kinasetyrosine kinase non-receptor protein 2
	Modification date	20200313	20200327
	UniProtAcc	Q9UIW2	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000251772, ENST00000393409, ENST00000505278,	ENST00000316664, ENST00000333602, ENST00000392400, ENST00000428187, ENST00000468819, ENST00000381916,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 6 X 7=336	6 X 5 X 4=120
	# samples	9	6
	** MAII score	log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PLXNA1 [Title/Abstract] AND TNK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PLXNA1(126710409)-TNK2(195615477), # samples:2
Anticipated loss of major functional domain due to fusion event.	PLXNA1-TNK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PLXNA1-TNK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PLXNA1-TNK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PLXNA1-TNK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TNK2	GO:0016310	phosphorylation	20333297\|20979614
Tgene	TNK2	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	10587647
Tgene	TNK2	GO:2000369	regulation of clathrin-dependent endocytosis	18262180

Fusion gene breakpoints across PLXNA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TNK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-D9-A6EA-06A	PLXNA1	chr3	126710409	+	TNK2	chr3	195615477	-
ChimerDB4	SKCM	TCGA-EE-A2A1-06A	PLXNA1	chr3	126710409	+	TNK2	chr3	195615477	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000393409

PLXNA1

chr3

126710409

ENST00000381916

TNK2

chr3

195615477

5284

1377

4466

1488

ENST00000251772

PLXNA1

chr3

126710409

ENST00000381916

TNK2

chr3

195615477

5284

1377

4466

1488

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393409	ENST00000381916	PLXNA1	chr3	126710409	+	TNK2	chr3	195615477	-	0.004131764	0.9958682
ENST00000251772	ENST00000381916	PLXNA1	chr3	126710409	+	TNK2	chr3	195615477	-	0.004131764	0.9958682

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>66525_66525_1_PLXNA1-TNK2_PLXNA1_chr3_126710409_ENST00000251772_TNK2_chr3_195615477_ENST00000381916_length(amino acids)=1488AA_BP=459
MPLPPRSLQVLLLLLLLLLLLPGMWAEAGLPRAGGGSQPPFRTFSASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVE
DNEKCYPPPSVQSCPHGLGSTDNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVQEAGSMAGVLIAGPPGQ
GQAKLFVGTPIDGKSEYFPTLSSRRLMANEEDADMFGFVYQDEFVSSQLKIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTSP
DAAGEHFFTSKIVRLCVDDPKFYSYVEFPIGCEQAGVEYRLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQKNRVKPPKESALCLF
TLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDDFCGQDFNQPLGGTVTIEGTPLFVDKDDGLTAVAAYDYRGRTVVFA
GTRSGRIRKRLGGGRMQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKALCKRKSW
MSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVL
SQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAA
RNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK
EGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCV
GPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKREPPPRPPQPA
FFTQKPTYDPVSEDQDPLSSDFKRLGLRKPGLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLL
DETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVPAGPSQGQTNYAFVPEQARPPPPLEDNLFLP
PQGGGKPPSSAQTAEIFQALQQECMRQLQAPAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPP
REPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGKKVSSTHYYLLPERPSYLE
RYQRFLREAQSPEEPTPLPVPLLLPPPSTPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPAD

--------------------------------------------------------------

>66525_66525_2_PLXNA1-TNK2_PLXNA1_chr3_126710409_ENST00000393409_TNK2_chr3_195615477_ENST00000381916_length(amino acids)=1488AA_BP=459
MPLPPRSLQVLLLLLLLLLLLPGMWAEAGLPRAGGGSQPPFRTFSASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVE
DNEKCYPPPSVQSCPHGLGSTDNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVQEAGSMAGVLIAGPPGQ
GQAKLFVGTPIDGKSEYFPTLSSRRLMANEEDADMFGFVYQDEFVSSQLKIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTSP
DAAGEHFFTSKIVRLCVDDPKFYSYVEFPIGCEQAGVEYRLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQKNRVKPPKESALCLF
TLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDDFCGQDFNQPLGGTVTIEGTPLFVDKDDGLTAVAAYDYRGRTVVFA
GTRSGRIRKRLGGGRMQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKALCKRKSW
MSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVL
SQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAA
RNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK
EGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCV
GPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKREPPPRPPQPA
FFTQKPTYDPVSEDQDPLSSDFKRLGLRKPGLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLL
DETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVPAGPSQGQTNYAFVPEQARPPPPLEDNLFLP
PQGGGKPPSSAQTAEIFQALQQECMRQLQAPAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPP
REPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGKKVSSTHYYLLPERPSYLE
RYQRFLREAQSPEEPTPLPVPLLLPPPSTPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPAD

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:126710409/chr3:195615477)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PLXNA1 Q9UIW2	.
FUNCTION: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). {ECO:0000250}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000316664

577_958

529.0

Compositional bias

Note=Pro-rich

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000333602

577_958

1039.0

Compositional bias

Note=Pro-rich

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000381916

577_958

57.0

1087.0

Compositional bias

Note=Pro-rich

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000392400

577_958

1039.0

Compositional bias

Note=Pro-rich

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000316664

126_385

529.0

Domain

Protein kinase

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000316664

388_448

529.0

Domain

SH3

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000316664

454_466

529.0

Domain

Note=CRIB

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000316664

958_996

529.0

Domain

Note=UBA

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000333602

126_385

1039.0

Domain

Protein kinase

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000333602

388_448

1039.0

Domain

SH3

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000333602

454_466

1039.0

Domain

Note=CRIB

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000333602

958_996

1039.0

Domain

Note=UBA

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000381916

126_385

57.0

1087.0

Domain

Protein kinase

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000381916

388_448

57.0

1087.0

Domain

SH3

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000381916

454_466

57.0

1087.0

Domain

Note=CRIB

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000381916

958_996

57.0

1087.0

Domain

Note=UBA

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000392400

126_385

1039.0

Domain

Protein kinase

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000392400

388_448

1039.0

Domain

SH3

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000392400

454_466

1039.0

Domain

Note=CRIB

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000392400

958_996

1039.0

Domain

Note=UBA

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000316664

132_140

529.0

Nucleotide binding

Note=ATP

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000333602

132_140

1039.0

Nucleotide binding

Note=ATP

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000381916

132_140

57.0

1087.0

Nucleotide binding

Note=ATP

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000392400

132_140

1039.0

Nucleotide binding

Note=ATP

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000316664

1_110

529.0

Region

Note=SAM-like domain

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000316664

733_876

529.0

Region

EBD domain

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000333602

1_110

1039.0

Region

Note=SAM-like domain

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000333602

733_876

1039.0

Region

EBD domain

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000381916

733_876

57.0

1087.0

Region

EBD domain

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000392400

1_110

1039.0

Region

Note=SAM-like domain

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000392400

733_876

1039.0

Region

EBD domain

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PLXNA1

chr3:126710409

chr3:195615477

ENST00000393409

1264_1317

459.0

1897.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PLXNA1

chr3:126710409

chr3:195615477

ENST00000393409

1048_1147

459.0

1897.0

Domain

Note=IPT/TIG 3

Hgene

PLXNA1

chr3:126710409

chr3:195615477

ENST00000393409

1150_1236

459.0

1897.0

Domain

Note=IPT/TIG 4

Hgene

PLXNA1

chr3:126710409

chr3:195615477

ENST00000393409

27_512

459.0

1897.0

Domain

Sema

Hgene

PLXNA1

chr3:126710409

chr3:195615477

ENST00000393409

864_959

459.0

1897.0

Domain

Note=IPT/TIG 1

Hgene

PLXNA1

chr3:126710409

chr3:195615477

ENST00000393409

961_1045

459.0

1897.0

Domain

Note=IPT/TIG 2

Hgene

PLXNA1

chr3:126710409

chr3:195615477

ENST00000393409

1266_1896

459.0

1897.0

Topological domain

Cytoplasmic

Hgene

PLXNA1

chr3:126710409

chr3:195615477

ENST00000393409

27_1244

459.0

1897.0

Topological domain

Extracellular

Hgene

PLXNA1

chr3:126710409

chr3:195615477

ENST00000393409

1245_1265

459.0

1897.0

Transmembrane

Helical

Tgene

TNK2

chr3:126710409

chr3:195615477

ENST00000381916

1_110

57.0

1087.0

Region

Note=SAM-like domain

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>2068_PLXNA1_126710409_TNK2_195615477_ranked_0.pdb	PLXNA1	126710409	126710409	ENST00000381916	TNK2	chr3	195615477	-	MPLPPRSLQVLLLLLLLLLLLPGMWAEAGLPRAGGGSQPPFRTFSASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVE DNEKCYPPPSVQSCPHGLGSTDNVNKLLLLDYAANRLLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVQEAGSMAGVLIAGPPGQ GQAKLFVGTPIDGKSEYFPTLSSRRLMANEEDADMFGFVYQDEFVSSQLKIPSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTSP DAAGEHFFTSKIVRLCVDDPKFYSYVEFPIGCEQAGVEYRLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQKNRVKPPKESALCLF TLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDDFCGQDFNQPLGGTVTIEGTPLFVDKDDGLTAVAAYDYRGRTVVFA GTRSGRIRKRLGGGRMQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKALCKRKSW MSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVL SQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAA RNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDK EGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCV GPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKREPPPRPPQPA FFTQKPTYDPVSEDQDPLSSDFKRLGLRKPGLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLL DETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVPAGPSQGQTNYAFVPEQARPPPPLEDNLFLP PQGGGKPPSSAQTAEIFQALQQECMRQLQAPAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPP REPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGKKVSSTHYYLLPERPSYLE RYQRFLREAQSPEEPTPLPVPLLLPPPSTPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPAD	1488

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PLXNA1_pLDDT.png

TNK2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PLXNA1
TNK2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to PLXNA1-TNK2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PLXNA1-TNK2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source