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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:POC1A-PBRM1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: POC1A-PBRM1
FusionPDB ID: 66810
FusionGDB2.0 ID: 66810
HgeneTgene
Gene symbol

POC1A

PBRM1

Gene ID

25886

55193

Gene namePOC1 centriolar protein Apolybromo 1
SynonymsPIX2|SOFT|WDR51ABAF180|PB1
Cytomap

3p21.2

3p21.1

Type of geneprotein-codingprotein-coding
DescriptionPOC1 centriolar protein homolog AWD repeat domain 51AWD repeat-containing protein 51Aproteome of centriole protein 1Aprotein polybromo-1BRG1-associated factor 180polybromo-1D
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000474012, ENST00000296484, 
ENST00000394970, 		ENST00000296302, 
ENST00000337303, ENST00000356770, 
ENST00000394830, ENST00000409057, 
ENST00000409114, ENST00000409767, 
ENST00000410007, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 4 X 5=8010 X 10 X 7=700
# samples 710
** MAII scorelog2(7/80*10)=-0.192645077942396
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/700*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: POC1A [Title/Abstract] AND PBRM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)POC1A(52172185)-PBRM1(52661386), # samples:1
Anticipated loss of major functional domain due to fusion event.POC1A-PBRM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
POC1A-PBRM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
POC1A-PBRM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
POC1A-PBRM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
POC1A-PBRM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
POC1A-PBRM1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
POC1A-PBRM1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
POC1A-PBRM1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
POC1A-PBRM1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
POC1A-PBRM1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across POC1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PBRM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A4MH-01APOC1Achr3

52172185

-PBRM1chr3

52661386

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296484POC1Achr352172185-ENST00000356770PBRM1chr352661386-70268534043141424
ENST00000296484POC1Achr352172185-ENST00000394830PBRM1chr352661386-43818534041581372
ENST00000296484POC1Achr352172185-ENST00000296302PBRM1chr352661386-45538534044791479
ENST00000296484POC1Achr352172185-ENST00000337303PBRM1chr352661386-42328534041581372
ENST00000296484POC1Achr352172185-ENST00000410007PBRM1chr352661386-43128534042391399
ENST00000296484POC1Achr352172185-ENST00000409057PBRM1chr352661386-43878534043141424
ENST00000296484POC1Achr352172185-ENST00000409114PBRM1chr352661386-44228534043681442
ENST00000296484POC1Achr352172185-ENST00000409767PBRM1chr352661386-42568534042031387
ENST00000394970POC1Achr352172185-ENST00000356770PBRM1chr352661386-730411317545921505
ENST00000394970POC1Achr352172185-ENST00000394830PBRM1chr352661386-465911317544361453
ENST00000394970POC1Achr352172185-ENST00000296302PBRM1chr352661386-483111317547571560
ENST00000394970POC1Achr352172185-ENST00000337303PBRM1chr352661386-451011317544361453
ENST00000394970POC1Achr352172185-ENST00000410007PBRM1chr352661386-459011317545171480
ENST00000394970POC1Achr352172185-ENST00000409057PBRM1chr352661386-466511317545921505
ENST00000394970POC1Achr352172185-ENST00000409114PBRM1chr352661386-470011317546461523
ENST00000394970POC1Achr352172185-ENST00000409767PBRM1chr352661386-453411317544811468

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296484ENST00000356770POC1Achr352172185-PBRM1chr352661386-6.76E-050.9999324
ENST00000296484ENST00000394830POC1Achr352172185-PBRM1chr352661386-0.0007044730.9992955
ENST00000296484ENST00000296302POC1Achr352172185-PBRM1chr352661386-0.000985980.999014
ENST00000296484ENST00000337303POC1Achr352172185-PBRM1chr352661386-0.0007347290.99926525
ENST00000296484ENST00000410007POC1Achr352172185-PBRM1chr352661386-0.0009898970.9990101
ENST00000296484ENST00000409057POC1Achr352172185-PBRM1chr352661386-0.0004427440.9995572
ENST00000296484ENST00000409114POC1Achr352172185-PBRM1chr352661386-0.0013432050.99865675
ENST00000296484ENST00000409767POC1Achr352172185-PBRM1chr352661386-0.0007770580.9992229
ENST00000394970ENST00000356770POC1Achr352172185-PBRM1chr352661386-8.75E-050.9999125
ENST00000394970ENST00000394830POC1Achr352172185-PBRM1chr352661386-0.000891510.9991085
ENST00000394970ENST00000296302POC1Achr352172185-PBRM1chr352661386-0.0011974810.99880254
ENST00000394970ENST00000337303POC1Achr352172185-PBRM1chr352661386-0.0009130060.999087
ENST00000394970ENST00000410007POC1Achr352172185-PBRM1chr352661386-0.0012198960.9987801
ENST00000394970ENST00000409057POC1Achr352172185-PBRM1chr352661386-0.0005437210.9994562
ENST00000394970ENST00000409114POC1Achr352172185-PBRM1chr352661386-0.0016074790.9983925
ENST00000394970ENST00000409767POC1Achr352172185-PBRM1chr352661386-0.0009622470.99903774

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>66810_66810_1_POC1A-PBRM1_POC1A_chr3_52172185_ENST00000296484_PBRM1_chr3_52661386_ENST00000296302_length(amino acids)=1479AA_BP=271
MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVP
NVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV
HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH
QAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKI
IEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQ
KLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDAL
VLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLF
QEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEK
SEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKS
DYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDE
KNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPE
ETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYY
FRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRK
INMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEERAAKVAEQQERERAAQQQQPSASPRAGTPVGALMGVVPPP
TPMGMLNQQLTPVAGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQ
VGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPS

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>66810_66810_2_POC1A-PBRM1_POC1A_chr3_52172185_ENST00000296484_PBRM1_chr3_52661386_ENST00000337303_length(amino acids)=1372AA_BP=271
MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVP
NVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV
HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH
QAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKI
IEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQ
KLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDAL
VLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLF
QEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEK
SEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKS
DYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDE
KNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPE
ETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYY
FRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRK
INMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPG
PHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALW

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>66810_66810_3_POC1A-PBRM1_POC1A_chr3_52172185_ENST00000296484_PBRM1_chr3_52661386_ENST00000356770_length(amino acids)=1424AA_BP=271
MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVP
NVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV
HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH
QAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKI
IEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQ
KLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDAL
VLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLF
QEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEK
SEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKS
DYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDE
KNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPE
ETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYY
FRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRK
INMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPP
GVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIE

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>66810_66810_4_POC1A-PBRM1_POC1A_chr3_52172185_ENST00000296484_PBRM1_chr3_52661386_ENST00000394830_length(amino acids)=1372AA_BP=271
MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVP
NVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV
HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH
QAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKI
IEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQ
KLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDAL
VLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLF
QEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEK
SEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFK
LCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVP
VEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCP
MTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAK
FAELEGGDDDIEEMGEEDSESTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGMM
GGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPG
PHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALW

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>66810_66810_5_POC1A-PBRM1_POC1A_chr3_52172185_ENST00000296484_PBRM1_chr3_52661386_ENST00000409057_length(amino acids)=1424AA_BP=271
MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVP
NVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV
HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH
QAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKI
IEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQ
KLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDAL
VLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLF
QEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEK
SEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKS
DYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDE
KNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPE
ETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYY
FRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRK
INMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPP
GVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIE

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>66810_66810_6_POC1A-PBRM1_POC1A_chr3_52172185_ENST00000296484_PBRM1_chr3_52661386_ENST00000409114_length(amino acids)=1442AA_BP=271
MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVP
NVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV
HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH
QAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDY
PDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKS
GISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNA
CTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDII
RKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIE
EDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETF
HLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVV
RVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVR
DGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLK
RFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTP
KSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEERAAKVAEQQERERAAQQQQPSASPR
AGTPVGALMGVVPPPTPMGMLNQQLTPVAGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAP
PPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRDTLNIRQAYNLE

--------------------------------------------------------------

>66810_66810_7_POC1A-PBRM1_POC1A_chr3_52172185_ENST00000296484_PBRM1_chr3_52661386_ENST00000409767_length(amino acids)=1387AA_BP=271
MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVP
NVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV
HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH
QAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDY
PDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKS
GISPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNA
CTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDII
RKNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIE
EDKLKREEEKREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETF
HLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVV
RVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVR
DGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLK
RFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTP
KSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGVMNQGVAPMVGTPAPGGSPYGQQVG
VLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHW

--------------------------------------------------------------

>66810_66810_8_POC1A-PBRM1_POC1A_chr3_52172185_ENST00000296484_PBRM1_chr3_52661386_ENST00000410007_length(amino acids)=1399AA_BP=271
MAAPCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVP
NVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV
HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH
QAKKKELARRDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKI
IEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQ
KLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDAL
VLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLF
QEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEK
SEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFK
LCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVP
VEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCP
MTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAK
FAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYS
FGELSRLVGTEWRNLETAKKAEYEGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTP
APGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHL

--------------------------------------------------------------

>66810_66810_9_POC1A-PBRM1_POC1A_chr3_52172185_ENST00000394970_PBRM1_chr3_52661386_ENST00000296302_length(amino acids)=1560AA_BP=352
MAALSVGCLGLGNWARRPWRRPPVIQLCFQSSGKKLRRFSFNCGGRGVPTRPALLLVAVGGAETERAATATAAAFGAASPAMAAPCAEDP
SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF
RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF
VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQAKKKELAR
RDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDK
YAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAV
KNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLET
RRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLE
RARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAG
LSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVS
KILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDS
RAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKM
FYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQK
EPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILF
SSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEERAAKVAEQQERERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQ
LTPVAGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQ
QAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAH

--------------------------------------------------------------

>66810_66810_10_POC1A-PBRM1_POC1A_chr3_52172185_ENST00000394970_PBRM1_chr3_52661386_ENST00000337303_length(amino acids)=1453AA_BP=352
MAALSVGCLGLGNWARRPWRRPPVIQLCFQSSGKKLRRFSFNCGGRGVPTRPALLLVAVGGAETERAATATAAAFGAASPAMAAPCAEDP
SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF
RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF
VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQAKKKELAR
RDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDK
YAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAV
KNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLET
RRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLE
RARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAG
LSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVS
KILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDS
RAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKM
FYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQK
EPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILF
SSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVI
QQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRD

--------------------------------------------------------------

>66810_66810_11_POC1A-PBRM1_POC1A_chr3_52172185_ENST00000394970_PBRM1_chr3_52661386_ENST00000356770_length(amino acids)=1505AA_BP=352
MAALSVGCLGLGNWARRPWRRPPVIQLCFQSSGKKLRRFSFNCGGRGVPTRPALLLVAVGGAETERAATATAAAFGAASPAMAAPCAEDP
SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF
RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF
VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQAKKKELAR
RDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDK
YAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAV
KNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLET
RRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLE
RARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAG
LSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVS
KILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDS
RAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKM
FYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQK
EPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILF
SSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIP
PPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSI

--------------------------------------------------------------

>66810_66810_12_POC1A-PBRM1_POC1A_chr3_52172185_ENST00000394970_PBRM1_chr3_52661386_ENST00000394830_length(amino acids)=1453AA_BP=352
MAALSVGCLGLGNWARRPWRRPPVIQLCFQSSGKKLRRFSFNCGGRGVPTRPALLLVAVGGAETERAATATAAAFGAASPAMAAPCAEDP
SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF
RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF
VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQAKKKELAR
RDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDK
YAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAV
KNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLET
RRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLE
RARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAG
LSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDE
DVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPG
CHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCA
VLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDD
DIEEMGEEDSESTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGMMGGYPPGLPP
LQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVI
QQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWRLRDLMLRD

--------------------------------------------------------------

>66810_66810_13_POC1A-PBRM1_POC1A_chr3_52172185_ENST00000394970_PBRM1_chr3_52661386_ENST00000409057_length(amino acids)=1505AA_BP=352
MAALSVGCLGLGNWARRPWRRPPVIQLCFQSSGKKLRRFSFNCGGRGVPTRPALLLVAVGGAETERAATATAAAFGAASPAMAAPCAEDP
SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF
RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF
VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQAKKKELAR
RDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDK
YAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAV
KNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLET
RRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLE
RARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAG
LSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVS
KILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDS
RAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKM
FYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQK
EPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILF
SSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIP
PPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSI

--------------------------------------------------------------

>66810_66810_14_POC1A-PBRM1_POC1A_chr3_52172185_ENST00000394970_PBRM1_chr3_52661386_ENST00000409114_length(amino acids)=1523AA_BP=352
MAALSVGCLGLGNWARRPWRRPPVIQLCFQSSGKKLRRFSFNCGGRGVPTRPALLLVAVGGAETERAATATAAAFGAASPAMAAPCAEDP
SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF
RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF
VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQAKKKELAR
RDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILE
PMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKY
MTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESL
IYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRY
RRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEE
KREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLE
KEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANA
DKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGP
IFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVV
DDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKK
EGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEERAAKVAEQQERERAAQQQQPSASPRAGTPVGALM
GVVPPPTPMGMLNQQLTPVAGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLH

--------------------------------------------------------------

>66810_66810_15_POC1A-PBRM1_POC1A_chr3_52172185_ENST00000394970_PBRM1_chr3_52661386_ENST00000409767_length(amino acids)=1468AA_BP=352
MAALSVGCLGLGNWARRPWRRPPVIQLCFQSSGKKLRRFSFNCGGRGVPTRPALLLVAVGGAETERAATATAAAFGAASPAMAAPCAEDP
SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF
RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF
VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQAKKKELAR
RDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILE
PMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKY
MTPMQQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESL
IYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRY
RRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEE
KREAEKSEDSSGAAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLE
KEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANA
DKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGP
IFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVV
DDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKK
EGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNLETAKKAEYEGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQA
PPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTT

--------------------------------------------------------------

>66810_66810_16_POC1A-PBRM1_POC1A_chr3_52172185_ENST00000394970_PBRM1_chr3_52661386_ENST00000410007_length(amino acids)=1480AA_BP=352
MAALSVGCLGLGNWARRPWRRPPVIQLCFQSSGKKLRRFSFNCGGRGVPTRPALLLVAVGGAETERAATATAAAFGAASPAMAAPCAEDP
SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF
RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF
VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQAKKKELAR
RDDIEDGDSMISSATSDTGSAKRKSKKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDK
YAGEEGMIEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKEKRKELGPLPDDDDMASPKLKLSRKSGISPKKSKYMTPMQQKLNEVYEAV
KNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLET
RRDLEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPNKPPLTFDIIRKNVENNRYRRLDLFQEHMFEVLE
RARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPALSYTTKHLHNDVEKERKEKLPKEIEEDKLKREEEKREAEKSEDSSGAAG
LSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDE
DVFVCESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDNFNLEKEKEDVPVEMSNGEPG
CHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCA
VLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAKFAELEGGDD
DIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVG
TEWRNLETAKKAEYEGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQ
QVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52172185/chr3:52661386)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOC1Achr3:52172185chr3:52661386ENST00000296484-711101_140271.0408.0RepeatNote=WD 3
HgenePOC1Achr3:52172185chr3:52661386ENST00000296484-711143_182271.0408.0RepeatNote=WD 4
HgenePOC1Achr3:52172185chr3:52661386ENST00000296484-71117_56271.0408.0RepeatNote=WD 1
HgenePOC1Achr3:52172185chr3:52661386ENST00000296484-711185_224271.0408.0RepeatNote=WD 5
HgenePOC1Achr3:52172185chr3:52661386ENST00000296484-711227_266271.0408.0RepeatNote=WD 6
HgenePOC1Achr3:52172185chr3:52661386ENST00000296484-71159_98271.0408.0RepeatNote=WD 2
HgenePOC1Achr3:52172185chr3:52661386ENST00000394970-710101_140271.0360.0RepeatNote=WD 3
HgenePOC1Achr3:52172185chr3:52661386ENST00000394970-710143_182271.0360.0RepeatNote=WD 4
HgenePOC1Achr3:52172185chr3:52661386ENST00000394970-71017_56271.0360.0RepeatNote=WD 1
HgenePOC1Achr3:52172185chr3:52661386ENST00000394970-710185_224271.0360.0RepeatNote=WD 5
HgenePOC1Achr3:52172185chr3:52661386ENST00000394970-710227_266271.0360.0RepeatNote=WD 6
HgenePOC1Achr3:52172185chr3:52661386ENST00000394970-71059_98271.0360.0RepeatNote=WD 2
HgenePOC1Achr3:52172185chr3:52661386ENST00000474012-711101_140233.0370.0RepeatNote=WD 3
HgenePOC1Achr3:52172185chr3:52661386ENST00000474012-711143_182233.0370.0RepeatNote=WD 4
HgenePOC1Achr3:52172185chr3:52661386ENST00000474012-71117_56233.0370.0RepeatNote=WD 1
HgenePOC1Achr3:52172185chr3:52661386ENST00000474012-711185_224233.0370.0RepeatNote=WD 5
HgenePOC1Achr3:52172185chr3:52661386ENST00000474012-71159_98233.0370.0RepeatNote=WD 2
TgenePBRM1chr3:52172185chr3:52661386ENST0000029630211301468_1599481.01690.0Compositional biasNote=Pro-rich
TgenePBRM1chr3:52172185chr3:52661386ENST000002963021130630_633481.01690.0Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52172185chr3:52661386ENST0000033730311281468_1599481.01583.0Compositional biasNote=Pro-rich
TgenePBRM1chr3:52172185chr3:52661386ENST000003373031128630_633481.01583.0Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52172185chr3:52661386ENST0000035677010281468_1599449.01603.0Compositional biasNote=Pro-rich
TgenePBRM1chr3:52172185chr3:52661386ENST000003567701028630_633449.01603.0Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52172185chr3:52661386ENST0000039483012301468_1599481.01583.0Compositional biasNote=Pro-rich
TgenePBRM1chr3:52172185chr3:52661386ENST000003948301230630_633481.01583.0Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52172185chr3:52661386ENST0000040905711291468_1599481.01635.0Compositional biasNote=Pro-rich
TgenePBRM1chr3:52172185chr3:52661386ENST000004090571129630_633481.01635.0Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52172185chr3:52661386ENST0000040911411301468_1599481.01653.0Compositional biasNote=Pro-rich
TgenePBRM1chr3:52172185chr3:52661386ENST000004091141130630_633481.01653.0Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52172185chr3:52661386ENST0000040976711291468_1599481.01598.0Compositional biasNote=Pro-rich
TgenePBRM1chr3:52172185chr3:52661386ENST000004097671129630_633481.01598.0Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52172185chr3:52661386ENST0000041000711291468_1599481.01610.0Compositional biasNote=Pro-rich
TgenePBRM1chr3:52172185chr3:52661386ENST000004100071129630_633481.01610.0Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52172185chr3:52661386ENST0000029630211301379_1447481.01690.0DNA bindingHMG box
TgenePBRM1chr3:52172185chr3:52661386ENST0000033730311281379_1447481.01583.0DNA bindingHMG box
TgenePBRM1chr3:52172185chr3:52661386ENST0000035677010281379_1447449.01603.0DNA bindingHMG box
TgenePBRM1chr3:52172185chr3:52661386ENST0000039483012301379_1447481.01583.0DNA bindingHMG box
TgenePBRM1chr3:52172185chr3:52661386ENST0000040905711291379_1447481.01635.0DNA bindingHMG box
TgenePBRM1chr3:52172185chr3:52661386ENST0000040911411301379_1447481.01653.0DNA bindingHMG box
TgenePBRM1chr3:52172185chr3:52661386ENST0000040976711291379_1447481.01598.0DNA bindingHMG box
TgenePBRM1chr3:52172185chr3:52661386ENST0000041000711291379_1447481.01610.0DNA bindingHMG box
TgenePBRM1chr3:52172185chr3:52661386ENST0000029630211301156_1272481.01690.0DomainBAH 2
TgenePBRM1chr3:52172185chr3:52661386ENST000002963021130538_608481.01690.0DomainBromo 4
TgenePBRM1chr3:52172185chr3:52661386ENST000002963021130676_746481.01690.0DomainBromo 5
TgenePBRM1chr3:52172185chr3:52661386ENST000002963021130792_862481.01690.0DomainBromo 6
TgenePBRM1chr3:52172185chr3:52661386ENST000002963021130956_1074481.01690.0DomainBAH 1
TgenePBRM1chr3:52172185chr3:52661386ENST0000033730311281156_1272481.01583.0DomainBAH 2
TgenePBRM1chr3:52172185chr3:52661386ENST000003373031128538_608481.01583.0DomainBromo 4
TgenePBRM1chr3:52172185chr3:52661386ENST000003373031128676_746481.01583.0DomainBromo 5
TgenePBRM1chr3:52172185chr3:52661386ENST000003373031128792_862481.01583.0DomainBromo 6
TgenePBRM1chr3:52172185chr3:52661386ENST000003373031128956_1074481.01583.0DomainBAH 1
TgenePBRM1chr3:52172185chr3:52661386ENST0000035677010281156_1272449.01603.0DomainBAH 2
TgenePBRM1chr3:52172185chr3:52661386ENST000003567701028538_608449.01603.0DomainBromo 4
TgenePBRM1chr3:52172185chr3:52661386ENST000003567701028676_746449.01603.0DomainBromo 5
TgenePBRM1chr3:52172185chr3:52661386ENST000003567701028792_862449.01603.0DomainBromo 6
TgenePBRM1chr3:52172185chr3:52661386ENST000003567701028956_1074449.01603.0DomainBAH 1
TgenePBRM1chr3:52172185chr3:52661386ENST0000039483012301156_1272481.01583.0DomainBAH 2
TgenePBRM1chr3:52172185chr3:52661386ENST000003948301230538_608481.01583.0DomainBromo 4
TgenePBRM1chr3:52172185chr3:52661386ENST000003948301230676_746481.01583.0DomainBromo 5
TgenePBRM1chr3:52172185chr3:52661386ENST000003948301230792_862481.01583.0DomainBromo 6
TgenePBRM1chr3:52172185chr3:52661386ENST000003948301230956_1074481.01583.0DomainBAH 1
TgenePBRM1chr3:52172185chr3:52661386ENST0000040905711291156_1272481.01635.0DomainBAH 2
TgenePBRM1chr3:52172185chr3:52661386ENST000004090571129538_608481.01635.0DomainBromo 4
TgenePBRM1chr3:52172185chr3:52661386ENST000004090571129676_746481.01635.0DomainBromo 5
TgenePBRM1chr3:52172185chr3:52661386ENST000004090571129792_862481.01635.0DomainBromo 6
TgenePBRM1chr3:52172185chr3:52661386ENST000004090571129956_1074481.01635.0DomainBAH 1
TgenePBRM1chr3:52172185chr3:52661386ENST0000040911411301156_1272481.01653.0DomainBAH 2
TgenePBRM1chr3:52172185chr3:52661386ENST000004091141130538_608481.01653.0DomainBromo 4
TgenePBRM1chr3:52172185chr3:52661386ENST000004091141130676_746481.01653.0DomainBromo 5
TgenePBRM1chr3:52172185chr3:52661386ENST000004091141130792_862481.01653.0DomainBromo 6
TgenePBRM1chr3:52172185chr3:52661386ENST000004091141130956_1074481.01653.0DomainBAH 1
TgenePBRM1chr3:52172185chr3:52661386ENST0000040976711291156_1272481.01598.0DomainBAH 2
TgenePBRM1chr3:52172185chr3:52661386ENST000004097671129538_608481.01598.0DomainBromo 4
TgenePBRM1chr3:52172185chr3:52661386ENST000004097671129676_746481.01598.0DomainBromo 5
TgenePBRM1chr3:52172185chr3:52661386ENST000004097671129792_862481.01598.0DomainBromo 6
TgenePBRM1chr3:52172185chr3:52661386ENST000004097671129956_1074481.01598.0DomainBAH 1
TgenePBRM1chr3:52172185chr3:52661386ENST0000041000711291156_1272481.01610.0DomainBAH 2
TgenePBRM1chr3:52172185chr3:52661386ENST000004100071129538_608481.01610.0DomainBromo 4
TgenePBRM1chr3:52172185chr3:52661386ENST000004100071129676_746481.01610.0DomainBromo 5
TgenePBRM1chr3:52172185chr3:52661386ENST000004100071129792_862481.01610.0DomainBromo 6
TgenePBRM1chr3:52172185chr3:52661386ENST000004100071129956_1074481.01610.0DomainBAH 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePOC1Achr3:52172185chr3:52661386ENST00000296484-711369_397271.0408.0Coiled coilOntology_term=ECO:0000255
HgenePOC1Achr3:52172185chr3:52661386ENST00000394970-710369_397271.0360.0Coiled coilOntology_term=ECO:0000255
HgenePOC1Achr3:52172185chr3:52661386ENST00000474012-711369_397233.0370.0Coiled coilOntology_term=ECO:0000255
HgenePOC1Achr3:52172185chr3:52661386ENST00000296484-711269_308271.0408.0RepeatNote=WD 7
HgenePOC1Achr3:52172185chr3:52661386ENST00000394970-710269_308271.0360.0RepeatNote=WD 7
HgenePOC1Achr3:52172185chr3:52661386ENST00000474012-711227_266233.0370.0RepeatNote=WD 6
HgenePOC1Achr3:52172185chr3:52661386ENST00000474012-711269_308233.0370.0RepeatNote=WD 7
TgenePBRM1chr3:52172185chr3:52661386ENST000002963021130200_270481.01690.0DomainBromo 2
TgenePBRM1chr3:52172185chr3:52661386ENST000002963021130400_470481.01690.0DomainBromo 3
TgenePBRM1chr3:52172185chr3:52661386ENST00000296302113064_134481.01690.0DomainBromo 1
TgenePBRM1chr3:52172185chr3:52661386ENST000003373031128200_270481.01583.0DomainBromo 2
TgenePBRM1chr3:52172185chr3:52661386ENST000003373031128400_470481.01583.0DomainBromo 3
TgenePBRM1chr3:52172185chr3:52661386ENST00000337303112864_134481.01583.0DomainBromo 1
TgenePBRM1chr3:52172185chr3:52661386ENST000003567701028200_270449.01603.0DomainBromo 2
TgenePBRM1chr3:52172185chr3:52661386ENST000003567701028400_470449.01603.0DomainBromo 3
TgenePBRM1chr3:52172185chr3:52661386ENST00000356770102864_134449.01603.0DomainBromo 1
TgenePBRM1chr3:52172185chr3:52661386ENST000003948301230200_270481.01583.0DomainBromo 2
TgenePBRM1chr3:52172185chr3:52661386ENST000003948301230400_470481.01583.0DomainBromo 3
TgenePBRM1chr3:52172185chr3:52661386ENST00000394830123064_134481.01583.0DomainBromo 1
TgenePBRM1chr3:52172185chr3:52661386ENST000004090571129200_270481.01635.0DomainBromo 2
TgenePBRM1chr3:52172185chr3:52661386ENST000004090571129400_470481.01635.0DomainBromo 3
TgenePBRM1chr3:52172185chr3:52661386ENST00000409057112964_134481.01635.0DomainBromo 1
TgenePBRM1chr3:52172185chr3:52661386ENST000004091141130200_270481.01653.0DomainBromo 2
TgenePBRM1chr3:52172185chr3:52661386ENST000004091141130400_470481.01653.0DomainBromo 3
TgenePBRM1chr3:52172185chr3:52661386ENST00000409114113064_134481.01653.0DomainBromo 1
TgenePBRM1chr3:52172185chr3:52661386ENST000004097671129200_270481.01598.0DomainBromo 2
TgenePBRM1chr3:52172185chr3:52661386ENST000004097671129400_470481.01598.0DomainBromo 3
TgenePBRM1chr3:52172185chr3:52661386ENST00000409767112964_134481.01598.0DomainBromo 1
TgenePBRM1chr3:52172185chr3:52661386ENST000004100071129200_270481.01610.0DomainBromo 2
TgenePBRM1chr3:52172185chr3:52661386ENST000004100071129400_470481.01610.0DomainBromo 3
TgenePBRM1chr3:52172185chr3:52661386ENST00000410007112964_134481.01610.0DomainBromo 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
POC1A
PBRM1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to POC1A-PBRM1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to POC1A-PBRM1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource