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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PPARA-FBLN1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPARA-FBLN1
FusionPDB ID: 67315
FusionGDB2.0 ID: 67315
HgeneTgene
Gene symbol

PPARA

FBLN1

Gene ID

5465

2192

Gene nameperoxisome proliferator activated receptor alphafibulin 1
SynonymsNR1C1|PPAR|PPARalpha|hPPARFBLN|FIBL1
Cytomap

22q13.31

22q13.31

Type of geneprotein-codingprotein-coding
Descriptionperoxisome proliferator-activated receptor alphaPPAR-alphanuclear receptor subfamily 1 group C member 1peroxisome proliferative activated receptor, alphaperoxisome proliferator-activated nuclear receptor alpha variant 3fibulin-1
Modification date2020032920200313
UniProtAcc.

P23142

Ensembl transtripts involved in fusion geneENST idsENST00000262735, ENST00000396000, 
ENST00000402126, ENST00000407236, 
ENST00000434345, ENST00000481567, 
ENST00000476366, ENST00000262722, 
ENST00000327858, ENST00000340923, 
ENST00000348697, ENST00000402984, 
ENST00000442170, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 10 X 10=150022 X 22 X 9=4356
# samples 1827
** MAII scorelog2(18/1500*10)=-3.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/4356*10)=-4.01197264166608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PPARA [Title/Abstract] AND FBLN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PPARA(46594488)-FBLN1(45942965), # samples:2
Anticipated loss of major functional domain due to fusion event.PPARA-FBLN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPARA-FBLN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPARA-FBLN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPARA-FBLN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPARA

GO:0000122

negative regulation of transcription by RNA polymerase II

9748239|12700342

HgenePPARA

GO:0010565

regulation of cellular ketone metabolic process

19955185

HgenePPARA

GO:0010745

negative regulation of macrophage derived foam cell differentiation

19114110

HgenePPARA

GO:0010871

negative regulation of receptor biosynthetic process

12700342

HgenePPARA

GO:0010887

negative regulation of cholesterol storage

19114110

HgenePPARA

GO:0010891

negative regulation of sequestering of triglyceride

12700342

HgenePPARA

GO:0019217

regulation of fatty acid metabolic process

19955185

HgenePPARA

GO:0045820

negative regulation of glycolytic process

19955185

HgenePPARA

GO:0045893

positive regulation of transcription, DNA-templated

12955147

HgenePPARA

GO:0045944

positive regulation of transcription by RNA polymerase II

9748239|19955185|20837115

HgenePPARA

GO:0050728

negative regulation of inflammatory response

21636785

HgenePPARA

GO:1902894

negative regulation of pri-miRNA transcription by RNA polymerase II

21636785

HgenePPARA

GO:1903038

negative regulation of leukocyte cell-cell adhesion

21636785

TgeneFBLN1

GO:0001933

negative regulation of protein phosphorylation

11792823

TgeneFBLN1

GO:0007162

negative regulation of cell adhesion

11792823

TgeneFBLN1

GO:0007229

integrin-mediated signaling pathway

11792823

TgeneFBLN1

GO:0070373

negative regulation of ERK1 and ERK2 cascade

11792823

TgeneFBLN1

GO:0072378

blood coagulation, fibrin clot formation

7642629

TgeneFBLN1

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

11792823

TgeneFBLN1

GO:2000146

negative regulation of cell motility

11792823

TgeneFBLN1

GO:2000647

negative regulation of stem cell proliferation

11238726


check buttonFusion gene breakpoints across PPARA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FBLN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-UU-A93S-01APPARAchr22

46594488

-FBLN1chr22

45942965

+
ChimerDB4BRCATCGA-UU-A93S-01APPARAchr22

46594488

+FBLN1chr22

45942965

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396000PPARAchr2246594488+ENST00000348697FBLN1chr2245942965+19524732561263335
ENST00000396000PPARAchr2246594488+ENST00000402984FBLN1chr2245942965+12904732561203315
ENST00000396000PPARAchr2246594488+ENST00000262722FBLN1chr2245942965+13004732561203315
ENST00000396000PPARAchr2246594488+ENST00000327858FBLN1chr2245942965+19534732561263335
ENST00000396000PPARAchr2246594488+ENST00000442170FBLN1chr2245942965+1667473256957233
ENST00000396000PPARAchr2246594488+ENST00000340923FBLN1chr2245942965+1490473256852198
ENST00000262735PPARAchr2246594488+ENST00000348697FBLN1chr2245942965+18693901731180335
ENST00000262735PPARAchr2246594488+ENST00000402984FBLN1chr2245942965+12073901731120315
ENST00000262735PPARAchr2246594488+ENST00000262722FBLN1chr2245942965+12173901731120315
ENST00000262735PPARAchr2246594488+ENST00000327858FBLN1chr2245942965+18703901731180335
ENST00000262735PPARAchr2246594488+ENST00000442170FBLN1chr2245942965+1584390173874233
ENST00000262735PPARAchr2246594488+ENST00000340923FBLN1chr2245942965+1407390173769198
ENST00000407236PPARAchr2246594488+ENST00000348697FBLN1chr2245942965+19004212041211335
ENST00000407236PPARAchr2246594488+ENST00000402984FBLN1chr2245942965+12384212041151315
ENST00000407236PPARAchr2246594488+ENST00000262722FBLN1chr2245942965+12484212041151315
ENST00000407236PPARAchr2246594488+ENST00000327858FBLN1chr2245942965+19014212041211335
ENST00000407236PPARAchr2246594488+ENST00000442170FBLN1chr2245942965+1615421204905233
ENST00000407236PPARAchr2246594488+ENST00000340923FBLN1chr2245942965+1438421204800198
ENST00000402126PPARAchr2246594488+ENST00000348697FBLN1chr2245942965+18153361191126335
ENST00000402126PPARAchr2246594488+ENST00000402984FBLN1chr2245942965+11533361191066315
ENST00000402126PPARAchr2246594488+ENST00000262722FBLN1chr2245942965+11633361191066315
ENST00000402126PPARAchr2246594488+ENST00000327858FBLN1chr2245942965+18163361191126335
ENST00000402126PPARAchr2246594488+ENST00000442170FBLN1chr2245942965+1530336119820233
ENST00000402126PPARAchr2246594488+ENST00000340923FBLN1chr2245942965+1353336119715198
ENST00000434345PPARAchr2246594488+ENST00000348697FBLN1chr2245942965+16872080998332
ENST00000434345PPARAchr2246594488+ENST00000402984FBLN1chr2245942965+10252080938312
ENST00000434345PPARAchr2246594488+ENST00000262722FBLN1chr2245942965+10352080938312
ENST00000434345PPARAchr2246594488+ENST00000327858FBLN1chr2245942965+16882080998332
ENST00000434345PPARAchr2246594488+ENST00000442170FBLN1chr2245942965+14022080692230
ENST00000434345PPARAchr2246594488+ENST00000340923FBLN1chr2245942965+12252080587195

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396000ENST00000348697PPARAchr2246594488+FBLN1chr2245942965+0.0008885690.9991115
ENST00000396000ENST00000402984PPARAchr2246594488+FBLN1chr2245942965+0.0119480270.988052
ENST00000396000ENST00000262722PPARAchr2246594488+FBLN1chr2245942965+0.0112069350.9887931
ENST00000396000ENST00000327858PPARAchr2246594488+FBLN1chr2245942965+0.001146730.9988532
ENST00000396000ENST00000442170PPARAchr2246594488+FBLN1chr2245942965+0.0038418230.9961582
ENST00000396000ENST00000340923PPARAchr2246594488+FBLN1chr2245942965+0.0022023760.9977976
ENST00000262735ENST00000348697PPARAchr2246594488+FBLN1chr2245942965+0.0010151330.9989849
ENST00000262735ENST00000402984PPARAchr2246594488+FBLN1chr2245942965+0.0169729980.98302704
ENST00000262735ENST00000262722PPARAchr2246594488+FBLN1chr2245942965+0.0160089580.983991
ENST00000262735ENST00000327858PPARAchr2246594488+FBLN1chr2245942965+0.0014036170.9985964
ENST00000262735ENST00000442170PPARAchr2246594488+FBLN1chr2245942965+0.0031681440.99683183
ENST00000262735ENST00000340923PPARAchr2246594488+FBLN1chr2245942965+0.0019833970.9980166
ENST00000407236ENST00000348697PPARAchr2246594488+FBLN1chr2245942965+0.0011856450.99881434
ENST00000407236ENST00000402984PPARAchr2246594488+FBLN1chr2245942965+0.0176249030.9823751
ENST00000407236ENST00000262722PPARAchr2246594488+FBLN1chr2245942965+0.0164936740.9835064
ENST00000407236ENST00000327858PPARAchr2246594488+FBLN1chr2245942965+0.0015297790.99847025
ENST00000407236ENST00000442170PPARAchr2246594488+FBLN1chr2245942965+0.0042062550.9957937
ENST00000407236ENST00000340923PPARAchr2246594488+FBLN1chr2245942965+0.0029951360.9970048
ENST00000402126ENST00000348697PPARAchr2246594488+FBLN1chr2245942965+0.0009914070.9990086
ENST00000402126ENST00000402984PPARAchr2246594488+FBLN1chr2245942965+0.0193908050.98060924
ENST00000402126ENST00000262722PPARAchr2246594488+FBLN1chr2245942965+0.0180217250.98197824
ENST00000402126ENST00000327858PPARAchr2246594488+FBLN1chr2245942965+0.0012985170.99870145
ENST00000402126ENST00000442170PPARAchr2246594488+FBLN1chr2245942965+0.0038980910.99610186
ENST00000402126ENST00000340923PPARAchr2246594488+FBLN1chr2245942965+0.0027541260.9972459
ENST00000434345ENST00000348697PPARAchr2246594488+FBLN1chr2245942965+0.0007410040.99925894
ENST00000434345ENST00000402984PPARAchr2246594488+FBLN1chr2245942965+0.0193991640.9806009
ENST00000434345ENST00000262722PPARAchr2246594488+FBLN1chr2245942965+0.0178099370.98219
ENST00000434345ENST00000327858PPARAchr2246594488+FBLN1chr2245942965+0.0010489840.99895096
ENST00000434345ENST00000442170PPARAchr2246594488+FBLN1chr2245942965+0.0033661770.9966338
ENST00000434345ENST00000340923PPARAchr2246594488+FBLN1chr2245942965+0.0018358110.99816424

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>67315_67315_1_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000262735_FBLN1_chr22_45942965_ENST00000262722_length(amino acids)=315AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG
FRCLAFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPH

--------------------------------------------------------------

>67315_67315_2_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000262735_FBLN1_chr22_45942965_ENST00000327858_length(amino acids)=335AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG
FRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITE

--------------------------------------------------------------

>67315_67315_3_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000262735_FBLN1_chr22_45942965_ENST00000340923_length(amino acids)=198AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG

--------------------------------------------------------------

>67315_67315_4_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000262735_FBLN1_chr22_45942965_ENST00000348697_length(amino acids)=335AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG
FRCLAFECPENYRRSAATQKSKKGRQNTPAGSSKEDCRVLPWKQGLEDTHLDAYLPCCRRFTRPEEIIFLRAITPPHPASQANIIFDITE

--------------------------------------------------------------

>67315_67315_5_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000262735_FBLN1_chr22_45942965_ENST00000402984_length(amino acids)=315AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG
FRCLAFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPH

--------------------------------------------------------------

>67315_67315_6_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000262735_FBLN1_chr22_45942965_ENST00000442170_length(amino acids)=233AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG

--------------------------------------------------------------

>67315_67315_7_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000396000_FBLN1_chr22_45942965_ENST00000262722_length(amino acids)=315AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG
FRCLAFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPH

--------------------------------------------------------------

>67315_67315_8_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000396000_FBLN1_chr22_45942965_ENST00000327858_length(amino acids)=335AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG
FRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITE

--------------------------------------------------------------

>67315_67315_9_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000396000_FBLN1_chr22_45942965_ENST00000340923_length(amino acids)=198AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG

--------------------------------------------------------------

>67315_67315_10_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000396000_FBLN1_chr22_45942965_ENST00000348697_length(amino acids)=335AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG
FRCLAFECPENYRRSAATQKSKKGRQNTPAGSSKEDCRVLPWKQGLEDTHLDAYLPCCRRFTRPEEIIFLRAITPPHPASQANIIFDITE

--------------------------------------------------------------

>67315_67315_11_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000396000_FBLN1_chr22_45942965_ENST00000402984_length(amino acids)=315AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG
FRCLAFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPH

--------------------------------------------------------------

>67315_67315_12_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000396000_FBLN1_chr22_45942965_ENST00000442170_length(amino acids)=233AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG

--------------------------------------------------------------

>67315_67315_13_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000402126_FBLN1_chr22_45942965_ENST00000262722_length(amino acids)=315AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG
FRCLAFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPH

--------------------------------------------------------------

>67315_67315_14_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000402126_FBLN1_chr22_45942965_ENST00000327858_length(amino acids)=335AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG
FRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITE

--------------------------------------------------------------

>67315_67315_15_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000402126_FBLN1_chr22_45942965_ENST00000340923_length(amino acids)=198AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG

--------------------------------------------------------------

>67315_67315_16_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000402126_FBLN1_chr22_45942965_ENST00000348697_length(amino acids)=335AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG
FRCLAFECPENYRRSAATQKSKKGRQNTPAGSSKEDCRVLPWKQGLEDTHLDAYLPCCRRFTRPEEIIFLRAITPPHPASQANIIFDITE

--------------------------------------------------------------

>67315_67315_17_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000402126_FBLN1_chr22_45942965_ENST00000402984_length(amino acids)=315AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG
FRCLAFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPH

--------------------------------------------------------------

>67315_67315_18_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000402126_FBLN1_chr22_45942965_ENST00000442170_length(amino acids)=233AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG

--------------------------------------------------------------

>67315_67315_19_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000407236_FBLN1_chr22_45942965_ENST00000262722_length(amino acids)=315AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG
FRCLAFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPH

--------------------------------------------------------------

>67315_67315_20_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000407236_FBLN1_chr22_45942965_ENST00000327858_length(amino acids)=335AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG
FRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITE

--------------------------------------------------------------

>67315_67315_21_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000407236_FBLN1_chr22_45942965_ENST00000340923_length(amino acids)=198AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG

--------------------------------------------------------------

>67315_67315_22_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000407236_FBLN1_chr22_45942965_ENST00000348697_length(amino acids)=335AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG
FRCLAFECPENYRRSAATQKSKKGRQNTPAGSSKEDCRVLPWKQGLEDTHLDAYLPCCRRFTRPEEIIFLRAITPPHPASQANIIFDITE

--------------------------------------------------------------

>67315_67315_23_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000407236_FBLN1_chr22_45942965_ENST00000402984_length(amino acids)=315AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG
FRCLAFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPH

--------------------------------------------------------------

>67315_67315_24_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000407236_FBLN1_chr22_45942965_ENST00000442170_length(amino acids)=233AA_BP=59
MVAMVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVY
GSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGG

--------------------------------------------------------------

>67315_67315_25_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000434345_FBLN1_chr22_45942965_ENST00000262722_length(amino acids)=312AA_BP=56
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVYGSY
QCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC
LAFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGV

--------------------------------------------------------------

>67315_67315_26_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000434345_FBLN1_chr22_45942965_ENST00000327858_length(amino acids)=332AA_BP=56
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVYGSY
QCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC
LAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNL

--------------------------------------------------------------

>67315_67315_27_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000434345_FBLN1_chr22_45942965_ENST00000340923_length(amino acids)=195AA_BP=56
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVYGSY
QCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC

--------------------------------------------------------------

>67315_67315_28_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000434345_FBLN1_chr22_45942965_ENST00000348697_length(amino acids)=332AA_BP=56
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVYGSY
QCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC
LAFECPENYRRSAATQKSKKGRQNTPAGSSKEDCRVLPWKQGLEDTHLDAYLPCCRRFTRPEEIIFLRAITPPHPASQANIIFDITEGNL

--------------------------------------------------------------

>67315_67315_29_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000434345_FBLN1_chr22_45942965_ENST00000402984_length(amino acids)=312AA_BP=56
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVYGSY
QCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC
LAFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGV

--------------------------------------------------------------

>67315_67315_30_PPARA-FBLN1_PPARA_chr22_46594488_ENST00000434345_FBLN1_chr22_45942965_ENST00000442170_length(amino acids)=230AA_BP=56
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDINECSSSPCSQECANVYGSY
QCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:46594488/chr22:45942965)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FBLN1

P23142

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP. {ECO:0000269|PubMed:11792823, ECO:0000269|PubMed:9393974, ECO:0000269|PubMed:9466671}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFBLN1chr22:46594488chr22:45942965ENST000002627221015441_480440.3333333333333684.0DomainEGF-like 7%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000002627221015481_524440.3333333333333684.0DomainEGF-like 8%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000002627221015525_578440.3333333333333684.0DomainEGF-like 9%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000003278581017441_480440.3333333333333704.0DomainEGF-like 7%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000003278581017481_524440.3333333333333704.0DomainEGF-like 8%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000003278581017525_578440.3333333333333704.0DomainEGF-like 9%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000003409231015441_480440.3333333333333567.0DomainEGF-like 7%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000003409231015481_524440.3333333333333567.0DomainEGF-like 8%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000003409231015525_578440.3333333333333567.0DomainEGF-like 9%3B calcium-binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPARAchr22:46594488chr22:45942965ENST00000262735+3899_17369.33333333333333469.0DNA bindingNuclear receptor
HgenePPARAchr22:46594488chr22:45942965ENST00000396000+3899_17369.33333333333333469.0DNA bindingNuclear receptor
HgenePPARAchr22:46594488chr22:45942965ENST00000402126+2799_17369.33333333333333469.0DNA bindingNuclear receptor
HgenePPARAchr22:46594488chr22:45942965ENST00000407236+3899_17369.33333333333333469.0DNA bindingNuclear receptor
HgenePPARAchr22:46594488chr22:45942965ENST00000434345+1599_17369.33333333333333188.33333333333334DNA bindingNuclear receptor
HgenePPARAchr22:46594488chr22:45942965ENST00000262735+38239_46669.33333333333333469.0DomainNR LBD
HgenePPARAchr22:46594488chr22:45942965ENST00000396000+38239_46669.33333333333333469.0DomainNR LBD
HgenePPARAchr22:46594488chr22:45942965ENST00000402126+27239_46669.33333333333333469.0DomainNR LBD
HgenePPARAchr22:46594488chr22:45942965ENST00000407236+38239_46669.33333333333333469.0DomainNR LBD
HgenePPARAchr22:46594488chr22:45942965ENST00000434345+15239_46669.33333333333333188.33333333333334DomainNR LBD
HgenePPARAchr22:46594488chr22:45942965ENST00000262735+38304_43369.33333333333333469.0RegionNote=Required for heterodimerization with RXRA
HgenePPARAchr22:46594488chr22:45942965ENST00000396000+38304_43369.33333333333333469.0RegionNote=Required for heterodimerization with RXRA
HgenePPARAchr22:46594488chr22:45942965ENST00000402126+27304_43369.33333333333333469.0RegionNote=Required for heterodimerization with RXRA
HgenePPARAchr22:46594488chr22:45942965ENST00000407236+38304_43369.33333333333333469.0RegionNote=Required for heterodimerization with RXRA
HgenePPARAchr22:46594488chr22:45942965ENST00000434345+15304_43369.33333333333333188.33333333333334RegionNote=Required for heterodimerization with RXRA
HgenePPARAchr22:46594488chr22:45942965ENST00000262735+38102_12269.33333333333333469.0Zinc fingerNR C4-type
HgenePPARAchr22:46594488chr22:45942965ENST00000262735+38139_16169.33333333333333469.0Zinc fingerNR C4-type
HgenePPARAchr22:46594488chr22:45942965ENST00000396000+38102_12269.33333333333333469.0Zinc fingerNR C4-type
HgenePPARAchr22:46594488chr22:45942965ENST00000396000+38139_16169.33333333333333469.0Zinc fingerNR C4-type
HgenePPARAchr22:46594488chr22:45942965ENST00000402126+27102_12269.33333333333333469.0Zinc fingerNR C4-type
HgenePPARAchr22:46594488chr22:45942965ENST00000402126+27139_16169.33333333333333469.0Zinc fingerNR C4-type
HgenePPARAchr22:46594488chr22:45942965ENST00000407236+38102_12269.33333333333333469.0Zinc fingerNR C4-type
HgenePPARAchr22:46594488chr22:45942965ENST00000407236+38139_16169.33333333333333469.0Zinc fingerNR C4-type
HgenePPARAchr22:46594488chr22:45942965ENST00000434345+15102_12269.33333333333333188.33333333333334Zinc fingerNR C4-type
HgenePPARAchr22:46594488chr22:45942965ENST00000434345+15139_16169.33333333333333188.33333333333334Zinc fingerNR C4-type
TgeneFBLN1chr22:46594488chr22:45942965ENST000002627221015112_144440.3333333333333684.0DomainAnaphylatoxin-like 3
TgeneFBLN1chr22:46594488chr22:45942965ENST000002627221015176_215440.3333333333333684.0DomainEGF-like 1
TgeneFBLN1chr22:46594488chr22:45942965ENST000002627221015216_261440.3333333333333684.0DomainEGF-like 2%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000002627221015262_307440.3333333333333684.0DomainEGF-like 3%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000002627221015308_355440.3333333333333684.0DomainEGF-like 4%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000002627221015356_398440.3333333333333684.0DomainEGF-like 5%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST00000262722101536_76440.3333333333333684.0DomainAnaphylatoxin-like 1
TgeneFBLN1chr22:46594488chr22:45942965ENST000002627221015399_440440.3333333333333684.0DomainEGF-like 6%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST00000262722101577_111440.3333333333333684.0DomainAnaphylatoxin-like 2
TgeneFBLN1chr22:46594488chr22:45942965ENST000003278581017112_144440.3333333333333704.0DomainAnaphylatoxin-like 3
TgeneFBLN1chr22:46594488chr22:45942965ENST000003278581017176_215440.3333333333333704.0DomainEGF-like 1
TgeneFBLN1chr22:46594488chr22:45942965ENST000003278581017216_261440.3333333333333704.0DomainEGF-like 2%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000003278581017262_307440.3333333333333704.0DomainEGF-like 3%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000003278581017308_355440.3333333333333704.0DomainEGF-like 4%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000003278581017356_398440.3333333333333704.0DomainEGF-like 5%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST00000327858101736_76440.3333333333333704.0DomainAnaphylatoxin-like 1
TgeneFBLN1chr22:46594488chr22:45942965ENST000003278581017399_440440.3333333333333704.0DomainEGF-like 6%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST00000327858101777_111440.3333333333333704.0DomainAnaphylatoxin-like 2
TgeneFBLN1chr22:46594488chr22:45942965ENST000003409231015112_144440.3333333333333567.0DomainAnaphylatoxin-like 3
TgeneFBLN1chr22:46594488chr22:45942965ENST000003409231015176_215440.3333333333333567.0DomainEGF-like 1
TgeneFBLN1chr22:46594488chr22:45942965ENST000003409231015216_261440.3333333333333567.0DomainEGF-like 2%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000003409231015262_307440.3333333333333567.0DomainEGF-like 3%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000003409231015308_355440.3333333333333567.0DomainEGF-like 4%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000003409231015356_398440.3333333333333567.0DomainEGF-like 5%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST00000340923101536_76440.3333333333333567.0DomainAnaphylatoxin-like 1
TgeneFBLN1chr22:46594488chr22:45942965ENST000003409231015399_440440.3333333333333567.0DomainEGF-like 6%3B calcium-binding
TgeneFBLN1chr22:46594488chr22:45942965ENST00000340923101577_111440.3333333333333567.0DomainAnaphylatoxin-like 2
TgeneFBLN1chr22:46594488chr22:45942965ENST000002627221015356_440440.3333333333333684.0RegionNote=Self-association and FN1-binding%3B calcium is necessary for homotypic binding%2C but not for heterotypic binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000003278581017356_440440.3333333333333704.0RegionNote=Self-association and FN1-binding%3B calcium is necessary for homotypic binding%2C but not for heterotypic binding
TgeneFBLN1chr22:46594488chr22:45942965ENST000003409231015356_440440.3333333333333567.0RegionNote=Self-association and FN1-binding%3B calcium is necessary for homotypic binding%2C but not for heterotypic binding


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PPARA
FBLN1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PPARA-FBLN1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PPARA-FBLN1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource