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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PPARG-PAX8

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PPARG-PAX8
	FusionPDB ID: 67353
	FusionGDB2.0 ID: 67353
		Hgene	Tgene
	Gene symbol	PPARG	PAX8
	Gene ID	5468	7849
	Gene name	peroxisome proliferator activated receptor gamma	paired box 8
	Synonyms	CIMT1\|GLM1\|NR1C3\|PPARG1\|PPARG2\|PPARgamma	-
	Cytomap	3p25.2	2q14.1
	Type of gene	protein-coding	protein-coding
	Description	peroxisome proliferator-activated receptor gammaPPAR-gammanuclear receptor subfamily 1 group C member 3peroxisome proliferator-activated nuclear receptor gamma variant 1	paired box protein Pax-8paired domain gene 8
	Modification date	20200329	20200313
	UniProtAcc	P37231	Q06710
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000309576, ENST00000397000, ENST00000397010, ENST00000397012, ENST00000397015, ENST00000397026, ENST00000539812, ENST00000287820,	ENST00000348715, ENST00000263334, ENST00000263335, ENST00000397647, ENST00000429538,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 9 X 5=315	5 X 6 X 4=120
	# samples	13	8
	** MAII score	log2(13/315*10)=-1.27684020535882 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PPARG [Title/Abstract] AND PAX8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PAX8(113992971)-PPARG(12421203), # samples:12 PPARG(12353952)-PAX8(113984833), # samples:13
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PPARG	GO:0000122	negative regulation of transcription by RNA polymerase II	12700342
Hgene	PPARG	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	18293083
Hgene	PPARG	GO:0007165	signal transduction	9568716
Hgene	PPARG	GO:0010742	macrophage derived foam cell differentiation	26504087
Hgene	PPARG	GO:0010745	negative regulation of macrophage derived foam cell differentiation	19114110
Hgene	PPARG	GO:0010871	negative regulation of receptor biosynthetic process	12700342
Hgene	PPARG	GO:0010887	negative regulation of cholesterol storage	19114110
Hgene	PPARG	GO:0010891	negative regulation of sequestering of triglyceride	12700342
Hgene	PPARG	GO:0016525	negative regulation of angiogenesis	28566713
Hgene	PPARG	GO:0030224	monocyte differentiation	9568716
Hgene	PPARG	GO:0032526	response to retinoic acid	16239304
Hgene	PPARG	GO:0042953	lipoprotein transport	9568716
Hgene	PPARG	GO:0043537	negative regulation of blood vessel endothelial cell migration	28566713
Hgene	PPARG	GO:0045713	low-density lipoprotein particle receptor biosynthetic process	9568716
Hgene	PPARG	GO:0045944	positive regulation of transcription by RNA polymerase II	9568715\|12700342\|16239304\|17611579
Hgene	PPARG	GO:0048469	cell maturation	9568716
Hgene	PPARG	GO:0048662	negative regulation of smooth muscle cell proliferation	20622039
Hgene	PPARG	GO:0051091	positive regulation of DNA-binding transcription factor activity	18293083
Hgene	PPARG	GO:0061614	pri-miRNA transcription by RNA polymerase II	28566713
Hgene	PPARG	GO:0071404	cellular response to low-density lipoprotein particle stimulus	9568716
Hgene	PPARG	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	28522568
Tgene	PAX8	GO:0006351	transcription, DNA-templated	9590296
Tgene	PAX8	GO:0045893	positive regulation of transcription, DNA-templated	9388203\|15356023\|15961562
Tgene	PAX8	GO:0045944	positive regulation of transcription by RNA polymerase II	9388203
Tgene	PAX8	GO:0071371	cellular response to gonadotropin stimulus	15961562

Fusion gene breakpoints across PPARG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PAX8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	THCA	TCGA-BJ-A0YZ-01A	PPARG	chr3	12353952	-	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-BJ-A0YZ-01A	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-BJ-A0YZ	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-DE-A4M9-01A	PPARG	chr3	12329174	+	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-DE-A4M9-01A	PPARG	chr3	12329519	+	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-DE-A4M9-01A	PPARG	chr3	12353952	-	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-DE-A4M9-01A	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-EM-A3AJ-01A	PPARG	chr3	12353952	-	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-EM-A3AJ-01A	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
ChimerDB4	THCA	TCGA-EM-A3AJ	PPARG	chr3	12353952	+	PAX8	chr2	113984833	-
ChimerKB3	.	.	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000397010	PPARG	chr3	12458653	+	ENST00000348715	PAX8	chr2	113999303	-	4779	1570	384	2165	593
ENST00000397010	PPARG	chr3	12458653	+	ENST00000397647	PAX8	chr2	113999303	-	4446	1570	384	1832	482
ENST00000397010	PPARG	chr3	12458653	+	ENST00000263335	PAX8	chr2	113999303	-	4548	1570	384	1934	516
ENST00000397010	PPARG	chr3	12458653	+	ENST00000429538	PAX8	chr2	113999303	-	4858	1570	384	2321	645
ENST00000397010	PPARG	chr3	12458653	+	ENST00000263334	PAX8	chr2	113999303	-	2166	1570	384	2165	593
ENST00000309576	PPARG	chr3	12458653	+	ENST00000348715	PAX8	chr2	113999303	-	4632	1423	237	2018	593
ENST00000309576	PPARG	chr3	12458653	+	ENST00000397647	PAX8	chr2	113999303	-	4299	1423	237	1685	482
ENST00000309576	PPARG	chr3	12458653	+	ENST00000263335	PAX8	chr2	113999303	-	4401	1423	237	1787	516
ENST00000309576	PPARG	chr3	12458653	+	ENST00000429538	PAX8	chr2	113999303	-	4711	1423	237	2174	645
ENST00000309576	PPARG	chr3	12458653	+	ENST00000263334	PAX8	chr2	113999303	-	2019	1423	237	2018	593
ENST00000397015	PPARG	chr3	12458653	+	ENST00000348715	PAX8	chr2	113999303	-	4517	1308	122	1903	593
ENST00000397015	PPARG	chr3	12458653	+	ENST00000397647	PAX8	chr2	113999303	-	4184	1308	122	1570	482
ENST00000397015	PPARG	chr3	12458653	+	ENST00000263335	PAX8	chr2	113999303	-	4286	1308	122	1672	516
ENST00000397015	PPARG	chr3	12458653	+	ENST00000429538	PAX8	chr2	113999303	-	4596	1308	122	2059	645
ENST00000397015	PPARG	chr3	12458653	+	ENST00000263334	PAX8	chr2	113999303	-	1904	1308	122	1903	594
ENST00000397012	PPARG	chr3	12458653	+	ENST00000348715	PAX8	chr2	113999303	-	4768	1559	373	2154	593
ENST00000397012	PPARG	chr3	12458653	+	ENST00000397647	PAX8	chr2	113999303	-	4435	1559	373	1821	482
ENST00000397012	PPARG	chr3	12458653	+	ENST00000263335	PAX8	chr2	113999303	-	4537	1559	373	1923	516
ENST00000397012	PPARG	chr3	12458653	+	ENST00000429538	PAX8	chr2	113999303	-	4847	1559	373	2310	645
ENST00000397012	PPARG	chr3	12458653	+	ENST00000263334	PAX8	chr2	113999303	-	2155	1559	373	2154	594
ENST00000397026	PPARG	chr3	12458653	+	ENST00000348715	PAX8	chr2	113999303	-	4796	1587	383	2182	599
ENST00000397026	PPARG	chr3	12458653	+	ENST00000397647	PAX8	chr2	113999303	-	4463	1587	383	1849	488
ENST00000397026	PPARG	chr3	12458653	+	ENST00000263335	PAX8	chr2	113999303	-	4565	1587	383	1951	522
ENST00000397026	PPARG	chr3	12458653	+	ENST00000429538	PAX8	chr2	113999303	-	4875	1587	383	2338	651
ENST00000397026	PPARG	chr3	12458653	+	ENST00000263334	PAX8	chr2	113999303	-	2183	1587	383	2182	600
ENST00000287820	PPARG	chr3	12458653	+	ENST00000348715	PAX8	chr2	113999303	-	4600	1391	121	1986	621
ENST00000287820	PPARG	chr3	12458653	+	ENST00000397647	PAX8	chr2	113999303	-	4267	1391	121	1653	510
ENST00000287820	PPARG	chr3	12458653	+	ENST00000263335	PAX8	chr2	113999303	-	4369	1391	121	1755	544
ENST00000287820	PPARG	chr3	12458653	+	ENST00000429538	PAX8	chr2	113999303	-	4679	1391	121	2142	673
ENST00000287820	PPARG	chr3	12458653	+	ENST00000263334	PAX8	chr2	113999303	-	1987	1391	121	1986	622

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>67353_67353_1_PPARG-PAX8_PPARG_chr3_12458653_ENST00000287820_PAX8_chr2_113999303_ENST00000263334_length(amino acids)=622AA_BP=423
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVV
ADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTT
DKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDA
FSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAAPPFWICSKSAPGSRPSM

--------------------------------------------------------------

>67353_67353_2_PPARG-PAX8_PPARG_chr3_12458653_ENST00000287820_PAX8_chr2_113999303_ENST00000263335_length(amino acids)=544AA_BP=423
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVV
ADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTT
DKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDA
FSQHHLEPLECPFERQHYPEAYASPSHTKGEQGERWWGPRCPDTHPTSPPADRAAMPPLPSQAWWQEVNTLAMPMATPPTPPTARPGASP

--------------------------------------------------------------

>67353_67353_3_PPARG-PAX8_PPARG_chr3_12458653_ENST00000287820_PAX8_chr2_113999303_ENST00000348715_length(amino acids)=621AA_BP=423
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVV
ADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTT
DKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDA
FSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAAPPFWICSKSAPGSRPSM

--------------------------------------------------------------

>67353_67353_4_PPARG-PAX8_PPARG_chr3_12458653_ENST00000287820_PAX8_chr2_113999303_ENST00000397647_length(amino acids)=510AA_BP=423
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVV
ADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTT
DKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDA

--------------------------------------------------------------

>67353_67353_5_PPARG-PAX8_PPARG_chr3_12458653_ENST00000287820_PAX8_chr2_113999303_ENST00000429538_length(amino acids)=673AA_BP=423
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVV
ADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTT
DKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDA
FSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSS
SSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGH

--------------------------------------------------------------

>67353_67353_6_PPARG-PAX8_PPARG_chr3_12458653_ENST00000309576_PAX8_chr2_113999303_ENST00000263334_length(amino acids)=593AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT
KGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAAPPFWICSKSAPGSRPSMPFPMLPPCTGSSRARPSSQGERWWGPRC

--------------------------------------------------------------

>67353_67353_7_PPARG-PAX8_PPARG_chr3_12458653_ENST00000309576_PAX8_chr2_113999303_ENST00000263335_length(amino acids)=516AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT

--------------------------------------------------------------

>67353_67353_8_PPARG-PAX8_PPARG_chr3_12458653_ENST00000309576_PAX8_chr2_113999303_ENST00000348715_length(amino acids)=593AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT
KGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAAPPFWICSKSAPGSRPSMPFPMLPPCTGSSRARPSSQGERWWGPRC

--------------------------------------------------------------

>67353_67353_9_PPARG-PAX8_PPARG_chr3_12458653_ENST00000309576_PAX8_chr2_113999303_ENST00000397647_length(amino acids)=482AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT

--------------------------------------------------------------

>67353_67353_10_PPARG-PAX8_PPARG_chr3_12458653_ENST00000309576_PAX8_chr2_113999303_ENST00000429538_length(amino acids)=645AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT
KGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAF
PHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTS

--------------------------------------------------------------

>67353_67353_11_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397010_PAX8_chr2_113999303_ENST00000263334_length(amino acids)=593AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT
KGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAAPPFWICSKSAPGSRPSMPFPMLPPCTGSSRARPSSQGERWWGPRC

--------------------------------------------------------------

>67353_67353_12_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397010_PAX8_chr2_113999303_ENST00000263335_length(amino acids)=516AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT

--------------------------------------------------------------

>67353_67353_13_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397010_PAX8_chr2_113999303_ENST00000348715_length(amino acids)=593AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT
KGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAAPPFWICSKSAPGSRPSMPFPMLPPCTGSSRARPSSQGERWWGPRC

--------------------------------------------------------------

>67353_67353_14_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397010_PAX8_chr2_113999303_ENST00000397647_length(amino acids)=482AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT

--------------------------------------------------------------

>67353_67353_15_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397010_PAX8_chr2_113999303_ENST00000429538_length(amino acids)=645AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT
KGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAF
PHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTS

--------------------------------------------------------------

>67353_67353_16_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397012_PAX8_chr2_113999303_ENST00000263334_length(amino acids)=594AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT
KGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAAPPFWICSKSAPGSRPSMPFPMLPPCTGSSRARPSSQGERWWGPRC

--------------------------------------------------------------

>67353_67353_17_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397012_PAX8_chr2_113999303_ENST00000263335_length(amino acids)=516AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT

--------------------------------------------------------------

>67353_67353_18_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397012_PAX8_chr2_113999303_ENST00000348715_length(amino acids)=593AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT
KGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAAPPFWICSKSAPGSRPSMPFPMLPPCTGSSRARPSSQGERWWGPRC

--------------------------------------------------------------

>67353_67353_19_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397012_PAX8_chr2_113999303_ENST00000397647_length(amino acids)=482AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT

--------------------------------------------------------------

>67353_67353_20_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397012_PAX8_chr2_113999303_ENST00000429538_length(amino acids)=645AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT
KGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAF
PHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTS

--------------------------------------------------------------

>67353_67353_21_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397015_PAX8_chr2_113999303_ENST00000263334_length(amino acids)=594AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT
KGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAAPPFWICSKSAPGSRPSMPFPMLPPCTGSSRARPSSQGERWWGPRC

--------------------------------------------------------------

>67353_67353_22_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397015_PAX8_chr2_113999303_ENST00000263335_length(amino acids)=516AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT

--------------------------------------------------------------

>67353_67353_23_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397015_PAX8_chr2_113999303_ENST00000348715_length(amino acids)=593AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT
KGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAAPPFWICSKSAPGSRPSMPFPMLPPCTGSSRARPSSQGERWWGPRC

--------------------------------------------------------------

>67353_67353_24_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397015_PAX8_chr2_113999303_ENST00000397647_length(amino acids)=482AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT

--------------------------------------------------------------

>67353_67353_25_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397015_PAX8_chr2_113999303_ENST00000429538_length(amino acids)=645AA_BP=395
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL
QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT
KGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAF
PHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTS

--------------------------------------------------------------

>67353_67353_26_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397026_PAX8_chr2_113999303_ENST00000263334_length(amino acids)=600AA_BP=401
MKGFSEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPAS
PPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVG
MSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKF
KHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLK
SLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAY
ASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAAPPFWICSKSAPGSRPSMPFPMLPPCTGSSRARPSSQGER

--------------------------------------------------------------

>67353_67353_27_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397026_PAX8_chr2_113999303_ENST00000263335_length(amino acids)=522AA_BP=401
MKGFSEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPAS
PPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVG
MSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKF
KHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLK
SLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAY

--------------------------------------------------------------

>67353_67353_28_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397026_PAX8_chr2_113999303_ENST00000348715_length(amino acids)=599AA_BP=401
MKGFSEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPAS
PPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVG
MSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKF
KHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLK
SLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAY
ASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAAPPFWICSKSAPGSRPSMPFPMLPPCTGSSRARPSSQGER

--------------------------------------------------------------

>67353_67353_29_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397026_PAX8_chr2_113999303_ENST00000397647_length(amino acids)=488AA_BP=401
MKGFSEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPAS
PPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVG
MSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKF
KHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLK
SLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAY

--------------------------------------------------------------

>67353_67353_30_PPARG-PAX8_PPARG_chr3_12458653_ENST00000397026_PAX8_chr2_113999303_ENST00000429538_length(amino acids)=651AA_BP=401
MKGFSEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPAS
PPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVG
MSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKF
KHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLK
SLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAY
ASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGV
PPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPY

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:113992971/chr2:12421203)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PPARG P37231	PAX8 Q06710
FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). {ECO:0000250\|UniProtKB:P37238, ECO:0000269\|PubMed:16150867, ECO:0000269\|PubMed:20829347, ECO:0000269\|PubMed:23525231, ECO:0000269\|PubMed:9065481}.; FUNCTION: (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein. {ECO:0000269\|PubMed:25504154}.	FUNCTION: Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (271) >>>271.pdbFusion protein BP residue: 395 CIF file (271) >>>271.cif	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-	MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHY EDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHE EPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDL NCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSD IDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIY DMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYA KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTR EFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDS CRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT	482
3D view using mol* of 271 (AA BP:395)


PDB file (282) >>>282.pdbFusion protein BP residue: 401 CIF file (282) >>>282.cif	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-	MKGFSEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSS ISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQL YNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLI YDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLL AEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDK SPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQ EITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEG QGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILS GGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAY	488
3D view using mol* of 282 (AA BP:401)


PDB file (319) >>>319.pdbFusion protein BP residue: 423 CIF file (319) >>>319.cif	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-	MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDL SVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQ EYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFH YGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLA VGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSY IKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGV HEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAV KFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDA FSQHHLEPLECPFERQHYPEAYASPSHTKGEQEVNTLAMPMATPPTPPTA	510
3D view using mol* of 319 (AA BP:423)


PDB file (330) >>>330.pdbFusion protein BP residue: 395 CIF file (330) >>>330.cif	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-	MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHY EDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHE EPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDL NCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSD IDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIY DMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYA KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTR EFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDS CRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT KGEQGERWWGPRCPDTHPTSPPADRAAMPPLPSQAWWQEVNTLAMPMATP	516
3D view using mol* of 330 (AA BP:395)


PDB file (343) >>>343.pdbFusion protein BP residue: 401 CIF file (343) >>>343.cif	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-	MKGFSEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSS ISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQL YNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLI YDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLL AEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDK SPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQ EITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEG QGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILS GGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAY ASPSHTKGEQGERWWGPRCPDTHPTSPPADRAAMPPLPSQAWWQEVNTLA	522
3D view using mol* of 343 (AA BP:401)


PDB file (383) >>>383.pdbFusion protein BP residue: 423 CIF file (383) >>>383.cif	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-	MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDL SVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQ EYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFH YGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLA VGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSY IKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGV HEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAV KFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDA FSQHHLEPLECPFERQHYPEAYASPSHTKGEQGERWWGPRCPDTHPTSPP	544
3D view using mol* of 383 (AA BP:423)


PDB file (458) >>>458.pdbFusion protein BP residue: 395 CIF file (458) >>>458.cif	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-	MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHY EDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHE EPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDL NCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSD IDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIY DMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYA KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTR EFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDS CRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT KGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAAPPFWI CSKSAPGSRPSMPFPMLPPCTGSSRARPSSQGERWWGPRCPDTHPTSPPA	593
3D view using mol* of 458 (AA BP:395)


PDB file (460) >>>460.pdbFusion protein BP residue: 395 CIF file (460) >>>460.cif	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-	MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHY EDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHE EPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDL NCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSD IDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIY DMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYA KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTR EFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDS CRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT KGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAAPPFWI CSKSAPGSRPSMPFPMLPPCTGSSRARPSSQGERWWGPRCPDTHPTSPPA	594
3D view using mol* of 460 (AA BP:395)


PDB file (472) >>>472.pdbFusion protein BP residue: 401 CIF file (472) >>>472.cif	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-	MKGFSEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSS ISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQL YNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLI YDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLL AEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDK SPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQ EITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEG QGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILS GGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAY ASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVA APPFWICSKSAPGSRPSMPFPMLPPCTGSSRARPSSQGERWWGPRCPDTH	599
3D view using mol* of 472 (AA BP:401)


PDB file (474) >>>474.pdbFusion protein BP residue: 401 CIF file (474) >>>474.cif	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-	MKGFSEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSS ISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQL YNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLI YDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLL AEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDK SPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQ EITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEG QGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILS GGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAY ASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVA APPFWICSKSAPGSRPSMPFPMLPPCTGSSRARPSSQGERWWGPRCPDTH PTSPPADRAAMPPLPSQAWWQEVNTLAMPMATPPTPPTARPGASPTPACX	600
3D view using mol* of 474 (AA BP:401)


PDB file (494) >>>494.pdbFusion protein BP residue: 423 CIF file (494) >>>494.cif	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-	MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDL SVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQ EYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFH YGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLA VGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSY IKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGV HEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAV KFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDA FSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKAT LTPSNTPLGRNLSTHQTYPVVAAPPFWICSKSAPGSRPSMPFPMLPPCTG SSRARPSSQGERWWGPRCPDTHPTSPPADRAAMPPLPSQAWWQEVNTLAM	621
3D view using mol* of 494 (AA BP:423)


PDB file (495) >>>495.pdbFusion protein BP residue: 423 CIF file (495) >>>495.cif	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-	MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDL SVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQ EYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFH YGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLA VGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSY IKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGV HEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAV KFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDA FSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKAT LTPSNTPLGRNLSTHQTYPVVAAPPFWICSKSAPGSRPSMPFPMLPPCTG SSRARPSSQGERWWGPRCPDTHPTSPPADRAAMPPLPSQAWWQEVNTLAM	622
3D view using mol* of 495 (AA BP:423)


PDB file (520) >>>520.pdbFusion protein BP residue: 395 CIF file (520) >>>520.cif	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-	MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHY EDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHE EPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDL NCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSD IDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIY DMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYA KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTR EFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGGDQDS CRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT KGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPF AIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAASVYGQF TGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAY	645
3D view using mol* of 520 (AA BP:395)


PDB file (527) >>>527.pdbFusion protein BP residue: 401 CIF file (527) >>>527.cif	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-	MKGFSEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSS ISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQL YNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLI YDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLL AEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDK SPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQ EITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEG QGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILS GGDQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAY ASPSHTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVA DPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQVGSGVPPFNAFPHAA SVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSE YSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDH	651
3D view using mol* of 527 (AA BP:401)


PDB file (546) >>>546.pdbFusion protein BP residue: 423 CIF file (546) >>>546.cif	PPARG	chr3	12458653	+	PAX8	chr2	113999303	-	MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDL SVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQ EYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFH YGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLA VGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSY IKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGV HEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAV KFNALELDDSDLAIFIAVIILSGGDQDSCRLSIDSQSSSSGPRKHLRTDA FSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKAT LTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSS AFLDLQQVGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPH IPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSS	673
3D view using mol* of 546 (AA BP:423)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PPARG_pLDDT.png

PAX8_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PPARG_PAX8_271_pLDDT.png (AA BP:395)

PPARG_PAX8_271_pLDDT_and_active_sites.png (AA BP:395)

PPARG_PAX8_271_violinplot.png (AA BP:395)

PPARG_PAX8_282_pLDDT.png (AA BP:401)

PPARG_PAX8_282_pLDDT_and_active_sites.png (AA BP:401)

PPARG_PAX8_282_violinplot.png (AA BP:401)

PPARG_PAX8_319_pLDDT.png (AA BP:423)

PPARG_PAX8_319_pLDDT_and_active_sites.png (AA BP:423)

PPARG_PAX8_319_violinplot.png (AA BP:423)

PPARG_PAX8_330_pLDDT.png (AA BP:395)

PPARG_PAX8_330_pLDDT_and_active_sites.png (AA BP:395)

PPARG_PAX8_330_violinplot.png (AA BP:395)

PPARG_PAX8_343_pLDDT.png (AA BP:401)

PPARG_PAX8_343_pLDDT_and_active_sites.png (AA BP:401)

PPARG_PAX8_343_violinplot.png (AA BP:401)

PPARG_PAX8_383_pLDDT.png (AA BP:423)

PPARG_PAX8_383_pLDDT_and_active_sites.png (AA BP:423)

PPARG_PAX8_383_violinplot.png (AA BP:423)

PPARG_PAX8_458_pLDDT.png (AA BP:395)

PPARG_PAX8_458_pLDDT_and_active_sites.png (AA BP:395)

PPARG_PAX8_458_violinplot.png (AA BP:395)

PPARG_PAX8_460_pLDDT.png (AA BP:395)

PPARG_PAX8_460_pLDDT_and_active_sites.png (AA BP:395)

PPARG_PAX8_460_violinplot.png (AA BP:395)

PPARG_PAX8_472_pLDDT.png (AA BP:401)

PPARG_PAX8_472_pLDDT_and_active_sites.png (AA BP:401)

PPARG_PAX8_472_violinplot.png (AA BP:401)

PPARG_PAX8_474_pLDDT.png (AA BP:401)

PPARG_PAX8_474_pLDDT_and_active_sites.png (AA BP:401)

PPARG_PAX8_474_violinplot.png (AA BP:401)

PPARG_PAX8_494_pLDDT.png (AA BP:423)

PPARG_PAX8_494_pLDDT_and_active_sites.png (AA BP:423)

PPARG_PAX8_494_violinplot.png (AA BP:423)

PPARG_PAX8_495_pLDDT.png (AA BP:423)

PPARG_PAX8_495_pLDDT_and_active_sites.png (AA BP:423)

PPARG_PAX8_495_violinplot.png (AA BP:423)

PPARG_PAX8_520_pLDDT.png (AA BP:395)

PPARG_PAX8_520_pLDDT_and_active_sites.png (AA BP:395)

PPARG_PAX8_520_violinplot.png (AA BP:395)

PPARG_PAX8_527_pLDDT.png (AA BP:401)

PPARG_PAX8_527_pLDDT_and_active_sites.png (AA BP:401)

PPARG_PAX8_527_violinplot.png (AA BP:401)

PPARG_PAX8_546_pLDDT.png (AA BP:423)

PPARG_PAX8_546_pLDDT_and_active_sites.png (AA BP:423)

PPARG_PAX8_546_violinplot.png (AA BP:423)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

PPARG_PAX8_271.png

PPARG_PAX8_282.png

PPARG_PAX8_319.png

PPARG_PAX8_330.png

PPARG_PAX8_343.png

PPARG_PAX8_383.png

PPARG_PAX8_458.png

PPARG_PAX8_460.png

PPARG_PAX8_472.png

PPARG_PAX8_474.png

PPARG_PAX8_494.png

PPARG_PAX8_495.png

PPARG_PAX8_520.png

PPARG_PAX8_527.png

PPARG_PAX8_546.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
271	1.198	258	1.245	515.529	0.361	0.904	1.173	2.331	0.729	3.198	0.801	Chain A: 222,227,228,229,230,249,255,256,258,259,2 62,264,267,272,277,280,281,282,283,284,285,286,288 ,289,291,292,295,323,326,327,329,330,332,333,339,3 40,341,342,343,344,348,353,360,363,364,367,384
282	1.1	518	1.153	1305.458	0.481	0.766	1.001	1.427	0.758	1.882	1.015	Chain A: 14,15,16,17,18,19,20,21,23,228,232,233,23 4,235,255,261,265,269,270,271,272,273,274,277,278, 280,283,286,287,288,289,290,291,292,293,294,295,29 6,297,298,299,301,323,325,326,327,328,329,330,332, 333,334,335,336,338,339,345,346,347,348,349,350,35 4,359,366,369,370,372,373,376,380,393,397,398,400, 402,403,404,406,407
319	1.063	751	1.121	2157.47	0.564	0.707	0.892	1.122	0.746	1.504	0.868	Chain A: 24,27,28,31,32,33,34,35,36,37,39,63,65,66 ,67,68,69,70,71,72,73,133,135,136,137,138,139,140, 142,143,154,182,183,184,197,221,225,228,229,232,23 6,239,240,242,243,244,246,247,248,331,332,333,334, 337,344,345,347,348,349,351,352,355,356,358,394,39 5,397,398,401,402,405,410,414,415,417,418,419,421, 422,423,424,425,426,428,429,430,431,432,433,443,44 6,447,448,451,452,456,457,458,459,460,461,462,463, 464,465,466,467,468,470,472,473
330	1.103	605	1.17	1833.678	0.536	0.741	0.958	1.605	0.657	2.445	0.948	Chain A: 105,106,107,108,109,110,112,126,193,194,1 97,198,201,209,211,212,213,214,215,216,218,219,282 ,293,315,316,318,319,320,321,322,323,324,326,327,3 28,359,360,362,363,366,367,369,370,373,374,377,379 ,382,383,386,387,390,391,394,395,396,397,398,399,4 00,401,418,419,421,422,423,425,426,428,429,430,431 ,432,433,434,435,436,437,438,439,440,441,442,480,4 81,482,483,484,486,487,488,490
343	1.116	525	1.178	1355.536	0.506	0.77	0.967	1.453	0.687	2.115	1.069	Chain A: 16,17,228,232,233,234,235,255,261,265,268 ,269,270,271,272,273,274,277,278,279,286,287,288,2 89,290,291,292,293,294,295,296,297,298,299,300,301 ,302,303,307,312,313,317,320,321,324,325,326,328,3 29,332,333,335,336,338,339,345,346,347,348,349,350 ,351,354,359,362,366,367,369,370,373,446,490,493,5 00,501
383	1.143	409	1.194	847.21	0.431	0.824	1.051	1.815	0.738	2.461	1.041	Chain A: 250,254,255,256,257,258,283,287,290,291,2 92,293,294,295,297,299,300,301,308,309,310,312,313 ,314,315,316,317,318,319,320,321,323,350,351,354,3 55,357,358,360,361,367,368,369,370,371,372,376,381 ,384,388,391,392,395,509,510,514,515
458	1.1294	549	1.1949	1145.62	0.4275	0.7802	1.0095	1.7358	0.654	2.6541	0.9195	Chain A: 8,9,10,11,12,13,15,17,222,226,227,228,229 ,230,255,259,262,263,264,265,266,267,273,277,279,2 80,281,282,283,284,285,286,287,288,289,290,291,292 ,293,294,295,297,301,306,311,314,315,318,319,322,3 23,326,327,329,330,332,333,339,340,341,342,343,344 ,348,353,359,360,363,364,367
460	1.1405	508	1.1842	1057.812	0.3736	0.8352	1.1107	1.8699	0.788	2.3731	0.8593	Chain A: 8,9,10,11,13,222,226,227,228,229,230,255, 259,262,263,264,265,266,267,273,279,280,281,282,28 3,284,285,286,287,288,289,290,291,292,293,294,295, 322,323,326,327,329,330,332,333,339,340,341,342,34 3,344,348,353,359,360,362,363,364,367,555,556,557, 558,559,560,561,562,563,566
472	1.1305	503	1.1737	1142.19	0.4291	0.8231	1.0695	1.7385	0.798	2.1785	0.9363	Chain A: 228,232,233,234,235,236,261,265,268,269,2 70,271,272,273,274,277,278,279,280,283,284,286,287 ,288,289,290,291,292,293,294,295,296,297,298,299,3 01,302,325,328,329,332,333,335,336,338,339,345,346 ,347,348,349,350,351,354,359,362,365,366,369,370,3 73,390,561,562,563,564,565,566,567,568,569,570
474	1.1367	473	1.1862	1143.905	0.4349	0.8197	1.0712	1.8159	0.7532	2.4108	0.8287	Chain A: 14,15,16,17,19,228,232,233,234,235,236,26 1,265,269,270,271,272,273,279,284,286,287,288,289, 290,291,292,293,294,295,296,297,298,299,301,328,32 9,332,333,335,336,338,339,345,346,347,348,349,351, 354,359,362,365,366,369,370,373,561,562,563,564,56 5,566,567,569,570
494	1.107	470	1.145	868.819	0.41	0.802	1.063	1.548	0.848	1.826	1.273	Chain A: 28,29,32,33,250,254,255,256,257,277,283,2 87,290,291,292,293,294,295,297,301,305,306,308,309 ,310,312,313,314,315,316,317,319,320,323,345,347,3 48,349,351,352,354,355,357,358,360,361,367,368,369 ,370,371,372,373,376,381,384,387,388,391,392,395,3 98,419,422,423,424,425,426
495	1.142	384	1.19	700.063	0.403	0.829	1.074	2.018	0.759	2.658	1.056	Chain A: 29,30,250,254,255,256,257,283,287,288,290 ,291,292,293,294,295,301,305,306,308,309,310,311,3 12,313,314,315,316,317,319,320,323,354,355,357,358 ,360,361,367,368,369,370,371,372,376,381,384,387,3 88,391,392,395
520	1.088	63	1.18	128.968	0.519	0.793	1.045	3.677	0.127	28.874	2.943	Chain A: 210,211,214,215,218,303,304,386,389,390,3 93,423,427,428,431
527	1.146	390	1.189	829.374	0.366	0.843	1.103	1.856	0.789	2.353	1.022	Chain A: 21,228,232,233,234,235,236,261,265,268,26 9,270,271,272,273,275,279,283,286,287,288,290,291, 292,293,294,295,296,297,298,299,301,329,332,333,33 4,335,336,338,339,345,346,347,348,349,350,351,354, 359,362,366,369,370,373,390,394
546	1.06	870	1.103	2395.169	0.528	0.732	0.925	1.086	0.847	1.282	1.099	Chain A: 25,28,29,30,31,32,33,34,35,36,37,39,239,2 42,243,246,250,254,255,256,257,258,283,287,291,292 ,293,294,295,301,307,308,309,310,311,312,313,314,3 15,316,317,319,320,323,331,332,337,341,344,345,347 ,348,349,351,352,354,355,356,357,358,360,361,367,3 68,369,370,371,372,373,376,381,384,385,387,388,390 ,391,392,394,395,397,398,401,402,405,407,410,411,4 14,415,417,418,419,421,422,423,424,425,426,427,428 ,429,430,432,440,441,442,443,444,446,447,448,449,4 50,451,455,456,459,460,461,462,463,640,641,642,643 ,644,645,646,648,649

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB	ZINC ID	DrugBank ID	Drug name	Docking score	Glide gscore
271	ZINC000003812841	DB00227	Lovastatin	-9.45986	-9.45986
271	ZINC000001542113	DB06684	Vilazodone	-7.6502	-8.7451
271	ZINC000003830391	DB01140	Cefadroxil	-8.45553	-8.66473
271	ZINC000021297660	DB00688	Mycophenolate mofetil	-6.89409	-8.65069
271	ZINC000096006023	DB06590	Ceftaroline fosamil	-8.32322	-8.62442
271	ZINC000028973446	DB00628	Clorazepic acid	-8.52398	-8.52398
271	ZINC000150588351	DB11574	Elbasvir	-7.00548	-8.29558
271	Capmatinib	DB11574		-8.28339	-8.28899
271	ZINC000003782807	DB00716	Nedocromil	-8.19662	-8.19662
271	ZINC000029571072	DB06636	Isavuconazonium	-7.63194	-8.13574
271	ZINC000000001464	DB01205	Flumazenil	-7.97215	-7.97355
271	ZINC000003873936	DB00251	Terconazole	-7.70092	-7.94742
271	ZINC000022059926	DB01155	Gemifloxacin	-7.87824	-7.91914
271	ZINC000043200832	DB09075	Edoxaban	-7.14561	-7.81561
271	ZINC000100017856	DB01117	Atovaquone	-7.76164	-7.76194
271	ZINC000000897256	DB00983	Formoterol	-5.43503	-7.74293
271	ZINC000000025958	DB12332	Rucaparib	-7.72587	-7.74087
271	ZINC000000007295	DB09119	Eslicarbazepine acetate	-7.72059	-7.72059
271	ZINC000000968328	DB00412	Rosiglitazone	-7.1508	-7.7176
271	ZINC000022059930	DB01155	Gemifloxacin	-6.10848	-7.71208

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID	DrugBank ID	Drug name	Drug type	SMILES	Drug group
ZINC000003812841	DB00227	Lovastatin	Small molecule	[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC	Approved\|Investigational
ZINC000001542113	DB06684	Vilazodone	Small molecule	NC(=O)C1=CC2=CC(=CC=C2O1)N1CCN(CCCCC2=CNC3=C2C=C(C=C3)C#N)CC1	Approved
ZINC000003830391	DB01140	Cefadroxil	Small molecule	[H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CC=C(O)C=C1)C(O)=O	Approved\|Vet_approved\|Withdrawn
ZINC000021297660	DB00688	Mycophenolate mofetil	Small molecule	COC1=C(CC=C(/C)CCC(=O)OCCN2CCOCC2)C(O)=C2C(=O)OCC2=C1C	Approved\|Investigational
ZINC000028973446	DB00628	Clorazepic acid	Small molecule	OC(=O)C1N=C(C2=CC=CC=C2)C2=C(NC1=O)C=CC(Cl)=C2	Approved\|Illicit
ZINC000150588351	DB11574	Elbasvir	Small molecule	[H][C@]1(CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C)C1=NC=C(N1)C1=CC2=C(C=C1)N1[C@@H](OC3=C(C=CC(=C3)C3=CN=C(N3)[C@]3([H])CCCN3C(=O)[C@@H](NC(=O)OC)C(C)C)C1=C2)C1=CC=CC=C1	Approved
ZINC000003782807	DB00716	Nedocromil	Small molecule	CCCC1=C2N(CC)C(=CC(=O)C2=CC2=C1OC(=CC2=O)C(O)=O)C(O)=O	Approved\|Investigational
ZINC000000001464	DB01205	Flumazenil	Small molecule	CCOC(=O)C1=C2CN(C)C(=O)C3=C(C=CC(F)=C3)N2C=N1	Approved
ZINC000003873936	DB00251	Terconazole	Small molecule	CC(C)N1CCN(CC1)C1=CC=C(OC[C@H]2CO[C@@](CN3C=NC=N3)(O2)C2=C(Cl)C=C(Cl)C=C2)C=C1	Approved
ZINC000043200832	DB09075	Edoxaban	Small molecule	CN(C)C(=O)[C@H]1CC[C@H](NC(=O)C(=O)NC2=NC=C(Cl)C=C2)[C@@H](C1)NC(=O)C1=NC2=C(CN(C)CC2)S1	Approved
ZINC000100017856	DB01117	Atovaquone	Small molecule	OC1=C([C@H]2CC[C@@H](CC2)C2=CC=C(Cl)C=C2)C(=O)C2=CC=CC=C2C1=O	Approved
ZINC000000025958	DB12332	Rucaparib	Small molecule	CNCC1=CC=C(C=C1)C1=C2CCNC(=O)C3=C2C(N1)=CC(F)=C3	Approved\|Investigational
ZINC000000007295	DB09119	Eslicarbazepine acetate	Small molecule	CC(=O)O[C@H]1CC2=CC=CC=C2N(C(N)=O)C2=CC=CC=C12	Approved
ZINC000022059930	DB01155	Gemifloxacin	Small molecule	CON=C1/CN(CC1CN)C1=NC2=C(C=C1F)C(=O)C(=CN2C1CC1)C(O)=O	Approved\|Investigational

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID	mol_MW	dipole	SASA	FOSA	FISA	PISA	WPSA	volume	donorHB	accptHB	IP	Human Oral Absorption	Percent Human Oral Absorption	Rule Of Five	Rule Of Three
ZINC000003812841	404.545	6.364	693.273	494.607	107.367	91.299	0	1328.33	1	6.7	9.043	3	100	0	1
ZINC000001542113	441.532	11.547	793.428	251.502	230.207	311.719	0	1413.848	3	7.5	8.378	1	65.799	0	2
ZINC000001542113	441.532	13.039	784.808	243.912	225.256	315.64	0	1401.798	3	7.5	8.283	1	66.453	0	2
ZINC000003830391	363.387	4.293	599.921	172.876	276.489	135.414	15.142	1057.325	4.25	8	8.995	1	14.682	0	1
ZINC000003830391	363.387	7.919	618.792	171.183	273.319	143.054	31.236	1086.809	4.25	8	9.217	1	16.581	0	1
ZINC000021297660	433.5	5.056	764.244	587.906	146.635	29.703	0	1395.182	0	9.2	9.357	1	76.892	0	1
ZINC000021297660	433.5	9.09	748.386	555.572	157.838	34.976	0	1369.479	0	9.2	9.232	1	73.591	0	1
ZINC000021297660	433.5	5.898	768.867	594.414	142.541	31.912	0	1394.187	0	9.2	9.386	1	77.73	0	1
ZINC000028973446	314.727	9.396	534.849	1.861	174.43	287.106	71.453	912.795	0	3.5	9.55	3	78.063	0	0
ZINC000150588351	882.03	6.572	1345.74	717.517	186.345	441.878	0	2635.972	2.5	13.25	8.001	1	68.973	3	1
ZINC000150588351	882.03	15.581	1298.014	670.728	196.39	430.896	0	2598.655	2.5	13.25	8.107	1	65.891	3	1
ZINC000150588351	882.03	7.694	1389.327	750.107	173.462	465.758	0	2673.848	2.5	13.25	8.124	1	73.085	3	1
ZINC000150588351	882.03	2.219	1373.023	721.483	195.055	456.485	0	2655.192	2.5	13.25	8.091	1	68.497	3	1
ZINC000150588351	882.03	13.761	1347.364	706.26	205.501	435.603	0	2635.257	2.5	13.25	8.253	1	64.824	3	1
ZINC000150588351	882.03	6.922	1403.807	740.212	182.531	481.064	0	2678.744	2.5	13.25	8.307	1	71.991	3	1
ZINC000150588351	882.03	13.99	1367.982	729.766	188.685	449.531	0	2678.673	2.5	13.25	7.973	1	70.208	3	2
ZINC000150588351	882.03	10.656	1391.126	719.587	194.166	477.373	0	2673.624	2.5	13.25	7.937	1	69.244	3	2
ZINC000150588351	882.03	8.233	1375.056	718.117	197.908	459.032	0	2655.63	2.5	13.25	7.962	1	67.787	3	2
ZINC000003782807	371.346	10.801	610.185	209.285	302.075	98.826	0	1090.928	2	9	8.974	1	34.108	0	1
ZINC000000001464	303.292	3.735	562.36	247.194	108.281	160.128	46.758	951.863	0	6.5	9.794	3	91.539	0	0
ZINC000003873936	532.469	4.431	860.629	401.681	59.053	283.132	116.762	1585.152	0	8.25	8.23	1	83.445	2	1
ZINC000003873936	532.469	3.621	825.535	406.455	39.012	260.021	120.047	1547.396	0	8.25	7.916	3	86.387	2	1
ZINC000003873936	532.469	4.897	820.088	399.474	44.446	254.924	121.243	1539.83	0	8.25	8.846	3	84.407	2	1
ZINC000022059926	389.385	5.386	675.076	333.398	232.638	67.96	41.08	1199.522	2	8.7	9.053	2	36.535	0	1
ZINC000022059926	389.385	4.357	656.741	321.575	225.557	68.441	41.167	1178.176	2	8.7	9.183	2	37.346	0	1
ZINC000043200832	548.058	9.441	913.361	465.639	180.782	154.069	112.871	1642.583	1.5	13.5	9.003	2	38.997	2	0
ZINC000043200832	548.058	6.463	912.632	460.161	190.9	150.844	110.726	1644.454	1.5	13.5	9.164	2	36.849	2	0
ZINC000043200832	548.058	9.846	916.93	470.459	180.251	153.57	112.65	1646.732	1.5	13.5	8.983	2	39.246	2	0
ZINC000100017856	366.843	2.476	635.971	145.612	116.349	302.491	71.519	1123.482	1	4.75	9.39	1	100	0	1
ZINC000000897256	344.41	5.264	632.493	247.284	157.494	227.715	0	1135.048	4	7.2	8.825	3	70.837	0	0
ZINC000000897256	344.41	6.478	644.939	257.318	179.642	207.979	0	1149.057	4	7.2	8.565	2	66.251	0	0
ZINC000000025958	323.369	9.363	601.398	214.232	112.926	227.819	46.421	1032.273	3	4	8.52	3	85.064	0	0
ZINC000000025958	323.369	9.466	597.964	212.386	112.007	227.152	46.419	1026.229	3	4	8.513	3	85.039	0	0
ZINC000000007295	296.325	6.9	521.101	122.894	126.907	271.299	0	932.49	2	4	9.099	3	84.364	0	0
ZINC000000968328	357.426	1.444	634.074	175.676	137.918	287.735	32.745	1113.731	1	5.25	8.373	3	96.012	0	0
ZINC000000968328	357.426	2.563	632.369	175.708	136.258	287.719	32.684	1111.853	1	5.25	8.348	3	96.294	0	0
ZINC000000968328	357.426	1.098	615.115	188.498	120.189	271.15	35.279	1101.068	1	5.25	8.417	3	100	0	0
ZINC000000968328	357.426	4.059	637.846	177.05	121.495	296.234	43.067	1111.876	1	5.25	8.521	3	100	0	0
ZINC000022059930	389.385	5.771	675.499	333.722	232.902	67.773	41.101	1199.671	2	8.7	9.049	2	36.482	0	1
ZINC000022059930	389.385	7.083	660.215	323.57	227.182	68.271	41.191	1181.717	2	8.7	9.157	2	37.113	0	1

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID	Smile	Surface Accessibility	Toxicity
ZINC000003812841	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	0.024963798	0.48330295
ZINC000001542113	N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5oc(C(N)=O)cc5c4)CC3)c2c1	0.202571924	0.261550466
ZINC000003830391	CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccc(O)cc3)[C@H]2SC1	0.0822826	0.17802178
ZINC000021297660	COc1c(C)c2c(c(O)c1C/C=C(C)CCC(=O)OCCN1CCOCC1)C(=O)OC2	0.148108632	0.352961747
ZINC000096006023	CCO/N=C(/C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(Sc3nc(-c4cc[n+](C)cc4)cs3)CS[C@H]12)c1nsc(NP(=O)(O)O)n1	0.027233582	0.191312451
ZINC000028973446	O=C(O)[C@H]1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O	0.168191138	0.395189961
ZINC000150588351	COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(-c2ccc3c(c2)O[C@@H](c2ccccc2)n2c-3cc3cc(-c4c[nH]c([C@@H]5CCCN5C(=O)[C@@H](NC(=O)OC)C(C)C)n4)ccc32)c[nH]1)C(C)C	0.015875917	0.217012798
ZINC000003782807	CCCc1c2oc(C(=O)O)cc(=O)c2cc2c(=O)cc(C(=O)O)n(CC)c12	0.158355381	0.176358315
ZINC000029571072	CNCC(=O)OCc1cccnc1N(C)C(=O)O[C@H](C)[n+]1cnn(C[C@](O)(c2cc(F)ccc2F)[C@@H](C)c2nc(-c3ccc(C#N)cc3)cs2)c1	0.025416027	0.235213823
ZINC000000001464	CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(F)ccc1-2	0.216870854	0.160947455
ZINC000003873936	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	0.082560545	0.329418045
ZINC000022059926	CO/N=C1CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)C[C@@H]1CN	0.077611514	0.258972331
ZINC000043200832	CN1CCc2nc(C(=O)N[C@@H]3C[C@@H](C(=O)N(C)C)CC[C@@H]3NC(=O)C(=O)Nc3ccc(Cl)cn3)sc2C1	0.053168582	0.122501005
ZINC000100017856	O=C1C(O)=C([C@@H]2CC[C@@H](c3ccc(Cl)cc3)CC2)C(=O)c2ccccc21	0.276473558	0.437817161
ZINC000000897256	COc1ccc(C[C@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	0.133863078	0.246482573
ZINC000000025958	CNCc1ccc(-c2[nH]c3cc(F)cc4c3c2CCNC4=O)cc1	0.204259799	0.179994505
ZINC000000007295	CC(=O)O[C@H]1Cc2ccccc2N(C(N)=O)c2ccccc21	0.170756409	0.26474101
ZINC000000968328	CN(CCOc1ccc(C[C@@H]2SC(=O)NC2=O)cc1)c1ccccn1	0.155326871	0.273380926
ZINC000022059930	CO/N=C1CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)C[C@H]1CN	0.077611514	0.258972331

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

PPARG

NCOA4, GADD45G, Gadd45b, DNTTIP2, PPARGC1A, HDAC3, HDAC4, RB1, EP300, EDF1, FABP1, NR0B2, SVIL, NRIP1, POU1F1, CREBBP, RXRA, MED24, MSX2, PML, ZBTB5, NR2E3, MAFF, ZBTB20, ZBTB3, ZNF496, ZBTB9, ZSCAN1, PIAS1, NCOR1, NCOR2, HMGA1, SP1, TFAP2A, CEBPB, MED1, ZNHIT3, TRIP4, JMJD1C, NFKBIB, SERPINH1, NCOA1, TRIM24, NCOA2, NCOA3, GRIP1, KAT5, LRIF1, HDAC1, MECP2, EZH2, NCOA6, NR0B1, COPS5, FHOD1, KIF1A, RXRB, ROBO4, KLF4, KDM4C, TNP1, KCTD13, RAD54L2, ANP32A, APP, RELA, UBC, CDC34, JAZF1, MED14, BCAS2, NEDD4, Rxra, SMARCD3, SMARCA4, CDK5, MIF4GD, USP7, ALOX15B, NR3C1, MUC1, NSD1, PAXIP1, ASH2L, RBBP5, PRKAA1, PRKAA2, CTNNB1, SFPQ, NR4A1, NR4A2, JUN, NFE2L3, PHB2, STAT5A, VDR, RXRG, MAP2K1, CAV1, SMAD3, PDIA2, PPM1B, Foxo1, daf-12, XRCC6, XRCC5, MAPK1, RANBP3, XPO1, Ncor1, JUND, LMO4, RFX5, CIITA, TCF4, NFKB1, PPARG, PRKCA, PIN1, STAT6, IKBKB, KAT2A, KIF11, CEP350, UBE2I, KLF5, IGFBP3, EGFR, MDM2, YWHAB, YWHAG, PPARGC1B, STAT1, STUB1, Pparg, FLYWCH2, PAK4, TNIP2, MFHAS1, TP53, VIMP, SELK, SIRT1, Smurf1, HSPA8, BAG2, RPS3, HNRNPM, HNRNPH1, TUFM, CCT3, DDX17, HSPA1B, TCP1, VCP, BAG5, DHX9, PGAM1, ATP5O, PGD, RUVBL1, RUVBL2, HSPA9, HSPA5, LCP1, CCT8, PPEF2, LGALS7, MRE11A, TOP2B, NAT10, TLN1, RPA2, LIG3, VPS29, RPS8, PBRM1, ZC3HAV1, KHSRP, GIGYF2, MCM7, HSPA6, TRIM28, HEATR1, LRPPRC, RPL10A, SAFB2, SF3B3, NOP14, RPL7A, RPL9, GTF2I, DNAJC7, EFTUD2, DDX18, SH3BGRL, DDX58, HNRNPK, DNAJA3, NUP93, NBN, PSMD11, ILF3, RAD50, SMARCA5, U2SURP, RSL1D1, PSMC1, NOP2, DDX52, UTP14A, ARPC2, ILF2, RPS4X, GTPBP4, H2AFY, DSP, NOP58, POF1B, LGALS3, GNL3, MSN, S100A9, HSP90AA1, DNAJA1, ARPC5, POLR1C, RRP9, UBR5, ATMIN, PROX1, SRSF1, NR1H3, NR1H2, Ppargc1a, MAPK9, ADCY4, GATA5, RARA, TRIM37, ESRRA, TRIM63, VHL, TRIM13, C6orf106, TRIM27, TRIB3, HDAC9, KMT2D, KDM6A, HIVEP1, SMARCA2, KMT2C, KAT2B, SMARCC1, SMARCD1, ZNF536, TBL1X, TADA2A, TADA3, NDUFA8, MLLT6, GPS2, BCL7A, ARID2, ZZZ3, ARID1B, KDM2B, DPF1, DPF2, TBL1XR1, CSRP2BP, BRD9, BRD7, MBIP, GLTSCR1, TRPS1,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PPARG
PAX8

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to PPARG-PAX8

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to PPARG-PAX8

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
PPARG	PAX8	Breast Invasive Ductal Carcinoma	MyCancerGenome
PPARG	PAX8	Invasive Breast Carcinoma	MyCancerGenome
PPARG	PAX8	Salivary Gland Adenoid Cystic Carcinoma	MyCancerGenome
PPARG	PAX8	Thyroid Gland Papillary Carcinoma	MyCancerGenome

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PPARG	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	6	CTD_human;GENOMICS_ENGLAND
Hgene	PPARG	C0238463	Papillary thyroid carcinoma	4	ORPHANET
Hgene	PPARG	C0002152	Alloxan Diabetes	3	CTD_human
Hgene	PPARG	C0002395	Alzheimer's Disease	3	CTD_human
Hgene	PPARG	C0011265	Presenile dementia	3	CTD_human
Hgene	PPARG	C0011853	Diabetes Mellitus, Experimental	3	CTD_human
Hgene	PPARG	C0020538	Hypertensive disease	3	CTD_human
Hgene	PPARG	C0021655	Insulin Resistance	3	CTD_human
Hgene	PPARG	C0022660	Kidney Failure, Acute	3	CTD_human
Hgene	PPARG	C0028754	Obesity	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	PPARG	C0035126	Reperfusion Injury	3	CTD_human
Hgene	PPARG	C0038433	Streptozotocin Diabetes	3	CTD_human
Hgene	PPARG	C0276496	Familial Alzheimer Disease (FAD)	3	CTD_human
Hgene	PPARG	C0494463	Alzheimer Disease, Late Onset	3	CTD_human
Hgene	PPARG	C0546126	Acute Confusional Senile Dementia	3	CTD_human
Hgene	PPARG	C0750900	Alzheimer's Disease, Focal Onset	3	CTD_human
Hgene	PPARG	C0750901	Alzheimer Disease, Early Onset	3	CTD_human
Hgene	PPARG	C0920563	Insulin Sensitivity	3	CTD_human
Hgene	PPARG	C1565662	Acute Kidney Insufficiency	3	CTD_human
Hgene	PPARG	C1720861	Familial Partial Lipodystrophy, Type 3	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	PPARG	C2609414	Acute kidney injury	3	CTD_human
Hgene	PPARG	C0021368	Inflammation	2	CTD_human
Hgene	PPARG	C0022116	Ischemia	2	CTD_human
Hgene	PPARG	C0024623	Malignant neoplasm of stomach	2	CTD_human
Hgene	PPARG	C0025202	melanoma	2	CTD_human
Hgene	PPARG	C0030297	Pancreatic Neoplasm	2	CTD_human
Hgene	PPARG	C0038356	Stomach Neoplasms	2	CTD_human
Hgene	PPARG	C0346647	Malignant neoplasm of pancreas	2	CTD_human
Hgene	PPARG	C1708349	Hereditary Diffuse Gastric Cancer	2	CTD_human
Hgene	PPARG	C0001418	Adenocarcinoma	1	CTD_human
Hgene	PPARG	C0004153	Atherosclerosis	1	CTD_human
Hgene	PPARG	C0004763	Barrett Esophagus	1	CTD_human
Hgene	PPARG	C0007102	Malignant tumor of colon	1	CTD_human;UNIPROT
Hgene	PPARG	C0009375	Colonic Neoplasms	1	CTD_human
Hgene	PPARG	C0009402	Colorectal Carcinoma	1	CTD_human
Hgene	PPARG	C0009404	Colorectal Neoplasms	1	CTD_human
Hgene	PPARG	C0010346	Crohn Disease	1	CTD_human
Hgene	PPARG	C0011849	Diabetes Mellitus	1	CTD_human
Hgene	PPARG	C0011859	Lipoatrophic Diabetes Mellitus	1	ORPHANET
Hgene	PPARG	C0011881	Diabetic Nephropathy	1	CTD_human
Hgene	PPARG	C0017658	Glomerulonephritis	1	CTD_human
Hgene	PPARG	C0017667	Nodular glomerulosclerosis	1	CTD_human
Hgene	PPARG	C0018801	Heart failure	1	CTD_human
Hgene	PPARG	C0018802	Congestive heart failure	1	CTD_human
Hgene	PPARG	C0023212	Left-Sided Heart Failure	1	CTD_human
Hgene	PPARG	C0023645	Lichen planus follicularis	1	GENOMICS_ENGLAND
Hgene	PPARG	C0023794	Lipoidosis	1	CTD_human
Hgene	PPARG	C0023903	Liver neoplasms	1	CTD_human
Hgene	PPARG	C0025517	Metabolic Diseases	1	CTD_human
Hgene	PPARG	C0027746	Nerve Degeneration	1	CTD_human
Hgene	PPARG	C0029408	Degenerative polyarthritis	1	CTD_human
Hgene	PPARG	C0030246	Pustulosis of Palms and Soles	1	CTD_human
Hgene	PPARG	C0030625	Passive Cutaneous Anaphylaxis	1	GENOMICS_ENGLAND
Hgene	PPARG	C0033860	Psoriasis	1	CTD_human
Hgene	PPARG	C0035078	Kidney Failure	1	CTD_human
Hgene	PPARG	C0038525	Subarachnoid Hemorrhage	1	CTD_human
Hgene	PPARG	C0040136	Thyroid Neoplasm	1	CTD_human
Hgene	PPARG	C0079772	T-Cell Lymphoma	1	CTD_human
Hgene	PPARG	C0085278	Antiphospholipid Syndrome	1	CTD_human
Hgene	PPARG	C0085413	Polycystic Kidney, Autosomal Dominant	1	CTD_human
Hgene	PPARG	C0086743	Osteoarthrosis Deformans	1	CTD_human
Hgene	PPARG	C0086873	Pseudopelade	1	GENOMICS_ENGLAND
Hgene	PPARG	C0151468	Thyroid Gland Follicular Adenoma	1	CTD_human
Hgene	PPARG	C0156147	Crohn's disease of large bowel	1	CTD_human
Hgene	PPARG	C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
Hgene	PPARG	C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
Hgene	PPARG	C0205643	Carcinoma, Cribriform	1	CTD_human
Hgene	PPARG	C0205644	Carcinoma, Granular Cell	1	CTD_human
Hgene	PPARG	C0205645	Adenocarcinoma, Tubular	1	CTD_human
Hgene	PPARG	C0206726	gliosarcoma	1	ORPHANET
Hgene	PPARG	C0221032	Familial generalized lipodystrophy	1	ORPHANET
Hgene	PPARG	C0221406	Pituitary-dependent Cushing's disease	1	CTD_human
Hgene	PPARG	C0235527	Heart Failure, Right-Sided	1	CTD_human
Hgene	PPARG	C0236811	Chronobiology Disorders	1	CTD_human
Hgene	PPARG	C0242339	Dyslipidemias	1	CTD_human
Hgene	PPARG	C0242488	Acute Lung Injury	1	CTD_human
Hgene	PPARG	C0267380	Crohn's disease of the ileum	1	CTD_human
Hgene	PPARG	C0270192	Perinatal Subarachnoid Hemorrhage	1	CTD_human
Hgene	PPARG	C0271694	Familial partial lipodystrophy	1	CTD_human
Hgene	PPARG	C0282548	Leukostasis	1	CTD_human
Hgene	PPARG	C0334588	Giant Cell Glioblastoma	1	ORPHANET
Hgene	PPARG	C0345904	Malignant neoplasm of liver	1	CTD_human
Hgene	PPARG	C0472383	Subarachnoid Hemorrhage, Spontaneous	1	CTD_human
Hgene	PPARG	C0525045	Mood Disorders	1	PSYGENET
Hgene	PPARG	C0549473	Thyroid carcinoma	1	CTD_human
Hgene	PPARG	C0598784	Dyslipoproteinemias	1	CTD_human
Hgene	PPARG	C0678202	Regional enteritis	1	CTD_human
Hgene	PPARG	C0751220	Inappropriate ACTH Secretion Syndrome	1	CTD_human
Hgene	PPARG	C0751530	Subarachnoid Hemorrhage, Aneurysmal	1	CTD_human
Hgene	PPARG	C0795688	Subarachnoid Hemorrhage, Intracranial	1	CTD_human
Hgene	PPARG	C0813142	Circadian Rhythm Disorders	1	CTD_human
Hgene	PPARG	C0887800	Psychogenic Inversion of Circadian Rhythm	1	CTD_human
Hgene	PPARG	C0887850	Polycystic Kidney, Type 1 Autosomal Dominant Disease	1	CTD_human
Hgene	PPARG	C0949272	IIeocolitis	1	CTD_human
Hgene	PPARG	C1258085	Barrett Epithelium	1	CTD_human
Hgene	PPARG	C1563937	Atherogenesis	1	CTD_human
Hgene	PPARG	C1565489	Renal Insufficiency	1	CTD_human
Hgene	PPARG	C1704377	Bright Disease	1	CTD_human
Hgene	PPARG	C1720859	Familial Partial Lipodystrophy, Type 1	1	CTD_human
Hgene	PPARG	C1720860	Familial Partial Lipodystrophy, Type 2	1	CTD_human
Hgene	PPARG	C1959583	Myocardial Failure	1	CTD_human
Hgene	PPARG	C1961112	Heart Decompensation	1	CTD_human
Hgene	PPARG	C2239176	Liver carcinoma	1	CTD_human
Hgene	PPARG	C2751306	Polycystic kidney disease, type 2	1	CTD_human
Hgene	PPARG	C2931367	Thyroid cancer, follicular	1	CTD_human
Hgene	PPARG	C2936846	Scarring alopecia	1	GENOMICS_ENGLAND
Tgene	PAX8	C0151516	Thyroid Hypoplasia	4	GENOMICS_ENGLAND;ORPHANET
Tgene	PAX8	C0238463	Papillary thyroid carcinoma	4	ORPHANET
Tgene	PAX8	C1869118	HYPOTHYROIDISM, CONGENITAL, DUE TO THYROID DYSGENESIS	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	PAX8	C0009402	Colorectal Carcinoma	1	CTD_human
Tgene	PAX8	C0009404	Colorectal Neoplasms	1	CTD_human
Tgene	PAX8	C0010308	Congenital Hypothyroidism	1	GENOMICS_ENGLAND
Tgene	PAX8	C0266283	Ectopic thyroid tissue (disorder)	1	ORPHANET
Tgene	PAX8	C1563716	Thyroid Dysgenesis	1	GENOMICS_ENGLAND
Tgene	PAX8	C2931367	Thyroid cancer, follicular	1	CTD_human