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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PPFIBP1-CCDC91

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPFIBP1-CCDC91
FusionPDB ID: 67454
FusionGDB2.0 ID: 67454
HgeneTgene
Gene symbol

PPFIBP1

CCDC91

Gene ID

8496

55297

Gene namePPFIA binding protein 1coiled-coil domain containing 91
SynonymsL2|SGT2|hSGT2|hSgt2pHSD8|p56
Cytomap

12p11.23-p11.22

12p11.22

Type of geneprotein-codingprotein-coding
Descriptionliprin-beta-1PTPRF interacting protein, binding protein 1 (liprin beta 1)PTPRF-interacting protein-binding protein 1liprin related proteinprotein-tyrosine phosphatase receptor-type f polypeptide-interacting protein-binding protein 1coiled-coil domain-containing protein 91GGA-binding partnerp56 accessory protein
Modification date2020031320200313
UniProtAcc

Q86W92

Q7Z6B0

Ensembl transtripts involved in fusion geneENST idsENST00000541633, ENST00000228425, 
ENST00000318304, ENST00000535047, 
ENST00000542629, ENST00000545334, 
ENST00000537927, 		ENST00000381256, 
ENST00000381259, ENST00000539107, 
ENST00000545336, ENST00000306172, 
ENST00000540401, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 14 X 13=364015 X 14 X 9=1890
# samples 2617
** MAII scorelog2(26/3640*10)=-3.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1890*10)=-3.47477958297073
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PPFIBP1 [Title/Abstract] AND CCDC91 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CCDC91(28343574)-PPFIBP1(27731085), # samples:1
PPFIBP1(27788048)-CCDC91(28515370), # samples:1
PPFIBP1(27731172)-CCDC91(28603094), # samples:1
Anticipated loss of major functional domain due to fusion event.PPFIBP1-CCDC91 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIBP1-CCDC91 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIBP1-CCDC91 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIBP1-CCDC91 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIBP1-CCDC91 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PPFIBP1-CCDC91 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PPFIBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCDC91 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-86-8673-01APPFIBP1chr12

27731172

+CCDC91chr12

28603094

+
ChimerDB4STADTCGA-BR-6709PPFIBP1chr12

27788048

+CCDC91chr12

28515370

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000318304PPFIBP1chr1227788048+ENST00000539107CCDC91chr1228515370+21885532501194314
ENST00000318304PPFIBP1chr1227788048+ENST00000545336CCDC91chr1228515370+22965532501302350
ENST00000318304PPFIBP1chr1227788048+ENST00000381256CCDC91chr1228515370+21875532501194314
ENST00000318304PPFIBP1chr1227788048+ENST00000381259CCDC91chr1228515370+22955532501302350
ENST00000535047PPFIBP1chr1227788048+ENST00000539107CCDC91chr1228515370+21745392361180314
ENST00000535047PPFIBP1chr1227788048+ENST00000545336CCDC91chr1228515370+22825392361288350
ENST00000535047PPFIBP1chr1227788048+ENST00000381256CCDC91chr1228515370+21735392361180314
ENST00000535047PPFIBP1chr1227788048+ENST00000381259CCDC91chr1228515370+22815392361288350
ENST00000542629PPFIBP1chr1227788048+ENST00000539107CCDC91chr1228515370+21705352321176314
ENST00000542629PPFIBP1chr1227788048+ENST00000545336CCDC91chr1228515370+22785352321284350
ENST00000542629PPFIBP1chr1227788048+ENST00000381256CCDC91chr1228515370+21695352321176314
ENST00000542629PPFIBP1chr1227788048+ENST00000381259CCDC91chr1228515370+22775352321284350
ENST00000228425PPFIBP1chr1227788048+ENST00000539107CCDC91chr1228515370+21385032001144314
ENST00000228425PPFIBP1chr1227788048+ENST00000545336CCDC91chr1228515370+22465032001252350
ENST00000228425PPFIBP1chr1227788048+ENST00000381256CCDC91chr1228515370+21375032001144314
ENST00000228425PPFIBP1chr1227788048+ENST00000381259CCDC91chr1228515370+22455032001252350

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000318304ENST00000539107PPFIBP1chr1227788048+CCDC91chr1228515370+0.0008235410.99917644
ENST00000318304ENST00000545336PPFIBP1chr1227788048+CCDC91chr1228515370+0.0008288470.99917114
ENST00000318304ENST00000381256PPFIBP1chr1227788048+CCDC91chr1228515370+0.0008340740.9991659
ENST00000318304ENST00000381259PPFIBP1chr1227788048+CCDC91chr1228515370+0.0008372450.9991628
ENST00000535047ENST00000539107PPFIBP1chr1227788048+CCDC91chr1228515370+0.0008664350.99913365
ENST00000535047ENST00000545336PPFIBP1chr1227788048+CCDC91chr1228515370+0.0008790110.999121
ENST00000535047ENST00000381256PPFIBP1chr1227788048+CCDC91chr1228515370+0.0008782740.9991217
ENST00000535047ENST00000381259PPFIBP1chr1227788048+CCDC91chr1228515370+0.0008882590.9991117
ENST00000542629ENST00000539107PPFIBP1chr1227788048+CCDC91chr1228515370+0.0008545070.9991455
ENST00000542629ENST00000545336PPFIBP1chr1227788048+CCDC91chr1228515370+0.000866320.99913365
ENST00000542629ENST00000381256PPFIBP1chr1227788048+CCDC91chr1228515370+0.0008664670.9991335
ENST00000542629ENST00000381259PPFIBP1chr1227788048+CCDC91chr1228515370+0.0008758950.9991241
ENST00000228425ENST00000539107PPFIBP1chr1227788048+CCDC91chr1228515370+0.0008104910.99918956
ENST00000228425ENST00000545336PPFIBP1chr1227788048+CCDC91chr1228515370+0.0008507090.9991493
ENST00000228425ENST00000381256PPFIBP1chr1227788048+CCDC91chr1228515370+0.0008212150.9991787
ENST00000228425ENST00000381259PPFIBP1chr1227788048+CCDC91chr1228515370+0.0008598510.99914014

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>67454_67454_1_PPFIBP1-CCDC91_PPFIBP1_chr12_27788048_ENST00000228425_CCDC91_chr12_28515370_ENST00000381256_length(amino acids)=314AA_BP=101
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMEKHKQELEDMRKAGHEALSIIVDEYKHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAA
KLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELI

--------------------------------------------------------------

>67454_67454_2_PPFIBP1-CCDC91_PPFIBP1_chr12_27788048_ENST00000228425_CCDC91_chr12_28515370_ENST00000381259_length(amino acids)=350AA_BP=101
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKE
KIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQE

--------------------------------------------------------------

>67454_67454_3_PPFIBP1-CCDC91_PPFIBP1_chr12_27788048_ENST00000228425_CCDC91_chr12_28515370_ENST00000539107_length(amino acids)=314AA_BP=101
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMEKHKQELEDMRKAGHEALSIIVDEYKHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAA
KLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELI

--------------------------------------------------------------

>67454_67454_4_PPFIBP1-CCDC91_PPFIBP1_chr12_27788048_ENST00000228425_CCDC91_chr12_28515370_ENST00000545336_length(amino acids)=350AA_BP=101
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKE
KIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQE

--------------------------------------------------------------

>67454_67454_5_PPFIBP1-CCDC91_PPFIBP1_chr12_27788048_ENST00000318304_CCDC91_chr12_28515370_ENST00000381256_length(amino acids)=314AA_BP=101
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMEKHKQELEDMRKAGHEALSIIVDEYKHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAA
KLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELI

--------------------------------------------------------------

>67454_67454_6_PPFIBP1-CCDC91_PPFIBP1_chr12_27788048_ENST00000318304_CCDC91_chr12_28515370_ENST00000381259_length(amino acids)=350AA_BP=101
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKE
KIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQE

--------------------------------------------------------------

>67454_67454_7_PPFIBP1-CCDC91_PPFIBP1_chr12_27788048_ENST00000318304_CCDC91_chr12_28515370_ENST00000539107_length(amino acids)=314AA_BP=101
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMEKHKQELEDMRKAGHEALSIIVDEYKHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAA
KLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELI

--------------------------------------------------------------

>67454_67454_8_PPFIBP1-CCDC91_PPFIBP1_chr12_27788048_ENST00000318304_CCDC91_chr12_28515370_ENST00000545336_length(amino acids)=350AA_BP=101
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKE
KIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQE

--------------------------------------------------------------

>67454_67454_9_PPFIBP1-CCDC91_PPFIBP1_chr12_27788048_ENST00000535047_CCDC91_chr12_28515370_ENST00000381256_length(amino acids)=314AA_BP=101
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMEKHKQELEDMRKAGHEALSIIVDEYKHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAA
KLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELI

--------------------------------------------------------------

>67454_67454_10_PPFIBP1-CCDC91_PPFIBP1_chr12_27788048_ENST00000535047_CCDC91_chr12_28515370_ENST00000381259_length(amino acids)=350AA_BP=101
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKE
KIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQE

--------------------------------------------------------------

>67454_67454_11_PPFIBP1-CCDC91_PPFIBP1_chr12_27788048_ENST00000535047_CCDC91_chr12_28515370_ENST00000539107_length(amino acids)=314AA_BP=101
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMEKHKQELEDMRKAGHEALSIIVDEYKHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAA
KLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELI

--------------------------------------------------------------

>67454_67454_12_PPFIBP1-CCDC91_PPFIBP1_chr12_27788048_ENST00000535047_CCDC91_chr12_28515370_ENST00000545336_length(amino acids)=350AA_BP=101
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKE
KIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQE

--------------------------------------------------------------

>67454_67454_13_PPFIBP1-CCDC91_PPFIBP1_chr12_27788048_ENST00000542629_CCDC91_chr12_28515370_ENST00000381256_length(amino acids)=314AA_BP=101
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMEKHKQELEDMRKAGHEALSIIVDEYKHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAA
KLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELI

--------------------------------------------------------------

>67454_67454_14_PPFIBP1-CCDC91_PPFIBP1_chr12_27788048_ENST00000542629_CCDC91_chr12_28515370_ENST00000381259_length(amino acids)=350AA_BP=101
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKE
KIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQE

--------------------------------------------------------------

>67454_67454_15_PPFIBP1-CCDC91_PPFIBP1_chr12_27788048_ENST00000542629_CCDC91_chr12_28515370_ENST00000539107_length(amino acids)=314AA_BP=101
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMEKHKQELEDMRKAGHEALSIIVDEYKHQRLLEMLDTEKELLKEKIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAA
KLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVKRTRDELI

--------------------------------------------------------------

>67454_67454_16_PPFIBP1-CCDC91_PPFIBP1_chr12_27788048_ENST00000542629_CCDC91_chr12_28515370_ENST00000545336_length(amino acids)=350AA_BP=101
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKE
KIKEALIQQSQEQKEILEKCLEEERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:28343574/chr12:27731085)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPFIBP1

Q86W92

CCDC91

Q7Z6B0

FUNCTION: May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}.FUNCTION: Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. {ECO:0000269|PubMed:17596511}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCCDC91chr12:27788048chr12:28515370ENST00000306172311249_407162.0412.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC91chr12:27788048chr12:28515370ENST00000381256411249_407192.0406.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC91chr12:27788048chr12:28515370ENST00000381259412249_407192.0442.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC91chr12:27788048chr12:28515370ENST00000539107512249_407192.0406.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC91chr12:27788048chr12:28515370ENST00000545336816249_407192.0442.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC91chr12:27788048chr12:28515370ENST00000306172311210_413162.0412.0RegionNote=Homodimerization
TgeneCCDC91chr12:27788048chr12:28515370ENST00000381256411210_413192.0406.0RegionNote=Homodimerization
TgeneCCDC91chr12:27788048chr12:28515370ENST00000381259412210_413192.0442.0RegionNote=Homodimerization
TgeneCCDC91chr12:27788048chr12:28515370ENST00000539107512210_413192.0406.0RegionNote=Homodimerization
TgeneCCDC91chr12:27788048chr12:28515370ENST00000545336816210_413192.0442.0RegionNote=Homodimerization

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000228425+430156_40590.01006.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000318304+429156_40590.01012.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000535047+46156_40590.0171.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000537927+127156_4050859.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000542629+428156_40590.0981.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000228425+430647_71190.01006.0DomainSAM 1
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000228425+430719_78290.01006.0DomainSAM 2
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000228425+430804_87690.01006.0DomainSAM 3
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000318304+429647_71190.01012.0DomainSAM 1
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000318304+429719_78290.01012.0DomainSAM 2
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000318304+429804_87690.01012.0DomainSAM 3
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000535047+46647_71190.0171.0DomainSAM 1
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000535047+46719_78290.0171.0DomainSAM 2
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000535047+46804_87690.0171.0DomainSAM 3
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000537927+127647_7110859.0DomainSAM 1
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000537927+127719_7820859.0DomainSAM 2
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000537927+127804_8760859.0DomainSAM 3
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000542629+428647_71190.0981.0DomainSAM 1
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000542629+428719_78290.0981.0DomainSAM 2
HgenePPFIBP1chr12:27788048chr12:28515370ENST00000542629+428804_87690.0981.0DomainSAM 3
TgeneCCDC91chr12:27788048chr12:28515370ENST00000306172311130_209162.0412.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC91chr12:27788048chr12:28515370ENST00000381256411130_209192.0406.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC91chr12:27788048chr12:28515370ENST00000381259412130_209192.0442.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC91chr12:27788048chr12:28515370ENST00000539107512130_209192.0406.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC91chr12:27788048chr12:28515370ENST00000545336816130_209192.0442.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC91chr12:27788048chr12:28515370ENST000003061723111_16162.0412.0RegionNote=GGA1-binding motif
TgeneCCDC91chr12:27788048chr12:28515370ENST000003812564111_16192.0406.0RegionNote=GGA1-binding motif
TgeneCCDC91chr12:27788048chr12:28515370ENST000003812594121_16192.0442.0RegionNote=GGA1-binding motif
TgeneCCDC91chr12:27788048chr12:28515370ENST000005391075121_16192.0406.0RegionNote=GGA1-binding motif
TgeneCCDC91chr12:27788048chr12:28515370ENST000005453368161_16192.0442.0RegionNote=GGA1-binding motif


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
PPFIBP1YWHAG, YWHAQ, SFN, S100A4, PPFIBP1, ELAVL1, SH3KBP1, GRK5, LATS2, YWHAB, CDKN1A, CEP250, CEP76, TP53, VCP, ENO1, MOV10, NXF1, PNKD, NTRK1, PPFIA1, PPFIA2, PPFIA3, TMEM17, PPP2R1A, DYNLL1, KIF21A, Myh9, Myo1c, Flnb, Scai, YWHAZ, CDH1, HAO2, RAPGEF5, KANK2, DCAF7, EFTUD2, ESR2, HRAS, KRAS, NRAS, LAMP1, KIAA1429, RPS6KA2, BICD1, TNFSF13B, ETAA1, PBX2, OBSL1, MAGEA3, PRKCZ, P4HB, PRRC2C, ESR1, ANLN, KIF14, KIF20A, nsp16, HULC, DNAJC5B, DNAJC5, PRKACA, ANK3, ARF6, B3GAT1, C11orf52, CAV1, CXADR, DIRAS3, EBAG9, EPB41L4A, EZR, FLOT1, GJA1, GJD3, LAMP2, LAMP3, LAMTOR1, LCK, LMAN1, LYN, MARCKS, MLLT4, OCLN, PANX1, PARD3, RAB11A, RAB2A, RAB35, RAB5A, RAB5C, RAB9A, RHOB, STX4, STX6, STX7, ZFPL1, VPS33B, SMAD4, YWHAH, DYNLL2, S100A6, S100B, TACR3, AKR7L, BTNL9, MFNG, GPR17, PPFIBP2, HSF2BP, GCGR, METTL21B, SNAP29, NPAS1, INF2, UBXN6, EMID1, PLBD1, MAB21L2, CPLX2, CHCHD4, SERBP1, MEIS2, BIRC8, COMTD1, SPN, MUM1, PSG11, BTF3, TOLLIP,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PPFIBP1all structure
CCDC91


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PPFIBP1-CCDC91


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PPFIBP1-CCDC91


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPFIBP1C0085269Plasma Cell Granuloma, Pulmonary1CTD_human