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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PPFIBP1-HP1BP3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPFIBP1-HP1BP3
FusionPDB ID: 67456
FusionGDB2.0 ID: 67456
HgeneTgene
Gene symbol

PPFIBP1

HP1BP3

Gene ID

8496

50809

Gene namePPFIA binding protein 1heterochromatin protein 1 binding protein 3
SynonymsL2|SGT2|hSGT2|hSgt2pHP1-BP74|HP1BP74
Cytomap

12p11.23-p11.22

1p36.12

Type of geneprotein-codingprotein-coding
Descriptionliprin-beta-1PTPRF interacting protein, binding protein 1 (liprin beta 1)PTPRF-interacting protein-binding protein 1liprin related proteinprotein-tyrosine phosphatase receptor-type f polypeptide-interacting protein-binding protein 1heterochromatin protein 1-binding protein 3
Modification date2020031320200313
UniProtAcc

Q86W92

Q5SSJ5

Ensembl transtripts involved in fusion geneENST idsENST00000228425, ENST00000318304, 
ENST00000537927, ENST00000542629, 
ENST00000535047, ENST00000541633, 
ENST00000545334, 		ENST00000375003, 
ENST00000375000, ENST00000487117, 
ENST00000312239, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 14 X 13=364022 X 14 X 10=3080
# samples 2624
** MAII scorelog2(26/3640*10)=-3.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/3080*10)=-3.68182403997374
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PPFIBP1 [Title/Abstract] AND HP1BP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PPFIBP1(27825416)-HP1BP3(21100103), # samples:1
Anticipated loss of major functional domain due to fusion event.PPFIBP1-HP1BP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIBP1-HP1BP3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIBP1-HP1BP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPFIBP1-HP1BP3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHP1BP3

GO:0071456

cellular response to hypoxia

25100860


check buttonFusion gene breakpoints across PPFIBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HP1BP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A15L-01APPFIBP1chr12

27825416

+HP1BP3chr1

21100103

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000537927PPFIBP1chr1227825416+ENST00000312239HP1BP3chr121100103-482013722572683808
ENST00000318304PPFIBP1chr1227825416+ENST00000312239HP1BP3chr121100103-510116532502964904
ENST00000542629PPFIBP1chr1227825416+ENST00000312239HP1BP3chr121100103-499015422322853873
ENST00000228425PPFIBP1chr1227825416+ENST00000312239HP1BP3chr121100103-500015522002863887

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000537927ENST00000312239PPFIBP1chr1227825416+HP1BP3chr121100103-0.0004316630.9995683
ENST00000318304ENST00000312239PPFIBP1chr1227825416+HP1BP3chr121100103-0.0004707560.99952924
ENST00000542629ENST00000312239PPFIBP1chr1227825416+HP1BP3chr121100103-0.0006095050.9993905
ENST00000228425ENST00000312239PPFIBP1chr1227825416+HP1BP3chr121100103-0.0006407060.9993593

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>67456_67456_1_PPFIBP1-HP1BP3_PPFIBP1_chr12_27825416_ENST00000228425_HP1BP3_chr1_21100103_ENST00000312239_length(amino acids)=887AA_BP=451
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKDELASLKEQLEEKESEVKRLQEKLVCK
MKGEGVEIVDRDENFKKKLKEKNIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVVLAQGKKGKDGEYEELLNSSSISSLL
DAQGFSDLEKSPSPTPVMGSPSCDPFNTSVPEEFHTTILQVSIPSLLPATVSMETSEKSKLTPKPETSFEENDGNIILGATVDTQLCDKL
FEKDQSKEKEKKVKKTIPSWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQA
LKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDI
RPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKK
TLQKCEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQKKTPAKSPGKAASVKQRG

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>67456_67456_2_PPFIBP1-HP1BP3_PPFIBP1_chr12_27825416_ENST00000318304_HP1BP3_chr1_21100103_ENST00000312239_length(amino acids)=904AA_BP=468
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKSLMAKLSSMKIKVGQMQYEKQRMEQKW
ESLKDELASLKEQLEEKESEVKRLQEKLVCKMKGEGVEIVDRDIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVVLAQGK
DGEYEELLNSSSISSLLDAQGFSDLEKSPSPTPVMGSPSCDPFNTSVPEEFHTTILQVSIPSLLPATVSMETSEKSKLTPKPETSFEEND
GNIILGATVDTQLCDKLFEKDQSKEKEKKVKKTIPSWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIH
KYPSLELERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYS
LIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVL
ENHPGTNSNYQMHLLKKTLQKCEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQK
KTPAKSPGKAASVKQRGSKPAPKVSAAQRGKARPLPKKAPPKAKTPAKKTRPSSTVIKKPSGGSSKKPATSARKEVKLPGKGKSTMKKSF

--------------------------------------------------------------

>67456_67456_3_PPFIBP1-HP1BP3_PPFIBP1_chr12_27825416_ENST00000537927_HP1BP3_chr1_21100103_ENST00000312239_length(amino acids)=808AA_BP=372
MLFKNTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAE
ISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKSLMAKLSSMKIKVGQMQYEKQRMEQKWESLKDE
LASLKEQLEEKESEVKRLQEKLVCKMKGEGVEIVDRDIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVVLAQGKDGEYEE
LLNSSSISSLLDAQGFSDLEKSPSPTPVMGSPSCDPFNTSVPEEFHTTILQVSIPSLLPATVSMETSEKSKLTPKPETSFEENDGNIILG
ATVDTQLCDKLFEKDQSKEKEKKVKKTIPSWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLE
LERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYV
SQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGT
NSNYQMHLLKKTLQKCEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQKKTPAKS

--------------------------------------------------------------

>67456_67456_4_PPFIBP1-HP1BP3_PPFIBP1_chr12_27825416_ENST00000542629_HP1BP3_chr1_21100103_ENST00000312239_length(amino acids)=873AA_BP=437
MGWNLPLTNNKMMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTA
ETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQK
LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKDELASLKEQLEEKESEVKRLQEKLVCK
MKGEGVEIVDRDIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVVLAQGKDGEYEELLNSSSISSLLDAQGFSDLEKSPSP
TPVMGSPSCDPFNTSVPEEFHTTILQVSIPSLLPATVSMETSEKSKLTPKPETSFEENDGNIILGATVDTQLCDKLFEKDQSKEKEKKVK
KTIPSWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQALKRELNRGVIKQVK
GKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVE
RGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKKTLQKCEKNGWMEQI
SGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQKKTPAKSPGKAASVKQRGSKPAPKVSAAQRGK

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:27825416/chr1:21100103)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPFIBP1

Q86W92

HP1BP3

Q5SSJ5

FUNCTION: May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. {ECO:0000269|PubMed:9624153}.FUNCTION: Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860). {ECO:0000269|PubMed:24830416, ECO:0000269|PubMed:25100860}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000228425+1530156_405439.66666666666671006.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000318304+1529156_405456.66666666666671012.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000542629+1428156_405425.6666666666667981.0Coiled coilOntology_term=ECO:0000255
TgeneHP1BP3chr12:27825416chr1:21100103ENST00000312239313454_553116.66666666666667554.0Compositional biasNote=Lys-rich
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500005454_5530134.0Compositional biasNote=Lys-rich
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500309454_5530402.0Compositional biasNote=Lys-rich
TgeneHP1BP3chr12:27825416chr1:21100103ENST00000312239313157_232116.66666666666667554.0DomainH15 1
TgeneHP1BP3chr12:27825416chr1:21100103ENST00000312239313255_330116.66666666666667554.0DomainH15 2
TgeneHP1BP3chr12:27825416chr1:21100103ENST00000312239313337_413116.66666666666667554.0DomainH15 3
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500005157_2320134.0DomainH15 1
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500005255_3300134.0DomainH15 2
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500005337_4130134.0DomainH15 3
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500309157_2320402.0DomainH15 1
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500309255_3300402.0DomainH15 2
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500309337_4130402.0DomainH15 3
TgeneHP1BP3chr12:27825416chr1:21100103ENST00000312239313255_259116.66666666666667554.0MotifPxVxL motif
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500005255_2590134.0MotifPxVxL motif
TgeneHP1BP3chr12:27825416chr1:21100103ENST0000037500309255_2590402.0MotifPxVxL motif

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000535047+16156_4050171.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000537927+1327156_405303.6666666666667859.0Coiled coilOntology_term=ECO:0000255
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000228425+1530647_711439.66666666666671006.0DomainSAM 1
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000228425+1530719_782439.66666666666671006.0DomainSAM 2
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000228425+1530804_876439.66666666666671006.0DomainSAM 3
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000318304+1529647_711456.66666666666671012.0DomainSAM 1
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000318304+1529719_782456.66666666666671012.0DomainSAM 2
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000318304+1529804_876456.66666666666671012.0DomainSAM 3
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000535047+16647_7110171.0DomainSAM 1
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000535047+16719_7820171.0DomainSAM 2
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000535047+16804_8760171.0DomainSAM 3
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000537927+1327647_711303.6666666666667859.0DomainSAM 1
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000537927+1327719_782303.6666666666667859.0DomainSAM 2
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000537927+1327804_876303.6666666666667859.0DomainSAM 3
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000542629+1428647_711425.6666666666667981.0DomainSAM 1
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000542629+1428719_782425.6666666666667981.0DomainSAM 2
HgenePPFIBP1chr12:27825416chr1:21100103ENST00000542629+1428804_876425.6666666666667981.0DomainSAM 3


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
PPFIBP1YWHAG, YWHAQ, SFN, S100A4, PPFIBP1, ELAVL1, SH3KBP1, GRK5, LATS2, YWHAB, CDKN1A, CEP250, CEP76, TP53, VCP, ENO1, MOV10, NXF1, PNKD, NTRK1, PPFIA1, PPFIA2, PPFIA3, TMEM17, PPP2R1A, DYNLL1, KIF21A, Myh9, Myo1c, Flnb, Scai, YWHAZ, CDH1, HAO2, RAPGEF5, KANK2, DCAF7, EFTUD2, ESR2, HRAS, KRAS, NRAS, LAMP1, KIAA1429, RPS6KA2, BICD1, TNFSF13B, ETAA1, PBX2, OBSL1, MAGEA3, PRKCZ, P4HB, PRRC2C, ESR1, ANLN, KIF14, KIF20A, nsp16, HULC, DNAJC5B, DNAJC5, PRKACA, ANK3, ARF6, B3GAT1, C11orf52, CAV1, CXADR, DIRAS3, EBAG9, EPB41L4A, EZR, FLOT1, GJA1, GJD3, LAMP2, LAMP3, LAMTOR1, LCK, LMAN1, LYN, MARCKS, MLLT4, OCLN, PANX1, PARD3, RAB11A, RAB2A, RAB35, RAB5A, RAB5C, RAB9A, RHOB, STX4, STX6, STX7, ZFPL1, VPS33B, SMAD4, YWHAH, DYNLL2, S100A6, S100B, TACR3, AKR7L, BTNL9, MFNG, GPR17, PPFIBP2, HSF2BP, GCGR, METTL21B, SNAP29, NPAS1, INF2, UBXN6, EMID1, PLBD1, MAB21L2, CPLX2, CHCHD4, SERBP1, MEIS2, BIRC8, COMTD1, SPN, MUM1, PSG11, BTF3, TOLLIP,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PPFIBP1all structure
HP1BP3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PPFIBP1-HP1BP3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PPFIBP1-HP1BP3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPFIBP1C0085269Plasma Cell Granuloma, Pulmonary1CTD_human