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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PPP1R12B-LGR6

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPP1R12B-LGR6
FusionPDB ID: 67767
FusionGDB2.0 ID: 67767
HgeneTgene
Gene symbol

PPP1R12B

LGR6

Gene ID

4660

59352

Gene nameprotein phosphatase 1 regulatory subunit 12Bleucine rich repeat containing G protein-coupled receptor 6
SynonymsMYPT2|PP1bp55GPCR|VTS20631
Cytomap

1q32.1

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 12Bmyosin phosphatase target subunit 2myosin phosphatase-targeting subunit 2protein phosphatase 1, regulatory (inhibitor) subunit 12Bleucine-rich repeat-containing G-protein coupled receptor 6gonadotropin receptor
Modification date2020031320200313
UniProtAcc.

Q9HBX8

Ensembl transtripts involved in fusion geneENST idsENST00000336894, ENST00000356764, 
ENST00000480184, ENST00000608999, 
ENST00000290419, ENST00000367270, 
ENST00000391959, 		ENST00000308543, 
ENST00000439764, ENST00000255432, 
ENST00000367278, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 9 X 4=4322 X 2 X 2=8
# samples 122
** MAII scorelog2(12/432*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: PPP1R12B [Title/Abstract] AND LGR6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PPP1R12B(202386045)-LGR6(202245434), # samples:1
Anticipated loss of major functional domain due to fusion event.PPP1R12B-LGR6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R12B-LGR6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R12B-LGR6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R12B-LGR6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLGR6

GO:0030177

positive regulation of Wnt signaling pathway

22615920

TgeneLGR6

GO:0030335

positive regulation of cell migration

22615920


check buttonFusion gene breakpoints across PPP1R12B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LGR6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-37-4130-01APPP1R12Bchr1

202386045

-LGR6chr1

202245434

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000608999PPP1R12Bchr1202386045-ENST00000367278LGR6chr1202245434+3625575603050996
ENST00000608999PPP1R12Bchr1202386045-ENST00000255432LGR6chr1202245434+3625575603050996
ENST00000336894PPP1R12Bchr1202386045-ENST00000367278LGR6chr1202245434+3622572573047996
ENST00000336894PPP1R12Bchr1202386045-ENST00000255432LGR6chr1202245434+3622572573047996
ENST00000480184PPP1R12Bchr1202386045-ENST00000367278LGR6chr1202245434+3604554393029996
ENST00000480184PPP1R12Bchr1202386045-ENST00000255432LGR6chr1202245434+3604554393029996
ENST00000356764PPP1R12Bchr1202386045-ENST00000367278LGR6chr1202245434+3596546313021996
ENST00000356764PPP1R12Bchr1202386045-ENST00000255432LGR6chr1202245434+3596546313021996

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000608999ENST00000367278PPP1R12Bchr1202386045-LGR6chr1202245434+0.0022230360.9977769
ENST00000608999ENST00000255432PPP1R12Bchr1202386045-LGR6chr1202245434+0.0022230360.9977769
ENST00000336894ENST00000367278PPP1R12Bchr1202386045-LGR6chr1202245434+0.0022911530.9977088
ENST00000336894ENST00000255432PPP1R12Bchr1202386045-LGR6chr1202245434+0.0022911530.9977088
ENST00000480184ENST00000367278PPP1R12Bchr1202386045-LGR6chr1202245434+0.0023701030.9976299
ENST00000480184ENST00000255432PPP1R12Bchr1202386045-LGR6chr1202245434+0.0023701030.9976299
ENST00000356764ENST00000367278PPP1R12Bchr1202386045-LGR6chr1202245434+0.0023330770.99766695
ENST00000356764ENST00000255432PPP1R12Bchr1202386045-LGR6chr1202245434+0.0023330770.99766695

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>67767_67767_1_PPP1R12B-LGR6_PPP1R12B_chr1_202386045_ENST00000336894_LGR6_chr1_202245434_ENST00000255432_length(amino acids)=996AA_BP=172
MKRSERGGSGNSSPNSNLVLVVLAAAAEAGAMAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDG
AVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAERLDANLIS
LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDL
NYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLE
ILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL
HSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRP
LGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVV
GAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVL
GCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFA
DGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALV
AFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGL

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>67767_67767_2_PPP1R12B-LGR6_PPP1R12B_chr1_202386045_ENST00000336894_LGR6_chr1_202245434_ENST00000367278_length(amino acids)=996AA_BP=172
MKRSERGGSGNSSPNSNLVLVVLAAAAEAGAMAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDG
AVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAERLDANLIS
LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDL
NYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLE
ILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL
HSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRP
LGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVV
GAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVL
GCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFA
DGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALV
AFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGL

--------------------------------------------------------------

>67767_67767_3_PPP1R12B-LGR6_PPP1R12B_chr1_202386045_ENST00000356764_LGR6_chr1_202245434_ENST00000255432_length(amino acids)=996AA_BP=172
MKRSERGGSGNSSPNSNLVLVVLAAAAEAGAMAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDG
AVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAERLDANLIS
LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDL
NYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLE
ILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL
HSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRP
LGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVV
GAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVL
GCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFA
DGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALV
AFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGL

--------------------------------------------------------------

>67767_67767_4_PPP1R12B-LGR6_PPP1R12B_chr1_202386045_ENST00000356764_LGR6_chr1_202245434_ENST00000367278_length(amino acids)=996AA_BP=172
MKRSERGGSGNSSPNSNLVLVVLAAAAEAGAMAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDG
AVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAERLDANLIS
LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDL
NYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLE
ILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL
HSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRP
LGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVV
GAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVL
GCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFA
DGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALV
AFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGL

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>67767_67767_5_PPP1R12B-LGR6_PPP1R12B_chr1_202386045_ENST00000480184_LGR6_chr1_202245434_ENST00000255432_length(amino acids)=996AA_BP=172
MKRSERGGSGNSSPNSNLVLVVLAAAAEAGAMAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDG
AVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAERLDANLIS
LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDL
NYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLE
ILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL
HSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRP
LGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVV
GAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVL
GCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFA
DGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALV
AFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGL

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>67767_67767_6_PPP1R12B-LGR6_PPP1R12B_chr1_202386045_ENST00000480184_LGR6_chr1_202245434_ENST00000367278_length(amino acids)=996AA_BP=172
MKRSERGGSGNSSPNSNLVLVVLAAAAEAGAMAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDG
AVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAERLDANLIS
LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDL
NYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLE
ILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL
HSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRP
LGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVV
GAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVL
GCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFA
DGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALV
AFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGL

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>67767_67767_7_PPP1R12B-LGR6_PPP1R12B_chr1_202386045_ENST00000608999_LGR6_chr1_202245434_ENST00000255432_length(amino acids)=996AA_BP=172
MKRSERGGSGNSSPNSNLVLVVLAAAAEAGAMAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDG
AVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAERLDANLIS
LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDL
NYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLE
ILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL
HSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRP
LGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVV
GAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVL
GCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFA
DGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALV
AFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGL

--------------------------------------------------------------

>67767_67767_8_PPP1R12B-LGR6_PPP1R12B_chr1_202386045_ENST00000608999_LGR6_chr1_202245434_ENST00000367278_length(amino acids)=996AA_BP=172
MKRSERGGSGNSSPNSNLVLVVLAAAAEAGAMAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDG
AVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAERLDANLIS
LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDL
NYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLE
ILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL
HSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRP
LGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVV
GAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVL
GCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFA
DGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALV
AFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:202386045/chr1:202245434)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LGR6

Q9HBX8

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:22615920}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000356764-2957_86140.66666666666666387.0RepeatNote=ANK 1
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000356764-2990_119140.66666666666666387.0RepeatNote=ANK 2
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000480184-21057_86140.66666666666666516.0RepeatNote=ANK 1
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000480184-21090_119140.66666666666666516.0RepeatNote=ANK 2
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318952_95590.66666666666667916.0Compositional biasNote=Poly-Gly
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318952_955142.66666666666666968.0Compositional biasNote=Poly-Gly
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016952_9550.0829.0Compositional biasNote=Poly-Gly
TgeneLGR6chr1:202386045chr1:202245434ENST0000043976401626_660.0829.0DomainNote=LRRNT
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318115_13690.66666666666667916.0RepeatNote=LRR 2
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318139_16090.66666666666667916.0RepeatNote=LRR 3
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318163_18690.66666666666667916.0RepeatNote=LRR 4
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318187_20890.66666666666667916.0RepeatNote=LRR 5
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318211_23290.66666666666667916.0RepeatNote=LRR 6
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318235_25690.66666666666667916.0RepeatNote=LRR 7
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318258_27990.66666666666667916.0RepeatNote=LRR 8
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318282_30390.66666666666667916.0RepeatNote=LRR 9
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318306_32890.66666666666667916.0RepeatNote=LRR 10
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318329_35090.66666666666667916.0RepeatNote=LRR 11
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318353_37490.66666666666667916.0RepeatNote=LRR 12
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318375_39690.66666666666667916.0RepeatNote=LRR 13
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318399_42090.66666666666667916.0RepeatNote=LRR 14
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318423_44390.66666666666667916.0RepeatNote=LRR 15
TgeneLGR6chr1:202386045chr1:202245434ENST0000025543231891_11290.66666666666667916.0RepeatNote=LRR 1
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318163_186142.66666666666666968.0RepeatNote=LRR 4
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318187_208142.66666666666666968.0RepeatNote=LRR 5
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318211_232142.66666666666666968.0RepeatNote=LRR 6
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318235_256142.66666666666666968.0RepeatNote=LRR 7
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318258_279142.66666666666666968.0RepeatNote=LRR 8
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318282_303142.66666666666666968.0RepeatNote=LRR 9
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318306_328142.66666666666666968.0RepeatNote=LRR 10
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318329_350142.66666666666666968.0RepeatNote=LRR 11
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318353_374142.66666666666666968.0RepeatNote=LRR 12
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318375_396142.66666666666666968.0RepeatNote=LRR 13
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318399_420142.66666666666666968.0RepeatNote=LRR 14
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318423_443142.66666666666666968.0RepeatNote=LRR 15
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016115_1360.0829.0RepeatNote=LRR 2
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016139_1600.0829.0RepeatNote=LRR 3
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016163_1860.0829.0RepeatNote=LRR 4
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016187_2080.0829.0RepeatNote=LRR 5
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016211_2320.0829.0RepeatNote=LRR 6
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016235_2560.0829.0RepeatNote=LRR 7
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016258_2790.0829.0RepeatNote=LRR 8
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016282_3030.0829.0RepeatNote=LRR 9
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016306_3280.0829.0RepeatNote=LRR 10
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016329_3500.0829.0RepeatNote=LRR 11
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016353_3740.0829.0RepeatNote=LRR 12
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016375_3960.0829.0RepeatNote=LRR 13
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016399_4200.0829.0RepeatNote=LRR 14
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016423_4430.0829.0RepeatNote=LRR 15
TgeneLGR6chr1:202386045chr1:202245434ENST0000043976401691_1120.0829.0RepeatNote=LRR 1
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318589_59890.66666666666667916.0Topological domainCytoplasmic
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318620_64490.66666666666667916.0Topological domainExtracellular
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318666_68790.66666666666667916.0Topological domainCytoplasmic
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318709_72790.66666666666667916.0Topological domainExtracellular
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318749_77490.66666666666667916.0Topological domainCytoplasmic
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318796_80990.66666666666667916.0Topological domainExtracellular
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318831_96790.66666666666667916.0Topological domainCytoplasmic
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318589_598142.66666666666666968.0Topological domainCytoplasmic
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318620_644142.66666666666666968.0Topological domainExtracellular
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318666_687142.66666666666666968.0Topological domainCytoplasmic
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318709_727142.66666666666666968.0Topological domainExtracellular
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318749_774142.66666666666666968.0Topological domainCytoplasmic
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318796_809142.66666666666666968.0Topological domainExtracellular
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318831_967142.66666666666666968.0Topological domainCytoplasmic
TgeneLGR6chr1:202386045chr1:202245434ENST0000043976401625_5670.0829.0Topological domainExtracellular
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016589_5980.0829.0Topological domainCytoplasmic
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016620_6440.0829.0Topological domainExtracellular
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016666_6870.0829.0Topological domainCytoplasmic
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016709_7270.0829.0Topological domainExtracellular
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016749_7740.0829.0Topological domainCytoplasmic
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016796_8090.0829.0Topological domainExtracellular
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016831_9670.0829.0Topological domainCytoplasmic
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318568_58890.66666666666667916.0TransmembraneHelical%3B Name%3D1
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318599_61990.66666666666667916.0TransmembraneHelical%3B Name%3D2
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318645_66590.66666666666667916.0TransmembraneHelical%3B Name%3D3
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318688_70890.66666666666667916.0TransmembraneHelical%3B Name%3D4
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318728_74890.66666666666667916.0TransmembraneHelical%3B Name%3D5
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318775_79590.66666666666667916.0TransmembraneHelical%3B Name%3D6
TgeneLGR6chr1:202386045chr1:202245434ENST00000255432318810_83090.66666666666667916.0TransmembraneHelical%3B Name%3D7
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318568_588142.66666666666666968.0TransmembraneHelical%3B Name%3D1
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318599_619142.66666666666666968.0TransmembraneHelical%3B Name%3D2
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318645_665142.66666666666666968.0TransmembraneHelical%3B Name%3D3
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318688_708142.66666666666666968.0TransmembraneHelical%3B Name%3D4
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318728_748142.66666666666666968.0TransmembraneHelical%3B Name%3D5
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318775_795142.66666666666666968.0TransmembraneHelical%3B Name%3D6
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318810_830142.66666666666666968.0TransmembraneHelical%3B Name%3D7
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016568_5880.0829.0TransmembraneHelical%3B Name%3D1
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016599_6190.0829.0TransmembraneHelical%3B Name%3D2
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016645_6650.0829.0TransmembraneHelical%3B Name%3D3
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016688_7080.0829.0TransmembraneHelical%3B Name%3D4
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016728_7480.0829.0TransmembraneHelical%3B Name%3D5
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016775_7950.0829.0TransmembraneHelical%3B Name%3D6
TgeneLGR6chr1:202386045chr1:202245434ENST00000439764016810_8300.0829.0TransmembraneHelical%3B Name%3D7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000356764-29336_379140.66666666666666387.0Compositional biasNote=Glu-rich
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000367270-113336_37902805.3333333333335Compositional biasNote=Glu-rich
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000391959-112336_3790209.0Compositional biasNote=Glu-rich
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000480184-210336_379140.66666666666666516.0Compositional biasNote=Glu-rich
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000356764-29123_152140.66666666666666387.0RepeatNote=ANK 3
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000356764-29216_245140.66666666666666387.0RepeatNote=ANK 4
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000356764-29249_278140.66666666666666387.0RepeatNote=ANK 5
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000367270-113123_15202805.3333333333335RepeatNote=ANK 3
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000367270-113216_24502805.3333333333335RepeatNote=ANK 4
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000367270-113249_27802805.3333333333335RepeatNote=ANK 5
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000367270-11357_8602805.3333333333335RepeatNote=ANK 1
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000367270-11390_11902805.3333333333335RepeatNote=ANK 2
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000391959-112123_1520209.0RepeatNote=ANK 3
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000391959-112216_2450209.0RepeatNote=ANK 4
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000391959-112249_2780209.0RepeatNote=ANK 5
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000391959-11257_860209.0RepeatNote=ANK 1
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000391959-11290_1190209.0RepeatNote=ANK 2
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000480184-210123_152140.66666666666666516.0RepeatNote=ANK 3
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000480184-210216_245140.66666666666666516.0RepeatNote=ANK 4
HgenePPP1R12Bchr1:202386045chr1:202245434ENST00000480184-210249_278140.66666666666666516.0RepeatNote=ANK 5
TgeneLGR6chr1:202386045chr1:202245434ENST0000025543231826_6690.66666666666667916.0DomainNote=LRRNT
TgeneLGR6chr1:202386045chr1:202245434ENST0000036727831826_66142.66666666666666968.0DomainNote=LRRNT
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318115_136142.66666666666666968.0RepeatNote=LRR 2
TgeneLGR6chr1:202386045chr1:202245434ENST00000367278318139_160142.66666666666666968.0RepeatNote=LRR 3
TgeneLGR6chr1:202386045chr1:202245434ENST0000036727831891_112142.66666666666666968.0RepeatNote=LRR 1
TgeneLGR6chr1:202386045chr1:202245434ENST0000025543231825_56790.66666666666667916.0Topological domainExtracellular
TgeneLGR6chr1:202386045chr1:202245434ENST0000036727831825_567142.66666666666666968.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PPP1R12B
LGR6


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PPP1R12B-LGR6


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PPP1R12B-LGR6


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource