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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PPP1R13L-MBOAT7

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPP1R13L-MBOAT7
FusionPDB ID: 67824
FusionGDB2.0 ID: 67824
HgeneTgene
Gene symbol

PPP1R13L

MBOAT7

Gene ID

10848

79143

Gene nameprotein phosphatase 1 regulatory subunit 13 likemembrane bound O-acyltransferase domain containing 7
SynonymsIASPP|NKIP1|RAI|RAI4BB1|LENG4|LPIAT|LPLAT|LRC4|MBOA7|MRT57|OACT7|hMBOA-7
Cytomap

19q13.32

19q13.42

Type of geneprotein-codingprotein-coding
DescriptionrelA-associated inhibitorNFkB interacting protein 1PPP1R13B-like proteininhibitor of ASPP proteininhibitor of apoptosis stimulating protein of p53protein iASPPprotein phosphatase 1, regulatory (inhibitor) subunit 13 likeretinoic acid induced 4lysophospholipid acyltransferase 71-acylglycerophosphatidylinositol O-acyltransferaseLPLAT 7bladder and breast carcinoma-overexpressed gene 1 proteinh-mboa-7leukocyte receptor cluster (LRC) member 4lyso-PI acyltransferaselysophosphatidylinositol ac
Modification date2020031320200313
UniProtAcc.

Q96N66

Ensembl transtripts involved in fusion geneENST idsENST00000360957, ENST00000418234, 
ENST00000391754, ENST00000474910, 
ENST00000338624, ENST00000431666, 
ENST00000245615, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 7 X 5=1757 X 7 X 3=147
# samples 79
** MAII scorelog2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/147*10)=-0.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PPP1R13L [Title/Abstract] AND MBOAT7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PPP1R13L(45885785)-MBOAT7(54678125), # samples:3
Anticipated loss of major functional domain due to fusion event.PPP1R13L-MBOAT7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R13L-MBOAT7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R13L-MBOAT7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R13L-MBOAT7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R13L-MBOAT7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PPP1R13L-MBOAT7 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PPP1R13L-MBOAT7 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PPP1R13L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MBOAT7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A891-01APPP1R13Lchr19

45885785

-MBOAT7chr19

54678125

-
ChimerDB4ESCATCGA-L5-A891PPP1R13Lchr19

45885784

-MBOAT7chr19

54678125

-
ChimerDB4ESCATCGA-L5-A891PPP1R13Lchr19

45885785

-MBOAT7chr19

54678125

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360957PPP1R13Lchr1945885785-ENST00000245615MBOAT7chr1954678125-3526250912700899
ENST00000418234PPP1R13Lchr1945885785-ENST00000245615MBOAT7chr1954678125-35442527372718893
ENST00000360957PPP1R13Lchr1945885784-ENST00000245615MBOAT7chr1954678125-3526250912700899
ENST00000418234PPP1R13Lchr1945885784-ENST00000245615MBOAT7chr1954678125-35442527372718893

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360957ENST00000245615PPP1R13Lchr1945885785-MBOAT7chr1954678125-0.0078400460.9921599
ENST00000418234ENST00000245615PPP1R13Lchr1945885785-MBOAT7chr1954678125-0.0070290140.992971
ENST00000360957ENST00000245615PPP1R13Lchr1945885784-MBOAT7chr1954678125-0.0078400460.9921599
ENST00000418234ENST00000245615PPP1R13Lchr1945885784-MBOAT7chr1954678125-0.0070290140.992971

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>67824_67824_1_PPP1R13L-MBOAT7_PPP1R13L_chr19_45885784_ENST00000360957_MBOAT7_chr19_54678125_ENST00000245615_length(amino acids)=899AA_BP=594
LEEAPRCQDLPGSAPAPAGTMDSEAFQSARDFLDMNFQSLAMKHMDLKQMELDTAAAKVDELTKQLESLWSDSPAPPGPQAGPPSRPPRY
SSSSIPEPFGSRGSPRKAATDGADTPFGRSESAPTLHPYSPLSPKGRPSSPRTPLYLQPDAYGSLDRATSPRPRAFDGAGSSLGRAPSPR
PGPGPLRQQGPPTPFDFLGRAGSPRGSPLAEGPQAFFPERGPSPRPPATAYDAPASAFGSSLLGSGGSAFAPPLRAQDDLTLRRRPPKAW
NESDLDVAYEKKPSQTASYERLDVFARPASPSLQLLPWRESSLDGLGGTGKDNLTSATLPRNYKVSPLASDRRSDAGSYRRSLGSAGPSG
TLPRSWQPVSRIPMPPSSPQPRGAPRQRPIPLSMIFKLQNAFWEHGASRAMLPGSPLFTRAPPPKLQPQPQPQPQPQSQPQPQLPPQPQT
QPQTPTPAPQHPQQTWPPVNEGPPKPPTELEPEPEIEGLLTPVLEAGDVDEGPVARPLSPTRLQPALPPEAQSVPELEEVARVLAEIPRP
LKRRGSMEQAPAVALPPTHKKQYQQIISRLFHRHGGPGPGGPEPELSPITEGSEARAGPPAPAPPAPIPPPAPSQSSPPEQPQSMEMRSV
LRKAGSPRKARRARLNPLVLLLDAALTGELEVVQQAVKEMNDPSQPNEEGITALHNAICGANYSIVDFLITAGANVNSPDSHGWTPLHCA
ASCNDTVICMALVQHGAAIFATTLSDGATAFEKCDPYREGYADCATYLADVEQSMGLMNSGAVYALWDYSAEFGDELSFREGESVTVLRR

--------------------------------------------------------------

>67824_67824_2_PPP1R13L-MBOAT7_PPP1R13L_chr19_45885784_ENST00000418234_MBOAT7_chr19_54678125_ENST00000245615_length(amino acids)=893AA_BP=588
MKFLKRQAPAPAGTMDSEAFQSARDFLDMNFQSLAMKHMDLKQMELDTAAAKVDELTKQLESLWSDSPAPPGPQAGPPSRPPRYSSSSIP
EPFGSRGSPRKAATDGADTPFGRSESAPTLHPYSPLSPKGRPSSPRTPLYLQPDAYGSLDRATSPRPRAFDGAGSSLGRAPSPRPGPGPL
RQQGPPTPFDFLGRAGSPRGSPLAEGPQAFFPERGPSPRPPATAYDAPASAFGSSLLGSGGSAFAPPLRAQDDLTLRRRPPKAWNESDLD
VAYEKKPSQTASYERLDVFARPASPSLQLLPWRESSLDGLGGTGKDNLTSATLPRNYKVSPLASDRRSDAGSYRRSLGSAGPSGTLPRSW
QPVSRIPMPPSSPQPRGAPRQRPIPLSMIFKLQNAFWEHGASRAMLPGSPLFTRAPPPKLQPQPQPQPQPQSQPQPQLPPQPQTQPQTPT
PAPQHPQQTWPPVNEGPPKPPTELEPEPEIEGLLTPVLEAGDVDEGPVARPLSPTRLQPALPPEAQSVPELEEVARVLAEIPRPLKRRGS
MEQAPAVALPPTHKKQYQQIISRLFHRHGGPGPGGPEPELSPITEGSEARAGPPAPAPPAPIPPPAPSQSSPPEQPQSMEMRSVLRKAGS
PRKARRARLNPLVLLLDAALTGELEVVQQAVKEMNDPSQPNEEGITALHNAICGANYSIVDFLITAGANVNSPDSHGWTPLHCAASCNDT
VICMALVQHGAAIFATTLSDGATAFEKCDPYREGYADCATYLADVEQSMGLMNSGAVYALWDYSAEFGDELSFREGESVTVLRRDGPEET

--------------------------------------------------------------

>67824_67824_3_PPP1R13L-MBOAT7_PPP1R13L_chr19_45885785_ENST00000360957_MBOAT7_chr19_54678125_ENST00000245615_length(amino acids)=899AA_BP=594
LEEAPRCQDLPGSAPAPAGTMDSEAFQSARDFLDMNFQSLAMKHMDLKQMELDTAAAKVDELTKQLESLWSDSPAPPGPQAGPPSRPPRY
SSSSIPEPFGSRGSPRKAATDGADTPFGRSESAPTLHPYSPLSPKGRPSSPRTPLYLQPDAYGSLDRATSPRPRAFDGAGSSLGRAPSPR
PGPGPLRQQGPPTPFDFLGRAGSPRGSPLAEGPQAFFPERGPSPRPPATAYDAPASAFGSSLLGSGGSAFAPPLRAQDDLTLRRRPPKAW
NESDLDVAYEKKPSQTASYERLDVFARPASPSLQLLPWRESSLDGLGGTGKDNLTSATLPRNYKVSPLASDRRSDAGSYRRSLGSAGPSG
TLPRSWQPVSRIPMPPSSPQPRGAPRQRPIPLSMIFKLQNAFWEHGASRAMLPGSPLFTRAPPPKLQPQPQPQPQPQSQPQPQLPPQPQT
QPQTPTPAPQHPQQTWPPVNEGPPKPPTELEPEPEIEGLLTPVLEAGDVDEGPVARPLSPTRLQPALPPEAQSVPELEEVARVLAEIPRP
LKRRGSMEQAPAVALPPTHKKQYQQIISRLFHRHGGPGPGGPEPELSPITEGSEARAGPPAPAPPAPIPPPAPSQSSPPEQPQSMEMRSV
LRKAGSPRKARRARLNPLVLLLDAALTGELEVVQQAVKEMNDPSQPNEEGITALHNAICGANYSIVDFLITAGANVNSPDSHGWTPLHCA
ASCNDTVICMALVQHGAAIFATTLSDGATAFEKCDPYREGYADCATYLADVEQSMGLMNSGAVYALWDYSAEFGDELSFREGESVTVLRR

--------------------------------------------------------------

>67824_67824_4_PPP1R13L-MBOAT7_PPP1R13L_chr19_45885785_ENST00000418234_MBOAT7_chr19_54678125_ENST00000245615_length(amino acids)=893AA_BP=588
MKFLKRQAPAPAGTMDSEAFQSARDFLDMNFQSLAMKHMDLKQMELDTAAAKVDELTKQLESLWSDSPAPPGPQAGPPSRPPRYSSSSIP
EPFGSRGSPRKAATDGADTPFGRSESAPTLHPYSPLSPKGRPSSPRTPLYLQPDAYGSLDRATSPRPRAFDGAGSSLGRAPSPRPGPGPL
RQQGPPTPFDFLGRAGSPRGSPLAEGPQAFFPERGPSPRPPATAYDAPASAFGSSLLGSGGSAFAPPLRAQDDLTLRRRPPKAWNESDLD
VAYEKKPSQTASYERLDVFARPASPSLQLLPWRESSLDGLGGTGKDNLTSATLPRNYKVSPLASDRRSDAGSYRRSLGSAGPSGTLPRSW
QPVSRIPMPPSSPQPRGAPRQRPIPLSMIFKLQNAFWEHGASRAMLPGSPLFTRAPPPKLQPQPQPQPQPQSQPQPQLPPQPQTQPQTPT
PAPQHPQQTWPPVNEGPPKPPTELEPEPEIEGLLTPVLEAGDVDEGPVARPLSPTRLQPALPPEAQSVPELEEVARVLAEIPRPLKRRGS
MEQAPAVALPPTHKKQYQQIISRLFHRHGGPGPGGPEPELSPITEGSEARAGPPAPAPPAPIPPPAPSQSSPPEQPQSMEMRSVLRKAGS
PRKARRARLNPLVLLLDAALTGELEVVQQAVKEMNDPSQPNEEGITALHNAICGANYSIVDFLITAGANVNSPDSHGWTPLHCAASCNDT
VICMALVQHGAAIFATTLSDGATAFEKCDPYREGYADCATYLADVEQSMGLMNSGAVYALWDYSAEFGDELSFREGESVTVLRRDGPEET

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:45885785/chr19:54678125)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MBOAT7

Q96N66

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128, PubMed:18094042). Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell (PubMed:18772128, PubMed:18094042). In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation (PubMed:32253259). {ECO:0000269|PubMed:18094042, ECO:0000269|PubMed:18772128, ECO:0000269|PubMed:32253259}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R13Lchr19:45885784chr19:54678125ENST00000360957-1213407_444816.0829.0Compositional biasNote=Gln-rich
HgenePPP1R13Lchr19:45885784chr19:54678125ENST00000360957-121354_602816.0829.0Compositional biasNote=Pro-rich
HgenePPP1R13Lchr19:45885784chr19:54678125ENST00000418234-1213407_444816.0829.0Compositional biasNote=Gln-rich
HgenePPP1R13Lchr19:45885784chr19:54678125ENST00000418234-121354_602816.0829.0Compositional biasNote=Pro-rich
HgenePPP1R13Lchr19:45885785chr19:54678125ENST00000360957-1213407_444816.0829.0Compositional biasNote=Gln-rich
HgenePPP1R13Lchr19:45885785chr19:54678125ENST00000360957-121354_602816.0829.0Compositional biasNote=Pro-rich
HgenePPP1R13Lchr19:45885785chr19:54678125ENST00000418234-1213407_444816.0829.0Compositional biasNote=Gln-rich
HgenePPP1R13Lchr19:45885785chr19:54678125ENST00000418234-121354_602816.0829.0Compositional biasNote=Pro-rich
HgenePPP1R13Lchr19:45885784chr19:54678125ENST00000360957-1213659_691816.0829.0RepeatNote=ANK 1
HgenePPP1R13Lchr19:45885784chr19:54678125ENST00000360957-1213692_724816.0829.0RepeatNote=ANK 2
HgenePPP1R13Lchr19:45885784chr19:54678125ENST00000418234-1213659_691816.0829.0RepeatNote=ANK 1
HgenePPP1R13Lchr19:45885784chr19:54678125ENST00000418234-1213692_724816.0829.0RepeatNote=ANK 2
HgenePPP1R13Lchr19:45885785chr19:54678125ENST00000360957-1213659_691816.0829.0RepeatNote=ANK 1
HgenePPP1R13Lchr19:45885785chr19:54678125ENST00000360957-1213692_724816.0829.0RepeatNote=ANK 2
HgenePPP1R13Lchr19:45885785chr19:54678125ENST00000418234-1213659_691816.0829.0RepeatNote=ANK 1
HgenePPP1R13Lchr19:45885785chr19:54678125ENST00000418234-1213692_724816.0829.0RepeatNote=ANK 2
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000024561568448_472343.6666666666667473.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000033862446448_472270.6666666666667400.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885784chr19:54678125ENST00000391754071_50345.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000039175407213_2310345.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885784chr19:54678125ENST000003917540723_330345.0Topological domainLumenal
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000039175407262_4260345.0Topological domainLumenal
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000039175407448_4720345.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885784chr19:54678125ENST000003917540758_730345.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885784chr19:54678125ENST000003917540794_1940345.0Topological domainLumenal
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000043166657448_472270.6666666666667400.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000024561568448_472343.6666666666667473.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000033862446448_472270.6666666666667400.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885785chr19:54678125ENST00000391754071_50345.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000039175407213_2310345.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885785chr19:54678125ENST000003917540723_330345.0Topological domainLumenal
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000039175407262_4260345.0Topological domainLumenal
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000039175407448_4720345.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885785chr19:54678125ENST000003917540758_730345.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885785chr19:54678125ENST000003917540794_1940345.0Topological domainLumenal
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000043166657448_472270.6666666666667400.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000024561568427_447343.6666666666667473.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000033862446427_447270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000039175407195_2120345.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000039175407232_2610345.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST000003917540734_570345.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000039175407427_4470345.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST00000391754076_220345.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST000003917540774_930345.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000043166657427_447270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000024561568427_447343.6666666666667473.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000033862446427_447270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000039175407195_2120345.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000039175407232_2610345.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST000003917540734_570345.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000039175407427_4470345.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST00000391754076_220345.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST000003917540774_930345.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000043166657427_447270.6666666666667400.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R13Lchr19:45885784chr19:54678125ENST00000360957-1213758_820816.0829.0DomainSH3
HgenePPP1R13Lchr19:45885784chr19:54678125ENST00000418234-1213758_820816.0829.0DomainSH3
HgenePPP1R13Lchr19:45885785chr19:54678125ENST00000360957-1213758_820816.0829.0DomainSH3
HgenePPP1R13Lchr19:45885785chr19:54678125ENST00000418234-1213758_820816.0829.0DomainSH3
TgeneMBOAT7chr19:45885784chr19:54678125ENST00000245615681_5343.6666666666667473.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000024561568213_231343.6666666666667473.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885784chr19:54678125ENST000002456156823_33343.6666666666667473.0Topological domainLumenal
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000024561568262_426343.6666666666667473.0Topological domainLumenal
TgeneMBOAT7chr19:45885784chr19:54678125ENST000002456156858_73343.6666666666667473.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885784chr19:54678125ENST000002456156894_194343.6666666666667473.0Topological domainLumenal
TgeneMBOAT7chr19:45885784chr19:54678125ENST00000338624461_5270.6666666666667400.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000033862446213_231270.6666666666667400.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885784chr19:54678125ENST000003386244623_33270.6666666666667400.0Topological domainLumenal
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000033862446262_426270.6666666666667400.0Topological domainLumenal
TgeneMBOAT7chr19:45885784chr19:54678125ENST000003386244658_73270.6666666666667400.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885784chr19:54678125ENST000003386244694_194270.6666666666667400.0Topological domainLumenal
TgeneMBOAT7chr19:45885784chr19:54678125ENST00000431666571_5270.6666666666667400.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000043166657213_231270.6666666666667400.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885784chr19:54678125ENST000004316665723_33270.6666666666667400.0Topological domainLumenal
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000043166657262_426270.6666666666667400.0Topological domainLumenal
TgeneMBOAT7chr19:45885784chr19:54678125ENST000004316665758_73270.6666666666667400.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885784chr19:54678125ENST000004316665794_194270.6666666666667400.0Topological domainLumenal
TgeneMBOAT7chr19:45885785chr19:54678125ENST00000245615681_5343.6666666666667473.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000024561568213_231343.6666666666667473.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885785chr19:54678125ENST000002456156823_33343.6666666666667473.0Topological domainLumenal
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000024561568262_426343.6666666666667473.0Topological domainLumenal
TgeneMBOAT7chr19:45885785chr19:54678125ENST000002456156858_73343.6666666666667473.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885785chr19:54678125ENST000002456156894_194343.6666666666667473.0Topological domainLumenal
TgeneMBOAT7chr19:45885785chr19:54678125ENST00000338624461_5270.6666666666667400.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000033862446213_231270.6666666666667400.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885785chr19:54678125ENST000003386244623_33270.6666666666667400.0Topological domainLumenal
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000033862446262_426270.6666666666667400.0Topological domainLumenal
TgeneMBOAT7chr19:45885785chr19:54678125ENST000003386244658_73270.6666666666667400.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885785chr19:54678125ENST000003386244694_194270.6666666666667400.0Topological domainLumenal
TgeneMBOAT7chr19:45885785chr19:54678125ENST00000431666571_5270.6666666666667400.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000043166657213_231270.6666666666667400.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885785chr19:54678125ENST000004316665723_33270.6666666666667400.0Topological domainLumenal
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000043166657262_426270.6666666666667400.0Topological domainLumenal
TgeneMBOAT7chr19:45885785chr19:54678125ENST000004316665758_73270.6666666666667400.0Topological domainCytoplasmic
TgeneMBOAT7chr19:45885785chr19:54678125ENST000004316665794_194270.6666666666667400.0Topological domainLumenal
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000024561568195_212343.6666666666667473.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000024561568232_261343.6666666666667473.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST000002456156834_57343.6666666666667473.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST00000245615686_22343.6666666666667473.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST000002456156874_93343.6666666666667473.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000033862446195_212270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000033862446232_261270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST000003386244634_57270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST00000338624466_22270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST000003386244674_93270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000043166657195_212270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST0000043166657232_261270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST000004316665734_57270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST00000431666576_22270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885784chr19:54678125ENST000004316665774_93270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000024561568195_212343.6666666666667473.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000024561568232_261343.6666666666667473.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST000002456156834_57343.6666666666667473.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST00000245615686_22343.6666666666667473.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST000002456156874_93343.6666666666667473.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000033862446195_212270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000033862446232_261270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST000003386244634_57270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST00000338624466_22270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST000003386244674_93270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000043166657195_212270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST0000043166657232_261270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST000004316665734_57270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST00000431666576_22270.6666666666667400.0TransmembraneHelical
TgeneMBOAT7chr19:45885785chr19:54678125ENST000004316665774_93270.6666666666667400.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1690_PPP1R13L_45885785_MBOAT7_54678125_ranked_0.pdbPPP1R13L4588578445885785ENST00000245615MBOAT7chr1954678125-
LEEAPRCQDLPGSAPAPAGTMDSEAFQSARDFLDMNFQSLAMKHMDLKQMELDTAAAKVDELTKQLESLWSDSPAPPGPQAGPPSRPPRY
SSSSIPEPFGSRGSPRKAATDGADTPFGRSESAPTLHPYSPLSPKGRPSSPRTPLYLQPDAYGSLDRATSPRPRAFDGAGSSLGRAPSPR
PGPGPLRQQGPPTPFDFLGRAGSPRGSPLAEGPQAFFPERGPSPRPPATAYDAPASAFGSSLLGSGGSAFAPPLRAQDDLTLRRRPPKAW
NESDLDVAYEKKPSQTASYERLDVFARPASPSLQLLPWRESSLDGLGGTGKDNLTSATLPRNYKVSPLASDRRSDAGSYRRSLGSAGPSG
TLPRSWQPVSRIPMPPSSPQPRGAPRQRPIPLSMIFKLQNAFWEHGASRAMLPGSPLFTRAPPPKLQPQPQPQPQPQSQPQPQLPPQPQT
QPQTPTPAPQHPQQTWPPVNEGPPKPPTELEPEPEIEGLLTPVLEAGDVDEGPVARPLSPTRLQPALPPEAQSVPELEEVARVLAEIPRP
LKRRGSMEQAPAVALPPTHKKQYQQIISRLFHRHGGPGPGGPEPELSPITEGSEARAGPPAPAPPAPIPPPAPSQSSPPEQPQSMEMRSV
LRKAGSPRKARRARLNPLVLLLDAALTGELEVVQQAVKEMNDPSQPNEEGITALHNAICGANYSIVDFLITAGANVNSPDSHGWTPLHCA
ASCNDTVICMALVQHGAAIFATTLSDGATAFEKCDPYREGYADCATYLADVEQSMGLMNSGAVYALWDYSAEFGDELSFREGESVTVLRR
899


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PPP1R13L_pLDDT.png
all structure
all structure
MBOAT7_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PPP1R13L
MBOAT7


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PPP1R13L-MBOAT7


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PPP1R13L-MBOAT7


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource