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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PPP1R1A-ITGA7

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPP1R1A-ITGA7
FusionPDB ID: 67862
FusionGDB2.0 ID: 67862
HgeneTgene
Gene symbol

PPP1R1A

ITGA7

Gene ID

5502

3679

Gene nameprotein phosphatase 1 regulatory inhibitor subunit 1Aintegrin subunit alpha 7
SynonymsI1|IPP1-
Cytomap

12q13.2

12q13.2

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase 1 regulatory subunit 1AI-1IPP-1inhibitor-1protein phosphatase inhibitor-1integrin alpha-7integrin alpha 7 chain
Modification date2020031320200328
UniProtAcc.

Q13683

Ensembl transtripts involved in fusion geneENST idsENST00000257905, ENST00000547431, 
ENST00000257879, ENST00000257880, 
ENST00000394229, ENST00000394230, 
ENST00000555728, ENST00000347027, 
ENST00000452168, ENST00000553804, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score1 X 1 X 1=15 X 3 X 5=75
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PPP1R1A [Title/Abstract] AND ITGA7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PPP1R1A(54982189)-ITGA7(56079072), # samples:1
Anticipated loss of major functional domain due to fusion event.PPP1R1A-ITGA7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R1A-ITGA7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R1A-ITGA7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R1A-ITGA7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP1R1A-ITGA7 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PPP1R1A-ITGA7 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PPP1R1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ITGA7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315420PPP1R1Achr12

54982189

-ITGA7chr12

56079072

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000547431PPP1R1Achr1254982189-ENST00000553804ITGA7chr1256079072-8331126001200
ENST00000547431PPP1R1Achr1254982189-ENST00000347027ITGA7chr1256079072-8291126001200
ENST00000547431PPP1R1Achr1254982189-ENST00000452168ITGA7chr1256079072-8291126001200
ENST00000257905PPP1R1Achr1254982189-ENST00000553804ITGA7chr1256079072-9762557430248
ENST00000257905PPP1R1Achr1254982189-ENST00000347027ITGA7chr1256079072-9722557430248
ENST00000257905PPP1R1Achr1254982189-ENST00000452168ITGA7chr1256079072-9722557430248

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000547431ENST00000553804PPP1R1Achr1254982189-ITGA7chr1256079072-0.726818740.2731813
ENST00000547431ENST00000347027PPP1R1Achr1254982189-ITGA7chr1256079072-0.719396530.28060344
ENST00000547431ENST00000452168PPP1R1Achr1254982189-ITGA7chr1256079072-0.719396530.28060344
ENST00000257905ENST00000553804PPP1R1Achr1254982189-ITGA7chr1256079072-0.81911930.18088074
ENST00000257905ENST00000347027PPP1R1Achr1254982189-ITGA7chr1256079072-0.816680250.18331973
ENST00000257905ENST00000452168PPP1R1Achr1254982189-ITGA7chr1256079072-0.816680250.18331973

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>67862_67862_1_PPP1R1A-ITGA7_PPP1R1A_chr12_54982189_ENST00000257905_ITGA7_chr12_56079072_ENST00000347027_length(amino acids)=248AA_BP=1
MHQDTPALLTLPHGPVPDLPTLISQHSKGKLGGRSSCGWERSVPLRKPILPNLDATPAAHSTLFIPRSHLWGRDGGQPQARLGHGNLGGA
WPWMPIGAQLGMPVSSQDGVCIRALPPGAAPVVPQDGARLLLLELLSVFPRNLHRMVLGHGGLGVLRPFEESHLLRRLGVKVRLQQRDRE

--------------------------------------------------------------

>67862_67862_2_PPP1R1A-ITGA7_PPP1R1A_chr12_54982189_ENST00000257905_ITGA7_chr12_56079072_ENST00000452168_length(amino acids)=248AA_BP=1
MHQDTPALLTLPHGPVPDLPTLISQHSKGKLGGRSSCGWERSVPLRKPILPNLDATPAAHSTLFIPRSHLWGRDGGQPQARLGHGNLGGA
WPWMPIGAQLGMPVSSQDGVCIRALPPGAAPVVPQDGARLLLLELLSVFPRNLHRMVLGHGGLGVLRPFEESHLLRRLGVKVRLQQRDRE

--------------------------------------------------------------

>67862_67862_3_PPP1R1A-ITGA7_PPP1R1A_chr12_54982189_ENST00000257905_ITGA7_chr12_56079072_ENST00000553804_length(amino acids)=248AA_BP=1
MHQDTPALLTLPHGPVPDLPTLISQHSKGKLGGRSSCGWERSVPLRKPILPNLDATPAAHSTLFIPRSHLWGRDGGQPQARLGHGNLGGA
WPWMPIGAQLGMPVSSQDGVCIRALPPGAAPVVPQDGARLLLLELLSVFPRNLHRMVLGHGGLGVLRPFEESHLLRRLGVKVRLQQRDRE

--------------------------------------------------------------

>67862_67862_4_PPP1R1A-ITGA7_PPP1R1A_chr12_54982189_ENST00000547431_ITGA7_chr12_56079072_ENST00000347027_length(amino acids)=200AA_BP=1
MHQDTPALLTLPHGPVPDLPTLISQHSKGKLGGRSSCGWERSVPLRKPILPNLDATPAAHSTLFIPRSHLWGRDGGQPQARLGHGNLGGA
WPWMPIGAQLGMPVSSQDGVCIRALPPGAAPVVPQDGARLLLLELLSVFPRNLHRMVLGHGGLGVLRPFEESHLLRRLGVKVRLQQRDRE

--------------------------------------------------------------

>67862_67862_5_PPP1R1A-ITGA7_PPP1R1A_chr12_54982189_ENST00000547431_ITGA7_chr12_56079072_ENST00000452168_length(amino acids)=200AA_BP=1
MHQDTPALLTLPHGPVPDLPTLISQHSKGKLGGRSSCGWERSVPLRKPILPNLDATPAAHSTLFIPRSHLWGRDGGQPQARLGHGNLGGA
WPWMPIGAQLGMPVSSQDGVCIRALPPGAAPVVPQDGARLLLLELLSVFPRNLHRMVLGHGGLGVLRPFEESHLLRRLGVKVRLQQRDRE

--------------------------------------------------------------

>67862_67862_6_PPP1R1A-ITGA7_PPP1R1A_chr12_54982189_ENST00000547431_ITGA7_chr12_56079072_ENST00000553804_length(amino acids)=200AA_BP=1
MHQDTPALLTLPHGPVPDLPTLISQHSKGKLGGRSSCGWERSVPLRKPILPNLDATPAAHSTLFIPRSHLWGRDGGQPQARLGHGNLGGA
WPWMPIGAQLGMPVSSQDGVCIRALPPGAAPVVPQDGARLLLLELLSVFPRNLHRMVLGHGGLGVLRPFEESHLLRRLGVKVRLQQRDRE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:54982189/chr12:56079072)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ITGA7

Q13683

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. {ECO:0000250, ECO:0000269|PubMed:10694445, ECO:0000269|PubMed:17641293, ECO:0000269|PubMed:9307969}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R1Achr12:54982189chr12:56079072ENST00000257905-179_1228.0172.0RegionNote=Essential for activity
TgeneITGA7chr12:54982189chr12:56079072ENST0000025787923251107_11111061.01138.0MotifNote=GFFKR motif
TgeneITGA7chr12:54982189chr12:56079072ENST0000045216823251107_1111968.01045.0MotifNote=GFFKR motif
TgeneITGA7chr12:54982189chr12:56079072ENST0000055380423251107_11111065.01142.0MotifNote=GFFKR motif
TgeneITGA7chr12:54982189chr12:56079072ENST0000055572824261107_11111105.01182.0MotifNote=GFFKR motif
TgeneITGA7chr12:54982189chr12:56079072ENST0000025787923251157_11761061.01138.0RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:54982189chr12:56079072ENST0000025788025271157_11761142.66666666666671163.0RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:54982189chr12:56079072ENST0000045216823251157_1176968.01045.0RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:54982189chr12:56079072ENST0000055380423251157_11761065.01142.0RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:54982189chr12:56079072ENST0000055572824261157_11761105.01182.0RegionNote=3 X 4 AA repeats of D-X-H-P
TgeneITGA7chr12:54982189chr12:56079072ENST0000025787923251157_11601061.01138.0RepeatNote=1
TgeneITGA7chr12:54982189chr12:56079072ENST0000025787923251165_11681061.01138.0RepeatNote=2
TgeneITGA7chr12:54982189chr12:56079072ENST0000025787923251173_11761061.01138.0RepeatNote=3
TgeneITGA7chr12:54982189chr12:56079072ENST0000025788025271157_11601142.66666666666671163.0RepeatNote=1
TgeneITGA7chr12:54982189chr12:56079072ENST0000025788025271165_11681142.66666666666671163.0RepeatNote=2
TgeneITGA7chr12:54982189chr12:56079072ENST0000025788025271173_11761142.66666666666671163.0RepeatNote=3
TgeneITGA7chr12:54982189chr12:56079072ENST0000045216823251157_1160968.01045.0RepeatNote=1
TgeneITGA7chr12:54982189chr12:56079072ENST0000045216823251165_1168968.01045.0RepeatNote=2
TgeneITGA7chr12:54982189chr12:56079072ENST0000045216823251173_1176968.01045.0RepeatNote=3
TgeneITGA7chr12:54982189chr12:56079072ENST0000055380423251157_11601065.01142.0RepeatNote=1
TgeneITGA7chr12:54982189chr12:56079072ENST0000055380423251165_11681065.01142.0RepeatNote=2
TgeneITGA7chr12:54982189chr12:56079072ENST0000055380423251173_11761065.01142.0RepeatNote=3
TgeneITGA7chr12:54982189chr12:56079072ENST0000055572824261157_11601105.01182.0RepeatNote=1
TgeneITGA7chr12:54982189chr12:56079072ENST0000055572824261165_11681105.01182.0RepeatNote=2
TgeneITGA7chr12:54982189chr12:56079072ENST0000055572824261173_11761105.01182.0RepeatNote=3
TgeneITGA7chr12:54982189chr12:56079072ENST0000025787923251104_11811061.01138.0Topological domainCytoplasmic
TgeneITGA7chr12:54982189chr12:56079072ENST0000045216823251104_1181968.01045.0Topological domainCytoplasmic
TgeneITGA7chr12:54982189chr12:56079072ENST0000055380423251104_11811065.01142.0Topological domainCytoplasmic
TgeneITGA7chr12:54982189chr12:56079072ENST0000055572824261104_11811105.01182.0Topological domainCytoplasmic
TgeneITGA7chr12:54982189chr12:56079072ENST0000025787923251083_11031061.01138.0TransmembraneHelical
TgeneITGA7chr12:54982189chr12:56079072ENST0000045216823251083_1103968.01045.0TransmembraneHelical
TgeneITGA7chr12:54982189chr12:56079072ENST0000055380423251083_11031065.01142.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP1R1Achr12:54982189chr12:56079072ENST00000257905-1742_5428.0172.0RegionEssential for activity
TgeneITGA7chr12:54982189chr12:56079072ENST000002578792325372_3801061.01138.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:54982189chr12:56079072ENST000002578792325434_4421061.01138.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:54982189chr12:56079072ENST000002578792325492_5001061.01138.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:54982189chr12:56079072ENST000002578802527372_3801142.66666666666671163.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:54982189chr12:56079072ENST000002578802527434_4421142.66666666666671163.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:54982189chr12:56079072ENST000002578802527492_5001142.66666666666671163.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:54982189chr12:56079072ENST000004521682325372_380968.01045.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:54982189chr12:56079072ENST000004521682325434_442968.01045.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:54982189chr12:56079072ENST000004521682325492_500968.01045.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:54982189chr12:56079072ENST000005538042325372_3801065.01142.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:54982189chr12:56079072ENST000005538042325434_4421065.01142.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:54982189chr12:56079072ENST000005538042325492_5001065.01142.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:54982189chr12:56079072ENST000005557282426372_3801105.01182.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:54982189chr12:56079072ENST000005557282426434_4421105.01182.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:54982189chr12:56079072ENST000005557282426492_5001105.01182.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA7chr12:54982189chr12:56079072ENST000002578792325953_9581061.01138.0Compositional biasNote=Poly-Arg
TgeneITGA7chr12:54982189chr12:56079072ENST000002578802527953_9581142.66666666666671163.0Compositional biasNote=Poly-Arg
TgeneITGA7chr12:54982189chr12:56079072ENST000004521682325953_958968.01045.0Compositional biasNote=Poly-Arg
TgeneITGA7chr12:54982189chr12:56079072ENST000005538042325953_9581065.01142.0Compositional biasNote=Poly-Arg
TgeneITGA7chr12:54982189chr12:56079072ENST000005557282426953_9581105.01182.0Compositional biasNote=Poly-Arg
TgeneITGA7chr12:54982189chr12:56079072ENST0000025788025271107_11111142.66666666666671163.0MotifNote=GFFKR motif
TgeneITGA7chr12:54982189chr12:56079072ENST000002578792325110_1751061.01138.0RepeatFG-GAP 2
TgeneITGA7chr12:54982189chr12:56079072ENST000002578792325185_2381061.01138.0RepeatFG-GAP 3
TgeneITGA7chr12:54982189chr12:56079072ENST000002578792325292_3491061.01138.0RepeatFG-GAP 4
TgeneITGA7chr12:54982189chr12:56079072ENST000002578792325350_4111061.01138.0RepeatFG-GAP 5
TgeneITGA7chr12:54982189chr12:56079072ENST00000257879232535_1031061.01138.0RepeatFG-GAP 1
TgeneITGA7chr12:54982189chr12:56079072ENST000002578792325412_4671061.01138.0RepeatFG-GAP 6
TgeneITGA7chr12:54982189chr12:56079072ENST000002578792325471_5301061.01138.0RepeatFG-GAP 7
TgeneITGA7chr12:54982189chr12:56079072ENST000002578802527110_1751142.66666666666671163.0RepeatFG-GAP 2
TgeneITGA7chr12:54982189chr12:56079072ENST000002578802527185_2381142.66666666666671163.0RepeatFG-GAP 3
TgeneITGA7chr12:54982189chr12:56079072ENST000002578802527292_3491142.66666666666671163.0RepeatFG-GAP 4
TgeneITGA7chr12:54982189chr12:56079072ENST000002578802527350_4111142.66666666666671163.0RepeatFG-GAP 5
TgeneITGA7chr12:54982189chr12:56079072ENST00000257880252735_1031142.66666666666671163.0RepeatFG-GAP 1
TgeneITGA7chr12:54982189chr12:56079072ENST000002578802527412_4671142.66666666666671163.0RepeatFG-GAP 6
TgeneITGA7chr12:54982189chr12:56079072ENST000002578802527471_5301142.66666666666671163.0RepeatFG-GAP 7
TgeneITGA7chr12:54982189chr12:56079072ENST000004521682325110_175968.01045.0RepeatFG-GAP 2
TgeneITGA7chr12:54982189chr12:56079072ENST000004521682325185_238968.01045.0RepeatFG-GAP 3
TgeneITGA7chr12:54982189chr12:56079072ENST000004521682325292_349968.01045.0RepeatFG-GAP 4
TgeneITGA7chr12:54982189chr12:56079072ENST000004521682325350_411968.01045.0RepeatFG-GAP 5
TgeneITGA7chr12:54982189chr12:56079072ENST00000452168232535_103968.01045.0RepeatFG-GAP 1
TgeneITGA7chr12:54982189chr12:56079072ENST000004521682325412_467968.01045.0RepeatFG-GAP 6
TgeneITGA7chr12:54982189chr12:56079072ENST000004521682325471_530968.01045.0RepeatFG-GAP 7
TgeneITGA7chr12:54982189chr12:56079072ENST000005538042325110_1751065.01142.0RepeatFG-GAP 2
TgeneITGA7chr12:54982189chr12:56079072ENST000005538042325185_2381065.01142.0RepeatFG-GAP 3
TgeneITGA7chr12:54982189chr12:56079072ENST000005538042325292_3491065.01142.0RepeatFG-GAP 4
TgeneITGA7chr12:54982189chr12:56079072ENST000005538042325350_4111065.01142.0RepeatFG-GAP 5
TgeneITGA7chr12:54982189chr12:56079072ENST00000553804232535_1031065.01142.0RepeatFG-GAP 1
TgeneITGA7chr12:54982189chr12:56079072ENST000005538042325412_4671065.01142.0RepeatFG-GAP 6
TgeneITGA7chr12:54982189chr12:56079072ENST000005538042325471_5301065.01142.0RepeatFG-GAP 7
TgeneITGA7chr12:54982189chr12:56079072ENST000005557282426110_1751105.01182.0RepeatFG-GAP 2
TgeneITGA7chr12:54982189chr12:56079072ENST000005557282426185_2381105.01182.0RepeatFG-GAP 3
TgeneITGA7chr12:54982189chr12:56079072ENST000005557282426292_3491105.01182.0RepeatFG-GAP 4
TgeneITGA7chr12:54982189chr12:56079072ENST000005557282426350_4111105.01182.0RepeatFG-GAP 5
TgeneITGA7chr12:54982189chr12:56079072ENST00000555728242635_1031105.01182.0RepeatFG-GAP 1
TgeneITGA7chr12:54982189chr12:56079072ENST000005557282426412_4671105.01182.0RepeatFG-GAP 6
TgeneITGA7chr12:54982189chr12:56079072ENST000005557282426471_5301105.01182.0RepeatFG-GAP 7
TgeneITGA7chr12:54982189chr12:56079072ENST00000257879232534_10821061.01138.0Topological domainExtracellular
TgeneITGA7chr12:54982189chr12:56079072ENST0000025788025271104_11811142.66666666666671163.0Topological domainCytoplasmic
TgeneITGA7chr12:54982189chr12:56079072ENST00000257880252734_10821142.66666666666671163.0Topological domainExtracellular
TgeneITGA7chr12:54982189chr12:56079072ENST00000452168232534_1082968.01045.0Topological domainExtracellular
TgeneITGA7chr12:54982189chr12:56079072ENST00000553804232534_10821065.01142.0Topological domainExtracellular
TgeneITGA7chr12:54982189chr12:56079072ENST00000555728242634_10821105.01182.0Topological domainExtracellular
TgeneITGA7chr12:54982189chr12:56079072ENST0000025788025271083_11031142.66666666666671163.0TransmembraneHelical
TgeneITGA7chr12:54982189chr12:56079072ENST0000055572824261083_11031105.01182.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PPP1R1A
ITGA7


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePPP1R1Achr12:54982189chr12:56079072ENST00000257905-17143_17128.0172.0PPP1R15A


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Related Drugs to PPP1R1A-ITGA7


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PPP1R1A-ITGA7


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource