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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PPP1R9A-FBXO16

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PPP1R9A-FBXO16
	FusionPDB ID: 67940
	FusionGDB2.0 ID: 67940
		Hgene	Tgene
	Gene symbol	PPP1R9A	FBXO16
	Gene ID	55607	157574
	Gene name	protein phosphatase 1 regulatory subunit 9A	F-box protein 16
	Synonyms	NRB1\|NRBI\|Neurabin-I	FBX16
	Cytomap	7q21.3	8p21.1
	Type of gene	protein-coding	protein-coding
	Description	neurabin-1neural tissue-specific F-actin-binding protein Iprotein phosphatase 1, regulatory (inhibitor) subunit 9A	F-box only protein 16
	Modification date	20200313	20200313
	UniProtAcc	.	Q8IX29
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000289495, ENST00000340694, ENST00000424654, ENST00000433360, ENST00000433881, ENST00000456331,	ENST00000517436, ENST00000519471, ENST00000346498, ENST00000380254, ENST00000518734,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 9 X 4=360	6 X 5 X 4=120
	# samples	10	7
	** MAII score	log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PPP1R9A [Title/Abstract] AND FBXO16 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PPP1R9A(94540820)-FBXO16(28309993), # samples:3
Anticipated loss of major functional domain due to fusion event.	PPP1R9A-FBXO16 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PPP1R9A-FBXO16 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PPP1R9A-FBXO16 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PPP1R9A-FBXO16 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across PPP1R9A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FBXO16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-24-2297-01A	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-
ChimerDB4	OV	TCGA-24-2297	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000433360	PPP1R9A	chr7	94540820	+	ENST00000380254	FBXO16	chr8	28309993	-	2364	1677	228	2048	606
ENST00000433360	PPP1R9A	chr7	94540820	+	ENST00000346498	FBXO16	chr8	28309993	-	2302	1677	228	2156	642
ENST00000433360	PPP1R9A	chr7	94540820	+	ENST00000518734	FBXO16	chr8	28309993	-	2133	1677	228	2048	606
ENST00000340694	PPP1R9A	chr7	94540820	+	ENST00000380254	FBXO16	chr8	28309993	-	2364	1677	228	2048	606
ENST00000340694	PPP1R9A	chr7	94540820	+	ENST00000346498	FBXO16	chr8	28309993	-	2302	1677	228	2156	642
ENST00000340694	PPP1R9A	chr7	94540820	+	ENST00000518734	FBXO16	chr8	28309993	-	2133	1677	228	2048	606
ENST00000424654	PPP1R9A	chr7	94540820	+	ENST00000380254	FBXO16	chr8	28309993	-	2326	1639	190	2010	606
ENST00000424654	PPP1R9A	chr7	94540820	+	ENST00000346498	FBXO16	chr8	28309993	-	2264	1639	190	2118	642
ENST00000424654	PPP1R9A	chr7	94540820	+	ENST00000518734	FBXO16	chr8	28309993	-	2095	1639	190	2010	606
ENST00000433881	PPP1R9A	chr7	94540820	+	ENST00000380254	FBXO16	chr8	28309993	-	2614	1927	478	2298	606
ENST00000433881	PPP1R9A	chr7	94540820	+	ENST00000346498	FBXO16	chr8	28309993	-	2552	1927	478	2406	642
ENST00000433881	PPP1R9A	chr7	94540820	+	ENST00000518734	FBXO16	chr8	28309993	-	2383	1927	478	2298	606
ENST00000289495	PPP1R9A	chr7	94540820	+	ENST00000380254	FBXO16	chr8	28309993	-	2298	1611	162	1982	606
ENST00000289495	PPP1R9A	chr7	94540820	+	ENST00000346498	FBXO16	chr8	28309993	-	2236	1611	162	2090	642
ENST00000289495	PPP1R9A	chr7	94540820	+	ENST00000518734	FBXO16	chr8	28309993	-	2067	1611	162	1982	606
ENST00000456331	PPP1R9A	chr7	94540820	+	ENST00000380254	FBXO16	chr8	28309993	-	2298	1611	162	1982	606
ENST00000456331	PPP1R9A	chr7	94540820	+	ENST00000346498	FBXO16	chr8	28309993	-	2236	1611	162	2090	642
ENST00000456331	PPP1R9A	chr7	94540820	+	ENST00000518734	FBXO16	chr8	28309993	-	2067	1611	162	1982	606

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000433360	ENST00000380254	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-	0.001198344	0.9988016
ENST00000433360	ENST00000346498	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-	0.001274105	0.99872583
ENST00000433360	ENST00000518734	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-	0.001237598	0.99876237
ENST00000340694	ENST00000380254	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-	0.001198344	0.9988016
ENST00000340694	ENST00000346498	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-	0.001274105	0.99872583
ENST00000340694	ENST00000518734	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-	0.001237598	0.99876237
ENST00000424654	ENST00000380254	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-	0.001196835	0.99880314
ENST00000424654	ENST00000346498	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-	0.001250372	0.9987496
ENST00000424654	ENST00000518734	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-	0.00126571	0.9987343
ENST00000433881	ENST00000380254	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-	0.00097839	0.99902165
ENST00000433881	ENST00000346498	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-	0.000990839	0.99900913
ENST00000433881	ENST00000518734	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-	0.000938105	0.9990619
ENST00000289495	ENST00000380254	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-	0.001196079	0.998804
ENST00000289495	ENST00000346498	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-	0.001252538	0.99874747
ENST00000289495	ENST00000518734	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-	0.001271076	0.99872893
ENST00000456331	ENST00000380254	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-	0.001196079	0.998804
ENST00000456331	ENST00000346498	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-	0.001252538	0.99874747
ENST00000456331	ENST00000518734	PPP1R9A	chr7	94540820	+	FBXO16	chr8	28309993	-	0.001271076	0.99872893

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>67940_67940_1_PPP1R9A-FBXO16_PPP1R9A_chr7_94540820_ENST00000289495_FBXO16_chr8_28309993_ENST00000346498_length(amino acids)=642AA_BP=483
MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ
MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK
KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL
KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ
LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY
YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP
TDIIRFNYLDNRDPMETVQQGRRKRNQMTPDFSRQSHDKKNKLQDRTRLRKAQSMMSLSASSPLKVPAHLAWPPPESVGLPDTATTAEIL

--------------------------------------------------------------

>67940_67940_2_PPP1R9A-FBXO16_PPP1R9A_chr7_94540820_ENST00000289495_FBXO16_chr8_28309993_ENST00000380254_length(amino acids)=606AA_BP=483
MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ
MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK
KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL
KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ
LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY
YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP

--------------------------------------------------------------

>67940_67940_3_PPP1R9A-FBXO16_PPP1R9A_chr7_94540820_ENST00000289495_FBXO16_chr8_28309993_ENST00000518734_length(amino acids)=606AA_BP=483
MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ
MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK
KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL
KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ
LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY
YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP

--------------------------------------------------------------

>67940_67940_4_PPP1R9A-FBXO16_PPP1R9A_chr7_94540820_ENST00000340694_FBXO16_chr8_28309993_ENST00000346498_length(amino acids)=642AA_BP=483
MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ
MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK
KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL
KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ
LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY
YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP
TDIIRFNYLDNRDPMETVQQGRRKRNQMTPDFSRQSHDKKNKLQDRTRLRKAQSMMSLSASSPLKVPAHLAWPPPESVGLPDTATTAEIL

--------------------------------------------------------------

>67940_67940_5_PPP1R9A-FBXO16_PPP1R9A_chr7_94540820_ENST00000340694_FBXO16_chr8_28309993_ENST00000380254_length(amino acids)=606AA_BP=483
MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ
MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK
KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL
KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ
LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY
YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP

--------------------------------------------------------------

>67940_67940_6_PPP1R9A-FBXO16_PPP1R9A_chr7_94540820_ENST00000340694_FBXO16_chr8_28309993_ENST00000518734_length(amino acids)=606AA_BP=483
MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ
MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK
KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL
KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ
LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY
YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP

--------------------------------------------------------------

>67940_67940_7_PPP1R9A-FBXO16_PPP1R9A_chr7_94540820_ENST00000424654_FBXO16_chr8_28309993_ENST00000346498_length(amino acids)=642AA_BP=483
MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ
MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK
KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL
KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ
LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY
YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP
TDIIRFNYLDNRDPMETVQQGRRKRNQMTPDFSRQSHDKKNKLQDRTRLRKAQSMMSLSASSPLKVPAHLAWPPPESVGLPDTATTAEIL

--------------------------------------------------------------

>67940_67940_8_PPP1R9A-FBXO16_PPP1R9A_chr7_94540820_ENST00000424654_FBXO16_chr8_28309993_ENST00000380254_length(amino acids)=606AA_BP=483
MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ
MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK
KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL
KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ
LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY
YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP

--------------------------------------------------------------

>67940_67940_9_PPP1R9A-FBXO16_PPP1R9A_chr7_94540820_ENST00000424654_FBXO16_chr8_28309993_ENST00000518734_length(amino acids)=606AA_BP=483
MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ
MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK
KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL
KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ
LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY
YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP

--------------------------------------------------------------

>67940_67940_10_PPP1R9A-FBXO16_PPP1R9A_chr7_94540820_ENST00000433360_FBXO16_chr8_28309993_ENST00000346498_length(amino acids)=642AA_BP=483
MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ
MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK
KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL
KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ
LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY
YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP
TDIIRFNYLDNRDPMETVQQGRRKRNQMTPDFSRQSHDKKNKLQDRTRLRKAQSMMSLSASSPLKVPAHLAWPPPESVGLPDTATTAEIL

--------------------------------------------------------------

>67940_67940_11_PPP1R9A-FBXO16_PPP1R9A_chr7_94540820_ENST00000433360_FBXO16_chr8_28309993_ENST00000380254_length(amino acids)=606AA_BP=483
MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ
MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK
KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL
KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ
LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY
YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP

--------------------------------------------------------------

>67940_67940_12_PPP1R9A-FBXO16_PPP1R9A_chr7_94540820_ENST00000433360_FBXO16_chr8_28309993_ENST00000518734_length(amino acids)=606AA_BP=483
MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ
MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK
KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL
KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ
LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY
YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP

--------------------------------------------------------------

>67940_67940_13_PPP1R9A-FBXO16_PPP1R9A_chr7_94540820_ENST00000433881_FBXO16_chr8_28309993_ENST00000346498_length(amino acids)=642AA_BP=483
MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ
MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK
KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL
KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ
LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY
YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP
TDIIRFNYLDNRDPMETVQQGRRKRNQMTPDFSRQSHDKKNKLQDRTRLRKAQSMMSLSASSPLKVPAHLAWPPPESVGLPDTATTAEIL

--------------------------------------------------------------

>67940_67940_14_PPP1R9A-FBXO16_PPP1R9A_chr7_94540820_ENST00000433881_FBXO16_chr8_28309993_ENST00000380254_length(amino acids)=606AA_BP=483
MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ
MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK
KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL
KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ
LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY
YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP

--------------------------------------------------------------

>67940_67940_15_PPP1R9A-FBXO16_PPP1R9A_chr7_94540820_ENST00000433881_FBXO16_chr8_28309993_ENST00000518734_length(amino acids)=606AA_BP=483
MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ
MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK
KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL
KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ
LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY
YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP

--------------------------------------------------------------

>67940_67940_16_PPP1R9A-FBXO16_PPP1R9A_chr7_94540820_ENST00000456331_FBXO16_chr8_28309993_ENST00000346498_length(amino acids)=642AA_BP=483
MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ
MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK
KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL
KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ
LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY
YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP
TDIIRFNYLDNRDPMETVQQGRRKRNQMTPDFSRQSHDKKNKLQDRTRLRKAQSMMSLSASSPLKVPAHLAWPPPESVGLPDTATTAEIL

--------------------------------------------------------------

>67940_67940_17_PPP1R9A-FBXO16_PPP1R9A_chr7_94540820_ENST00000456331_FBXO16_chr8_28309993_ENST00000380254_length(amino acids)=606AA_BP=483
MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ
MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK
KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL
KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ
LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY
YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP

--------------------------------------------------------------

>67940_67940_18_PPP1R9A-FBXO16_PPP1R9A_chr7_94540820_ENST00000456331_FBXO16_chr8_28309993_ENST00000518734_length(amino acids)=606AA_BP=483
MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ
MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK
KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL
KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ
LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY
YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:94540820/chr8:28309993)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	FBXO16 Q8IX29
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000340694

447_450

465.0

1099.0

Compositional bias

Note=Poly-Glu

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000424654

447_450

465.0

1254.0

Compositional bias

Note=Poly-Glu

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000433360

447_450

465.0

1375.0

Compositional bias

Note=Poly-Glu

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000433881

447_450

465.0

1099.0

Compositional bias

Note=Poly-Glu

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000456331

447_450

465.0

1254.0

Compositional bias

Note=Poly-Glu

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000340694

1_144

465.0

1099.0

Region

Note=Actin-binding

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000424654

1_144

465.0

1254.0

Region

Note=Actin-binding

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000433360

1_144

465.0

1375.0

Region

Note=Actin-binding

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000433881

1_144

465.0

1099.0

Region

Note=Actin-binding

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000456331

1_144

465.0

1254.0

Region

Note=Actin-binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000340694

1033_1090

465.0

1099.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000340694

597_627

465.0

1099.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000340694

670_824

465.0

1099.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000424654

1033_1090

465.0

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000424654

597_627

465.0

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000424654

670_824

465.0

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000433360

1033_1090

465.0

1375.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000433360

597_627

465.0

1375.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000433360

670_824

465.0

1375.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000433881

1033_1090

465.0

1099.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000433881

597_627

465.0

1099.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000433881

670_824

465.0

1099.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000456331

1033_1090

465.0

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000456331

597_627

465.0

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000456331

670_824

465.0

1254.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000340694

829_833

465.0

1099.0

Compositional bias

Note=Poly-Asn

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000424654

829_833

465.0

1254.0

Compositional bias

Note=Poly-Asn

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000433360

829_833

465.0

1375.0

Compositional bias

Note=Poly-Asn

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000433881

829_833

465.0

1099.0

Compositional bias

Note=Poly-Asn

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000456331

829_833

465.0

1254.0

Compositional bias

Note=Poly-Asn

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000340694

504_592

465.0

1099.0

Domain

PDZ

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000340694

988_1051

465.0

1099.0

Domain

SAM

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000424654

504_592

465.0

1254.0

Domain

PDZ

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000424654

988_1051

465.0

1254.0

Domain

SAM

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000433360

504_592

465.0

1375.0

Domain

PDZ

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000433360

988_1051

465.0

1375.0

Domain

SAM

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000433881

504_592

465.0

1099.0

Domain

PDZ

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000433881

988_1051

465.0

1099.0

Domain

SAM

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000456331

504_592

465.0

1254.0

Domain

PDZ

Hgene

PPP1R9A

chr7:94540820

chr8:28309993

ENST00000456331

988_1051

465.0

1254.0

Domain

SAM

Tgene

FBXO16

chr7:94540820

chr8:28309993

ENST00000380254

86_132

169.0

293.0

Domain

F-box

Tgene

FBXO16

chr7:94540820

chr8:28309993

ENST00000518734

86_132

157.0

281.0

Domain

F-box

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1345_PPP1R9A_94540820_FBXO16_28309993_1345_PPP1R9A_94540820_FBXO16_28309993_ranked_0.pdb	PPP1R9A	94540820	94540820	ENST00000518734	FBXO16	chr8	28309993	-	MVFFFDHYEHWLFTPEVKMLKTESSGERTTLRSASPHRNAYRTEFQALKSTFDKPKSDGEQKTKEGEGSQQSRGRKYGSNVNRIKNLFMQ MGMEPNENAAVIAKTRGKGGHSSPQRRMKPKEFLEKTDGSVVKLESSVSERISRFDTMYDGPSYSKFTETRKMFERSVHESGQNNRYSPK KEKAGGSEPQDEWGGSKSNRGSTDSLDSLSSRTEAVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHL KDSNSWPPSNKRGVDTEDAHKSNATPVPEVASKSTSLASIPGEEIQQSKEPEDSTSNQQTPDSIDKDGPEEPCAESKAMPKSEIPSPQSQ LLEDAEANLVGREAAKQQRKELAGGDFTSPDASASSCGKEVPEDSNNFDGSHVYMHSDYNVYRVRSRYNSDWGETGTEQDEEEDSDENSY YQPDMEYSEIVGLPEEEEIPANRKIKFSSAPIKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHP TDIIRFNYLDNRDPMETVQQGRRKRNQMTPDFSRQSHDKKNKLQDRTRLRKAQSMMSLSASSPLKVPAHLAWPPPESVGLPDTATTAEIL	642

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PPP1R9A_pLDDT.png

FBXO16_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PPP1R9A
FBXO16

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	PPP1R9A	chr7:94540820	chr8:28309993	ENST00000340694	+	2	16	425_502	465.0	1099.0	protein phosphatase 1
Hgene	PPP1R9A	chr7:94540820	chr8:28309993	ENST00000424654	+	2	18	425_502	465.0	1254.0	protein phosphatase 1
Hgene	PPP1R9A	chr7:94540820	chr8:28309993	ENST00000433360	+	2	20	425_502	465.0	1375.0	protein phosphatase 1
Hgene	PPP1R9A	chr7:94540820	chr8:28309993	ENST00000433881	+	2	16	425_502	465.0	1099.0	protein phosphatase 1
Hgene	PPP1R9A	chr7:94540820	chr8:28309993	ENST00000456331	+	1	17	425_502	465.0	1254.0	protein phosphatase 1
Hgene	PPP1R9A	chr7:94540820	chr8:28309993	ENST00000340694	+	2	16	597_1090	465.0	1099.0	TGN38
Hgene	PPP1R9A	chr7:94540820	chr8:28309993	ENST00000424654	+	2	18	597_1090	465.0	1254.0	TGN38
Hgene	PPP1R9A	chr7:94540820	chr8:28309993	ENST00000433360	+	2	20	597_1090	465.0	1375.0	TGN38
Hgene	PPP1R9A	chr7:94540820	chr8:28309993	ENST00000433881	+	2	16	597_1090	465.0	1099.0	TGN38
Hgene	PPP1R9A	chr7:94540820	chr8:28309993	ENST00000456331	+	1	17	597_1090	465.0	1254.0	TGN38

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Related Drugs to PPP1R9A-FBXO16

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to PPP1R9A-FBXO16

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source