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Fusion Protein:PPP2R4-GLUL |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: PPP2R4-GLUL | FusionPDB ID: 68052 | FusionGDB2.0 ID: 68052 | Hgene | Tgene | Gene symbol | PPP2R4 | GLUL | Gene ID | 5524 | 2752 |
| Gene name | protein phosphatase 2 phosphatase activator | glutamate-ammonia ligase | |
| Synonyms | PP2A|PPP2R4|PR53 | GLNS|GS|PIG43|PIG59 | |
| Cytomap | 9q34.11 | 1q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 2A activatorPP2A phosphatase activatorPP2A subunit B' isoform PR53phosphotyrosyl phosphatase activatorprotein phosphatase 2 regulatory subunit 4protein phosphatase 2A activator, regulatory subunit 4protein phosph | glutamine synthetasecell proliferation-inducing protein 59glutamate decarboxylaseglutamine synthasepalmitoyltransferase GLULproliferation-inducing protein 43 | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | . | P15104 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000337738, ENST00000348141, ENST00000357197, ENST00000358994, ENST00000393370, ENST00000452489, ENST00000347048, ENST00000355007, ENST00000414510, ENST00000419582, ENST00000423100, ENST00000432124, ENST00000432651, ENST00000434095, ENST00000435132, ENST00000435305, ENST00000436883, ENST00000524946, | ENST00000339526, ENST00000491322, ENST00000311223, ENST00000331872, ENST00000417584, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 10 X 9 X 8=720 | 18 X 16 X 6=1728 |
| # samples | 12 | 20 | |
| ** MAII score | log2(12/720*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/1728*10)=-3.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: PPP2R4 [Title/Abstract] AND GLUL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | PPP2R4(131891278)-GLUL(182354526), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | PPP2R4-GLUL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PPP2R4-GLUL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPP2R4 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity | 16916641 |
| Hgene | PPP2R4 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 16916641 |
| Hgene | PPP2R4 | GO:0035307 | positive regulation of protein dephosphorylation | 16916641 |
| Hgene | PPP2R4 | GO:0035308 | negative regulation of protein dephosphorylation | 16916641 |
| Hgene | PPP2R4 | GO:0043065 | positive regulation of apoptotic process | 17333320 |
| Hgene | PPP2R4 | GO:0043666 | regulation of phosphoprotein phosphatase activity | 16916641 |
| Tgene | GLUL | GO:0008283 | cell proliferation | 18662667 |
| Tgene | GLUL | GO:0010594 | regulation of endothelial cell migration | 30158707 |
| Tgene | GLUL | GO:0018345 | protein palmitoylation | 30158707 |
| Tgene | GLUL | GO:1903670 | regulation of sprouting angiogenesis | 30158707 |
| Fusion gene breakpoints across PPP2R4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across GLUL (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | TCGA-E2-A1BC-11A | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000358994 | PPP2R4 | chr9 | 131891278 | + | ENST00000331872 | GLUL | chr1 | 182354526 | - | 3594 | 539 | 8 | 559 | 183 |
| ENST00000358994 | PPP2R4 | chr9 | 131891278 | + | ENST00000417584 | GLUL | chr1 | 182354526 | - | 3593 | 539 | 8 | 559 | 183 |
| ENST00000358994 | PPP2R4 | chr9 | 131891278 | + | ENST00000311223 | GLUL | chr1 | 182354526 | - | 3593 | 539 | 8 | 559 | 183 |
| ENST00000393370 | PPP2R4 | chr9 | 131891278 | + | ENST00000331872 | GLUL | chr1 | 182354526 | - | 3665 | 610 | 169 | 630 | 153 |
| ENST00000393370 | PPP2R4 | chr9 | 131891278 | + | ENST00000417584 | GLUL | chr1 | 182354526 | - | 3664 | 610 | 169 | 630 | 153 |
| ENST00000393370 | PPP2R4 | chr9 | 131891278 | + | ENST00000311223 | GLUL | chr1 | 182354526 | - | 3664 | 610 | 169 | 630 | 153 |
| ENST00000337738 | PPP2R4 | chr9 | 131891278 | + | ENST00000331872 | GLUL | chr1 | 182354526 | - | 3754 | 699 | 153 | 719 | 188 |
| ENST00000337738 | PPP2R4 | chr9 | 131891278 | + | ENST00000417584 | GLUL | chr1 | 182354526 | - | 3753 | 699 | 153 | 719 | 188 |
| ENST00000337738 | PPP2R4 | chr9 | 131891278 | + | ENST00000311223 | GLUL | chr1 | 182354526 | - | 3753 | 699 | 153 | 719 | 188 |
| ENST00000348141 | PPP2R4 | chr9 | 131891278 | + | ENST00000331872 | GLUL | chr1 | 182354526 | - | 3665 | 610 | 151 | 630 | 159 |
| ENST00000348141 | PPP2R4 | chr9 | 131891278 | + | ENST00000417584 | GLUL | chr1 | 182354526 | - | 3664 | 610 | 151 | 630 | 159 |
| ENST00000348141 | PPP2R4 | chr9 | 131891278 | + | ENST00000311223 | GLUL | chr1 | 182354526 | - | 3664 | 610 | 151 | 630 | 159 |
| ENST00000452489 | PPP2R4 | chr9 | 131891278 | + | ENST00000331872 | GLUL | chr1 | 182354526 | - | 3700 | 645 | 99 | 665 | 188 |
| ENST00000452489 | PPP2R4 | chr9 | 131891278 | + | ENST00000417584 | GLUL | chr1 | 182354526 | - | 3699 | 645 | 99 | 665 | 188 |
| ENST00000452489 | PPP2R4 | chr9 | 131891278 | + | ENST00000311223 | GLUL | chr1 | 182354526 | - | 3699 | 645 | 99 | 665 | 188 |
| ENST00000357197 | PPP2R4 | chr9 | 131891278 | + | ENST00000331872 | GLUL | chr1 | 182354526 | - | 3487 | 432 | 178 | 750 | 190 |
| ENST00000357197 | PPP2R4 | chr9 | 131891278 | + | ENST00000417584 | GLUL | chr1 | 182354526 | - | 3486 | 432 | 178 | 750 | 190 |
| ENST00000357197 | PPP2R4 | chr9 | 131891278 | + | ENST00000311223 | GLUL | chr1 | 182354526 | - | 3486 | 432 | 178 | 750 | 190 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000358994 | ENST00000331872 | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - | 0.002108957 | 0.997891 |
| ENST00000358994 | ENST00000417584 | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - | 0.00273607 | 0.9972639 |
| ENST00000358994 | ENST00000311223 | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - | 0.00273607 | 0.9972639 |
| ENST00000393370 | ENST00000331872 | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - | 0.008337422 | 0.9916626 |
| ENST00000393370 | ENST00000417584 | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - | 0.012430579 | 0.9875694 |
| ENST00000393370 | ENST00000311223 | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - | 0.012430579 | 0.9875694 |
| ENST00000337738 | ENST00000331872 | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - | 0.014727949 | 0.98527205 |
| ENST00000337738 | ENST00000417584 | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - | 0.018767018 | 0.981233 |
| ENST00000337738 | ENST00000311223 | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - | 0.018767018 | 0.981233 |
| ENST00000348141 | ENST00000331872 | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - | 0.008161619 | 0.9918384 |
| ENST00000348141 | ENST00000417584 | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - | 0.012141221 | 0.9878588 |
| ENST00000348141 | ENST00000311223 | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - | 0.012141221 | 0.9878588 |
| ENST00000452489 | ENST00000331872 | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - | 0.015089328 | 0.98491067 |
| ENST00000452489 | ENST00000417584 | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - | 0.01920186 | 0.9807982 |
| ENST00000452489 | ENST00000311223 | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - | 0.01920186 | 0.9807982 |
| ENST00000357197 | ENST00000331872 | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - | 0.00855967 | 0.9914403 |
| ENST00000357197 | ENST00000417584 | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - | 0.012607782 | 0.98739225 |
| ENST00000357197 | ENST00000311223 | PPP2R4 | chr9 | 131891278 | + | GLUL | chr1 | 182354526 | - | 0.012607782 | 0.98739225 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >68052_68052_1_PPP2R4-GLUL_PPP2R4_chr9_131891278_ENST00000337738_GLUL_chr1_182354526_ENST00000311223_length(amino acids)=188AA_BP= MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFI LTLNEGVKGKKLTFEYRVSEMWNEVHEEKEQAAKQSVSCDECIPLPRAGHCAPSEVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKL -------------------------------------------------------------- >68052_68052_2_PPP2R4-GLUL_PPP2R4_chr9_131891278_ENST00000337738_GLUL_chr1_182354526_ENST00000331872_length(amino acids)=188AA_BP= MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFI LTLNEGVKGKKLTFEYRVSEMWNEVHEEKEQAAKQSVSCDECIPLPRAGHCAPSEVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKL -------------------------------------------------------------- >68052_68052_3_PPP2R4-GLUL_PPP2R4_chr9_131891278_ENST00000337738_GLUL_chr1_182354526_ENST00000417584_length(amino acids)=188AA_BP= MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFI LTLNEGVKGKKLTFEYRVSEMWNEVHEEKEQAAKQSVSCDECIPLPRAGHCAPSEVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKL -------------------------------------------------------------- >68052_68052_4_PPP2R4-GLUL_PPP2R4_chr9_131891278_ENST00000348141_GLUL_chr1_182354526_ENST00000311223_length(amino acids)=159AA_BP= MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQVPFGTVAYA -------------------------------------------------------------- >68052_68052_5_PPP2R4-GLUL_PPP2R4_chr9_131891278_ENST00000348141_GLUL_chr1_182354526_ENST00000331872_length(amino acids)=159AA_BP= MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQVPFGTVAYA -------------------------------------------------------------- >68052_68052_6_PPP2R4-GLUL_PPP2R4_chr9_131891278_ENST00000348141_GLUL_chr1_182354526_ENST00000417584_length(amino acids)=159AA_BP= MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQVPFGTVAYA -------------------------------------------------------------- >68052_68052_7_PPP2R4-GLUL_PPP2R4_chr9_131891278_ENST00000357197_GLUL_chr1_182354526_ENST00000311223_length(amino acids)=190AA_BP= MAGARWLRASGSRRQILQRRPLQPLRTSSFQKRRSTQFQTWANGSVLRSLFSTRWTGGLMRLLQWTSPLGLGIRHTGPGMPNLMRYIEEA IEKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNE -------------------------------------------------------------- >68052_68052_8_PPP2R4-GLUL_PPP2R4_chr9_131891278_ENST00000357197_GLUL_chr1_182354526_ENST00000331872_length(amino acids)=190AA_BP= MAGARWLRASGSRRQILQRRPLQPLRTSSFQKRRSTQFQTWANGSVLRSLFSTRWTGGLMRLLQWTSPLGLGIRHTGPGMPNLMRYIEEA IEKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNE -------------------------------------------------------------- >68052_68052_9_PPP2R4-GLUL_PPP2R4_chr9_131891278_ENST00000357197_GLUL_chr1_182354526_ENST00000417584_length(amino acids)=190AA_BP= MAGARWLRASGSRRQILQRRPLQPLRTSSFQKRRSTQFQTWANGSVLRSLFSTRWTGGLMRLLQWTSPLGLGIRHTGPGMPNLMRYIEEA IEKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNE -------------------------------------------------------------- >68052_68052_10_PPP2R4-GLUL_PPP2R4_chr9_131891278_ENST00000358994_GLUL_chr1_182354526_ENST00000311223_length(amino acids)=183AA_BP= MWRRKEEVTVQLSLPCPHMSSKLLEPAGAHLSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQN FIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFEYRVSEVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEVHR -------------------------------------------------------------- >68052_68052_11_PPP2R4-GLUL_PPP2R4_chr9_131891278_ENST00000358994_GLUL_chr1_182354526_ENST00000331872_length(amino acids)=183AA_BP= MWRRKEEVTVQLSLPCPHMSSKLLEPAGAHLSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQN FIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFEYRVSEVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEVHR -------------------------------------------------------------- >68052_68052_12_PPP2R4-GLUL_PPP2R4_chr9_131891278_ENST00000358994_GLUL_chr1_182354526_ENST00000417584_length(amino acids)=183AA_BP= MWRRKEEVTVQLSLPCPHMSSKLLEPAGAHLSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQN FIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFEYRVSEVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEVHR -------------------------------------------------------------- >68052_68052_13_PPP2R4-GLUL_PPP2R4_chr9_131891278_ENST00000393370_GLUL_chr1_182354526_ENST00000311223_length(amino acids)=153AA_BP= MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFI -------------------------------------------------------------- >68052_68052_14_PPP2R4-GLUL_PPP2R4_chr9_131891278_ENST00000393370_GLUL_chr1_182354526_ENST00000331872_length(amino acids)=153AA_BP= MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFI -------------------------------------------------------------- >68052_68052_15_PPP2R4-GLUL_PPP2R4_chr9_131891278_ENST00000393370_GLUL_chr1_182354526_ENST00000417584_length(amino acids)=153AA_BP= MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFI -------------------------------------------------------------- >68052_68052_16_PPP2R4-GLUL_PPP2R4_chr9_131891278_ENST00000452489_GLUL_chr1_182354526_ENST00000311223_length(amino acids)=188AA_BP= MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFI LTLNEGVKGKKLTFEYRVSEMWNEVHEEKEQAAKQSVSCDECIPLPRAGHCAPSEVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKL -------------------------------------------------------------- >68052_68052_17_PPP2R4-GLUL_PPP2R4_chr9_131891278_ENST00000452489_GLUL_chr1_182354526_ENST00000331872_length(amino acids)=188AA_BP= MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFI LTLNEGVKGKKLTFEYRVSEMWNEVHEEKEQAAKQSVSCDECIPLPRAGHCAPSEVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKL -------------------------------------------------------------- >68052_68052_18_PPP2R4-GLUL_PPP2R4_chr9_131891278_ENST00000452489_GLUL_chr1_182354526_ENST00000417584_length(amino acids)=188AA_BP= MSSGSSEPLVEPGRGRVGARVKGERGLQASGSAPGRSKMAEGERQPPPDSSEEAPPATQNFIIPKKEIHTVPDMGKWKRSQAYADYIGFI LTLNEGVKGKKLTFEYRVSEMWNEVHEEKEQAAKQSVSCDECIPLPRAGHCAPSEVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKL -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:131891278/chr1:182354526) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | GLUL |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:30158707, PubMed:16267323). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed:30158707). Plays a role in ribosomal 40S subunit biogenesis (PubMed:26711351). {ECO:0000250|UniProtKB:P15105, ECO:0000269|PubMed:16267323, ECO:0000269|PubMed:18662667, ECO:0000269|PubMed:26711351, ECO:0000269|PubMed:30158707}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | GLUL | chr9:131891278 | chr1:182354526 | ENST00000311223 | 0 | 8 | 203_208 | 0 | 374.0 | Nucleotide binding | ATP | |
| Tgene | GLUL | chr9:131891278 | chr1:182354526 | ENST00000311223 | 0 | 8 | 255_257 | 0 | 374.0 | Nucleotide binding | ATP | |
| Tgene | GLUL | chr9:131891278 | chr1:182354526 | ENST00000311223 | 0 | 8 | 336_338 | 0 | 374.0 | Nucleotide binding | ADP | |
| Tgene | GLUL | chr9:131891278 | chr1:182354526 | ENST00000331872 | 0 | 7 | 203_208 | 0 | 374.0 | Nucleotide binding | ATP | |
| Tgene | GLUL | chr9:131891278 | chr1:182354526 | ENST00000331872 | 0 | 7 | 255_257 | 0 | 374.0 | Nucleotide binding | ATP | |
| Tgene | GLUL | chr9:131891278 | chr1:182354526 | ENST00000331872 | 0 | 7 | 336_338 | 0 | 374.0 | Nucleotide binding | ADP | |
| Tgene | GLUL | chr9:131891278 | chr1:182354526 | ENST00000339526 | 0 | 7 | 203_208 | 0 | 374.0 | Nucleotide binding | ATP | |
| Tgene | GLUL | chr9:131891278 | chr1:182354526 | ENST00000339526 | 0 | 7 | 255_257 | 0 | 374.0 | Nucleotide binding | ATP | |
| Tgene | GLUL | chr9:131891278 | chr1:182354526 | ENST00000339526 | 0 | 7 | 336_338 | 0 | 374.0 | Nucleotide binding | ADP | |
| Tgene | GLUL | chr9:131891278 | chr1:182354526 | ENST00000417584 | 0 | 7 | 203_208 | 0 | 374.0 | Nucleotide binding | ATP | |
| Tgene | GLUL | chr9:131891278 | chr1:182354526 | ENST00000417584 | 0 | 7 | 255_257 | 0 | 374.0 | Nucleotide binding | ATP | |
| Tgene | GLUL | chr9:131891278 | chr1:182354526 | ENST00000417584 | 0 | 7 | 336_338 | 0 | 374.0 | Nucleotide binding | ADP | |
| Tgene | GLUL | chr9:131891278 | chr1:182354526 | ENST00000311223 | 0 | 8 | 246_247 | 0 | 374.0 | Region | L-glutamate binding | |
| Tgene | GLUL | chr9:131891278 | chr1:182354526 | ENST00000331872 | 0 | 7 | 246_247 | 0 | 374.0 | Region | L-glutamate binding | |
| Tgene | GLUL | chr9:131891278 | chr1:182354526 | ENST00000339526 | 0 | 7 | 246_247 | 0 | 374.0 | Region | L-glutamate binding | |
| Tgene | GLUL | chr9:131891278 | chr1:182354526 | ENST00000417584 | 0 | 7 | 246_247 | 0 | 374.0 | Region | L-glutamate binding |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PPP2R4 | chr9:131891278 | chr1:182354526 | ENST00000337738 | + | 1 | 11 | 183_189 | 0 | 359.0 | Nucleotide binding | Note=ATP |
| Hgene | PPP2R4 | chr9:131891278 | chr1:182354526 | ENST00000337738 | + | 1 | 11 | 240_242 | 0 | 359.0 | Nucleotide binding | Note=ATP |
| Hgene | PPP2R4 | chr9:131891278 | chr1:182354526 | ENST00000337738 | + | 1 | 11 | 342_343 | 0 | 359.0 | Nucleotide binding | Note=ATP |
| Hgene | PPP2R4 | chr9:131891278 | chr1:182354526 | ENST00000355007 | + | 1 | 9 | 183_189 | 0 | 282.0 | Nucleotide binding | Note=ATP |
| Hgene | PPP2R4 | chr9:131891278 | chr1:182354526 | ENST00000355007 | + | 1 | 9 | 240_242 | 0 | 282.0 | Nucleotide binding | Note=ATP |
| Hgene | PPP2R4 | chr9:131891278 | chr1:182354526 | ENST00000355007 | + | 1 | 9 | 342_343 | 0 | 282.0 | Nucleotide binding | Note=ATP |
| Hgene | PPP2R4 | chr9:131891278 | chr1:182354526 | ENST00000357197 | + | 1 | 9 | 183_189 | 0 | 295.0 | Nucleotide binding | Note=ATP |
| Hgene | PPP2R4 | chr9:131891278 | chr1:182354526 | ENST00000357197 | + | 1 | 9 | 240_242 | 0 | 295.0 | Nucleotide binding | Note=ATP |
| Hgene | PPP2R4 | chr9:131891278 | chr1:182354526 | ENST00000357197 | + | 1 | 9 | 342_343 | 0 | 295.0 | Nucleotide binding | Note=ATP |
| Hgene | PPP2R4 | chr9:131891278 | chr1:182354526 | ENST00000358994 | + | 1 | 11 | 183_189 | 0 | 324.0 | Nucleotide binding | Note=ATP |
| Hgene | PPP2R4 | chr9:131891278 | chr1:182354526 | ENST00000358994 | + | 1 | 11 | 240_242 | 0 | 324.0 | Nucleotide binding | Note=ATP |
| Hgene | PPP2R4 | chr9:131891278 | chr1:182354526 | ENST00000358994 | + | 1 | 11 | 342_343 | 0 | 324.0 | Nucleotide binding | Note=ATP |
| Hgene | PPP2R4 | chr9:131891278 | chr1:182354526 | ENST00000393370 | + | 1 | 10 | 183_189 | 0 | 324.0 | Nucleotide binding | Note=ATP |
| Hgene | PPP2R4 | chr9:131891278 | chr1:182354526 | ENST00000393370 | + | 1 | 10 | 240_242 | 0 | 324.0 | Nucleotide binding | Note=ATP |
| Hgene | PPP2R4 | chr9:131891278 | chr1:182354526 | ENST00000393370 | + | 1 | 10 | 342_343 | 0 | 324.0 | Nucleotide binding | Note=ATP |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| PPP2R4 | |
| GLUL |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to PPP2R4-GLUL |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to PPP2R4-GLUL |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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