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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PPP2R5C-SCN1B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PPP2R5C-SCN1B
	FusionPDB ID: 68084
	FusionGDB2.0 ID: 68084
		Hgene	Tgene
	Gene symbol	PPP2R5C	SCN1B
	Gene ID	5527	6324
	Gene name	protein phosphatase 2 regulatory subunit B'gamma	sodium voltage-gated channel beta subunit 1
	Synonyms	B56G\|B56gamma\|PR61G	ATFB13\|BRGDA5\|EIEE52\|GEFSP1
	Cytomap	14q32.31	19q13.11
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoformB' alpha regulatory subunitPP2A B subunit isoform B'-gammaPP2A B subunit isoform B56-gammaPP2A B subunit isoform PR61-gammaPP2A B subunit isoform R5-gammaprotein phosphat	sodium channel subunit beta-1sodium channel, voltage gated, type I beta subunitsodium channel, voltage-gated, type I, beta
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000334743, ENST00000350249, ENST00000445439, ENST00000556946, ENST00000557095, ENST00000557714, ENST00000328724, ENST00000422945, ENST00000554442, ENST00000556068, ENST00000556260,	ENST00000596348, ENST00000262631, ENST00000415950, ENST00000595652,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	18 X 11 X 8=1584	4 X 2 X 4=32
	# samples	19	5
	** MAII score	log2(19/1584*10)=-3.05950101174866 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/32*10)=0.643856189774725 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PPP2R5C [Title/Abstract] AND SCN1B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PPP2R5C(102276373)-SCN1B(35523432), # samples:2
Anticipated loss of major functional domain due to fusion event.	PPP2R5C-SCN1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PPP2R5C-SCN1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PPP2R5C-SCN1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PPP2R5C-SCN1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PPP2R5C	GO:0008285	negative regulation of cell proliferation	17245430
Tgene	SCN1B	GO:0010765	positive regulation of sodium ion transport	19808477
Tgene	SCN1B	GO:0035725	sodium ion transmembrane transport	18464934\|19808477\|21051419
Tgene	SCN1B	GO:0051899	membrane depolarization	21051419
Tgene	SCN1B	GO:2000649	regulation of sodium ion transmembrane transporter activity	19808477

Fusion gene breakpoints across PPP2R5C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SCN1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-B6-A0RT-01A	PPP2R5C	chr14	102276373	-	SCN1B	chr19	35523432	+
ChimerDB4	BRCA	TCGA-B6-A0RT-01A	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000350249	PPP2R5C	chr14	102276373	+	ENST00000262631	SCN1B	chr19	35523432	+	1508	234	1453	239	404
ENST00000350249	PPP2R5C	chr14	102276373	+	ENST00000595652	SCN1B	chr19	35523432	+	920	234	140	637	165
ENST00000350249	PPP2R5C	chr14	102276373	+	ENST00000415950	SCN1B	chr19	35523432	+	1173	234	140	1000	286
ENST00000445439	PPP2R5C	chr14	102276373	+	ENST00000262631	SCN1B	chr19	35523432	+	1416	142	1361	147	404
ENST00000445439	PPP2R5C	chr14	102276373	+	ENST00000595652	SCN1B	chr19	35523432	+	828	142	48	545	165
ENST00000445439	PPP2R5C	chr14	102276373	+	ENST00000415950	SCN1B	chr19	35523432	+	1081	142	48	908	286
ENST00000334743	PPP2R5C	chr14	102276373	+	ENST00000262631	SCN1B	chr19	35523432	+	1416	142	1361	147	404
ENST00000334743	PPP2R5C	chr14	102276373	+	ENST00000595652	SCN1B	chr19	35523432	+	828	142	48	545	165
ENST00000334743	PPP2R5C	chr14	102276373	+	ENST00000415950	SCN1B	chr19	35523432	+	1081	142	48	908	286
ENST00000557095	PPP2R5C	chr14	102276373	+	ENST00000262631	SCN1B	chr19	35523432	+	1406	132	1351	137	404
ENST00000557095	PPP2R5C	chr14	102276373	+	ENST00000595652	SCN1B	chr19	35523432	+	818	132	38	535	165
ENST00000557095	PPP2R5C	chr14	102276373	+	ENST00000415950	SCN1B	chr19	35523432	+	1071	132	38	898	286
ENST00000556946	PPP2R5C	chr14	102276373	+	ENST00000262631	SCN1B	chr19	35523432	+	1476	202	1421	207	404
ENST00000556946	PPP2R5C	chr14	102276373	+	ENST00000595652	SCN1B	chr19	35523432	+	888	202	108	605	165
ENST00000556946	PPP2R5C	chr14	102276373	+	ENST00000415950	SCN1B	chr19	35523432	+	1141	202	108	968	286
ENST00000557714	PPP2R5C	chr14	102276373	+	ENST00000262631	SCN1B	chr19	35523432	+	1442	168	1387	173	404
ENST00000557714	PPP2R5C	chr14	102276373	+	ENST00000595652	SCN1B	chr19	35523432	+	854	168	74	571	165
ENST00000557714	PPP2R5C	chr14	102276373	+	ENST00000415950	SCN1B	chr19	35523432	+	1107	168	74	934	286

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000350249	ENST00000262631	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+	0.003830905	0.99616903
ENST00000350249	ENST00000595652	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+	0.005253967	0.9947461
ENST00000350249	ENST00000415950	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+	0.07820682	0.92179316
ENST00000445439	ENST00000262631	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+	0.003236794	0.9967632
ENST00000445439	ENST00000595652	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+	0.004143187	0.9958568
ENST00000445439	ENST00000415950	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+	0.06454196	0.93545806
ENST00000334743	ENST00000262631	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+	0.003236794	0.9967632
ENST00000334743	ENST00000595652	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+	0.004143187	0.9958568
ENST00000334743	ENST00000415950	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+	0.06454196	0.93545806
ENST00000557095	ENST00000262631	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+	0.003232145	0.9967679
ENST00000557095	ENST00000595652	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+	0.004449267	0.99555075
ENST00000557095	ENST00000415950	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+	0.06777503	0.932225
ENST00000556946	ENST00000262631	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+	0.003954795	0.9960452
ENST00000556946	ENST00000595652	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+	0.005653873	0.9943461
ENST00000556946	ENST00000415950	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+	0.068916135	0.9310838
ENST00000557714	ENST00000262631	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+	0.003228804	0.99677116
ENST00000557714	ENST00000595652	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+	0.004077133	0.9959229
ENST00000557714	ENST00000415950	PPP2R5C	chr14	102276373	+	SCN1B	chr19	35523432	+	0.062479295	0.9375207

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>68084_68084_1_PPP2R5C-SCN1B_PPP2R5C_chr14_102276373_ENST00000334743_SCN1B_chr19_35523432_ENST00000262631_length(amino acids)=404AA_BP=1
MNGPLSRWPQFKAGERGRGWAGAGVHYREGGPQVQPEEAGGEMMPGRGSRSGSQNPLPQTAPAHHRDPCRQAGRRRGGAGPRSACLKRPM
CANQQGGGVRGRCPHLTAPLPKQAAEAGWGQRQYCFTHHAWRCAAGGAGAGGGESGGASQAPCPLPPQWLRRQDSEAFWGPGVATPTLGA
GGAWRVPITAGSSLRRGPGPGLFGHLDARAVLFAFRGDGQVFRGILLCSSLRGGSDLLVAVNHLCHEPYGQHHNEHIHHDLRHDGCHVSV
GFVHYLNVDLLDDAGVVLVVFEEEQAVDVALVVARVVVGDIGDEDRQILQVFGAPAAIPHHAALEALILLQLQHLILIAQDLDKLLSALL

--------------------------------------------------------------

>68084_68084_2_PPP2R5C-SCN1B_PPP2R5C_chr14_102276373_ENST00000334743_SCN1B_chr19_35523432_ENST00000415950_length(amino acids)=286AA_BP=31
MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKILR
YENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKGESGAACPFTVTH
RRARWRDRWQAVDRTGWLCAWPANRPQQRAEGEGSSPSCPLQLWPLFLSSPRRGQSMPVPHRRSGYRTQLCHLCCMTSGRCLLSLSQRVV

--------------------------------------------------------------

>68084_68084_3_PPP2R5C-SCN1B_PPP2R5C_chr14_102276373_ENST00000334743_SCN1B_chr19_35523432_ENST00000595652_length(amino acids)=165AA_BP=31
MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKKIH

--------------------------------------------------------------

>68084_68084_4_PPP2R5C-SCN1B_PPP2R5C_chr14_102276373_ENST00000350249_SCN1B_chr19_35523432_ENST00000262631_length(amino acids)=404AA_BP=1
MNGPLSRWPQFKAGERGRGWAGAGVHYREGGPQVQPEEAGGEMMPGRGSRSGSQNPLPQTAPAHHRDPCRQAGRRRGGAGPRSACLKRPM
CANQQGGGVRGRCPHLTAPLPKQAAEAGWGQRQYCFTHHAWRCAAGGAGAGGGESGGASQAPCPLPPQWLRRQDSEAFWGPGVATPTLGA
GGAWRVPITAGSSLRRGPGPGLFGHLDARAVLFAFRGDGQVFRGILLCSSLRGGSDLLVAVNHLCHEPYGQHHNEHIHHDLRHDGCHVSV
GFVHYLNVDLLDDAGVVLVVFEEEQAVDVALVVARVVVGDIGDEDRQILQVFGAPAAIPHHAALEALILLQLQHLILIAQDLDKLLSALL

--------------------------------------------------------------

>68084_68084_5_PPP2R5C-SCN1B_PPP2R5C_chr14_102276373_ENST00000350249_SCN1B_chr19_35523432_ENST00000415950_length(amino acids)=286AA_BP=31
MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKILR
YENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKGESGAACPFTVTH
RRARWRDRWQAVDRTGWLCAWPANRPQQRAEGEGSSPSCPLQLWPLFLSSPRRGQSMPVPHRRSGYRTQLCHLCCMTSGRCLLSLSQRVV

--------------------------------------------------------------

>68084_68084_6_PPP2R5C-SCN1B_PPP2R5C_chr14_102276373_ENST00000350249_SCN1B_chr19_35523432_ENST00000595652_length(amino acids)=165AA_BP=31
MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKKIH

--------------------------------------------------------------

>68084_68084_7_PPP2R5C-SCN1B_PPP2R5C_chr14_102276373_ENST00000445439_SCN1B_chr19_35523432_ENST00000262631_length(amino acids)=404AA_BP=1
MNGPLSRWPQFKAGERGRGWAGAGVHYREGGPQVQPEEAGGEMMPGRGSRSGSQNPLPQTAPAHHRDPCRQAGRRRGGAGPRSACLKRPM
CANQQGGGVRGRCPHLTAPLPKQAAEAGWGQRQYCFTHHAWRCAAGGAGAGGGESGGASQAPCPLPPQWLRRQDSEAFWGPGVATPTLGA
GGAWRVPITAGSSLRRGPGPGLFGHLDARAVLFAFRGDGQVFRGILLCSSLRGGSDLLVAVNHLCHEPYGQHHNEHIHHDLRHDGCHVSV
GFVHYLNVDLLDDAGVVLVVFEEEQAVDVALVVARVVVGDIGDEDRQILQVFGAPAAIPHHAALEALILLQLQHLILIAQDLDKLLSALL

--------------------------------------------------------------

>68084_68084_8_PPP2R5C-SCN1B_PPP2R5C_chr14_102276373_ENST00000445439_SCN1B_chr19_35523432_ENST00000415950_length(amino acids)=286AA_BP=31
MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKILR
YENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKGESGAACPFTVTH
RRARWRDRWQAVDRTGWLCAWPANRPQQRAEGEGSSPSCPLQLWPLFLSSPRRGQSMPVPHRRSGYRTQLCHLCCMTSGRCLLSLSQRVV

--------------------------------------------------------------

>68084_68084_9_PPP2R5C-SCN1B_PPP2R5C_chr14_102276373_ENST00000445439_SCN1B_chr19_35523432_ENST00000595652_length(amino acids)=165AA_BP=31
MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKKIH

--------------------------------------------------------------

>68084_68084_10_PPP2R5C-SCN1B_PPP2R5C_chr14_102276373_ENST00000556946_SCN1B_chr19_35523432_ENST00000262631_length(amino acids)=404AA_BP=1
MNGPLSRWPQFKAGERGRGWAGAGVHYREGGPQVQPEEAGGEMMPGRGSRSGSQNPLPQTAPAHHRDPCRQAGRRRGGAGPRSACLKRPM
CANQQGGGVRGRCPHLTAPLPKQAAEAGWGQRQYCFTHHAWRCAAGGAGAGGGESGGASQAPCPLPPQWLRRQDSEAFWGPGVATPTLGA
GGAWRVPITAGSSLRRGPGPGLFGHLDARAVLFAFRGDGQVFRGILLCSSLRGGSDLLVAVNHLCHEPYGQHHNEHIHHDLRHDGCHVSV
GFVHYLNVDLLDDAGVVLVVFEEEQAVDVALVVARVVVGDIGDEDRQILQVFGAPAAIPHHAALEALILLQLQHLILIAQDLDKLLSALL

--------------------------------------------------------------

>68084_68084_11_PPP2R5C-SCN1B_PPP2R5C_chr14_102276373_ENST00000556946_SCN1B_chr19_35523432_ENST00000415950_length(amino acids)=286AA_BP=31
MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKILR
YENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKGESGAACPFTVTH
RRARWRDRWQAVDRTGWLCAWPANRPQQRAEGEGSSPSCPLQLWPLFLSSPRRGQSMPVPHRRSGYRTQLCHLCCMTSGRCLLSLSQRVV

--------------------------------------------------------------

>68084_68084_12_PPP2R5C-SCN1B_PPP2R5C_chr14_102276373_ENST00000556946_SCN1B_chr19_35523432_ENST00000595652_length(amino acids)=165AA_BP=31
MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKKIH

--------------------------------------------------------------

>68084_68084_13_PPP2R5C-SCN1B_PPP2R5C_chr14_102276373_ENST00000557095_SCN1B_chr19_35523432_ENST00000262631_length(amino acids)=404AA_BP=1
MNGPLSRWPQFKAGERGRGWAGAGVHYREGGPQVQPEEAGGEMMPGRGSRSGSQNPLPQTAPAHHRDPCRQAGRRRGGAGPRSACLKRPM
CANQQGGGVRGRCPHLTAPLPKQAAEAGWGQRQYCFTHHAWRCAAGGAGAGGGESGGASQAPCPLPPQWLRRQDSEAFWGPGVATPTLGA
GGAWRVPITAGSSLRRGPGPGLFGHLDARAVLFAFRGDGQVFRGILLCSSLRGGSDLLVAVNHLCHEPYGQHHNEHIHHDLRHDGCHVSV
GFVHYLNVDLLDDAGVVLVVFEEEQAVDVALVVARVVVGDIGDEDRQILQVFGAPAAIPHHAALEALILLQLQHLILIAQDLDKLLSALL

--------------------------------------------------------------

>68084_68084_14_PPP2R5C-SCN1B_PPP2R5C_chr14_102276373_ENST00000557095_SCN1B_chr19_35523432_ENST00000415950_length(amino acids)=286AA_BP=31
MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKILR
YENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKGESGAACPFTVTH
RRARWRDRWQAVDRTGWLCAWPANRPQQRAEGEGSSPSCPLQLWPLFLSSPRRGQSMPVPHRRSGYRTQLCHLCCMTSGRCLLSLSQRVV

--------------------------------------------------------------

>68084_68084_15_PPP2R5C-SCN1B_PPP2R5C_chr14_102276373_ENST00000557095_SCN1B_chr19_35523432_ENST00000595652_length(amino acids)=165AA_BP=31
MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKKIH

--------------------------------------------------------------

>68084_68084_16_PPP2R5C-SCN1B_PPP2R5C_chr14_102276373_ENST00000557714_SCN1B_chr19_35523432_ENST00000262631_length(amino acids)=404AA_BP=1
MNGPLSRWPQFKAGERGRGWAGAGVHYREGGPQVQPEEAGGEMMPGRGSRSGSQNPLPQTAPAHHRDPCRQAGRRRGGAGPRSACLKRPM
CANQQGGGVRGRCPHLTAPLPKQAAEAGWGQRQYCFTHHAWRCAAGGAGAGGGESGGASQAPCPLPPQWLRRQDSEAFWGPGVATPTLGA
GGAWRVPITAGSSLRRGPGPGLFGHLDARAVLFAFRGDGQVFRGILLCSSLRGGSDLLVAVNHLCHEPYGQHHNEHIHHDLRHDGCHVSV
GFVHYLNVDLLDDAGVVLVVFEEEQAVDVALVVARVVVGDIGDEDRQILQVFGAPAAIPHHAALEALILLQLQHLILIAQDLDKLLSALL

--------------------------------------------------------------

>68084_68084_17_PPP2R5C-SCN1B_PPP2R5C_chr14_102276373_ENST00000557714_SCN1B_chr19_35523432_ENST00000415950_length(amino acids)=286AA_BP=31
MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKILR
YENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKGESGAACPFTVTH
RRARWRDRWQAVDRTGWLCAWPANRPQQRAEGEGSSPSCPLQLWPLFLSSPRRGQSMPVPHRRSGYRTQLCHLCCMTSGRCLLSLSQRVV

--------------------------------------------------------------

>68084_68084_18_PPP2R5C-SCN1B_PPP2R5C_chr14_102276373_ENST00000557714_SCN1B_chr19_35523432_ENST00000595652_length(amino acids)=165AA_BP=31
MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKKIH

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:102276373/chr19:35523432)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SCN1B

chr14:102276373

chr19:35523432

ENST00000262631

22_150

13.333333333333334

377.3333333333333

Domain

Note=Ig-like C2-type

Tgene

SCN1B

chr14:102276373

chr19:35523432

ENST00000415950

22_150

13.333333333333334

269.0

Domain

Note=Ig-like C2-type

Tgene

SCN1B

chr14:102276373

chr19:35523432

ENST00000262631

183_218

13.333333333333334

377.3333333333333

Topological domain

Cytoplasmic

Tgene

SCN1B

chr14:102276373

chr19:35523432

ENST00000262631

19_160

13.333333333333334

377.3333333333333

Topological domain

Extracellular

Tgene

SCN1B

chr14:102276373

chr19:35523432

ENST00000415950

183_218

13.333333333333334

269.0

Topological domain

Cytoplasmic

Tgene

SCN1B

chr14:102276373

chr19:35523432

ENST00000415950

19_160

13.333333333333334

269.0

Topological domain

Extracellular

Tgene

SCN1B

chr14:102276373

chr19:35523432

ENST00000262631

161_182

13.333333333333334

377.3333333333333

Transmembrane

Helical

Tgene

SCN1B

chr14:102276373

chr19:35523432

ENST00000415950

161_182

13.333333333333334

269.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PPP2R5C

chr14:102276373

chr19:35523432

ENST00000328724

416_422

541.0

Motif

Nuclear localization signal

Hgene

PPP2R5C

chr14:102276373

chr19:35523432

ENST00000334743

416_422

31.333333333333332

525.0

Motif

Nuclear localization signal

Hgene

PPP2R5C

chr14:102276373

chr19:35523432

ENST00000350249

416_422

31.333333333333332

486.0

Motif

Nuclear localization signal

Hgene

PPP2R5C

chr14:102276373

chr19:35523432

ENST00000422945

416_422

556.0

Motif

Nuclear localization signal

Hgene

PPP2R5C

chr14:102276373

chr19:35523432

ENST00000445439

416_422

31.333333333333332

450.0

Motif

Nuclear localization signal

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PPP2R5C
SCN1B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to PPP2R5C-SCN1B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PPP2R5C-SCN1B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source