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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PPP3CB-CAMK2G

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPP3CB-CAMK2G
FusionPDB ID: 68140
FusionGDB2.0 ID: 68140
HgeneTgene
Gene symbol

PPP3CB

CAMK2G

Gene ID

5532

818

Gene nameprotein phosphatase 3 catalytic subunit betacalcium/calmodulin dependent protein kinase II gamma
SynonymsCALNA2|CALNB|CNA2|PP2BbetaCAMK|CAMK-II|CAMKG|MRD59
Cytomap

10q22.2

10q22.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 2B catalytic subunit beta isoformCAM-PRP catalytic subunitCNA betacalcineurin A betacalcineurin A2calmodulin-dependent calcineurin A subunit beta isoformprotein phosphatase 2B, catalytic subunit, beta isoformprocalcium/calmodulin-dependent protein kinase type II subunit gammacaMK-II subunit gammacalcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
Modification date2020031320200313
UniProtAcc.

Q13555

Ensembl transtripts involved in fusion geneENST idsENST00000360663, ENST00000394828, 
ENST00000394829, ENST00000544628, 
ENST00000342558, ENST00000394822, 
ENST00000495897, ENST00000545874, 
ENST00000444854, ENST00000472912, 
ENST00000305762, ENST00000322635, 
ENST00000322680, ENST00000351293, 
ENST00000372765, ENST00000394762, 
ENST00000423381, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 9 X 5=4059 X 8 X 6=432
# samples 1011
** MAII scorelog2(10/405*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/432*10)=-1.97352778863881
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PPP3CB [Title/Abstract] AND CAMK2G [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PPP3CB(75204483)-CAMK2G(75620647), # samples:2
Anticipated loss of major functional domain due to fusion event.PPP3CB-CAMK2G seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP3CB-CAMK2G seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP3CB-CAMK2G seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP3CB-CAMK2G seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPP3CB-CAMK2G seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PPP3CB-CAMK2G seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PPP3CB-CAMK2G seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PPP3CB-CAMK2G seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP3CB

GO:0006470

protein dephosphorylation

19154138|26794871

HgenePPP3CB

GO:0033173

calcineurin-NFAT signaling cascade

19154138|22688515

HgenePPP3CB

GO:0035690

cellular response to drug

11005320

HgenePPP3CB

GO:0045944

positive regulation of transcription by RNA polymerase II

22688515


check buttonFusion gene breakpoints across PPP3CB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CAMK2G (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A09Q-01APPP3CBchr10

75204483

-CAMK2Gchr10

75620647

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360663PPP3CBchr1075204483-ENST00000351293CAMK2Gchr1075620647-482314781122805897
ENST00000360663PPP3CBchr1075204483-ENST00000322635CAMK2Gchr1075620647-491914781122901929
ENST00000360663PPP3CBchr1075204483-ENST00000394762CAMK2Gchr1075620647-493714781122919935
ENST00000360663PPP3CBchr1075204483-ENST00000423381CAMK2Gchr1075620647-510214781123084990
ENST00000360663PPP3CBchr1075204483-ENST00000322680CAMK2Gchr1075620647-500614781122988958
ENST00000360663PPP3CBchr1075204483-ENST00000305762CAMK2Gchr1075620647-313814781122907931
ENST00000360663PPP3CBchr1075204483-ENST00000372765CAMK2Gchr1075620647-309914781122868918
ENST00000394828PPP3CBchr1075204483-ENST00000351293CAMK2Gchr1075620647-484915041352831898
ENST00000394828PPP3CBchr1075204483-ENST00000322635CAMK2Gchr1075620647-494515041352927930
ENST00000394828PPP3CBchr1075204483-ENST00000394762CAMK2Gchr1075620647-496315041352945936
ENST00000394828PPP3CBchr1075204483-ENST00000423381CAMK2Gchr1075620647-512815041353110991
ENST00000394828PPP3CBchr1075204483-ENST00000322680CAMK2Gchr1075620647-503215041353014959
ENST00000394828PPP3CBchr1075204483-ENST00000305762CAMK2Gchr1075620647-316415041352933932
ENST00000394828PPP3CBchr1075204483-ENST00000372765CAMK2Gchr1075620647-312515041352894919
ENST00000394829PPP3CBchr1075204483-ENST00000351293CAMK2Gchr1075620647-484915041352831898
ENST00000394829PPP3CBchr1075204483-ENST00000322635CAMK2Gchr1075620647-494515041352927930
ENST00000394829PPP3CBchr1075204483-ENST00000394762CAMK2Gchr1075620647-496315041352945936
ENST00000394829PPP3CBchr1075204483-ENST00000423381CAMK2Gchr1075620647-512815041353110991
ENST00000394829PPP3CBchr1075204483-ENST00000322680CAMK2Gchr1075620647-503215041353014959
ENST00000394829PPP3CBchr1075204483-ENST00000305762CAMK2Gchr1075620647-316415041352933932
ENST00000394829PPP3CBchr1075204483-ENST00000372765CAMK2Gchr1075620647-312515041352894919

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360663ENST00000351293PPP3CBchr1075204483-CAMK2Gchr1075620647-0.000522290.9994777
ENST00000360663ENST00000322635PPP3CBchr1075204483-CAMK2Gchr1075620647-0.0004778670.9995221
ENST00000360663ENST00000394762PPP3CBchr1075204483-CAMK2Gchr1075620647-0.000517890.9994821
ENST00000360663ENST00000423381PPP3CBchr1075204483-CAMK2Gchr1075620647-0.0005197850.9994802
ENST00000360663ENST00000322680PPP3CBchr1075204483-CAMK2Gchr1075620647-0.0004474370.99955255
ENST00000360663ENST00000305762PPP3CBchr1075204483-CAMK2Gchr1075620647-0.000389850.9996101
ENST00000360663ENST00000372765PPP3CBchr1075204483-CAMK2Gchr1075620647-0.0004791690.9995209
ENST00000394828ENST00000351293PPP3CBchr1075204483-CAMK2Gchr1075620647-0.000509170.99949086
ENST00000394828ENST00000322635PPP3CBchr1075204483-CAMK2Gchr1075620647-0.0004894510.9995105
ENST00000394828ENST00000394762PPP3CBchr1075204483-CAMK2Gchr1075620647-0.0005270960.9994729
ENST00000394828ENST00000423381PPP3CBchr1075204483-CAMK2Gchr1075620647-0.0005316020.9994684
ENST00000394828ENST00000322680PPP3CBchr1075204483-CAMK2Gchr1075620647-0.0004734190.9995266
ENST00000394828ENST00000305762PPP3CBchr1075204483-CAMK2Gchr1075620647-0.0003885520.99961144
ENST00000394828ENST00000372765PPP3CBchr1075204483-CAMK2Gchr1075620647-0.0005006310.9994993
ENST00000394829ENST00000351293PPP3CBchr1075204483-CAMK2Gchr1075620647-0.000509170.99949086
ENST00000394829ENST00000322635PPP3CBchr1075204483-CAMK2Gchr1075620647-0.0004894510.9995105
ENST00000394829ENST00000394762PPP3CBchr1075204483-CAMK2Gchr1075620647-0.0005270960.9994729
ENST00000394829ENST00000423381PPP3CBchr1075204483-CAMK2Gchr1075620647-0.0005316020.9994684
ENST00000394829ENST00000322680PPP3CBchr1075204483-CAMK2Gchr1075620647-0.0004734190.9995266
ENST00000394829ENST00000305762PPP3CBchr1075204483-CAMK2Gchr1075620647-0.0003885520.99961144
ENST00000394829ENST00000372765PPP3CBchr1075204483-CAMK2Gchr1075620647-0.0005006310.9994993

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>68140_68140_1_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000360663_CAMK2G_chr10_75620647_ENST00000305762_length(amino acids)=931AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGGR
QTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLK
PENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKA
GAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAK
SLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQL
IEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTS

--------------------------------------------------------------

>68140_68140_2_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000360663_CAMK2G_chr10_75620647_ENST00000322635_length(amino acids)=929AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGGR
QTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLK
PENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKA
GAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGR
QSSAPASPAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSSVHLMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIE
AINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQS

--------------------------------------------------------------

>68140_68140_3_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000360663_CAMK2G_chr10_75620647_ENST00000322680_length(amino acids)=958AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGGR
QTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLK
PENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKA
GAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAK
SLLNKKSDGGVKPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKAAPLRTGNGSSVPEGRSSRDRTAP
SAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVH

--------------------------------------------------------------

>68140_68140_4_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000360663_CAMK2G_chr10_75620647_ENST00000351293_length(amino acids)=897AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGGR
QTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLK
PENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKA
GAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAK
SLLNKKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEG

--------------------------------------------------------------

>68140_68140_5_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000360663_CAMK2G_chr10_75620647_ENST00000372765_length(amino acids)=918AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGGR
QTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLK
PENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKA
GAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGR
QSSAPASPAASAAGLAGQAAKSLLNKKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYT
KICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDG

--------------------------------------------------------------

>68140_68140_6_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000360663_CAMK2G_chr10_75620647_ENST00000394762_length(amino acids)=935AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGGR
QTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLK
PENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKA
GAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAK
SLLNKKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKAAPLRTGNGSSVPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIKI
TEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGR

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>68140_68140_7_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000360663_CAMK2G_chr10_75620647_ENST00000423381_length(amino acids)=990AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGGR
QTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLK
PENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKA
GAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGR
QSSAPASPAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNT
TTEDEDLKAAPLRTGNGSSVPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNL
VEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ

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>68140_68140_8_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000394828_CAMK2G_chr10_75620647_ENST00000305762_length(amino acids)=932AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGG
RQTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDL
KPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIK
AGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAA
KSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQ
LIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRT

--------------------------------------------------------------

>68140_68140_9_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000394828_CAMK2G_chr10_75620647_ENST00000322635_length(amino acids)=930AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGG
RQTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDL
KPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIK
AGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVG
RQSSAPASPAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSSVHLMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLI
EAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQ

--------------------------------------------------------------

>68140_68140_10_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000394828_CAMK2G_chr10_75620647_ENST00000322680_length(amino acids)=959AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGG
RQTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDL
KPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIK
AGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAA
KSLLNKKSDGGVKPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKAAPLRTGNGSSVPEGRSSRDRTA
PSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHV

--------------------------------------------------------------

>68140_68140_11_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000394828_CAMK2G_chr10_75620647_ENST00000351293_length(amino acids)=898AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGG
RQTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDL
KPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIK
AGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAA
KSLLNKKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVE

--------------------------------------------------------------

>68140_68140_12_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000394828_CAMK2G_chr10_75620647_ENST00000372765_length(amino acids)=919AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGG
RQTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDL
KPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIK
AGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVG
RQSSAPASPAASAAGLAGQAAKSLLNKKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAY
TKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRD

--------------------------------------------------------------

>68140_68140_13_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000394828_CAMK2G_chr10_75620647_ENST00000394762_length(amino acids)=936AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGG
RQTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDL
KPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIK
AGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAA
KSLLNKKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKAAPLRTGNGSSVPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIK
ITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQG

--------------------------------------------------------------

>68140_68140_14_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000394828_CAMK2G_chr10_75620647_ENST00000423381_length(amino acids)=991AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGG
RQTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDL
KPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIK
AGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVG
RQSSAPASPAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCN
TTTEDEDLKAAPLRTGNGSSVPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGN
LVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPL

--------------------------------------------------------------

>68140_68140_15_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000394829_CAMK2G_chr10_75620647_ENST00000305762_length(amino acids)=932AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGG
RQTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDL
KPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIK
AGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAA
KSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQ
LIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRT

--------------------------------------------------------------

>68140_68140_16_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000394829_CAMK2G_chr10_75620647_ENST00000322635_length(amino acids)=930AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGG
RQTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDL
KPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIK
AGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVG
RQSSAPASPAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSSVHLMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLI
EAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQ

--------------------------------------------------------------

>68140_68140_17_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000394829_CAMK2G_chr10_75620647_ENST00000322680_length(amino acids)=959AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGG
RQTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDL
KPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIK
AGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAA
KSLLNKKSDGGVKPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKAAPLRTGNGSSVPEGRSSRDRTA
PSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHV

--------------------------------------------------------------

>68140_68140_18_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000394829_CAMK2G_chr10_75620647_ENST00000351293_length(amino acids)=898AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGG
RQTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDL
KPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIK
AGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAA
KSLLNKKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVE

--------------------------------------------------------------

>68140_68140_19_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000394829_CAMK2G_chr10_75620647_ENST00000372765_length(amino acids)=919AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGG
RQTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDL
KPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIK
AGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVG
RQSSAPASPAASAAGLAGQAAKSLLNKKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAY
TKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRD

--------------------------------------------------------------

>68140_68140_20_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000394829_CAMK2G_chr10_75620647_ENST00000394762_length(amino acids)=936AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGG
RQTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDL
KPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIK
AGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAA
KSLLNKKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKAAPLRTGNGSSVPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIK
ITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQG

--------------------------------------------------------------

>68140_68140_21_PPP3CB-CAMK2G_PPP3CB_chr10_75204483_ENST00000394829_CAMK2G_chr10_75620647_ENST00000423381_length(amino acids)=991AA_BP=2
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEV
EAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYN
YPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGG
RQTLQSDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDL
KPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIK
AGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVG
RQSSAPASPAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCN
TTTEDEDLKAAPLRTGNGSSVPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGN
LVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:75204483/chr10:75620647)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAMK2G

Q13555

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. {ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP3CBchr10:75204483chr10:75620647ENST00000360663-121411_21455.3333333333333525.0Compositional biasPoly-Pro
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394828-121311_21456.3333333333333516.0Compositional biasPoly-Pro
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394829-121411_21456.3333333333333526.0Compositional biasPoly-Pro
HgenePPP3CBchr10:75204483chr10:75620647ENST00000360663-1214316_320455.3333333333333525.0MotifSAPNY motif
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394828-1213316_320456.3333333333333516.0MotifSAPNY motif
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394829-1214316_320456.3333333333333526.0MotifSAPNY motif
HgenePPP3CBchr10:75204483chr10:75620647ENST00000360663-1214357_379455.3333333333333525.0RegionCalcineurin B binding
HgenePPP3CBchr10:75204483chr10:75620647ENST00000360663-1214401_415455.3333333333333525.0RegionCalmodulin-binding
HgenePPP3CBchr10:75204483chr10:75620647ENST00000360663-1214416_423455.3333333333333525.0RegionAutoinhibitory segment
HgenePPP3CBchr10:75204483chr10:75620647ENST00000360663-121465_356455.3333333333333525.0RegionCatalytic
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394828-1213357_379456.3333333333333516.0RegionCalcineurin B binding
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394828-1213401_415456.3333333333333516.0RegionCalmodulin-binding
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394828-1213416_423456.3333333333333516.0RegionAutoinhibitory segment
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394828-121365_356456.3333333333333516.0RegionCatalytic
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394829-1214357_379456.3333333333333526.0RegionCalcineurin B binding
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394829-1214401_415456.3333333333333526.0RegionCalmodulin-binding
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394829-1214416_423456.3333333333333526.0RegionAutoinhibitory segment
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394829-121465_356456.3333333333333526.0RegionCatalytic
TgeneCAMK2Gchr10:75204483chr10:75620647ENST00000305762121283_29253.333333333333336631.0RegionNote=Autoinhibitory domain
TgeneCAMK2Gchr10:75204483chr10:75620647ENST00000305762121291_30153.333333333333336631.0RegionCalmodulin-binding
TgeneCAMK2Gchr10:75204483chr10:75620647ENST00000305762121294_31653.333333333333336631.0RegionNote=Calmodulin-binding
TgeneCAMK2Gchr10:75204483chr10:75620647ENST00000322635121283_29253.3333333333333361185.0RegionNote=Autoinhibitory domain
TgeneCAMK2Gchr10:75204483chr10:75620647ENST00000322635121291_30153.3333333333333361185.0RegionCalmodulin-binding
TgeneCAMK2Gchr10:75204483chr10:75620647ENST00000322635121294_31653.3333333333333361185.0RegionNote=Calmodulin-binding
TgeneCAMK2Gchr10:75204483chr10:75620647ENST00000322680121283_29253.3333333333333361212.3333333333333RegionNote=Autoinhibitory domain
TgeneCAMK2Gchr10:75204483chr10:75620647ENST00000322680121291_30153.3333333333333361212.3333333333333RegionCalmodulin-binding
TgeneCAMK2Gchr10:75204483chr10:75620647ENST00000322680121294_31653.3333333333333361212.3333333333333RegionNote=Calmodulin-binding
TgeneCAMK2Gchr10:75204483chr10:75620647ENST00000351293119283_29253.3333333333333361173.3333333333333RegionNote=Autoinhibitory domain
TgeneCAMK2Gchr10:75204483chr10:75620647ENST00000351293119291_30153.3333333333333361173.3333333333333RegionCalmodulin-binding
TgeneCAMK2Gchr10:75204483chr10:75620647ENST00000351293119294_31653.3333333333333361173.3333333333333RegionNote=Calmodulin-binding
TgeneCAMK2Gchr10:75204483chr10:75620647ENST00000394762120283_29253.3333333333333361189.3333333333333RegionNote=Autoinhibitory domain
TgeneCAMK2Gchr10:75204483chr10:75620647ENST00000394762120291_30153.3333333333333361189.3333333333333RegionCalmodulin-binding
TgeneCAMK2Gchr10:75204483chr10:75620647ENST00000394762120294_31653.3333333333333361189.3333333333333RegionNote=Calmodulin-binding
TgeneCAMK2Gchr10:75204483chr10:75620647ENST00000423381123283_29253.3333333333333361244.3333333333333RegionNote=Autoinhibitory domain
TgeneCAMK2Gchr10:75204483chr10:75620647ENST00000423381123291_30153.3333333333333361244.3333333333333RegionCalmodulin-binding
TgeneCAMK2Gchr10:75204483chr10:75620647ENST00000423381123294_31653.3333333333333361244.3333333333333RegionNote=Calmodulin-binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394822-11311_210515.0Compositional biasPoly-Pro
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394822-113316_3200515.0MotifSAPNY motif
HgenePPP3CBchr10:75204483chr10:75620647ENST00000360663-1214474_496455.3333333333333525.0RegionAutoinhibitory domain
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394822-113357_3790515.0RegionCalcineurin B binding
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394822-113401_4150515.0RegionCalmodulin-binding
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394822-113416_4230515.0RegionAutoinhibitory segment
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394822-113474_4960515.0RegionAutoinhibitory domain
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394822-11365_3560515.0RegionCatalytic
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394828-1213474_496456.3333333333333516.0RegionAutoinhibitory domain
HgenePPP3CBchr10:75204483chr10:75620647ENST00000394829-1214474_496456.3333333333333526.0RegionAutoinhibitory domain
TgeneCAMK2Gchr10:75204483chr10:75620647ENST0000030576212114_27253.333333333333336631.0DomainProtein kinase
TgeneCAMK2Gchr10:75204483chr10:75620647ENST0000032263512114_27253.3333333333333361185.0DomainProtein kinase
TgeneCAMK2Gchr10:75204483chr10:75620647ENST0000032268012114_27253.3333333333333361212.3333333333333DomainProtein kinase
TgeneCAMK2Gchr10:75204483chr10:75620647ENST0000035129311914_27253.3333333333333361173.3333333333333DomainProtein kinase
TgeneCAMK2Gchr10:75204483chr10:75620647ENST0000039476212014_27253.3333333333333361189.3333333333333DomainProtein kinase
TgeneCAMK2Gchr10:75204483chr10:75620647ENST0000042338112314_27253.3333333333333361244.3333333333333DomainProtein kinase
TgeneCAMK2Gchr10:75204483chr10:75620647ENST0000030576212120_2853.333333333333336631.0Nucleotide bindingATP
TgeneCAMK2Gchr10:75204483chr10:75620647ENST0000032263512120_2853.3333333333333361185.0Nucleotide bindingATP
TgeneCAMK2Gchr10:75204483chr10:75620647ENST0000032268012120_2853.3333333333333361212.3333333333333Nucleotide bindingATP
TgeneCAMK2Gchr10:75204483chr10:75620647ENST0000035129311920_2853.3333333333333361173.3333333333333Nucleotide bindingATP
TgeneCAMK2Gchr10:75204483chr10:75620647ENST0000039476212020_2853.3333333333333361189.3333333333333Nucleotide bindingATP
TgeneCAMK2Gchr10:75204483chr10:75620647ENST0000042338112320_2853.3333333333333361244.3333333333333Nucleotide bindingATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PPP3CB
CAMK2G


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PPP3CB-CAMK2G


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PPP3CB-CAMK2G


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource