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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PPP4R1-DPP4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPP4R1-DPP4
FusionPDB ID: 68181
FusionGDB2.0 ID: 68181
HgeneTgene
Gene symbol

PPP4R1

DPP4

Gene ID

9989

1803

Gene nameprotein phosphatase 4 regulatory subunit 1dipeptidyl peptidase 4
SynonymsMEG1|PP4(Rmeg)|PP4R1ADABP|ADCP2|CD26|DPPIV|TP103
Cytomap

18p11.22

2q24.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 4 regulatory subunit 1serine/threonine phosphatase 4dipeptidyl peptidase 4ADCP-2DPP IVT-cell activation antigen CD26adenosine deaminase complexing protein 2dipeptidyl peptidase IVdipeptidylpeptidase 4dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
Modification date2020031320200322
UniProtAcc.

P27487

Ensembl transtripts involved in fusion geneENST idsENST00000400555, ENST00000400556, 
ENST00000580583, 		ENST00000491591, 
ENST00000360534, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 13 X 9=15214 X 4 X 2=32
# samples 145
** MAII scorelog2(14/1521*10)=-3.44152142077953
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PPP4R1 [Title/Abstract] AND DPP4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PPP4R1(9561978)-DPP4(162851882), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDPP4

GO:0001666

response to hypoxia

16670267

TgeneDPP4

GO:0006508

proteolysis

27198182

TgeneDPP4

GO:0008284

positive regulation of cell proliferation

17549790

TgeneDPP4

GO:0010716

negative regulation of extracellular matrix disassembly

16651416

TgeneDPP4

GO:0031295

T cell costimulation

10900005|17287217

TgeneDPP4

GO:0033632

regulation of cell-cell adhesion mediated by integrin

11772392

TgeneDPP4

GO:0042110

T cell activation

7594462

TgeneDPP4

GO:0043542

endothelial cell migration

16651416


check buttonFusion gene breakpoints across PPP4R1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DPP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-EY-A3L3-01APPP4R1chr18

9561978

-DPP4chr2

162851882

-
ChimerDB4UCECTCGA-EY-A3L3PPP4R1chr18

9561977

-DPP4chr2

162851882

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000400556PPP4R1chr189561978-ENST00000360534DPP4chr2162851882-32071916742164696
ENST00000400555PPP4R1chr189561978-ENST00000360534DPP4chr2162851882-31671876852124679
ENST00000400556PPP4R1chr189561977-ENST00000360534DPP4chr2162851882-32071916742164696
ENST00000400555PPP4R1chr189561977-ENST00000360534DPP4chr2162851882-31671876852124679

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000400556ENST00000360534PPP4R1chr189561978-DPP4chr2162851882-0.0003852470.9996147
ENST00000400555ENST00000360534PPP4R1chr189561978-DPP4chr2162851882-0.0009300010.99907
ENST00000400556ENST00000360534PPP4R1chr189561977-DPP4chr2162851882-0.0003852470.9996147
ENST00000400555ENST00000360534PPP4R1chr189561977-DPP4chr2162851882-0.0009300010.99907

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>68181_68181_1_PPP4R1-DPP4_PPP4R1_chr18_9561977_ENST00000400555_DPP4_chr2_162851882_ENST00000360534_length(amino acids)=679AA_BP=596
MADLSLLQEDLQEDADGSLDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELM
EQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSNDDVKTEAVAIM
CKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEI
RRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQVRPEDTPSDLSVSNSSV
ILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEID
LDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLDAHEETISIEKRSDLQDE
LDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSA

--------------------------------------------------------------

>68181_68181_2_PPP4R1-DPP4_PPP4R1_chr18_9561977_ENST00000400556_DPP4_chr2_162851882_ENST00000360534_length(amino acids)=696AA_BP=613
MADLSLLQEDLQEDADGFGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLER
ISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIEL
TAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRK
ACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQ
VRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQ
ELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLD
AHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQNSTVMSRAENFKQVEY

--------------------------------------------------------------

>68181_68181_3_PPP4R1-DPP4_PPP4R1_chr18_9561978_ENST00000400555_DPP4_chr2_162851882_ENST00000360534_length(amino acids)=679AA_BP=596
MADLSLLQEDLQEDADGSLDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLERISRLADDSEPTVRAELM
EQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIELTAPDSNDDVKTEAVAIM
CKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEI
RRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQVRPEDTPSDLSVSNSSV
ILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQELYNSFHFWRTPLPEID
LDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLDAHEETISIEKRSDLQDE
LDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSA

--------------------------------------------------------------

>68181_68181_4_PPP4R1-DPP4_PPP4R1_chr18_9561978_ENST00000400556_DPP4_chr2_162851882_ENST00000360534_length(amino acids)=696AA_BP=613
MADLSLLQEDLQEDADGFGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERDCIAVLER
ISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVETKVCPVLIEL
TAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRK
ACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRTRDQEAPEDVQ
VRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGTTSQDSALLDQ
ELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVLSAALRASSLD
AHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQNSTVMSRAENFKQVEY

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:9561978/chr2:162851882)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DPP4

P27487

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:17287217). Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:14691230). Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM (PubMed:16651416, PubMed:10593948). May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation (PubMed:18708048). When overexpressed, enhanced cell proliferation, a process inhibited by GPC3 (PubMed:17549790). Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32 (PubMed:16254193, PubMed:10570924). Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (PubMed:10593948). {ECO:0000269|PubMed:10570924, ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:10951221, ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:14691230, ECO:0000269|PubMed:16254193, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:17549790, ECO:0000269|PubMed:18708048}.; FUNCTION: (Microbial infection) Acts as a receptor for human coronavirus MERS-CoV-2. {ECO:0000269|PubMed:23835475}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320127_164597.0934.0RepeatNote=HEAT 5
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320168_206597.0934.0RepeatNote=HEAT 6
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-13201_25597.0934.0RepeatNote=HEAT 1
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320208_246597.0934.0RepeatNote=HEAT 7
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320248_285597.0934.0RepeatNote=HEAT 8
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-132026_63597.0934.0RepeatNote=HEAT 2
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320287_324597.0934.0RepeatNote=HEAT 9
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320505_542597.0934.0RepeatNote=HEAT 10
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-132065_81597.0934.0RepeatNote=HEAT 3
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-132082_119597.0934.0RepeatNote=HEAT 4
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320127_164614.0951.0RepeatNote=HEAT 5
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320168_206614.0951.0RepeatNote=HEAT 6
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-13201_25614.0951.0RepeatNote=HEAT 1
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320208_246614.0951.0RepeatNote=HEAT 7
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320248_285614.0951.0RepeatNote=HEAT 8
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-132026_63614.0951.0RepeatNote=HEAT 2
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320287_324614.0951.0RepeatNote=HEAT 9
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320505_542614.0951.0RepeatNote=HEAT 10
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320568_606614.0951.0RepeatNote=HEAT 11
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-132065_81614.0951.0RepeatNote=HEAT 3
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-132082_119614.0951.0RepeatNote=HEAT 4
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320127_164597.0934.0RepeatNote=HEAT 5
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320168_206597.0934.0RepeatNote=HEAT 6
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-13201_25597.0934.0RepeatNote=HEAT 1
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320208_246597.0934.0RepeatNote=HEAT 7
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320248_285597.0934.0RepeatNote=HEAT 8
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-132026_63597.0934.0RepeatNote=HEAT 2
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320287_324597.0934.0RepeatNote=HEAT 9
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320505_542597.0934.0RepeatNote=HEAT 10
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-132065_81597.0934.0RepeatNote=HEAT 3
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-132082_119597.0934.0RepeatNote=HEAT 4
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320127_164614.0951.0RepeatNote=HEAT 5
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320168_206614.0951.0RepeatNote=HEAT 6
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-13201_25614.0951.0RepeatNote=HEAT 1
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320208_246614.0951.0RepeatNote=HEAT 7
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320248_285614.0951.0RepeatNote=HEAT 8
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-132026_63614.0951.0RepeatNote=HEAT 2
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320287_324614.0951.0RepeatNote=HEAT 9
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320505_542614.0951.0RepeatNote=HEAT 10
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320568_606614.0951.0RepeatNote=HEAT 11
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-132065_81614.0951.0RepeatNote=HEAT 3
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-132082_119614.0951.0RepeatNote=HEAT 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320568_606597.0934.0RepeatNote=HEAT 11
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320698_734597.0934.0RepeatNote=HEAT 12
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320799_837597.0934.0RepeatNote=HEAT 13
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400555-1320861_898597.0934.0RepeatNote=HEAT 14
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320698_734614.0951.0RepeatNote=HEAT 12
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320799_837614.0951.0RepeatNote=HEAT 13
HgenePPP4R1chr18:9561977chr2:162851882ENST00000400556-1320861_898614.0951.0RepeatNote=HEAT 14
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320568_606597.0934.0RepeatNote=HEAT 11
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320698_734597.0934.0RepeatNote=HEAT 12
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320799_837597.0934.0RepeatNote=HEAT 13
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400555-1320861_898597.0934.0RepeatNote=HEAT 14
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320698_734614.0951.0RepeatNote=HEAT 12
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320799_837614.0951.0RepeatNote=HEAT 13
HgenePPP4R1chr18:9561978chr2:162851882ENST00000400556-1320861_898614.0951.0RepeatNote=HEAT 14
TgeneDPP4chr18:9561977chr2:162851882ENST0000036053422261_6684.0767.0Topological domainCytoplasmic
TgeneDPP4chr18:9561977chr2:162851882ENST00000360534222629_766684.0767.0Topological domainExtracellular
TgeneDPP4chr18:9561978chr2:162851882ENST0000036053422261_6684.0767.0Topological domainCytoplasmic
TgeneDPP4chr18:9561978chr2:162851882ENST00000360534222629_766684.0767.0Topological domainExtracellular
TgeneDPP4chr18:9561977chr2:162851882ENST0000036053422267_28684.0767.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneDPP4chr18:9561978chr2:162851882ENST0000036053422267_28684.0767.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PPP4R1
DPP4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PPP4R1-DPP4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PPP4R1-DPP4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource