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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PPP6R3-YAP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PPP6R3-YAP1
	FusionPDB ID: 68322
	FusionGDB2.0 ID: 68322
		Hgene	Tgene
	Gene symbol	PPP6R3	YAP1
	Gene ID	55291	10413
	Gene name	protein phosphatase 6 regulatory subunit 3	Yes1 associated transcriptional regulator
	Synonyms	C11orf23\|PP6R3\|SAP190\|SAPL\|SAPLa\|SAPS3	COB1\|YAP\|YAP2\|YAP65\|YKI
	Cytomap	11q13.2	11q22.1
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein phosphatase 6 regulatory subunit 3SAPS domain family, member 3sporulation-induced transcript 4-associated protein SAPL	transcriptional coactivator YAP165 kDa Yes-associated proteinYes associated protein 1protein yorkie homologyes-associated protein 1yes-associated protein 2yes-associated protein YAP65 homologyorkie homolog
	Modification date	20200313	20200329
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000265636, ENST00000265637, ENST00000393799, ENST00000393800, ENST00000393801, ENST00000524845, ENST00000524904, ENST00000527403, ENST00000529710, ENST00000530427, ENST00000534534,	ENST00000528834, ENST00000282441, ENST00000345877, ENST00000524575, ENST00000526343, ENST00000531439, ENST00000537274,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	34 X 21 X 15=10710	20 X 10 X 13=2600
	# samples	43	21
	** MAII score	log2(43/10710*10)=-4.63847801004816 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(21/2600*10)=-3.63005039024969 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PPP6R3 [Title/Abstract] AND YAP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PPP6R3(68326147)-YAP1(102098200), # samples:3
Anticipated loss of major functional domain due to fusion event.	PPP6R3-YAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PPP6R3-YAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PPP6R3-YAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PPP6R3-YAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PPP6R3	GO:0043666	regulation of phosphoprotein phosphatase activity	16716191
Tgene	YAP1	GO:0006974	cellular response to DNA damage stimulus	18280240
Tgene	YAP1	GO:0008283	cell proliferation	17974916
Tgene	YAP1	GO:0032570	response to progesterone	16772533
Tgene	YAP1	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	16772533
Tgene	YAP1	GO:0045893	positive regulation of transcription, DNA-templated	20368466
Tgene	YAP1	GO:0045944	positive regulation of transcription by RNA polymerase II	25796446
Tgene	YAP1	GO:0050767	regulation of neurogenesis	25433207
Tgene	YAP1	GO:0050847	progesterone receptor signaling pathway	16772533
Tgene	YAP1	GO:0060242	contact inhibition	17974916
Tgene	YAP1	GO:0065003	protein-containing complex assembly	20368466
Tgene	YAP1	GO:0071480	cellular response to gamma radiation	18280240
Tgene	YAP1	GO:0072091	regulation of stem cell proliferation	25433207

Fusion gene breakpoints across PPP6R3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across YAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-BT-A20N-01A	PPP6R3	chr11	68326147	-	YAP1	chr11	102098200	+
ChimerDB4	BLCA	TCGA-BT-A20N-01A	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000393799	PPP6R3	chr11	68326147	+	ENST00000526343	YAP1	chr11	102098200	+	2116	1112	267	1463	398
ENST00000393799	PPP6R3	chr11	68326147	+	ENST00000282441	YAP1	chr11	102098200	+	4947	1112	267	1463	398
ENST00000393799	PPP6R3	chr11	68326147	+	ENST00000537274	YAP1	chr11	102098200	+	4947	1112	267	1463	398
ENST00000393799	PPP6R3	chr11	68326147	+	ENST00000345877	YAP1	chr11	102098200	+	4947	1112	267	1463	398
ENST00000393799	PPP6R3	chr11	68326147	+	ENST00000531439	YAP1	chr11	102098200	+	1487	1112	267	1463	398
ENST00000393799	PPP6R3	chr11	68326147	+	ENST00000524575	YAP1	chr11	102098200	+	1676	1112	267	1463	398
ENST00000393800	PPP6R3	chr11	68326147	+	ENST00000526343	YAP1	chr11	102098200	+	2103	1099	254	1450	398
ENST00000393800	PPP6R3	chr11	68326147	+	ENST00000282441	YAP1	chr11	102098200	+	4934	1099	254	1450	398
ENST00000393800	PPP6R3	chr11	68326147	+	ENST00000537274	YAP1	chr11	102098200	+	4934	1099	254	1450	398
ENST00000393800	PPP6R3	chr11	68326147	+	ENST00000345877	YAP1	chr11	102098200	+	4934	1099	254	1450	398
ENST00000393800	PPP6R3	chr11	68326147	+	ENST00000531439	YAP1	chr11	102098200	+	1474	1099	254	1450	398
ENST00000393800	PPP6R3	chr11	68326147	+	ENST00000524575	YAP1	chr11	102098200	+	1663	1099	254	1450	398
ENST00000524845	PPP6R3	chr11	68326147	+	ENST00000526343	YAP1	chr11	102098200	+	2085	1081	236	1432	398
ENST00000524845	PPP6R3	chr11	68326147	+	ENST00000282441	YAP1	chr11	102098200	+	4916	1081	236	1432	398
ENST00000524845	PPP6R3	chr11	68326147	+	ENST00000537274	YAP1	chr11	102098200	+	4916	1081	236	1432	398
ENST00000524845	PPP6R3	chr11	68326147	+	ENST00000345877	YAP1	chr11	102098200	+	4916	1081	236	1432	398
ENST00000524845	PPP6R3	chr11	68326147	+	ENST00000531439	YAP1	chr11	102098200	+	1456	1081	236	1432	398
ENST00000524845	PPP6R3	chr11	68326147	+	ENST00000524575	YAP1	chr11	102098200	+	1645	1081	236	1432	398
ENST00000265637	PPP6R3	chr11	68326147	+	ENST00000526343	YAP1	chr11	102098200	+	1931	927	82	1278	398
ENST00000265637	PPP6R3	chr11	68326147	+	ENST00000282441	YAP1	chr11	102098200	+	4762	927	82	1278	398
ENST00000265637	PPP6R3	chr11	68326147	+	ENST00000537274	YAP1	chr11	102098200	+	4762	927	82	1278	398
ENST00000265637	PPP6R3	chr11	68326147	+	ENST00000345877	YAP1	chr11	102098200	+	4762	927	82	1278	398
ENST00000265637	PPP6R3	chr11	68326147	+	ENST00000531439	YAP1	chr11	102098200	+	1302	927	82	1278	398
ENST00000265637	PPP6R3	chr11	68326147	+	ENST00000524575	YAP1	chr11	102098200	+	1491	927	82	1278	398
ENST00000524904	PPP6R3	chr11	68326147	+	ENST00000526343	YAP1	chr11	102098200	+	2079	1075	230	1426	398
ENST00000524904	PPP6R3	chr11	68326147	+	ENST00000282441	YAP1	chr11	102098200	+	4910	1075	230	1426	398
ENST00000524904	PPP6R3	chr11	68326147	+	ENST00000537274	YAP1	chr11	102098200	+	4910	1075	230	1426	398
ENST00000524904	PPP6R3	chr11	68326147	+	ENST00000345877	YAP1	chr11	102098200	+	4910	1075	230	1426	398
ENST00000524904	PPP6R3	chr11	68326147	+	ENST00000531439	YAP1	chr11	102098200	+	1450	1075	230	1426	398
ENST00000524904	PPP6R3	chr11	68326147	+	ENST00000524575	YAP1	chr11	102098200	+	1639	1075	230	1426	398
ENST00000393801	PPP6R3	chr11	68326147	+	ENST00000526343	YAP1	chr11	102098200	+	2064	1060	215	1411	398
ENST00000393801	PPP6R3	chr11	68326147	+	ENST00000282441	YAP1	chr11	102098200	+	4895	1060	215	1411	398
ENST00000393801	PPP6R3	chr11	68326147	+	ENST00000537274	YAP1	chr11	102098200	+	4895	1060	215	1411	398
ENST00000393801	PPP6R3	chr11	68326147	+	ENST00000345877	YAP1	chr11	102098200	+	4895	1060	215	1411	398
ENST00000393801	PPP6R3	chr11	68326147	+	ENST00000531439	YAP1	chr11	102098200	+	1435	1060	215	1411	398
ENST00000393801	PPP6R3	chr11	68326147	+	ENST00000524575	YAP1	chr11	102098200	+	1624	1060	215	1411	398
ENST00000265636	PPP6R3	chr11	68326147	+	ENST00000526343	YAP1	chr11	102098200	+	2126	1122	277	1473	398
ENST00000265636	PPP6R3	chr11	68326147	+	ENST00000282441	YAP1	chr11	102098200	+	4957	1122	277	1473	398
ENST00000265636	PPP6R3	chr11	68326147	+	ENST00000537274	YAP1	chr11	102098200	+	4957	1122	277	1473	398
ENST00000265636	PPP6R3	chr11	68326147	+	ENST00000345877	YAP1	chr11	102098200	+	4957	1122	277	1473	398
ENST00000265636	PPP6R3	chr11	68326147	+	ENST00000531439	YAP1	chr11	102098200	+	1497	1122	277	1473	398
ENST00000265636	PPP6R3	chr11	68326147	+	ENST00000524575	YAP1	chr11	102098200	+	1686	1122	277	1473	398
ENST00000529710	PPP6R3	chr11	68326147	+	ENST00000526343	YAP1	chr11	102098200	+	2126	1122	277	1473	398
ENST00000529710	PPP6R3	chr11	68326147	+	ENST00000282441	YAP1	chr11	102098200	+	4957	1122	277	1473	398
ENST00000529710	PPP6R3	chr11	68326147	+	ENST00000537274	YAP1	chr11	102098200	+	4957	1122	277	1473	398
ENST00000529710	PPP6R3	chr11	68326147	+	ENST00000345877	YAP1	chr11	102098200	+	4957	1122	277	1473	398
ENST00000529710	PPP6R3	chr11	68326147	+	ENST00000531439	YAP1	chr11	102098200	+	1497	1122	277	1473	398
ENST00000529710	PPP6R3	chr11	68326147	+	ENST00000524575	YAP1	chr11	102098200	+	1686	1122	277	1473	398
ENST00000527403	PPP6R3	chr11	68326147	+	ENST00000526343	YAP1	chr11	102098200	+	2001	997	152	1348	398
ENST00000527403	PPP6R3	chr11	68326147	+	ENST00000282441	YAP1	chr11	102098200	+	4832	997	152	1348	398
ENST00000527403	PPP6R3	chr11	68326147	+	ENST00000537274	YAP1	chr11	102098200	+	4832	997	152	1348	398
ENST00000527403	PPP6R3	chr11	68326147	+	ENST00000345877	YAP1	chr11	102098200	+	4832	997	152	1348	398
ENST00000527403	PPP6R3	chr11	68326147	+	ENST00000531439	YAP1	chr11	102098200	+	1372	997	152	1348	398
ENST00000527403	PPP6R3	chr11	68326147	+	ENST00000524575	YAP1	chr11	102098200	+	1561	997	152	1348	398

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393799	ENST00000526343	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.001879587	0.99812037
ENST00000393799	ENST00000282441	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000285432	0.99971455
ENST00000393799	ENST00000537274	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000285432	0.99971455
ENST00000393799	ENST00000345877	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000285432	0.99971455
ENST00000393799	ENST00000531439	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.005352806	0.9946472
ENST00000393799	ENST00000524575	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.00430133	0.9956987
ENST00000393800	ENST00000526343	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.001813367	0.99818665
ENST00000393800	ENST00000282441	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000280482	0.99971944
ENST00000393800	ENST00000537274	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000280482	0.99971944
ENST00000393800	ENST00000345877	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000280482	0.99971944
ENST00000393800	ENST00000531439	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.005213504	0.9947865
ENST00000393800	ENST00000524575	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.004218139	0.9957819
ENST00000524845	ENST00000526343	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.001897238	0.99810284
ENST00000524845	ENST00000282441	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000279492	0.9997205
ENST00000524845	ENST00000537274	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000279492	0.9997205
ENST00000524845	ENST00000345877	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000279492	0.9997205
ENST00000524845	ENST00000531439	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.005796937	0.99420303
ENST00000524845	ENST00000524575	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.004644651	0.99535537
ENST00000265637	ENST00000526343	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.002232057	0.9977679
ENST00000265637	ENST00000282441	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000280689	0.9997193
ENST00000265637	ENST00000537274	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000280689	0.9997193
ENST00000265637	ENST00000345877	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000280689	0.9997193
ENST00000265637	ENST00000531439	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.008800529	0.99119943
ENST00000265637	ENST00000524575	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.006644549	0.9933555
ENST00000524904	ENST00000526343	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.001912455	0.99808747
ENST00000524904	ENST00000282441	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000281132	0.99971884
ENST00000524904	ENST00000537274	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000281132	0.99971884
ENST00000524904	ENST00000345877	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000281132	0.99971884
ENST00000524904	ENST00000531439	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.005899435	0.9941005
ENST00000524904	ENST00000524575	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.004722171	0.9952779
ENST00000393801	ENST00000526343	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.002033719	0.9979663
ENST00000393801	ENST00000282441	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000285367	0.99971455
ENST00000393801	ENST00000537274	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000285367	0.99971455
ENST00000393801	ENST00000345877	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000285367	0.99971455
ENST00000393801	ENST00000531439	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.00642157	0.99357843
ENST00000393801	ENST00000524575	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.00503859	0.9949614
ENST00000265636	ENST00000526343	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.00185358	0.9981464
ENST00000265636	ENST00000282441	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000288693	0.99971133
ENST00000265636	ENST00000537274	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000288693	0.99971133
ENST00000265636	ENST00000345877	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000288693	0.99971133
ENST00000265636	ENST00000531439	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.005374426	0.9946255
ENST00000265636	ENST00000524575	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.004436193	0.99556386
ENST00000529710	ENST00000526343	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.00185358	0.9981464
ENST00000529710	ENST00000282441	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000288693	0.99971133
ENST00000529710	ENST00000537274	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000288693	0.99971133
ENST00000529710	ENST00000345877	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000288693	0.99971133
ENST00000529710	ENST00000531439	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.005374426	0.9946255
ENST00000529710	ENST00000524575	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.004436193	0.99556386
ENST00000527403	ENST00000526343	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.00195969	0.9980404
ENST00000527403	ENST00000282441	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000282299	0.99971765
ENST00000527403	ENST00000537274	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000282299	0.99971765
ENST00000527403	ENST00000345877	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.000282299	0.99971765
ENST00000527403	ENST00000531439	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.006344402	0.99365556
ENST00000527403	ENST00000524575	PPP6R3	chr11	68326147	+	YAP1	chr11	102098200	+	0.004884745	0.9951153

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>68322_68322_1_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000265636_YAP1_chr11_102098200_ENST00000282441_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_2_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000265636_YAP1_chr11_102098200_ENST00000345877_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_3_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000265636_YAP1_chr11_102098200_ENST00000524575_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_4_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000265636_YAP1_chr11_102098200_ENST00000526343_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_5_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000265636_YAP1_chr11_102098200_ENST00000531439_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_6_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000265636_YAP1_chr11_102098200_ENST00000537274_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_7_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000265637_YAP1_chr11_102098200_ENST00000282441_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_8_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000265637_YAP1_chr11_102098200_ENST00000345877_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_9_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000265637_YAP1_chr11_102098200_ENST00000524575_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_10_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000265637_YAP1_chr11_102098200_ENST00000526343_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_11_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000265637_YAP1_chr11_102098200_ENST00000531439_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_12_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000265637_YAP1_chr11_102098200_ENST00000537274_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_13_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000393799_YAP1_chr11_102098200_ENST00000282441_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_14_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000393799_YAP1_chr11_102098200_ENST00000345877_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_15_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000393799_YAP1_chr11_102098200_ENST00000524575_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_16_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000393799_YAP1_chr11_102098200_ENST00000526343_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_17_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000393799_YAP1_chr11_102098200_ENST00000531439_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_18_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000393799_YAP1_chr11_102098200_ENST00000537274_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_19_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000393800_YAP1_chr11_102098200_ENST00000282441_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_20_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000393800_YAP1_chr11_102098200_ENST00000345877_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_21_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000393800_YAP1_chr11_102098200_ENST00000524575_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_22_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000393800_YAP1_chr11_102098200_ENST00000526343_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_23_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000393800_YAP1_chr11_102098200_ENST00000531439_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_24_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000393800_YAP1_chr11_102098200_ENST00000537274_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_25_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000393801_YAP1_chr11_102098200_ENST00000282441_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_26_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000393801_YAP1_chr11_102098200_ENST00000345877_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_27_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000393801_YAP1_chr11_102098200_ENST00000524575_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_28_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000393801_YAP1_chr11_102098200_ENST00000526343_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_29_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000393801_YAP1_chr11_102098200_ENST00000531439_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_30_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000393801_YAP1_chr11_102098200_ENST00000537274_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_31_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000524845_YAP1_chr11_102098200_ENST00000282441_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_32_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000524845_YAP1_chr11_102098200_ENST00000345877_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_33_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000524845_YAP1_chr11_102098200_ENST00000524575_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_34_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000524845_YAP1_chr11_102098200_ENST00000526343_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_35_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000524845_YAP1_chr11_102098200_ENST00000531439_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_36_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000524845_YAP1_chr11_102098200_ENST00000537274_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_37_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000524904_YAP1_chr11_102098200_ENST00000282441_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_38_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000524904_YAP1_chr11_102098200_ENST00000345877_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_39_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000524904_YAP1_chr11_102098200_ENST00000524575_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_40_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000524904_YAP1_chr11_102098200_ENST00000526343_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_41_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000524904_YAP1_chr11_102098200_ENST00000531439_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_42_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000524904_YAP1_chr11_102098200_ENST00000537274_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_43_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000527403_YAP1_chr11_102098200_ENST00000282441_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_44_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000527403_YAP1_chr11_102098200_ENST00000345877_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_45_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000527403_YAP1_chr11_102098200_ENST00000524575_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_46_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000527403_YAP1_chr11_102098200_ENST00000526343_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_47_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000527403_YAP1_chr11_102098200_ENST00000531439_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_48_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000527403_YAP1_chr11_102098200_ENST00000537274_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_49_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000529710_YAP1_chr11_102098200_ENST00000282441_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_50_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000529710_YAP1_chr11_102098200_ENST00000345877_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_51_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000529710_YAP1_chr11_102098200_ENST00000524575_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_52_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000529710_YAP1_chr11_102098200_ENST00000526343_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_53_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000529710_YAP1_chr11_102098200_ENST00000531439_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

>68322_68322_54_PPP6R3-YAP1_PPP6R3_chr11_68326147_ENST00000529710_YAP1_chr11_102098200_ENST00000537274_length(amino acids)=398AA_BP=282
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVS
QMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQ
DVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQ
ILLTLLETRRPTGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIE

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:68326147/chr11:102098200)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000524575

298_359

209.66666666666666

327.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000524575

230_263

209.66666666666666

327.0

Domain

WW 2

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000524575

291_504

209.66666666666666

327.0

Region

Note=Transactivation domain

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000282441

298_359

387.6666666666667

505.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000282441

86_100

387.6666666666667

505.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000345877

298_359

337.6666666666667

455.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000345877

86_100

337.6666666666667

455.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000524575

86_100

209.66666666666666

327.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000526343

298_359

333.6666666666667

451.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000526343

86_100

333.6666666666667

451.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000531439

298_359

371.6666666666667

489.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000531439

86_100

371.6666666666667

489.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000537274

298_359

375.6666666666667

493.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000537274

86_100

375.6666666666667

493.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000282441

3_49

387.6666666666667

505.0

Compositional bias

Note=Pro-rich

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000345877

3_49

337.6666666666667

455.0

Compositional bias

Note=Pro-rich

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000524575

3_49

209.66666666666666

327.0

Compositional bias

Note=Pro-rich

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000526343

3_49

333.6666666666667

451.0

Compositional bias

Note=Pro-rich

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000531439

3_49

371.6666666666667

489.0

Compositional bias

Note=Pro-rich

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000537274

3_49

375.6666666666667

493.0

Compositional bias

Note=Pro-rich

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000282441

171_204

387.6666666666667

505.0

Domain

WW 1

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000282441

230_263

387.6666666666667

505.0

Domain

WW 2

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000345877

171_204

337.6666666666667

455.0

Domain

WW 1

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000345877

230_263

337.6666666666667

455.0

Domain

WW 2

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000524575

171_204

209.66666666666666

327.0

Domain

WW 1

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000526343

171_204

333.6666666666667

451.0

Domain

WW 1

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000526343

230_263

333.6666666666667

451.0

Domain

WW 2

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000531439

171_204

371.6666666666667

489.0

Domain

WW 1

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000531439

230_263

371.6666666666667

489.0

Domain

WW 2

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000537274

171_204

375.6666666666667

493.0

Domain

WW 1

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000537274

230_263

375.6666666666667

493.0

Domain

WW 2

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000282441

291_504

387.6666666666667

505.0

Region

Note=Transactivation domain

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000345877

291_504

337.6666666666667

455.0

Region

Note=Transactivation domain

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000526343

291_504

333.6666666666667

451.0

Region

Note=Transactivation domain

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000531439

291_504

371.6666666666667

489.0

Region

Note=Transactivation domain

Tgene

YAP1

chr11:68326147

chr11:102098200

ENST00000537274

291_504

375.6666666666667

493.0

Region

Note=Transactivation domain

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PPP6R3
YAP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to PPP6R3-YAP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PPP6R3-YAP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source