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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PREP-SIM1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PREP-SIM1
	FusionPDB ID: 68526
	FusionGDB2.0 ID: 68526
		Hgene	Tgene
	Gene symbol	PREP	SIM1
	Gene ID	5550	6492
	Gene name	prolyl endopeptidase	SIM bHLH transcription factor 1
	Synonyms	PE\|PEP	bHLHe14
	Cytomap	6q21	6q16.3
	Type of gene	protein-coding	protein-coding
	Description	prolyl endopeptidasedJ355L5.1 (prolyl endopeptidase)post-proline cleaving enzymeprolyl oligopeptidase	single-minded homolog 1class E basic helix-loop-helix protein 14single-minded family bHLH transcription factor 1
	Modification date	20200313	20200313
	UniProtAcc	PNOC	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000369110,	ENST00000262901, ENST00000369208,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	14 X 10 X 6=840	4 X 4 X 3=48
	# samples	16	5
	** MAII score	log2(16/840*10)=-2.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PREP [Title/Abstract] AND SIM1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PREP(105736633)-SIM1(100868834), # samples:2
Anticipated loss of major functional domain due to fusion event.	PREP-SIM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PREP-SIM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PREP-SIM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PREP-SIM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across PREP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SIM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-46-6026-01A	PREP	chr6	105736633	-	SIM1	chr6	100868834	-
ChimerDB4	LUSC	TCGA-46-6026	PREP	chr6	105736632	-	SIM1	chr6	100868834	-
ChimerDB4	LUSC	TCGA-46-6026	PREP	chr6	105736633	-	SIM1	chr6	100868834	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000369110	PREP	chr6	105736633	-	ENST00000369208	SIM1	chr6	100868834	-	8296	1647	73	2949	958
ENST00000369110	PREP	chr6	105736633	-	ENST00000262901	SIM1	chr6	100868834	-	4439	1647	73	2949	958
ENST00000369110	PREP	chr6	105736632	-	ENST00000369208	SIM1	chr6	100868834	-	8296	1647	73	2949	958
ENST00000369110	PREP	chr6	105736632	-	ENST00000262901	SIM1	chr6	100868834	-	4439	1647	73	2949	958

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000369110	ENST00000369208	PREP	chr6	105736633	-	SIM1	chr6	100868834	-	9.53E-05	0.99990463
ENST00000369110	ENST00000262901	PREP	chr6	105736633	-	SIM1	chr6	100868834	-	0.000312876	0.9996872
ENST00000369110	ENST00000369208	PREP	chr6	105736632	-	SIM1	chr6	100868834	-	9.53E-05	0.99990463
ENST00000369110	ENST00000262901	PREP	chr6	105736632	-	SIM1	chr6	100868834	-	0.000312876	0.9996872

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>68526_68526_1_PREP-SIM1_PREP_chr6_105736632_ENST00000369110_SIM1_chr6_100868834_ENST00000262901_length(amino acids)=958AA_BP=524
MPPAAPQLPAPQPRLAASPASSGPLPEPAPLHAAPCLSPAMLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKIT
VPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFA
YGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPD
EPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRQSPNYRVINIDFRD
PEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHC
DLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYRDTEYKGLQLSLDQIS
ASKPAFSYTSSSTPTMTDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQLLDPADRPGSQHDASCAYRQ
FSDRSSLCYGFALDHSRLVEERHFHTQACEGGRCEAGRYFLGTPQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHW
DEDSVVSSPDPGSASESGDRYRTEQYQSSPHEPSKIETLIRATQQMIKEEENRLQLRKAPSDQLASINGAGKKHSLCFANYQQPPPTGEV
CHGSALANTSPCDHIQQREGKMLSPHENDYDNSPTALSRISSPNSDRISKSSLILAKDYLHSDISPHQTAGDHPTVSPNCFGSHRQYFDK

--------------------------------------------------------------

>68526_68526_2_PREP-SIM1_PREP_chr6_105736632_ENST00000369110_SIM1_chr6_100868834_ENST00000369208_length(amino acids)=958AA_BP=524
MPPAAPQLPAPQPRLAASPASSGPLPEPAPLHAAPCLSPAMLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKIT
VPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFA
YGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPD
EPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRQSPNYRVINIDFRD
PEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHC
DLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYRDTEYKGLQLSLDQIS
ASKPAFSYTSSSTPTMTDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQLLDPADRPGSQHDASCAYRQ
FSDRSSLCYGFALDHSRLVEERHFHTQACEGGRCEAGRYFLGTPQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHW
DEDSVVSSPDPGSASESGDRYRTEQYQSSPHEPSKIETLIRATQQMIKEEENRLQLRKAPSDQLASINGAGKKHSLCFANYQQPPPTGEV
CHGSALANTSPCDHIQQREGKMLSPHENDYDNSPTALSRISSPNSDRISKSSLILAKDYLHSDISPHQTAGDHPTVSPNCFGSHRQYFDK

--------------------------------------------------------------

>68526_68526_3_PREP-SIM1_PREP_chr6_105736633_ENST00000369110_SIM1_chr6_100868834_ENST00000262901_length(amino acids)=958AA_BP=524
MPPAAPQLPAPQPRLAASPASSGPLPEPAPLHAAPCLSPAMLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKIT
VPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFA
YGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPD
EPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRQSPNYRVINIDFRD
PEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHC
DLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYRDTEYKGLQLSLDQIS
ASKPAFSYTSSSTPTMTDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQLLDPADRPGSQHDASCAYRQ
FSDRSSLCYGFALDHSRLVEERHFHTQACEGGRCEAGRYFLGTPQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHW
DEDSVVSSPDPGSASESGDRYRTEQYQSSPHEPSKIETLIRATQQMIKEEENRLQLRKAPSDQLASINGAGKKHSLCFANYQQPPPTGEV
CHGSALANTSPCDHIQQREGKMLSPHENDYDNSPTALSRISSPNSDRISKSSLILAKDYLHSDISPHQTAGDHPTVSPNCFGSHRQYFDK

--------------------------------------------------------------

>68526_68526_4_PREP-SIM1_PREP_chr6_105736633_ENST00000369110_SIM1_chr6_100868834_ENST00000369208_length(amino acids)=958AA_BP=524
MPPAAPQLPAPQPRLAASPASSGPLPEPAPLHAAPCLSPAMLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKIT
VPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFA
YGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPD
EPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRQSPNYRVINIDFRD
PEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHC
DLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYRDTEYKGLQLSLDQIS
ASKPAFSYTSSSTPTMTDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQLLDPADRPGSQHDASCAYRQ
FSDRSSLCYGFALDHSRLVEERHFHTQACEGGRCEAGRYFLGTPQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHW
DEDSVVSSPDPGSASESGDRYRTEQYQSSPHEPSKIETLIRATQQMIKEEENRLQLRKAPSDQLASINGAGKKHSLCFANYQQPPPTGEV
CHGSALANTSPCDHIQQREGKMLSPHENDYDNSPTALSRISSPNSDRISKSSLILAKDYLHSDISPHQTAGDHPTVSPNCFGSHRQYFDK

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:105736633/chr6:100868834)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PREP PNOC	.
176	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SIM1

chr6:105736632

chr6:100868834

ENST00000262901

336_766

332.6666666666667

767.0

Domain

Single-minded C-terminal

Tgene

SIM1

chr6:105736632

chr6:100868834

ENST00000369208

336_766

332.6666666666667

767.0

Domain

Single-minded C-terminal

Tgene

SIM1

chr6:105736633

chr6:100868834

ENST00000262901

336_766

332.6666666666667

767.0

Domain

Single-minded C-terminal

Tgene

SIM1

chr6:105736633

chr6:100868834

ENST00000369208

336_766

332.6666666666667

767.0

Domain

Single-minded C-terminal

Tgene

SIM1

chr6:105736632

chr6:100868834

ENST00000262901

368_387

332.6666666666667

767.0

Motif

Nuclear localization signal

Tgene

SIM1

chr6:105736632

chr6:100868834

ENST00000369208

368_387

332.6666666666667

767.0

Motif

Nuclear localization signal

Tgene

SIM1

chr6:105736633

chr6:100868834

ENST00000262901

368_387

332.6666666666667

767.0

Motif

Nuclear localization signal

Tgene

SIM1

chr6:105736633

chr6:100868834

ENST00000369208

368_387

332.6666666666667

767.0

Motif

Nuclear localization signal

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SIM1

chr6:105736632

chr6:100868834

ENST00000262901

1_53

332.6666666666667

767.0

Domain

bHLH

Tgene

SIM1

chr6:105736632

chr6:100868834

ENST00000262901

218_288

332.6666666666667

767.0

Domain

PAS 2

Tgene

SIM1

chr6:105736632

chr6:100868834

ENST00000262901

292_335

332.6666666666667

767.0

Domain

Note=PAC

Tgene

SIM1

chr6:105736632

chr6:100868834

ENST00000262901

77_147

332.6666666666667

767.0

Domain

PAS 1

Tgene

SIM1

chr6:105736632

chr6:100868834

ENST00000369208

1_53

332.6666666666667

767.0

Domain

bHLH

Tgene

SIM1

chr6:105736632

chr6:100868834

ENST00000369208

218_288

332.6666666666667

767.0

Domain

PAS 2

Tgene

SIM1

chr6:105736632

chr6:100868834

ENST00000369208

292_335

332.6666666666667

767.0

Domain

Note=PAC

Tgene

SIM1

chr6:105736632

chr6:100868834

ENST00000369208

77_147

332.6666666666667

767.0

Domain

PAS 1

Tgene

SIM1

chr6:105736633

chr6:100868834

ENST00000262901

1_53

332.6666666666667

767.0

Domain

bHLH

Tgene

SIM1

chr6:105736633

chr6:100868834

ENST00000262901

218_288

332.6666666666667

767.0

Domain

PAS 2

Tgene

SIM1

chr6:105736633

chr6:100868834

ENST00000262901

292_335

332.6666666666667

767.0

Domain

Note=PAC

Tgene

SIM1

chr6:105736633

chr6:100868834

ENST00000262901

77_147

332.6666666666667

767.0

Domain

PAS 1

Tgene

SIM1

chr6:105736633

chr6:100868834

ENST00000369208

1_53

332.6666666666667

767.0

Domain

bHLH

Tgene

SIM1

chr6:105736633

chr6:100868834

ENST00000369208

218_288

332.6666666666667

767.0

Domain

PAS 2

Tgene

SIM1

chr6:105736633

chr6:100868834

ENST00000369208

292_335

332.6666666666667

767.0

Domain

Note=PAC

Tgene

SIM1

chr6:105736633

chr6:100868834

ENST00000369208

77_147

332.6666666666667

767.0

Domain

PAS 1

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1756_PREP_105736633_SIM1_100868834_ranked_0.pdb	PREP	105736632	105736633	ENST00000262901	SIM1	chr6	100868834	-	MPPAAPQLPAPQPRLAASPASSGPLPEPAPLHAAPCLSPAMLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKIT VPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFA YGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPD EPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRQSPNYRVINIDFRD PEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHC DLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYRDTEYKGLQLSLDQIS ASKPAFSYTSSSTPTMTDNRKGAKSRLSSSKSKSRTSPYPQYSGFHTERSESDHDSQWGGSPLTDTASPQLLDPADRPGSQHDASCAYRQ FSDRSSLCYGFALDHSRLVEERHFHTQACEGGRCEAGRYFLGTPQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHW DEDSVVSSPDPGSASESGDRYRTEQYQSSPHEPSKIETLIRATQQMIKEEENRLQLRKAPSDQLASINGAGKKHSLCFANYQQPPPTGEV CHGSALANTSPCDHIQQREGKMLSPHENDYDNSPTALSRISSPNSDRISKSSLILAKDYLHSDISPHQTAGDHPTVSPNCFGSHRQYFDK	958

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PREP_pLDDT.png

SIM1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PREP
SIM1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to PREP-SIM1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to PREP-SIM1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source