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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PRKAR1A-PITPNC1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PRKAR1A-PITPNC1
FusionPDB ID: 68661
FusionGDB2.0 ID: 68661
HgeneTgene
Gene symbol

PRKAR1A

PITPNC1

Gene ID

5573

26207

Gene nameprotein kinase cAMP-dependent type I regulatory subunit alphaphosphatidylinositol transfer protein cytoplasmic 1
SynonymsACRDYS1|ADOHR|CAR|CNC|CNC1|PKR1|PPNAD1|PRKAR1|TSE1M-RDGB-beta|MRDGBbeta|RDGB-BETA|RDGBB|RDGBB1
Cytomap

17q24.2

17q24.2

Type of geneprotein-codingprotein-coding
DescriptioncAMP-dependent protein kinase type I-alpha regulatory subunitCarney complex type 1cAMP-dependent protein kinase regulatory subunit RIalphacAMP-dependent protein kinase type I-alpha regulatory chainepididymis secretory sperm binding proteinprotein kincytoplasmic phosphatidylinositol transfer protein 1M-rdgB betamammalian rdgB homolog betaretinal degeneration B beta 1retinal degeneration B homolog beta
Modification date2020032920200313
UniProtAcc

P10644

.
Ensembl transtripts involved in fusion geneENST idsENST00000358598, ENST00000392711, 
ENST00000536854, ENST00000586397, 
ENST00000588188, ENST00000589228, 
ENST00000299954, ENST00000335257, 
ENST00000580974, ENST00000581322, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 15 X 8=180031 X 22 X 12=8184
# samples 1852
** MAII scorelog2(18/1800*10)=-3.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(52/8184*10)=-3.97622261671687
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PRKAR1A [Title/Abstract] AND PITPNC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PRKAR1A(66511717)-PITPNC1(65528918), # samples:3
Anticipated loss of major functional domain due to fusion event.PRKAR1A-PITPNC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PRKAR1A-PITPNC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKAR1A

GO:2000480

negative regulation of cAMP-dependent protein kinase activity

21812984

TgenePITPNC1

GO:0015914

phospholipid transport

22822086


check buttonFusion gene breakpoints across PRKAR1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PITPNC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-D5-6929-01APRKAR1Achr17

66511717

-PITPNC1chr17

65528918

+
ChimerDB4COADTCGA-D5-6929-01APRKAR1Achr17

66511717

+PITPNC1chr17

65528918

+
ChimerDB4COADTCGA-D5-6929PRKAR1Achr17

66511717

+PITPNC1chr17

65528917

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358598PRKAR1Achr1766511717+ENST00000580974PITPNC1chr1765528918+57322941171052311
ENST00000358598PRKAR1Achr1766511717+ENST00000299954PITPNC1chr1765528918+20052941171052311
ENST00000358598PRKAR1Achr1766511717+ENST00000335257PITPNC1chr1765528918+18862941171244375
ENST00000358598PRKAR1Achr1766511717+ENST00000581322PITPNC1chr1765528918+13702941171244375
ENST00000392711PRKAR1Achr1766511717+ENST00000580974PITPNC1chr1765528918+57993611841119311
ENST00000392711PRKAR1Achr1766511717+ENST00000299954PITPNC1chr1765528918+20723611841119311
ENST00000392711PRKAR1Achr1766511717+ENST00000335257PITPNC1chr1765528918+19533611841311375
ENST00000392711PRKAR1Achr1766511717+ENST00000581322PITPNC1chr1765528918+14373611841311375
ENST00000589228PRKAR1Achr1766511717+ENST00000580974PITPNC1chr1765528918+5743305561063335
ENST00000589228PRKAR1Achr1766511717+ENST00000299954PITPNC1chr1765528918+2016305561063335
ENST00000589228PRKAR1Achr1766511717+ENST00000335257PITPNC1chr1765528918+1897305561255399
ENST00000589228PRKAR1Achr1766511717+ENST00000581322PITPNC1chr1765528918+1381305561255399
ENST00000536854PRKAR1Achr1766511717+ENST00000580974PITPNC1chr1765528918+58534152051173322
ENST00000536854PRKAR1Achr1766511717+ENST00000299954PITPNC1chr1765528918+21264152051173322
ENST00000536854PRKAR1Achr1766511717+ENST00000335257PITPNC1chr1765528918+20074152051365386
ENST00000536854PRKAR1Achr1766511717+ENST00000581322PITPNC1chr1765528918+14914152051365386
ENST00000586397PRKAR1Achr1766511717+ENST00000580974PITPNC1chr1765528918+61947565281514328
ENST00000586397PRKAR1Achr1766511717+ENST00000299954PITPNC1chr1765528918+24677565281514328
ENST00000586397PRKAR1Achr1766511717+ENST00000335257PITPNC1chr1765528918+23487565281706392
ENST00000586397PRKAR1Achr1766511717+ENST00000581322PITPNC1chr1765528918+18327565281706392
ENST00000588188PRKAR1Achr1766511717+ENST00000580974PITPNC1chr1765528918+56151770935311
ENST00000588188PRKAR1Achr1766511717+ENST00000299954PITPNC1chr1765528918+18881770935311
ENST00000588188PRKAR1Achr1766511717+ENST00000335257PITPNC1chr1765528918+176917701127375
ENST00000588188PRKAR1Achr1766511717+ENST00000581322PITPNC1chr1765528918+125317701127375
ENST00000358598PRKAR1Achr1766511717+ENST00000580974PITPNC1chr1765528917+57322941171052311
ENST00000358598PRKAR1Achr1766511717+ENST00000299954PITPNC1chr1765528917+20052941171052311
ENST00000358598PRKAR1Achr1766511717+ENST00000335257PITPNC1chr1765528917+18862941171244375
ENST00000358598PRKAR1Achr1766511717+ENST00000581322PITPNC1chr1765528917+13702941171244375
ENST00000392711PRKAR1Achr1766511717+ENST00000580974PITPNC1chr1765528917+57993611841119311
ENST00000392711PRKAR1Achr1766511717+ENST00000299954PITPNC1chr1765528917+20723611841119311
ENST00000392711PRKAR1Achr1766511717+ENST00000335257PITPNC1chr1765528917+19533611841311375
ENST00000392711PRKAR1Achr1766511717+ENST00000581322PITPNC1chr1765528917+14373611841311375
ENST00000589228PRKAR1Achr1766511717+ENST00000580974PITPNC1chr1765528917+5743305561063335
ENST00000589228PRKAR1Achr1766511717+ENST00000299954PITPNC1chr1765528917+2016305561063335
ENST00000589228PRKAR1Achr1766511717+ENST00000335257PITPNC1chr1765528917+1897305561255399
ENST00000589228PRKAR1Achr1766511717+ENST00000581322PITPNC1chr1765528917+1381305561255399
ENST00000536854PRKAR1Achr1766511717+ENST00000580974PITPNC1chr1765528917+58534152051173322
ENST00000536854PRKAR1Achr1766511717+ENST00000299954PITPNC1chr1765528917+21264152051173322
ENST00000536854PRKAR1Achr1766511717+ENST00000335257PITPNC1chr1765528917+20074152051365386
ENST00000536854PRKAR1Achr1766511717+ENST00000581322PITPNC1chr1765528917+14914152051365386
ENST00000586397PRKAR1Achr1766511717+ENST00000580974PITPNC1chr1765528917+61947565281514328
ENST00000586397PRKAR1Achr1766511717+ENST00000299954PITPNC1chr1765528917+24677565281514328
ENST00000586397PRKAR1Achr1766511717+ENST00000335257PITPNC1chr1765528917+23487565281706392
ENST00000586397PRKAR1Achr1766511717+ENST00000581322PITPNC1chr1765528917+18327565281706392
ENST00000588188PRKAR1Achr1766511717+ENST00000580974PITPNC1chr1765528917+56151770935311
ENST00000588188PRKAR1Achr1766511717+ENST00000299954PITPNC1chr1765528917+18881770935311
ENST00000588188PRKAR1Achr1766511717+ENST00000335257PITPNC1chr1765528917+176917701127375
ENST00000588188PRKAR1Achr1766511717+ENST00000581322PITPNC1chr1765528917+125317701127375

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358598ENST00000580974PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0002277950.99977225
ENST00000358598ENST00000299954PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0006623590.9993376
ENST00000358598ENST00000335257PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0007578630.9992422
ENST00000358598ENST00000581322PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0022774030.99772257
ENST00000392711ENST00000580974PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0002225640.9997775
ENST00000392711ENST00000299954PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0008439670.999156
ENST00000392711ENST00000335257PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0009015260.99909854
ENST00000392711ENST00000581322PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0028370880.9971629
ENST00000589228ENST00000580974PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0002178160.99978215
ENST00000589228ENST00000299954PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0007269970.999273
ENST00000589228ENST00000335257PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0007894510.9992105
ENST00000589228ENST00000581322PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0026348270.9973652
ENST00000536854ENST00000580974PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0002117750.9997882
ENST00000536854ENST00000299954PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0006688110.99933124
ENST00000536854ENST00000335257PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0006873160.99931264
ENST00000536854ENST00000581322PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0020137640.9979862
ENST00000586397ENST00000580974PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0001892760.99981076
ENST00000586397ENST00000299954PRKAR1Achr1766511717+PITPNC1chr1765528918+0.000271760.99972826
ENST00000586397ENST00000335257PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0002909510.99970907
ENST00000586397ENST00000581322PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0004128410.9995871
ENST00000588188ENST00000580974PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0002048970.99979514
ENST00000588188ENST00000299954PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0005020060.999498
ENST00000588188ENST00000335257PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0005236930.9994764
ENST00000588188ENST00000581322PRKAR1Achr1766511717+PITPNC1chr1765528918+0.0016037880.9983962
ENST00000358598ENST00000580974PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0002277950.99977225
ENST00000358598ENST00000299954PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0006623590.9993376
ENST00000358598ENST00000335257PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0007578630.9992422
ENST00000358598ENST00000581322PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0022774030.99772257
ENST00000392711ENST00000580974PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0002225640.9997775
ENST00000392711ENST00000299954PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0008439670.999156
ENST00000392711ENST00000335257PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0009015260.99909854
ENST00000392711ENST00000581322PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0028370880.9971629
ENST00000589228ENST00000580974PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0002178160.99978215
ENST00000589228ENST00000299954PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0007269970.999273
ENST00000589228ENST00000335257PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0007894510.9992105
ENST00000589228ENST00000581322PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0026348270.9973652
ENST00000536854ENST00000580974PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0002117750.9997882
ENST00000536854ENST00000299954PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0006688110.99933124
ENST00000536854ENST00000335257PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0006873160.99931264
ENST00000536854ENST00000581322PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0020137640.9979862
ENST00000586397ENST00000580974PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0001892760.99981076
ENST00000586397ENST00000299954PRKAR1Achr1766511717+PITPNC1chr1765528917+0.000271760.99972826
ENST00000586397ENST00000335257PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0002909510.99970907
ENST00000586397ENST00000581322PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0004128410.9995871
ENST00000588188ENST00000580974PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0002048970.99979514
ENST00000588188ENST00000299954PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0005020060.999498
ENST00000588188ENST00000335257PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0005236930.9994764
ENST00000588188ENST00000581322PRKAR1Achr1766511717+PITPNC1chr1765528917+0.0016037880.9983962

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>68661_68661_1_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000358598_PITPNC1_chr17_65528917_ENST00000299954_length(amino acids)=311AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY

--------------------------------------------------------------

>68661_68661_2_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000358598_PITPNC1_chr17_65528917_ENST00000335257_length(amino acids)=375AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY
DMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTLPDPEKKATLNL

--------------------------------------------------------------

>68661_68661_3_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000358598_PITPNC1_chr17_65528917_ENST00000580974_length(amino acids)=311AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY

--------------------------------------------------------------

>68661_68661_4_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000358598_PITPNC1_chr17_65528917_ENST00000581322_length(amino acids)=375AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY
DMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTLPDPEKKATLNL

--------------------------------------------------------------

>68661_68661_5_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000358598_PITPNC1_chr17_65528918_ENST00000299954_length(amino acids)=311AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY

--------------------------------------------------------------

>68661_68661_6_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000358598_PITPNC1_chr17_65528918_ENST00000335257_length(amino acids)=375AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY
DMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTLPDPEKKATLNL

--------------------------------------------------------------

>68661_68661_7_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000358598_PITPNC1_chr17_65528918_ENST00000580974_length(amino acids)=311AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY

--------------------------------------------------------------

>68661_68661_8_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000358598_PITPNC1_chr17_65528918_ENST00000581322_length(amino acids)=375AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY
DMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTLPDPEKKATLNL

--------------------------------------------------------------

>68661_68661_9_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000392711_PITPNC1_chr17_65528917_ENST00000299954_length(amino acids)=311AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY

--------------------------------------------------------------

>68661_68661_10_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000392711_PITPNC1_chr17_65528917_ENST00000335257_length(amino acids)=375AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY
DMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTLPDPEKKATLNL

--------------------------------------------------------------

>68661_68661_11_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000392711_PITPNC1_chr17_65528917_ENST00000580974_length(amino acids)=311AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY

--------------------------------------------------------------

>68661_68661_12_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000392711_PITPNC1_chr17_65528917_ENST00000581322_length(amino acids)=375AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY
DMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTLPDPEKKATLNL

--------------------------------------------------------------

>68661_68661_13_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000392711_PITPNC1_chr17_65528918_ENST00000299954_length(amino acids)=311AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY

--------------------------------------------------------------

>68661_68661_14_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000392711_PITPNC1_chr17_65528918_ENST00000335257_length(amino acids)=375AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY
DMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTLPDPEKKATLNL

--------------------------------------------------------------

>68661_68661_15_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000392711_PITPNC1_chr17_65528918_ENST00000580974_length(amino acids)=311AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY

--------------------------------------------------------------

>68661_68661_16_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000392711_PITPNC1_chr17_65528918_ENST00000581322_length(amino acids)=375AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY
DMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTLPDPEKKATLNL

--------------------------------------------------------------

>68661_68661_17_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000536854_PITPNC1_chr17_65528917_ENST00000299954_length(amino acids)=322AA_BP=70
MTSAPVSAERTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRG
EGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSNDTIFDN
EAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGH

--------------------------------------------------------------

>68661_68661_18_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000536854_PITPNC1_chr17_65528917_ENST00000335257_length(amino acids)=386AA_BP=70
MTSAPVSAERTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRG
EGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSNDTIFDN
EAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGH
RQAFAWVDEWYDMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTL

--------------------------------------------------------------

>68661_68661_19_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000536854_PITPNC1_chr17_65528917_ENST00000580974_length(amino acids)=322AA_BP=70
MTSAPVSAERTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRG
EGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDN
EAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGH

--------------------------------------------------------------

>68661_68661_20_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000536854_PITPNC1_chr17_65528917_ENST00000581322_length(amino acids)=386AA_BP=70
MTSAPVSAERTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRG
EGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDN
EAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGH
RQAFAWVDEWYDMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTL

--------------------------------------------------------------

>68661_68661_21_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000536854_PITPNC1_chr17_65528918_ENST00000299954_length(amino acids)=322AA_BP=70
MTSAPVSAERTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRG
EGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSNDTIFDN
EAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGH

--------------------------------------------------------------

>68661_68661_22_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000536854_PITPNC1_chr17_65528918_ENST00000335257_length(amino acids)=386AA_BP=70
MTSAPVSAERTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRG
EGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSNDTIFDN
EAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGH
RQAFAWVDEWYDMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTL

--------------------------------------------------------------

>68661_68661_23_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000536854_PITPNC1_chr17_65528918_ENST00000580974_length(amino acids)=322AA_BP=70
MTSAPVSAERTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRG
EGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDN
EAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGH

--------------------------------------------------------------

>68661_68661_24_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000536854_PITPNC1_chr17_65528918_ENST00000581322_length(amino acids)=386AA_BP=70
MTSAPVSAERTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRG
EGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDN
EAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGH
RQAFAWVDEWYDMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTL

--------------------------------------------------------------

>68661_68661_25_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000586397_PITPNC1_chr17_65528917_ENST00000299954_length(amino acids)=328AA_BP=76
MLYSLYKHVCVFFSQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSH
EQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSN
DTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRD

--------------------------------------------------------------

>68661_68661_26_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000586397_PITPNC1_chr17_65528917_ENST00000335257_length(amino acids)=392AA_BP=76
MLYSLYKHVCVFFSQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSH
EQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSN
DTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRD
ILLIGHRQAFAWVDEWYDMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSA

--------------------------------------------------------------

>68661_68661_27_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000586397_PITPNC1_chr17_65528917_ENST00000580974_length(amino acids)=328AA_BP=76
MLYSLYKHVCVFFSQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSH
EQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSN
DTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRD

--------------------------------------------------------------

>68661_68661_28_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000586397_PITPNC1_chr17_65528917_ENST00000581322_length(amino acids)=392AA_BP=76
MLYSLYKHVCVFFSQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSH
EQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSN
DTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRD
ILLIGHRQAFAWVDEWYDMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSA

--------------------------------------------------------------

>68661_68661_29_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000586397_PITPNC1_chr17_65528918_ENST00000299954_length(amino acids)=328AA_BP=76
MLYSLYKHVCVFFSQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSH
EQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSN
DTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRD

--------------------------------------------------------------

>68661_68661_30_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000586397_PITPNC1_chr17_65528918_ENST00000335257_length(amino acids)=392AA_BP=76
MLYSLYKHVCVFFSQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSH
EQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSN
DTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRD
ILLIGHRQAFAWVDEWYDMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSA

--------------------------------------------------------------

>68661_68661_31_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000586397_PITPNC1_chr17_65528918_ENST00000580974_length(amino acids)=328AA_BP=76
MLYSLYKHVCVFFSQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSH
EQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSN
DTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRD

--------------------------------------------------------------

>68661_68661_32_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000586397_PITPNC1_chr17_65528918_ENST00000581322_length(amino acids)=392AA_BP=76
MLYSLYKHVCVFFSQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSH
EQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSN
DTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRD
ILLIGHRQAFAWVDEWYDMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSA

--------------------------------------------------------------

>68661_68661_33_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000588188_PITPNC1_chr17_65528917_ENST00000299954_length(amino acids)=311AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY

--------------------------------------------------------------

>68661_68661_34_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000588188_PITPNC1_chr17_65528917_ENST00000335257_length(amino acids)=375AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY
DMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTLPDPEKKATLNL

--------------------------------------------------------------

>68661_68661_35_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000588188_PITPNC1_chr17_65528917_ENST00000580974_length(amino acids)=311AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY

--------------------------------------------------------------

>68661_68661_36_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000588188_PITPNC1_chr17_65528917_ENST00000581322_length(amino acids)=375AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY
DMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTLPDPEKKATLNL

--------------------------------------------------------------

>68661_68661_37_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000588188_PITPNC1_chr17_65528918_ENST00000299954_length(amino acids)=311AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY

--------------------------------------------------------------

>68661_68661_38_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000588188_PITPNC1_chr17_65528918_ENST00000335257_length(amino acids)=375AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY
DMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTLPDPEKKATLNL

--------------------------------------------------------------

>68661_68661_39_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000588188_PITPNC1_chr17_65528918_ENST00000580974_length(amino acids)=311AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY

--------------------------------------------------------------

>68661_68661_40_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000588188_PITPNC1_chr17_65528918_ENST00000581322_length(amino acids)=375AA_BP=59
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLYMISKHSHEQSDRGEGVEVVQNEPF
EDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCF
IDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWY
DMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTLPDPEKKATLNL

--------------------------------------------------------------

>68661_68661_41_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000589228_PITPNC1_chr17_65528917_ENST00000299954_length(amino acids)=335AA_BP=83
MRELGTPPPRTRSLAPAAARPQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLY
MISKHSHEQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKY
EDNKGSNDTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQF

--------------------------------------------------------------

>68661_68661_42_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000589228_PITPNC1_chr17_65528917_ENST00000335257_length(amino acids)=399AA_BP=83
MRELGTPPPRTRSLAPAAARPQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLY
MISKHSHEQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKY
EDNKGSNDTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQF
VHKVVRDILLIGHRQAFAWVDEWYDMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKD

--------------------------------------------------------------

>68661_68661_43_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000589228_PITPNC1_chr17_65528917_ENST00000580974_length(amino acids)=335AA_BP=83
MRELGTPPPRTRSLAPAAARPQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLY
MISKHSHEQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKY
EDNKGSNDTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQF

--------------------------------------------------------------

>68661_68661_44_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000589228_PITPNC1_chr17_65528917_ENST00000581322_length(amino acids)=399AA_BP=83
MRELGTPPPRTRSLAPAAARPQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLY
MISKHSHEQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKY
EDNKGSNDTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQF
VHKVVRDILLIGHRQAFAWVDEWYDMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKD

--------------------------------------------------------------

>68661_68661_45_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000589228_PITPNC1_chr17_65528918_ENST00000299954_length(amino acids)=335AA_BP=83
MRELGTPPPRTRSLAPAAARPQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLY
MISKHSHEQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKY
EDNKGSNDTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQF

--------------------------------------------------------------

>68661_68661_46_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000589228_PITPNC1_chr17_65528918_ENST00000335257_length(amino acids)=399AA_BP=83
MRELGTPPPRTRSLAPAAARPQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLY
MISKHSHEQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYKCSFLPKFSIHIETKY
EDNKGSNDTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQF
VHKVVRDILLIGHRQAFAWVDEWYDMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKD

--------------------------------------------------------------

>68661_68661_47_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000589228_PITPNC1_chr17_65528918_ENST00000580974_length(amino acids)=335AA_BP=83
MRELGTPPPRTRSLAPAAARPQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLY
MISKHSHEQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKY
EDNKGSNDTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQF

--------------------------------------------------------------

>68661_68661_48_PRKAR1A-PITPNC1_PRKAR1A_chr17_66511717_ENST00000589228_PITPNC1_chr17_65528918_ENST00000581322_length(amino acids)=399AA_BP=83
MRELGTPPPRTRSLAPAAARPQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKYKIGQLY
MISKHSHEQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKY
EDNKGSNDTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQF
VHKVVRDILLIGHRQAFAWVDEWYDMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKD

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:66511717/chr17:65528918)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRKAR1A

P10644

.
FUNCTION: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:26405036}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000358598+21196_10059.0382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000392711+21196_10059.0382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000536854+31296_10059.0382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000586397+11096_10059.0382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000589228+21196_10059.0382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000358598+21196_10059.0382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000392711+21196_10059.0382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000536854+31296_10059.0382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000586397+11096_10059.0382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000589228+21196_10059.0382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000358598+211137_25459.0382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000358598+211255_38159.0382.0Nucleotide bindingNote=cAMP 2
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000392711+211137_25459.0382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000392711+211255_38159.0382.0Nucleotide bindingNote=cAMP 2
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000536854+312137_25459.0382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000536854+312255_38159.0382.0Nucleotide bindingNote=cAMP 2
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000586397+110137_25459.0382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000586397+110255_38159.0382.0Nucleotide bindingNote=cAMP 2
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000589228+211137_25459.0382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000589228+211255_38159.0382.0Nucleotide bindingNote=cAMP 2
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000358598+211137_25459.0382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000358598+211255_38159.0382.0Nucleotide bindingNote=cAMP 2
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000392711+211137_25459.0382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000392711+211255_38159.0382.0Nucleotide bindingNote=cAMP 2
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000536854+312137_25459.0382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000536854+312255_38159.0382.0Nucleotide bindingNote=cAMP 2
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000586397+110137_25459.0382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000586397+110255_38159.0382.0Nucleotide bindingNote=cAMP 2
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000589228+211137_25459.0382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000589228+211255_38159.0382.0Nucleotide bindingNote=cAMP 2
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000358598+2111_13659.0382.0RegionNote=Dimerization and phosphorylation
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000392711+2111_13659.0382.0RegionNote=Dimerization and phosphorylation
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000536854+3121_13659.0382.0RegionNote=Dimerization and phosphorylation
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000586397+1101_13659.0382.0RegionNote=Dimerization and phosphorylation
HgenePRKAR1Achr17:66511717chr17:65528917ENST00000589228+2111_13659.0382.0RegionNote=Dimerization and phosphorylation
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000358598+2111_13659.0382.0RegionNote=Dimerization and phosphorylation
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000392711+2111_13659.0382.0RegionNote=Dimerization and phosphorylation
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000536854+3121_13659.0382.0RegionNote=Dimerization and phosphorylation
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000586397+1101_13659.0382.0RegionNote=Dimerization and phosphorylation
HgenePRKAR1Achr17:66511717chr17:65528918ENST00000589228+2111_13659.0382.0RegionNote=Dimerization and phosphorylation


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
PRKAR1APRKAR1B, AKAP1, MYO7A, AKAP10, C2orf88, PLEKHF2, PYCARD, NPRL2, UBE2M, NUAK1, MCRS1, PRKACA, PRKAR1A, AKAP4, ARFGEF2, ARFGEF1, EGFR, GRB2, PRKX, AKAP11, Rrp1b, GABARAPL1, WNK1, UBC, PJA2, CBS, NELL2, C2orf44, BAHD1, ZBED1, MAPK6, TAB1, ELAVL1, SLC2A4, CUL3, PATZ1, PRKACB, PRPF31, SAFB, HSP90AA4P, MEN1, SLC38A5, Akap7, SMURF1, PRPF40A, SMAD2, CDK2, CCNE1, RFC2, PPP1CA, NPM1, SOX2, HIVEP1, CAPN11, SETD7, SET, DYRK1B, DYRK1A, GSK3B, ARPC3, PFDN5, AGO2, AGO3, CEP250, RAF1, CUL7, CCDC8, ILK, MTOR, BTRC, STOML2, PRKACG, PALM2-AKAP2, AKAP3, GPR161, ANKRD26, FRMD5, IFI16, XPO1, VAPA, Prkacb, Prkar2a, Gsk3b, VAPB, PRKAR2B, IQCB1, YWHAZ, DPB3, TCD1, EGLN3, HRAS, KRAS, NRAS, RECQL4, MCL1, MAPK12, TK1, FGFR3, FABP4, AGPAT1, MAP3K5, SPHK2, CANX, RC3H2, PLK1, BIRC3, NFX1, AKAP7, RSPH3, SPG20, DTX1, C11orf49, AKAP5, FAM153B, FBXW8, OBSL1, ARAF, BAD, MAPK7, AKAP12, HSPA8, HSPB1, JUP, PGAM5, GRWD1, AP3S1, RPL6, HIST1H1C, CORO1B, KHDRBS1, ADRM1, HIGD1A, SLC25A11, ROCK1, MEPCE, HIST1H1E, DOCK4, HIGD1C, GNL3, RPL36A, RPL8, STK39, GTF3C5, BCCIP, PDCD2L, UHRF1, ZFP91, GATAD2B, DDX42, CCDC108, LLGL2, SUZ12, USP10, C1QBP, NAP1L1, PYCR1, S100A7A, S100A7, MCM3, GART, EPB41L2, RBFOX3, RBFOX2, RBFOX1, CAMSAP3, FAT1, KDELR1, CFL1, G6PD, SERPINH1, SNRNP40, MAGEB2, HLA-C, HLA-A, COQ6, NXF1, VPS29, GPX8, MOB2, ACACA, AHSA1, MGEA5, AP1G1, ADAM10, PRKCA, PRKCB, PRKCI, PRKCZ, PTK6, RPS6KA3, SH3GL3, ESR1, MAP1LC3B, CDCA5, TULP3, SREBF2, nsp8ab, PTP4A3, ASXL1, DNAJB6, DNAJC28, OGT, KLHL28, EIF1AX, SBNO1, METTL15, FYN, SH3PXD2B, PLCB3, PAXBP1, NBR1, CALCOCO2, SQSTM1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PRKAR1Aall structure
PITPNC1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PRKAR1A-PITPNC1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PRKAR1A-PITPNC1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRKAR1AC2607929Carney Complex, Type 110CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgenePRKAR1AC3276228ACRODYSOSTOSIS 1 WITH OR WITHOUT HORMONE RESISTANCE8CTD_human;GENOMICS_ENGLAND;UNIPROT
HgenePRKAR1AC0406810Carney Complex6CLINGEN;CTD_human;GENOMICS_ENGLAND
HgenePRKAR1AC0220659Acrodysostosis4CTD_human;GENOMICS_ENGLAND;ORPHANET
HgenePRKAR1AC0010481Cushing Syndrome2CTD_human
HgenePRKAR1AC1864846PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 1 (disorder)2CTD_human;GENOMICS_ENGLAND
HgenePRKAR1AC0001627Congenital adrenal hyperplasia1CTD_human
HgenePRKAR1AC0002170Alopecia1CTD_human
HgenePRKAR1AC0020456Hyperglycemia1CTD_human
HgenePRKAR1AC0021655Insulin Resistance1CTD_human
HgenePRKAR1AC0023487Acute Promyelocytic Leukemia1CTD_human;ORPHANET
HgenePRKAR1AC0026846Muscular Atrophy1CTD_human
HgenePRKAR1AC0028754Obesity1CTD_human
HgenePRKAR1AC0086873Pseudopelade1CTD_human
HgenePRKAR1AC0162311Androgenetic Alopecia1CTD_human
HgenePRKAR1AC0263477Female pattern alopecia (disorder)1CTD_human
HgenePRKAR1AC0270948Neurogenic Muscular Atrophy1CTD_human
HgenePRKAR1AC0920563Insulin Sensitivity1CTD_human
HgenePRKAR1AC1850635Atrial myxoma, familial1CTD_human;ORPHANET
HgenePRKAR1AC1854540Carney Complex, Type 21CTD_human
HgenePRKAR1AC1855520Hyperglycemia, Postprandial1CTD_human
HgenePRKAR1AC3553250ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE1CTD_human
HgenePRKAR1AC3887949Apparent mineralocorticoid excess1CTD_human
HgenePRKAR1AC4083212Alopecia, Male Pattern1CTD_human
HgenePRKAR1AC4304832Primary pigmented nodular adrenocortical disease1ORPHANET
HgenePRKAR1AC4721502Peripheral dysostosis1CTD_human