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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PRKAR1A-RET

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PRKAR1A-RET
FusionPDB ID: 68664
FusionGDB2.0 ID: 68664
HgeneTgene
Gene symbol

PRKAR1A

RET

Gene ID

5573

5979

Gene nameprotein kinase cAMP-dependent type I regulatory subunit alpharet proto-oncogene
SynonymsACRDYS1|ADOHR|CAR|CNC|CNC1|PKR1|PPNAD1|PRKAR1|TSE1CDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1
Cytomap

17q24.2

10q11.21

Type of geneprotein-codingprotein-coding
DescriptioncAMP-dependent protein kinase type I-alpha regulatory subunitCarney complex type 1cAMP-dependent protein kinase regulatory subunit RIalphacAMP-dependent protein kinase type I-alpha regulatory chainepididymis secretory sperm binding proteinprotein kinproto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
Modification date2020032920200322
UniProtAcc

P10644

RTL1

Ensembl transtripts involved in fusion geneENST idsENST00000358598, ENST00000392711, 
ENST00000536854, ENST00000586397, 
ENST00000588188, ENST00000589228, 
ENST00000340058, ENST00000355710, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 15 X 8=180032 X 31 X 11=10912
# samples 1848
** MAII scorelog2(18/1800*10)=-3.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(48/10912*10)=-4.50673733341565
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PRKAR1A [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PRKAR1A(66522054)-RET(43612031), # samples:2
Anticipated loss of major functional domain due to fusion event.PRKAR1A-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PRKAR1A-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PRKAR1A-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PRKAR1A-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKAR1A

GO:2000480

negative regulation of cAMP-dependent protein kinase activity

21812984

TgeneRET

GO:0030155

regulation of cell adhesion

21357690

TgeneRET

GO:0030335

positive regulation of cell migration

20702524

TgeneRET

GO:0033619

membrane protein proteolysis

21357690

TgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

TgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

TgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check buttonFusion gene breakpoints across PRKAR1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4papilary thyroid carcinomaL03357PRKAR1Achr17

66522054

RETchr10

43612031
ChimerKB3..PRKAR1Achr17

66522053

+RETchr10

43612031

+
ChiTaRS5.0N/AL03357PRKAR1Achr17

66522054

+RETchr10

43612031

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358598PRKAR1Achr1766522053+ENST00000355710RETchr1043612031+41168251172033638
ENST00000358598PRKAR1Achr1766522053+ENST00000340058RETchr1043612031+26588251171907596
ENST00000392711PRKAR1Achr1766522053+ENST00000355710RETchr1043612031+41838921842100638
ENST00000392711PRKAR1Achr1766522053+ENST00000340058RETchr1043612031+27258921841974596
ENST00000589228PRKAR1Achr1766522053+ENST00000355710RETchr1043612031+4127836562044662
ENST00000589228PRKAR1Achr1766522053+ENST00000340058RETchr1043612031+2669836561918620
ENST00000536854PRKAR1Achr1766522053+ENST00000355710RETchr1043612031+42379462052154649
ENST00000536854PRKAR1Achr1766522053+ENST00000340058RETchr1043612031+27799462052028607
ENST00000586397PRKAR1Achr1766522053+ENST00000355710RETchr1043612031+457812875282495655
ENST00000586397PRKAR1Achr1766522053+ENST00000340058RETchr1043612031+312012875282369613
ENST00000588188PRKAR1Achr1766522053+ENST00000355710RETchr1043612031+399970801916638
ENST00000588188PRKAR1Achr1766522053+ENST00000340058RETchr1043612031+254170801790596
ENST00000358598PRKAR1Achr1766522054ENST00000355710RETchr104361203141168251172033638
ENST00000358598PRKAR1Achr1766522054ENST00000340058RETchr104361203126588251171907596
ENST00000392711PRKAR1Achr1766522054ENST00000355710RETchr104361203141838921842100638
ENST00000392711PRKAR1Achr1766522054ENST00000340058RETchr104361203127258921841974596
ENST00000589228PRKAR1Achr1766522054ENST00000355710RETchr10436120314127836562044662
ENST00000589228PRKAR1Achr1766522054ENST00000340058RETchr10436120312669836561918620
ENST00000536854PRKAR1Achr1766522054ENST00000355710RETchr104361203142379462052154649
ENST00000536854PRKAR1Achr1766522054ENST00000340058RETchr104361203127799462052028607
ENST00000586397PRKAR1Achr1766522054ENST00000355710RETchr1043612031457812875282495655
ENST00000586397PRKAR1Achr1766522054ENST00000340058RETchr1043612031312012875282369613
ENST00000588188PRKAR1Achr1766522054ENST00000355710RETchr1043612031399970801916638
ENST00000588188PRKAR1Achr1766522054ENST00000340058RETchr1043612031254170801790596

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358598ENST00000355710PRKAR1Achr1766522054RETchr10436120310.0014130150.998587
ENST00000358598ENST00000340058PRKAR1Achr1766522054RETchr10436120310.0044381370.99556184
ENST00000392711ENST00000355710PRKAR1Achr1766522054RETchr10436120310.0015014780.99849856
ENST00000392711ENST00000340058PRKAR1Achr1766522054RETchr10436120310.0045484880.9954515
ENST00000589228ENST00000355710PRKAR1Achr1766522054RETchr10436120310.0014502880.99854964
ENST00000589228ENST00000340058PRKAR1Achr1766522054RETchr10436120310.0044721430.9955278
ENST00000536854ENST00000355710PRKAR1Achr1766522054RETchr10436120310.0013383430.99866164
ENST00000536854ENST00000340058PRKAR1Achr1766522054RETchr10436120310.0039679270.99603206
ENST00000586397ENST00000355710PRKAR1Achr1766522054RETchr10436120310.0009353560.9990646
ENST00000586397ENST00000340058PRKAR1Achr1766522054RETchr10436120310.0020618470.9979381
ENST00000588188ENST00000355710PRKAR1Achr1766522054RETchr10436120310.0013312660.9986688
ENST00000588188ENST00000340058PRKAR1Achr1766522054RETchr10436120310.0039509230.9960491

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>68664_68664_1_PRKAR1A-RET_PRKAR1A_chr17_66522053_ENST00000358598_RET_chr10_43612031_ENST00000340058_length(amino acids)=596AA_BP=236
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPV
VKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL
KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS
SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDH
IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYL

--------------------------------------------------------------

>68664_68664_2_PRKAR1A-RET_PRKAR1A_chr17_66522053_ENST00000358598_RET_chr10_43612031_ENST00000355710_length(amino acids)=638AA_BP=236
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPV
VKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL
KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS
SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDH
IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYL
DLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAA

--------------------------------------------------------------

>68664_68664_3_PRKAR1A-RET_PRKAR1A_chr17_66522053_ENST00000392711_RET_chr10_43612031_ENST00000340058_length(amino acids)=596AA_BP=236
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPV
VKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL
KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS
SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDH
IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYL

--------------------------------------------------------------

>68664_68664_4_PRKAR1A-RET_PRKAR1A_chr17_66522053_ENST00000392711_RET_chr10_43612031_ENST00000355710_length(amino acids)=638AA_BP=236
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPV
VKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL
KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS
SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDH
IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYL
DLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAA

--------------------------------------------------------------

>68664_68664_5_PRKAR1A-RET_PRKAR1A_chr17_66522053_ENST00000536854_RET_chr10_43612031_ENST00000340058_length(amino acids)=607AA_BP=247
MTSAPVSAERTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSRE
DEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGD
EGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKTLGEGEF
GKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPG
YLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPV
KWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL

--------------------------------------------------------------

>68664_68664_6_PRKAR1A-RET_PRKAR1A_chr17_66522053_ENST00000536854_RET_chr10_43612031_ENST00000355710_length(amino acids)=649AA_BP=247
MTSAPVSAERTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSRE
DEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGD
EGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKTLGEGEF
GKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPG
YLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPV
KWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL
EKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSV

--------------------------------------------------------------

>68664_68664_7_PRKAR1A-RET_PRKAR1A_chr17_66522053_ENST00000586397_RET_chr10_43612031_ENST00000340058_length(amino acids)=613AA_BP=253
MLYSLYKHVCVFFSQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGT
RTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGET
VIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKT
LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRES
RKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRS
QGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFA

--------------------------------------------------------------

>68664_68664_8_PRKAR1A-RET_PRKAR1A_chr17_66522053_ENST00000586397_RET_chr10_43612031_ENST00000355710_length(amino acids)=655AA_BP=253
MLYSLYKHVCVFFSQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGT
RTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGET
VIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKT
LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRES
RKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRS
QGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFA
DISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPR

--------------------------------------------------------------

>68664_68664_9_PRKAR1A-RET_PRKAR1A_chr17_66522053_ENST00000588188_RET_chr10_43612031_ENST00000340058_length(amino acids)=596AA_BP=236
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPV
VKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL
KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS
SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDH
IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYL

--------------------------------------------------------------

>68664_68664_10_PRKAR1A-RET_PRKAR1A_chr17_66522053_ENST00000588188_RET_chr10_43612031_ENST00000355710_length(amino acids)=638AA_BP=236
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPV
VKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL
KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS
SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDH
IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYL
DLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAA

--------------------------------------------------------------

>68664_68664_11_PRKAR1A-RET_PRKAR1A_chr17_66522053_ENST00000589228_RET_chr10_43612031_ENST00000340058_length(amino acids)=620AA_BP=260
MRELGTPPPRTRSLAPAAARPQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQ
NLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSV
SFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRK
NLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSL
RGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE
DSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEP

--------------------------------------------------------------

>68664_68664_12_PRKAR1A-RET_PRKAR1A_chr17_66522053_ENST00000589228_RET_chr10_43612031_ENST00000355710_length(amino acids)=662AA_BP=260
MRELGTPPPRTRSLAPAAARPQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQ
NLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSV
SFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRK
NLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSL
RGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE
DSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEP
DKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADG

--------------------------------------------------------------

>68664_68664_13_PRKAR1A-RET_PRKAR1A_chr17_66522054_ENST00000358598_RET_chr10_43612031_ENST00000340058_length(amino acids)=596AA_BP=236
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPV
VKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL
KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS
SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDH
IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYL

--------------------------------------------------------------

>68664_68664_14_PRKAR1A-RET_PRKAR1A_chr17_66522054_ENST00000358598_RET_chr10_43612031_ENST00000355710_length(amino acids)=638AA_BP=236
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPV
VKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL
KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS
SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDH
IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYL
DLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAA

--------------------------------------------------------------

>68664_68664_15_PRKAR1A-RET_PRKAR1A_chr17_66522054_ENST00000392711_RET_chr10_43612031_ENST00000340058_length(amino acids)=596AA_BP=236
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPV
VKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL
KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS
SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDH
IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYL

--------------------------------------------------------------

>68664_68664_16_PRKAR1A-RET_PRKAR1A_chr17_66522054_ENST00000392711_RET_chr10_43612031_ENST00000355710_length(amino acids)=638AA_BP=236
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPV
VKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL
KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS
SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDH
IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYL
DLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAA

--------------------------------------------------------------

>68664_68664_17_PRKAR1A-RET_PRKAR1A_chr17_66522054_ENST00000536854_RET_chr10_43612031_ENST00000340058_length(amino acids)=607AA_BP=247
MTSAPVSAERTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSRE
DEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGD
EGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKTLGEGEF
GKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPG
YLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPV
KWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL

--------------------------------------------------------------

>68664_68664_18_PRKAR1A-RET_PRKAR1A_chr17_66522054_ENST00000536854_RET_chr10_43612031_ENST00000355710_length(amino acids)=649AA_BP=247
MTSAPVSAERTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSRE
DEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGD
EGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKTLGEGEF
GKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPG
YLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPV
KWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL
EKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSV

--------------------------------------------------------------

>68664_68664_19_PRKAR1A-RET_PRKAR1A_chr17_66522054_ENST00000586397_RET_chr10_43612031_ENST00000340058_length(amino acids)=613AA_BP=253
MLYSLYKHVCVFFSQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGT
RTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGET
VIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKT
LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRES
RKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRS
QGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFA

--------------------------------------------------------------

>68664_68664_20_PRKAR1A-RET_PRKAR1A_chr17_66522054_ENST00000586397_RET_chr10_43612031_ENST00000355710_length(amino acids)=655AA_BP=253
MLYSLYKHVCVFFSQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGT
RTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGET
VIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKT
LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRES
RKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRS
QGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFA
DISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPR

--------------------------------------------------------------

>68664_68664_21_PRKAR1A-RET_PRKAR1A_chr17_66522054_ENST00000588188_RET_chr10_43612031_ENST00000340058_length(amino acids)=596AA_BP=236
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPV
VKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL
KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS
SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDH
IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYL

--------------------------------------------------------------

>68664_68664_22_PRKAR1A-RET_PRKAR1A_chr17_66522054_ENST00000588188_RET_chr10_43612031_ENST00000355710_length(amino acids)=638AA_BP=236
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPV
VKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQG
ETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL
KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS
SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDH
IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYL
DLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAA

--------------------------------------------------------------

>68664_68664_23_PRKAR1A-RET_PRKAR1A_chr17_66522054_ENST00000589228_RET_chr10_43612031_ENST00000340058_length(amino acids)=620AA_BP=260
MRELGTPPPRTRSLAPAAARPQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQ
NLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSV
SFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRK
NLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSL
RGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE
DSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEP

--------------------------------------------------------------

>68664_68664_24_PRKAR1A-RET_PRKAR1A_chr17_66522054_ENST00000589228_RET_chr10_43612031_ENST00000355710_length(amino acids)=662AA_BP=260
MRELGTPPPRTRSLAPAAARPQRTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQ
NLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSV
SFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRK
NLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSL
RGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE
DSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEP
DKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:66522054/chr10:43612031)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRKAR1A

P10644

RET

RTL1

FUNCTION: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:26405036}.1358

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000358598+71196_100236.0382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000392711+71196_100236.0382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000536854+81296_100236.0382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000586397+61096_100236.0382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000589228+71196_100236.0382.0MotifNote=Pseudophosphorylation motif
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000358598+7111_136236.0382.0RegionNote=Dimerization and phosphorylation
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000392711+7111_136236.0382.0RegionNote=Dimerization and phosphorylation
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000536854+8121_136236.0382.0RegionNote=Dimerization and phosphorylation
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000586397+6101_136236.0382.0RegionNote=Dimerization and phosphorylation
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000589228+7111_136236.0382.0RegionNote=Dimerization and phosphorylation
TgeneRETchr17:66522054chr10:43612031ENST000003400581019724_1016712.01073.0DomainProtein kinase
TgeneRETchr17:66522054chr10:43612031ENST000003557101020724_1016712.01115.0DomainProtein kinase
TgeneRETchr17:66522054chr10:43612031ENST000003400581019730_738712.01073.0Nucleotide bindingATP
TgeneRETchr17:66522054chr10:43612031ENST000003557101020730_738712.01115.0Nucleotide bindingATP
TgeneRETchr17:66522054chr10:43612031ENST000003400581019805_807712.01073.0RegionNote=Inhibitors binding
TgeneRETchr17:66522054chr10:43612031ENST000003557101020805_807712.01115.0RegionNote=Inhibitors binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000358598+711137_254236.0382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000358598+711255_381236.0382.0Nucleotide bindingNote=cAMP 2
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000392711+711137_254236.0382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000392711+711255_381236.0382.0Nucleotide bindingNote=cAMP 2
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000536854+812137_254236.0382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000536854+812255_381236.0382.0Nucleotide bindingNote=cAMP 2
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000586397+610137_254236.0382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000586397+610255_381236.0382.0Nucleotide bindingNote=cAMP 2
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000589228+711137_254236.0382.0Nucleotide bindingNote=cAMP 1
HgenePRKAR1Achr17:66522054chr10:43612031ENST00000589228+711255_381236.0382.0Nucleotide bindingNote=cAMP 2
TgeneRETchr17:66522054chr10:43612031ENST000003400581019168_272712.01073.0DomainCadherin
TgeneRETchr17:66522054chr10:43612031ENST000003557101020168_272712.01115.0DomainCadherin
TgeneRETchr17:66522054chr10:43612031ENST00000340058101929_635712.01073.0Topological domainExtracellular
TgeneRETchr17:66522054chr10:43612031ENST000003400581019658_1114712.01073.0Topological domainCytoplasmic
TgeneRETchr17:66522054chr10:43612031ENST00000355710102029_635712.01115.0Topological domainExtracellular
TgeneRETchr17:66522054chr10:43612031ENST000003557101020658_1114712.01115.0Topological domainCytoplasmic
TgeneRETchr17:66522054chr10:43612031ENST000003400581019636_657712.01073.0TransmembraneHelical
TgeneRETchr17:66522054chr10:43612031ENST000003557101020636_657712.01115.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (467) >>>467.pdbFusion protein BP residue: 236
CIF file (467) >>>467.cif		PRKAR1Achr1766522053+RETchr1043612031+
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFL
REYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAI
SAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIF
DAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSF
GELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVL
GKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEF
NVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGY
LGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLA
ARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDH
IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNC
SEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDS
596
3D view using mol* of 467 (AA BP:236)
PDB file (479) >>>479.pdbFusion protein BP residue: 247
CIF file (479) >>>479.cif		PRKAR1Achr1766522053+RETchr1043612031+
MTSAPVSAERTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLC
TARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNP
VVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFS
HLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNE
WATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDP
KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENAS
PSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGF
LRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPV
KWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK
TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDY
LDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRI
607
3D view using mol* of 479 (AA BP:247)
PDB file (483) >>>483.pdbFusion protein BP residue: 253
CIF file (483) >>>483.cif		PRKAR1Achr1766522053+RETchr1043612031+
MLYSLYKHVCVFFSQRTMESGSTAASEEARSLRECELYVQKHNIQALLKD
SIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEIS
PPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIE
KNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETD
VYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRR
ILMEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKM
LKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKY
GSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQIS
QGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRS
QGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPER
LFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM
VKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIEN
613
3D view using mol* of 483 (AA BP:253)
PDB file (493) >>>493.pdbFusion protein BP residue: 260
CIF file (493) >>>493.cif		PRKAR1Achr1766522053+RETchr1043612031+
MRELGTPPPRTRSLAPAAARPQRTMESGSTAASEEARSLRECELYVQKHN
IQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTD
SREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMA
ALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYV
IDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGI
DRDSYRRILMEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGY
TTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLL
IVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLI
SFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE
DSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPY
PGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADIS
KDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRAL
620
3D view using mol* of 493 (AA BP:260)
PDB file (509) >>>509.pdbFusion protein BP residue: 236
CIF file (509) >>>509.cif		PRKAR1Achr1766522053+RETchr1043612031+
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFL
REYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAI
SAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIF
DAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSF
GELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDPKWEFPRKNLVL
GKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEF
NVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGY
LGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLA
ARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDH
IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNC
SEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDS
LIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVP
638
3D view using mol* of 509 (AA BP:236)
PDB file (523) >>>523.pdbFusion protein BP residue: 247
CIF file (523) >>>523.cif		PRKAR1Achr1766522053+RETchr1043612031+
MTSAPVSAERTMESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLC
TARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNP
VVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFS
HLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNE
WATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMEDP
KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENAS
PSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGF
LRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL
AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPV
KWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK
TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDY
LDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMS
649
3D view using mol* of 523 (AA BP:247)
PDB file (533) >>>533.pdbFusion protein BP residue: 253
CIF file (533) >>>533.cif		PRKAR1Achr1766522053+RETchr1043612031+
MLYSLYKHVCVFFSQRTMESGSTAASEEARSLRECELYVQKHNIQALLKD
SIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEIS
PPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIE
KNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETD
VYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRR
ILMEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKM
LKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKY
GSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQIS
QGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRS
QGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPER
LFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM
VKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIEN
KLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLM
655
3D view using mol* of 533 (AA BP:253)
PDB file (541) >>>541.pdbFusion protein BP residue: 260
CIF file (541) >>>541.cif		PRKAR1Achr1766522053+RETchr1043612031+
MRELGTPPPRTRSLAPAAARPQRTMESGSTAASEEARSLRECELYVQKHN
IQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTD
SREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMA
ALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYV
IDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGI
DRDSYRRILMEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGY
TTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLL
IVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLI
SFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE
DSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPY
PGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADIS
KDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRAL
PSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLS
662
3D view using mol* of 541 (AA BP:260)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PRKAR1A_pLDDT.png
all structure
all structure
RET_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PRKAR1A_RET_467_pLDDT.png (AA BP:236)
all structure
PRKAR1A_RET_467_pLDDT_and_active_sites.png (AA BP:236)
all structure
PRKAR1A_RET_467_violinplot.png (AA BP:236)
all structure
PRKAR1A_RET_479_pLDDT.png (AA BP:247)
all structure
PRKAR1A_RET_479_pLDDT_and_active_sites.png (AA BP:247)
all structure
PRKAR1A_RET_479_violinplot.png (AA BP:247)
all structure
PRKAR1A_RET_483_pLDDT.png (AA BP:253)
all structure
PRKAR1A_RET_483_pLDDT_and_active_sites.png (AA BP:253)
all structure
PRKAR1A_RET_483_violinplot.png (AA BP:253)
all structure
PRKAR1A_RET_493_pLDDT.png (AA BP:260)
all structure
PRKAR1A_RET_493_pLDDT_and_active_sites.png (AA BP:260)
all structure
PRKAR1A_RET_493_violinplot.png (AA BP:260)
all structure
PRKAR1A_RET_509_pLDDT.png (AA BP:236)
all structure
PRKAR1A_RET_509_pLDDT_and_active_sites.png (AA BP:236)
all structure
PRKAR1A_RET_509_violinplot.png (AA BP:236)
all structure
PRKAR1A_RET_523_pLDDT.png (AA BP:247)
all structure
PRKAR1A_RET_523_pLDDT_and_active_sites.png (AA BP:247)
all structure
PRKAR1A_RET_523_violinplot.png (AA BP:247)
all structure
PRKAR1A_RET_533_pLDDT.png (AA BP:253)
all structure
PRKAR1A_RET_533_pLDDT_and_active_sites.png (AA BP:253)
all structure
PRKAR1A_RET_533_violinplot.png (AA BP:253)
all structure
PRKAR1A_RET_541_pLDDT.png (AA BP:260)
all structure
PRKAR1A_RET_541_pLDDT_and_active_sites.png (AA BP:260)
all structure
PRKAR1A_RET_541_violinplot.png (AA BP:260)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
PRKAR1A_RET_467.png
all structure
PRKAR1A_RET_479.png
all structure
PRKAR1A_RET_483.png
all structure
PRKAR1A_RET_493.png
all structure
PRKAR1A_RET_509.png
all structure
PRKAR1A_RET_523.png
all structure
PRKAR1A_RET_533.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
4671.09641251.1515300.4680.47480.75680.95831.64590.74422.21161.5353Chain A: 254,255,256,257,258,259,260,262,280,282,2
99,303,312,326,328,329,330,331,332,334,335,402,403
,405,415,416
4791.04874281.08031406.9860.53170.73830.940.86550.92850.93210.822Chain A: 140,143,144,145,146,147,148,149,150,151,1
52,157,161,176,185,195,203,205,208,209,210,211,212
,213,214,215,220,221,222,223,224,226,265,266,267,2
68,269,270,271,272,273,291,293,295,301,302,303,305
,306,307,310,312,313,314,316,323,337,339,341,342,3
45,346,403,404,405,406,408,409,413,414,416,426,427
,429,430,432,433,434,435,437,439,440,441,442,443,4
44,446,447,448,449,463
4831.0931301.151293.2650.4780.7460.9251.6180.7242.2351.457Chain A: 271,272,273,274,275,276,277,278,279,297,2
99,316,320,329,343,345,346,347,348,349,351,352,419
,420,422,432,433
4931.0771111.126307.6710.5240.7420.8991.4190.7941.7880.993Chain A: 278,279,280,281,283,284,286,304,306,323,3
27,336,352,353,354,355,356,358,359,426,427,429,439
,440
5091.0026031.0041850.1420.5610.7010.8910.5231.0920.4790.993Chain A: 104,105,106,107,110,113,115,129,132,133,1
34,135,136,138,139,140,141,142,144,145,146,148,150
,165,184,191,192,194,195,196,197,198,199,200,201,2
02,203,204,209,210,211,212,213,215,232,233,234,237
,238,239,240,241,242,243,244,245,246,254,255,256,2
57,258,259,260,262,280,282,289,290,291,292,294,295
,299,301,303,304,305,306,307,312,313,314,318,320,3
21,322,326,328,329,330,331,332,334,335,392,395,397
,402,403,405,415,416,419,421,422,423,424,425,426,4
28,429,430,431,432,433,435,436,437,438
5231.0445870.991791.4890.480.7631.0170.4651.2520.3710.747Chain A: 138,140,141,142,143,144,145,146,147,148,1
49,150,151,152,153,154,157,161,176,189,190,195,197
,203,205,206,207,208,209,210,211,212,213,214,215,2
20,221,222,223,224,226,265,267,268,269,270,271,273
,291,293,296,300,301,302,303,305,306,307,309,310,3
14,316,323,339,340,341,342,348,352,403,408,409,411
,413,414,416,426,427,428,429,430,432,433,434,435,4
36,437,439,440,441,442,443,444,446,447,448,449,450
,451,452,478,485,486,488,489,490,491,492,631,634,6
35,636,637,638,640,641,642
5331.1031191.145297.7240.3990.7911.0371.6990.8272.0541.139Chain A: 271,272,273,274,276,277,279,297,299,316,3
20,329,343,345,346,347,348,349,351,352,419,420,422
,432,433
5411.0211131.063477.4560.6320.6810.8290.6240.8750.7140.418Chain A: 395,397,398,401,402,404,405,433,434,435,5
54,557,558,560,561,564,602,603,604,605,606,607,608


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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
467ZINC000019632917DB00475Chlordiazepoxide-9.24018-9.28808
467BaricitinibDB00475-8.31886-8.31886
467ZINC000022059930DB01155Gemifloxacin-8.19933-8.24023
467ZINC000003938686DB09073Palbociclib-7.79101-8.19791
467ZINC000008214418DB09135Ioxilan-8.0831-8.0831
467ZINC000013537284DB00969Alosetron-6.92779-7.83109
467ZINC000003787097DB06771Besifloxacin-6.43591-7.76901
467ZINC000022059926DB01155Gemifloxacin-7.6697-7.7106
467ZINC000003830944DB01362Iohexol-7.57651-7.57651
467ZINC000011681534DB04861Nebivolol-7.50378-7.52358
467ZINC000001536779DB00476Duloxetine-7.4662-7.4669
467ZINC000000001735DB00350Minoxidil-7.45511-7.45511
467ZINC000001530636DB00927Famotidine-6.53008-7.44498
467ZINC000000897256DB00983Formoterol-5.12805-7.43595
467ZINC000003827556DB11943Delafloxacin-5.86931-7.43511
467ZINC000008577218DB00158Folic acid-6.2912-7.4326
467ZINC000003830960DB09156Iopromide-7.3709-7.3709
467ZINC000095619105DB00353Methylergometrine-6.72056-7.34826
467ZINC000004098633DB11263Polydatin-7.32373-7.32373
467ZINC000001530775DB00738Pentamidine-7.30548-7.30548

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000019632917DB00475ChlordiazepoxideSmall moleculeCNC1=NC2=C(C=C(Cl)C=C2)C(C2=CC=CC=C2)=[N+]([O-])C1Approved|Illicit|Investigational
ZINC000022059930DB01155GemifloxacinSmall moleculeCON=C1/CN(CC1CN)C1=NC2=C(C=C1F)C(=O)C(=CN2C1CC1)C(O)=OApproved|Investigational
ZINC000003938686DB09073PalbociclibSmall moleculeCC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N3CCNCC3)N=C2N(C2CCCC2)C1=OApproved|Investigational
ZINC000008214418DB09135IoxilanSmall moleculeCC(=O)N(CC(O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCCO)=C1IApproved
ZINC000013537284DB00969AlosetronSmall moleculeCN1C2=C(C3=CC=CC=C13)C(=O)N(CC1=C(C)NC=N1)CC2Approved|Withdrawn
ZINC000003787097DB06771BesifloxacinSmall moleculeN[C@@H]1CCCCN(C1)C1=C(F)C=C2C(=O)C(=CN(C3CC3)C2=C1Cl)C(O)=OApproved
ZINC000011681534DB04861NebivololSmall moleculeOC(CNCC(O)C1CCC2=C(O1)C=CC(F)=C2)C1CCC2=C(O1)C=CC(F)=C2Approved|Investigational
ZINC000001536779DB00476DuloxetineSmall moleculeCNCC[C@H](OC1=CC=CC2=CC=CC=C12)C1=CC=CS1Approved
ZINC000000001735DB00350MinoxidilSmall moleculeNC1=CC(=NC(N)=[N+]1[O-])N1CCCCC1Approved|Investigational
ZINC000001530636DB00927FamotidineSmall moleculeNC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1Approved
ZINC000003827556DB11943DelafloxacinSmall moleculeNC1=NC(N2C=C(C(O)=O)C(=O)C3=CC(F)=C(N4CC(O)C4)C(Cl)=C23)=C(F)C=C1FApproved|Investigational
ZINC000008577218DB00158Folic acidSmall moleculeNC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=CN=C2N1Approved|Nutraceutical|Vet_approved
ZINC000095619105DB00353MethylergometrineSmall molecule[H][C@@]12CC3=CNC4=CC=CC(=C34)C1=C[C@H](CN2C)C(=O)N[C@@H](CC)COApproved
ZINC000004098633DB11263PolydatinSmall moleculeOC[C@H]1O[C@@H](OC2=CC(C=CC3=CC=C(O)C=C3)=CC(O)=C2)[C@H](O)[C@@H](O)[C@@H]1OApproved
ZINC000001530775DB00738PentamidineSmall moleculeNC(=N)C1=CC=C(OCCCCCOC2=CC=C(C=C2)C(N)=N)C=C1Approved|Investigational

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000019632917299.7594.645553.04137.02264.707279.78871.524941.819138.565310000
ZINC000019632917299.7595.502549.003118.96574.766283.8271.453935.577138.408310000
ZINC000022059930389.3855.771675.499333.722232.90267.77341.1011199.67128.79.049236.48201
ZINC000022059930389.3857.083660.215323.57227.18268.27141.1911181.71728.79.157237.11301
ZINC000003938686447.5398.82766.315477.598137.176151.54101402.5882118.081376.62700
ZINC000003938686447.5398.648773.964490.638134.585148.74101410.0512118.181377.38600
ZINC000003938686447.5399.527761.155473.791137.885149.47801397.3732118.061376.300
ZINC000008214418791.1161.945763.111318.983317.0489.77117.311418.936716.59.19911.20931
ZINC000013537284294.35511.018558.659261.63964.423232.5970975.98514.58.467310000
ZINC000013537284294.3552.688556.854260.96665.507230.3810971.56114.58.221310000
ZINC000013537284294.35511.062555.086259.10266.238229.7460970.70114.58.471310000
ZINC000003787097393.8454.658626.791306.654201.43960.43658.2621137.68725.58.886248.67901
ZINC000003787097393.8458.875614.969305.177195.95359.53854.3011129.72125.59.012249.49601
ZINC000022059926389.3855.386675.076333.398232.63867.9641.081199.52228.79.053236.53501
ZINC000022059926389.3854.357656.741321.575225.55768.44141.1671178.17628.79.183237.34601
ZINC000003830944821.1433.746800.499332.755343.8249.483114.4361490.981818.29.7011031
ZINC000011681534405.4412.335727.789280.70885.7267.62193.761272.95136.49.228395.43300
ZINC000011681534405.4416.385707.131273.32277.744262.30193.7651256.16536.49.073396.54300
ZINC000001536779297.4140.915589.154161.20524.056372.40131.4911019.20912.258.31310000
ZINC000000001735209.255.141437.436217.593169.97449.8690711.86443.57.733376.87300
ZINC000001530636337.4328.496521.83399.501273.3951.82697.115914.026798.5235.23410
ZINC000001530636337.43213.115494.303116.816261.31243.15673.019882.5675.58.82239.67810
ZINC000001530636337.4326.659521.267100.72277.97650.89391.678913.905798.611234.15111
ZINC000001530636337.43211.671559.823101.56332.16638.03588.062950.185798.602223.15711
ZINC000001530636337.4328.716590.73582.084369.40446.6192.637969.1575.58.538220.34511
ZINC000001530636337.4323.147583.852100.402354.87439.07989.497971.384798.705218.77711
ZINC000000897256344.415.264632.493247.284157.494227.71501135.04847.28.825370.83700
ZINC000000897256344.416.478644.939257.318179.642207.97901149.05747.28.565266.25100
ZINC000003827556440.7657.343641.991114.171269.717120.689137.4141132.35936.78.856257.44801
ZINC000003827556440.7659.028639.547117.652265.215120.459136.2211128.10136.79.031258.22101
ZINC000008577218441.40213.51755.446101.238451.657202.55101308.0746.2512.758.351021
ZINC000008577218441.40214.14754.923100.926451.592202.40501306.4516.2512.758.3021021
ZINC000008577218441.40214.323755.349100.67452.288202.39101307.5776.2512.758.3991021
ZINC000003830960791.11613.331796.713372.732270.92213.115139.9441454.391616.59.452212.86430
ZINC000095619105339.4366.831600.645317.592.61190.53501100.13736.28.178379.75600
ZINC000095619105339.43610.096604.175300.341117.817186.01601100.59436.28.245373.09800
ZINC000095619105339.4365.417629.729335.94894.395199.38601126.84236.27.973279.88201
ZINC000004098633390.3897.667669.829130.628272.364266.83701181.188610.758.482240.08510
ZINC000001530775340.4248.052698.011179.111218.326300.57401179.9564.58.662263.34410


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000019632917CNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=[N+]([O-])C10.1473206730.447326601
ZINC000022059930CO/N=C1CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)C[C@H]1CN0.0776115140.258972331
ZINC000003938686CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O0.1541407730.105977064
ZINC000008214418CC(=O)N(C[C@H](O)CO)c1c(I)c(C(=O)NCCO)c(I)c(C(=O)NC[C@H](O)CO)c1I0.0550759120.216199147
ZINC000013537284Cc1nc[nH]c1CN1CCc2c(c3ccccc3n2C)C1=O0.1673991990.254688426
ZINC000003787097N[C@@H]1CCCCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C10.1258950860.168671155
ZINC000022059926CO/N=C1CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)C[C@@H]1CN0.0776115140.258972331
ZINC000003830944CC(=O)N(C[C@@H](O)CO)c1c(I)c(C(=O)NC[C@H](O)CO)c(I)c(C(=O)NC[C@H](O)CO)c1I0.0423322430.211666342
ZINC000011681534O[C@H](CNC[C@@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@@H]1CCc2cc(F)ccc2O10.0555500820.198725964
ZINC000001536779CNCC[C@H](Oc1cccc2ccccc12)c1cccs10.1985804770.408385121
ZINC000000001735Nc1cc(N2CCCCC2)nc(N)[n+]1[O-]0.1297409460.395964399
ZINC000001530636N=C(N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs10.0885838660.372327259
ZINC000000897256COc1ccc(C[C@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc10.1338630780.246482573
ZINC000003827556Nc1nc(-n2cc(C(=O)O)c(=O)c3cc(F)c(N4CC(O)C4)c(Cl)c32)c(F)cc1F0.1372155140.181774775
ZINC000008577218Nc1nc(O)c2nc(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cnc2n10.1276881860.392534973
ZINC000003830960COCC(=O)Nc1c(I)c(C(=O)NC[C@@H](O)CO)c(I)c(C(=O)N(C)C[C@@H](O)CO)c1I0.0609495530.263153665
ZINC000095619105CC[C@@H](CO)NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C10.0594048910.283665454
ZINC000004098633OC[C@H]1O[C@@H](Oc2cc(O)cc(/C=C/c3ccc(O)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O0.0678823180.512213372
ZINC000001530775N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc10.370358210.393925825


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
PRKAR1APRKAR1B, AKAP1, MYO7A, AKAP10, C2orf88, PLEKHF2, PYCARD, NPRL2, UBE2M, NUAK1, MCRS1, PRKACA, PRKAR1A, AKAP4, ARFGEF2, ARFGEF1, EGFR, GRB2, PRKX, AKAP11, Rrp1b, GABARAPL1, WNK1, UBC, PJA2, CBS, NELL2, C2orf44, BAHD1, ZBED1, MAPK6, TAB1, ELAVL1, SLC2A4, CUL3, PATZ1, PRKACB, PRPF31, SAFB, HSP90AA4P, MEN1, SLC38A5, Akap7, SMURF1, PRPF40A, SMAD2, CDK2, CCNE1, RFC2, PPP1CA, NPM1, SOX2, HIVEP1, CAPN11, SETD7, SET, DYRK1B, DYRK1A, GSK3B, ARPC3, PFDN5, AGO2, AGO3, CEP250, RAF1, CUL7, CCDC8, ILK, MTOR, BTRC, STOML2, PRKACG, PALM2-AKAP2, AKAP3, GPR161, ANKRD26, FRMD5, IFI16, XPO1, VAPA, Prkacb, Prkar2a, Gsk3b, VAPB, PRKAR2B, IQCB1, YWHAZ, DPB3, TCD1, EGLN3, HRAS, KRAS, NRAS, RECQL4, MCL1, MAPK12, TK1, FGFR3, FABP4, AGPAT1, MAP3K5, SPHK2, CANX, RC3H2, PLK1, BIRC3, NFX1, AKAP7, RSPH3, SPG20, DTX1, C11orf49, AKAP5, FAM153B, FBXW8, OBSL1, ARAF, BAD, MAPK7, AKAP12, HSPA8, HSPB1, JUP, PGAM5, GRWD1, AP3S1, RPL6, HIST1H1C, CORO1B, KHDRBS1, ADRM1, HIGD1A, SLC25A11, ROCK1, MEPCE, HIST1H1E, DOCK4, HIGD1C, GNL3, RPL36A, RPL8, STK39, GTF3C5, BCCIP, PDCD2L, UHRF1, ZFP91, GATAD2B, DDX42, CCDC108, LLGL2, SUZ12, USP10, C1QBP, NAP1L1, PYCR1, S100A7A, S100A7, MCM3, GART, EPB41L2, RBFOX3, RBFOX2, RBFOX1, CAMSAP3, FAT1, KDELR1, CFL1, G6PD, SERPINH1, SNRNP40, MAGEB2, HLA-C, HLA-A, COQ6, NXF1, VPS29, GPX8, MOB2, ACACA, AHSA1, MGEA5, AP1G1, ADAM10, PRKCA, PRKCB, PRKCI, PRKCZ, PTK6, RPS6KA3, SH3GL3, ESR1, MAP1LC3B, CDCA5, TULP3, SREBF2, nsp8ab, PTP4A3, ASXL1, DNAJB6, DNAJC28, OGT, KLHL28, EIF1AX, SBNO1, METTL15, FYN, SH3PXD2B, PLCB3, PAXBP1, NBR1, CALCOCO2, SQSTM1,
RETSTAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26, Shc1, PIK3R1, FBXO7, NEDD4, SHANK2, LRRK1, PTK6, CTNNB1, SHC4, ERBB2, ADAM10, SPINT2, PCDH7, LRIG2, APP, GDNF, IGF1R, CLU, EPCAM, CDH2, TGFBR1, PTK7, FAT1, DHCR24, SMN1, PCDH19, NCSTN, CERS2, CHP1, FANCD2, ITM2C, SEL1L, PCDHGB5, CKB, NRP1, PLXNB2, NCK2, CTNND1, TULP3, PTPN1, NF2, CRKL, CAMLG, NUMB, BASP1, ROR2, NOTCH2, PTPN13, ANK3, RAB3GAP1, PEA15, LLGL1, GPRIN3, RAPH1, MARK2, CYFIP1, ARC, GPRIN1, ANKLE2, VRK2, MIB1, PHACTR4, UNC5B, TMEM57, SYAP1, FAF2, ERBB2IP, FAM129B, KIAA1715, PEAK1, VANGL2, BAIAP2, EPN1, NUMBL, PRKAR2A, GAB1, PTPRA, DDX39A, TIMP1, EPHB4, MANEA, SRY, RABAC1, LEMD3, TMEM214, PDZD8, GPR50, SMIM5, RNF149, SDF2L1, BMPR1A, PLEKHH3, ACVR2A,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PRKAR1Aall structure
RETall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PRKAR1A-RET


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PRKAR1A-RET


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRKAR1AC2607929Carney Complex, Type 110CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgenePRKAR1AC3276228ACRODYSOSTOSIS 1 WITH OR WITHOUT HORMONE RESISTANCE8CTD_human;GENOMICS_ENGLAND;UNIPROT
HgenePRKAR1AC0406810Carney Complex6CLINGEN;CTD_human;GENOMICS_ENGLAND
HgenePRKAR1AC0220659Acrodysostosis4CTD_human;GENOMICS_ENGLAND;ORPHANET
HgenePRKAR1AC0010481Cushing Syndrome2CTD_human
HgenePRKAR1AC1864846PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 1 (disorder)2CTD_human;GENOMICS_ENGLAND
HgenePRKAR1AC0001627Congenital adrenal hyperplasia1CTD_human
HgenePRKAR1AC0002170Alopecia1CTD_human
HgenePRKAR1AC0020456Hyperglycemia1CTD_human
HgenePRKAR1AC0021655Insulin Resistance1CTD_human
HgenePRKAR1AC0023487Acute Promyelocytic Leukemia1CTD_human;ORPHANET
HgenePRKAR1AC0026846Muscular Atrophy1CTD_human
HgenePRKAR1AC0028754Obesity1CTD_human
HgenePRKAR1AC0086873Pseudopelade1CTD_human
HgenePRKAR1AC0162311Androgenetic Alopecia1CTD_human
HgenePRKAR1AC0263477Female pattern alopecia (disorder)1CTD_human
HgenePRKAR1AC0270948Neurogenic Muscular Atrophy1CTD_human
HgenePRKAR1AC0920563Insulin Sensitivity1CTD_human
HgenePRKAR1AC1850635Atrial myxoma, familial1CTD_human;ORPHANET
HgenePRKAR1AC1854540Carney Complex, Type 21CTD_human
HgenePRKAR1AC1855520Hyperglycemia, Postprandial1CTD_human
HgenePRKAR1AC3553250ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE1CTD_human
HgenePRKAR1AC3887949Apparent mineralocorticoid excess1CTD_human
HgenePRKAR1AC4083212Alopecia, Male Pattern1CTD_human
HgenePRKAR1AC4304832Primary pigmented nodular adrenocortical disease1ORPHANET
HgenePRKAR1AC4721502Peripheral dysostosis1CTD_human
TgeneRETC1833921Familial medullary thyroid carcinoma23CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 116GENOMICS_ENGLAND;UNIPROT
TgeneRETC0025268Multiple Endocrine Neoplasia Type 2a15CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome12CLINGEN
TgeneRETC0025269Multiple Endocrine Neoplasia Type 2b10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC0238463Papillary thyroid carcinoma3CTD_human;ORPHANET
TgeneRETC1275808Congenital central hypoventilation3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRETC1859049CCHS WITH HIRSCHSPRUNG DISEASE3CTD_human;ORPHANET
TgeneRETC0009402Colorectal Carcinoma2CTD_human;UNIPROT
TgeneRETC0009404Colorectal Neoplasms2CTD_human
TgeneRETC0019569Hirschsprung Disease2CTD_human
TgeneRETC0027662Multiple Endocrine Neoplasia2CTD_human;GENOMICS_ENGLAND
TgeneRETC0085758Aganglionosis, Colonic2CTD_human
TgeneRETC0266294Unilateral agenesis of kidney2ORPHANET
TgeneRETC1257840Aganglionosis, Rectosigmoid Colon2CTD_human
TgeneRETC3661523Congenital Intestinal Aganglionosis2CTD_human
TgeneRETC0006413Burkitt Lymphoma1CTD_human
TgeneRETC0031511Pheochromocytoma1CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRETC0038220Status Epilepticus1CTD_human
TgeneRETC0040136Thyroid Neoplasm1CGI;CTD_human
TgeneRETC0151468Thyroid Gland Follicular Adenoma1CTD_human
TgeneRETC0206693Medullary carcinoma1CTD_human
TgeneRETC0238462Medullary carcinoma of thyroid1CGI;CTD_human
TgeneRETC0270823Petit mal status1CTD_human
TgeneRETC0311335Grand Mal Status Epilepticus1CTD_human
TgeneRETC0343640African Burkitt's lymphoma1CTD_human
TgeneRETC0393734Complex Partial Status Epilepticus1CTD_human
TgeneRETC0549473Thyroid carcinoma1CGI;CTD_human;UNIPROT
TgeneRETC0740340Amyloidosis, Familial1CTD_human
TgeneRETC0751522Status Epilepticus, Subclinical1CTD_human
TgeneRETC0751523Non-Convulsive Status Epilepticus1CTD_human
TgeneRETC0751524Simple Partial Status Epilepticus1CTD_human
TgeneRETC1257877Pheochromocytoma, Extra-Adrenal1CTD_human
TgeneRETC1609433Congenital absence of kidneys syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneRETC3501843Nonmedullary Thyroid Carcinoma1CTD_human
TgeneRETC3501844Familial Nonmedullary Thyroid Cancer1CTD_human
TgeneRETC4721444Burkitt Leukemia1CTD_human