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Fusion Protein:PRKCA-NCOR1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: PRKCA-NCOR1 | FusionPDB ID: 68711 | FusionGDB2.0 ID: 68711 | Hgene | Tgene | Gene symbol | PRKCA | NCOR1 | Gene ID | 5578 | 9611 |
| Gene name | protein kinase C alpha | nuclear receptor corepressor 1 | |
| Synonyms | AAG6|PKC-alpha|PKCA|PKCI+/-|PKCalpha|PRKACA | N-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoR | |
| Cytomap | 17q24.2 | 17p12-p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein kinase C alpha typePKC-Aaging-associated gene 6 | nuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1 | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | PICK1 | O75376 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000413366, ENST00000583361, | ENST00000395848, ENST00000583226, ENST00000268712, ENST00000395851, ENST00000395857, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 44 X 23 X 14=14168 | 14 X 14 X 6=1176 |
| # samples | 46 | 14 | |
| ** MAII score | log2(46/14168*10)=-4.94485844580754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/1176*10)=-3.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: PRKCA [Title/Abstract] AND NCOR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | PRKCA(64641629)-NCOR1(15943808), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | PRKCA-NCOR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PRKCA-NCOR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PRKCA-NCOR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PRKCA-NCOR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRKCA | GO:0006468 | protein phosphorylation | 10770950 |
| Hgene | PRKCA | GO:0035408 | histone H3-T6 phosphorylation | 20228790 |
| Hgene | PRKCA | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 20011604 |
| Hgene | PRKCA | GO:0090330 | regulation of platelet aggregation | 12724315 |
| Tgene | NCOR1 | GO:0046329 | negative regulation of JNK cascade | 11931768 |
| Fusion gene breakpoints across PRKCA (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across NCOR1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-VQ-A91Y | PRKCA | chr17 | 64641629 | + | NCOR1 | chr17 | 15943808 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000413366 | PRKCA | chr17 | 64641629 | + | ENST00000268712 | NCOR1 | chr17 | 15943808 | - | 4338 | 555 | 14 | 1198 | 394 |
| ENST00000413366 | PRKCA | chr17 | 64641629 | + | ENST00000395851 | NCOR1 | chr17 | 15943808 | - | 2091 | 555 | 14 | 1198 | 394 |
| ENST00000413366 | PRKCA | chr17 | 64641629 | + | ENST00000395857 | NCOR1 | chr17 | 15943808 | - | 1403 | 555 | 14 | 1198 | 394 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000413366 | ENST00000268712 | PRKCA | chr17 | 64641629 | + | NCOR1 | chr17 | 15943808 | - | 0.000169605 | 0.99983037 |
| ENST00000413366 | ENST00000395851 | PRKCA | chr17 | 64641629 | + | NCOR1 | chr17 | 15943808 | - | 0.000532926 | 0.9994671 |
| ENST00000413366 | ENST00000395857 | PRKCA | chr17 | 64641629 | + | NCOR1 | chr17 | 15943808 | - | 0.005996216 | 0.99400383 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >68711_68711_1_PRKCA-NCOR1_PRKCA_chr17_64641629_ENST00000413366_NCOR1_chr17_15943808_ENST00000268712_length(amino acids)=394AA_BP=180 MGGTMADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC PGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVT AAAQPGTEIFNLPAVTTSGSVSSRGHSFADPASNLGLEDIIRKALMGSFDDKVEDHGVVMSQPMGVVPGTANTSVVTSGETRREEGDPSP HSGGVCKPKLISKSNSRKSKSPIPGQGYLGTERPSSVSSVHSEGDYHRQTPGWAWEDRPSSTGSTQFPYNPLTMRMLSSTPPTPIACAPS -------------------------------------------------------------- >68711_68711_2_PRKCA-NCOR1_PRKCA_chr17_64641629_ENST00000413366_NCOR1_chr17_15943808_ENST00000395851_length(amino acids)=394AA_BP=180 MGGTMADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC PGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVT AAAQPGTEIFNLPAVTTSGSVSSRGHSFADPASNLGLEDIIRKALMGSFDDKVEDHGVVMSQPMGVVPGTANTSVVTSGETRREEGDPSP HSGGVCKPKLISKSNSRKSKSPIPGQGYLGTERPSSVSSVHSEGDYHRQTPGWAWEDRPSSTGSTQFPYNPLTMRMLSSTPPTPIACAPS -------------------------------------------------------------- >68711_68711_3_PRKCA-NCOR1_PRKCA_chr17_64641629_ENST00000413366_NCOR1_chr17_15943808_ENST00000395857_length(amino acids)=394AA_BP=180 MGGTMADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC PGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVT AAAQPGTEIFNLPAVTTSGSVSSRGHSFADPASNLGLEDIIRKALMGSFDDKVEDHGVVMSQPMGVVPGTANTSVVTSGETRREEGDPSP HSGGVCKPKLISKSNSRKSKSPIPGQGYLGTERPSSVSSVHSEGDYHRQTPGWAWEDRPSSTGSTQFPYNPLTMRMLSSTPPTPIACAPS -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:64641629/chr17:15943808) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRKCA | NCOR1 |
| 415 | FUNCTION: Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PRKCA | chr17:64641629 | chr17:15943808 | ENST00000413366 | + | 5 | 17 | 101_151 | 176.33333333333334 | 673.0 | Zinc finger | Phorbol-ester/DAG-type 2 |
| Hgene | PRKCA | chr17:64641629 | chr17:15943808 | ENST00000413366 | + | 5 | 17 | 36_86 | 176.33333333333334 | 673.0 | Zinc finger | Phorbol-ester/DAG-type 1 |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395848 | 0 | 19 | 174_216 | 0 | 915.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395848 | 0 | 19 | 299_328 | 0 | 915.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395848 | 0 | 19 | 501_557 | 0 | 915.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395848 | 0 | 19 | 1032_1035 | 0 | 915.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395848 | 0 | 19 | 1707_1712 | 0 | 915.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395848 | 0 | 19 | 1952_1963 | 0 | 915.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395848 | 0 | 19 | 58_64 | 0 | 915.0 | Compositional bias | Note=Poly-Gln | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395848 | 0 | 19 | 593_603 | 0 | 915.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395848 | 0 | 19 | 607_617 | 0 | 915.0 | Compositional bias | Note=Pro-rich | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395848 | 0 | 19 | 435_486 | 0 | 915.0 | Domain | SANT 1 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395848 | 0 | 19 | 623_674 | 0 | 915.0 | Domain | SANT 2 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 2263_2267 | 2226.3333333333335 | 2441.0 | Motif | Note=CORNR box 3 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395848 | 0 | 19 | 1933_1937 | 0 | 915.0 | Motif | Note=CORNR box 1 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395848 | 0 | 19 | 2055_2059 | 0 | 915.0 | Motif | Note=CORNR box 2 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395848 | 0 | 19 | 2263_2267 | 0 | 915.0 | Motif | Note=CORNR box 3 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 2263_2267 | 2123.3333333333335 | 2338.0 | Motif | Note=CORNR box 3 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395848 | 0 | 19 | 2032_2115 | 0 | 915.0 | Region | ID1 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395848 | 0 | 19 | 2212_2273 | 0 | 915.0 | Region | ID2 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 2212_2273 | 2123.3333333333335 | 2338.0 | Region | ID2 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PRKCA | chr17:64641629 | chr17:15943808 | ENST00000413366 | + | 5 | 17 | 158_275 | 176.33333333333334 | 673.0 | Domain | C2 |
| Hgene | PRKCA | chr17:64641629 | chr17:15943808 | ENST00000413366 | + | 5 | 17 | 339_597 | 176.33333333333334 | 673.0 | Domain | Protein kinase |
| Hgene | PRKCA | chr17:64641629 | chr17:15943808 | ENST00000413366 | + | 5 | 17 | 598_668 | 176.33333333333334 | 673.0 | Domain | AGC-kinase C-terminal |
| Hgene | PRKCA | chr17:64641629 | chr17:15943808 | ENST00000413366 | + | 5 | 17 | 345_353 | 176.33333333333334 | 673.0 | Nucleotide binding | ATP |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 174_216 | 2226.3333333333335 | 2441.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 299_328 | 2226.3333333333335 | 2441.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 501_557 | 2226.3333333333335 | 2441.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 174_216 | 2123.3333333333335 | 2338.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 299_328 | 2123.3333333333335 | 2338.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 501_557 | 2123.3333333333335 | 2338.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 1032_1035 | 2226.3333333333335 | 2441.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 1707_1712 | 2226.3333333333335 | 2441.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 1952_1963 | 2226.3333333333335 | 2441.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 58_64 | 2226.3333333333335 | 2441.0 | Compositional bias | Note=Poly-Gln | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 593_603 | 2226.3333333333335 | 2441.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 607_617 | 2226.3333333333335 | 2441.0 | Compositional bias | Note=Pro-rich | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 1032_1035 | 2123.3333333333335 | 2338.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 1707_1712 | 2123.3333333333335 | 2338.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 1952_1963 | 2123.3333333333335 | 2338.0 | Compositional bias | Note=Poly-Ser | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 58_64 | 2123.3333333333335 | 2338.0 | Compositional bias | Note=Poly-Gln | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 593_603 | 2123.3333333333335 | 2338.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 607_617 | 2123.3333333333335 | 2338.0 | Compositional bias | Note=Pro-rich | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 435_486 | 2226.3333333333335 | 2441.0 | Domain | SANT 1 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 623_674 | 2226.3333333333335 | 2441.0 | Domain | SANT 2 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 435_486 | 2123.3333333333335 | 2338.0 | Domain | SANT 1 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 623_674 | 2123.3333333333335 | 2338.0 | Domain | SANT 2 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 1933_1937 | 2226.3333333333335 | 2441.0 | Motif | Note=CORNR box 1 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 2055_2059 | 2226.3333333333335 | 2441.0 | Motif | Note=CORNR box 2 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 1933_1937 | 2123.3333333333335 | 2338.0 | Motif | Note=CORNR box 1 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 2055_2059 | 2123.3333333333335 | 2338.0 | Motif | Note=CORNR box 2 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 2032_2115 | 2226.3333333333335 | 2441.0 | Region | ID1 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 2212_2273 | 2226.3333333333335 | 2441.0 | Region | ID2 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 2032_2115 | 2123.3333333333335 | 2338.0 | Region | ID1 |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| PRKCA | |
| NCOR1 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 1501_2440 | 2226.3333333333335 | 2441.0 | C1D | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 1501_2440 | 2123.3333333333335 | 2338.0 | C1D | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 988_1816 | 2226.3333333333335 | 2441.0 | ETO | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 988_1816 | 2123.3333333333335 | 2338.0 | ETO | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 254_312 | 2226.3333333333335 | 2441.0 | SIN3A/B | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 254_312 | 2123.3333333333335 | 2338.0 | SIN3A/B | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000268712 | 41 | 46 | 1_373 | 2226.3333333333335 | 2441.0 | ZBTB33 and HEXIM1 | |
| Tgene | NCOR1 | chr17:64641629 | chr17:15943808 | ENST00000395851 | 40 | 45 | 1_373 | 2123.3333333333335 | 2338.0 | ZBTB33 and HEXIM1 |
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Related Drugs to PRKCA-NCOR1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to PRKCA-NCOR1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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