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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PRMT2-WRB

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PRMT2-WRB
	FusionPDB ID: 68926
	FusionGDB2.0 ID: 68926
		Hgene	Tgene
	Gene symbol	PRMT2	WRB
	Gene ID	3275	7485
	Gene name	protein arginine methyltransferase 2	guided entry of tail-anchored proteins factor 1
	Synonyms	HRMT1L1	CHD5\|WRB
	Cytomap	21q22.3	21q22.2
	Type of gene	protein-coding	protein-coding
	Description	protein arginine N-methyltransferase 2HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1HMT1 hnRNP methyltransferase-like 1PRMT2 alphaPRMT2 betaPRMT2 gammahistone-arginine N-methyltransferase PRMT2	tail-anchored protein insertion receptor WRBcongenital heart disease 5 proteintryptophan rich basic protein
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000491389, ENST00000291705, ENST00000334494, ENST00000355680, ENST00000397628, ENST00000397637, ENST00000397638, ENST00000440086, ENST00000451211, ENST00000458387,	ENST00000333781, ENST00000380708, ENST00000398753, ENST00000541890, ENST00000466787,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	11 X 9 X 7=693	8 X 7 X 6=336
	# samples	12	8
	** MAII score	log2(12/693*10)=-2.5298209465287 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PRMT2 [Title/Abstract] AND WRB [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PRMT2(48069651)-WRB(40762624), # samples:3
Anticipated loss of major functional domain due to fusion event.	PRMT2-WRB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PRMT2-WRB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PRMT2-WRB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PRMT2-WRB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PRMT2-WRB seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. PRMT2-WRB seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PRMT2-WRB seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PRMT2-WRB seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PRMT2	GO:0016571	histone methylation	19405910
Hgene	PRMT2	GO:0032088	negative regulation of NF-kappaB transcription factor activity	16648481
Hgene	PRMT2	GO:0045892	negative regulation of transcription, DNA-templated	16648481
Hgene	PRMT2	GO:0045893	positive regulation of transcription, DNA-templated	12039952
Hgene	PRMT2	GO:0060765	regulation of androgen receptor signaling pathway	17587566

Fusion gene breakpoints across PRMT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across WRB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-D6-A4ZB-01A	PRMT2	chr21	48069651	-	WRB	chr21	40762624	+
ChimerDB4	HNSC	TCGA-D6-A4ZB-01A	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+
ChimerDB4	HNSC	TCGA-D6-A4ZB	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000355680	PRMT2	chr21	48069651	+	ENST00000333781	WRB	chr21	40762624	+	2789	1416	762	1838	358
ENST00000355680	PRMT2	chr21	48069651	+	ENST00000541890	WRB	chr21	40762624	+	2675	1416	762	1832	356
ENST00000355680	PRMT2	chr21	48069651	+	ENST00000398753	WRB	chr21	40762624	+	2016	1416	762	1838	358
ENST00000355680	PRMT2	chr21	48069651	+	ENST00000380708	WRB	chr21	40762624	+	2789	1416	762	1838	358
ENST00000397638	PRMT2	chr21	48069651	+	ENST00000333781	WRB	chr21	40762624	+	2232	859	205	1281	358
ENST00000397638	PRMT2	chr21	48069651	+	ENST00000541890	WRB	chr21	40762624	+	2118	859	205	1275	356
ENST00000397638	PRMT2	chr21	48069651	+	ENST00000398753	WRB	chr21	40762624	+	1459	859	205	1281	358
ENST00000397638	PRMT2	chr21	48069651	+	ENST00000380708	WRB	chr21	40762624	+	2232	859	205	1281	358
ENST00000291705	PRMT2	chr21	48069651	+	ENST00000333781	WRB	chr21	40762624	+	2202	829	175	1251	358
ENST00000291705	PRMT2	chr21	48069651	+	ENST00000541890	WRB	chr21	40762624	+	2088	829	175	1245	356
ENST00000291705	PRMT2	chr21	48069651	+	ENST00000398753	WRB	chr21	40762624	+	1429	829	175	1251	358
ENST00000291705	PRMT2	chr21	48069651	+	ENST00000380708	WRB	chr21	40762624	+	2202	829	175	1251	358
ENST00000458387	PRMT2	chr21	48069651	+	ENST00000333781	WRB	chr21	40762624	+	2202	829	175	1251	358
ENST00000458387	PRMT2	chr21	48069651	+	ENST00000541890	WRB	chr21	40762624	+	2088	829	175	1245	356
ENST00000458387	PRMT2	chr21	48069651	+	ENST00000398753	WRB	chr21	40762624	+	1429	829	175	1251	358
ENST00000458387	PRMT2	chr21	48069651	+	ENST00000380708	WRB	chr21	40762624	+	2202	829	175	1251	358
ENST00000451211	PRMT2	chr21	48069651	+	ENST00000333781	WRB	chr21	40762624	+	2202	829	175	1251	358
ENST00000451211	PRMT2	chr21	48069651	+	ENST00000541890	WRB	chr21	40762624	+	2088	829	175	1245	356
ENST00000451211	PRMT2	chr21	48069651	+	ENST00000398753	WRB	chr21	40762624	+	1429	829	175	1251	358
ENST00000451211	PRMT2	chr21	48069651	+	ENST00000380708	WRB	chr21	40762624	+	2202	829	175	1251	358
ENST00000397637	PRMT2	chr21	48069651	+	ENST00000333781	WRB	chr21	40762624	+	2981	1608	954	2030	358
ENST00000397637	PRMT2	chr21	48069651	+	ENST00000541890	WRB	chr21	40762624	+	2867	1608	954	2024	356
ENST00000397637	PRMT2	chr21	48069651	+	ENST00000398753	WRB	chr21	40762624	+	2208	1608	954	2030	358
ENST00000397637	PRMT2	chr21	48069651	+	ENST00000380708	WRB	chr21	40762624	+	2981	1608	954	2030	358
ENST00000334494	PRMT2	chr21	48069651	+	ENST00000333781	WRB	chr21	40762624	+	2194	821	167	1243	358
ENST00000334494	PRMT2	chr21	48069651	+	ENST00000541890	WRB	chr21	40762624	+	2080	821	167	1237	356
ENST00000334494	PRMT2	chr21	48069651	+	ENST00000398753	WRB	chr21	40762624	+	1421	821	167	1243	358
ENST00000334494	PRMT2	chr21	48069651	+	ENST00000380708	WRB	chr21	40762624	+	2194	821	167	1243	358
ENST00000440086	PRMT2	chr21	48069651	+	ENST00000333781	WRB	chr21	40762624	+	2166	793	139	1215	358
ENST00000440086	PRMT2	chr21	48069651	+	ENST00000541890	WRB	chr21	40762624	+	2052	793	139	1209	356
ENST00000440086	PRMT2	chr21	48069651	+	ENST00000398753	WRB	chr21	40762624	+	1393	793	139	1215	358
ENST00000440086	PRMT2	chr21	48069651	+	ENST00000380708	WRB	chr21	40762624	+	2166	793	139	1215	358

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000355680	ENST00000333781	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.001860339	0.9981396
ENST00000355680	ENST00000541890	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.010939954	0.98906004
ENST00000355680	ENST00000398753	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.005555236	0.9944448
ENST00000355680	ENST00000380708	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.001860339	0.9981396
ENST00000397638	ENST00000333781	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.001395745	0.99860424
ENST00000397638	ENST00000541890	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.011277307	0.9887227
ENST00000397638	ENST00000398753	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.005845159	0.9941549
ENST00000397638	ENST00000380708	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.001395745	0.99860424
ENST00000291705	ENST00000333781	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.001415124	0.99858487
ENST00000291705	ENST00000541890	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.012625229	0.9873748
ENST00000291705	ENST00000398753	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.006600681	0.9933994
ENST00000291705	ENST00000380708	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.001415124	0.99858487
ENST00000458387	ENST00000333781	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.001415124	0.99858487
ENST00000458387	ENST00000541890	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.012625229	0.9873748
ENST00000458387	ENST00000398753	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.006600681	0.9933994
ENST00000458387	ENST00000380708	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.001415124	0.99858487
ENST00000451211	ENST00000333781	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.001415124	0.99858487
ENST00000451211	ENST00000541890	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.012625229	0.9873748
ENST00000451211	ENST00000398753	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.006600681	0.9933994
ENST00000451211	ENST00000380708	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.001415124	0.99858487
ENST00000397637	ENST00000333781	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.001877181	0.99812275
ENST00000397637	ENST00000541890	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.009085845	0.9909142
ENST00000397637	ENST00000398753	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.00539547	0.9946045
ENST00000397637	ENST00000380708	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.001877181	0.99812275
ENST00000334494	ENST00000333781	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.001349934	0.99865013
ENST00000334494	ENST00000541890	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.012513447	0.9874865
ENST00000334494	ENST00000398753	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.006568097	0.993432
ENST00000334494	ENST00000380708	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.001349934	0.99865013
ENST00000440086	ENST00000333781	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.001425095	0.99857485
ENST00000440086	ENST00000541890	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.012774116	0.98722583
ENST00000440086	ENST00000398753	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.006912514	0.9930875
ENST00000440086	ENST00000380708	PRMT2	chr21	48069651	+	WRB	chr21	40762624	+	0.001425095	0.99857485

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>68926_68926_1_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000291705_WRB_chr21_40762624_ENST00000333781_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_2_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000291705_WRB_chr21_40762624_ENST00000380708_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_3_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000291705_WRB_chr21_40762624_ENST00000398753_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_4_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000291705_WRB_chr21_40762624_ENST00000541890_length(amino acids)=356AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_5_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000334494_WRB_chr21_40762624_ENST00000333781_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_6_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000334494_WRB_chr21_40762624_ENST00000380708_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_7_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000334494_WRB_chr21_40762624_ENST00000398753_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_8_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000334494_WRB_chr21_40762624_ENST00000541890_length(amino acids)=356AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_9_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000355680_WRB_chr21_40762624_ENST00000333781_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_10_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000355680_WRB_chr21_40762624_ENST00000380708_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_11_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000355680_WRB_chr21_40762624_ENST00000398753_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_12_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000355680_WRB_chr21_40762624_ENST00000541890_length(amino acids)=356AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_13_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000397637_WRB_chr21_40762624_ENST00000333781_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_14_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000397637_WRB_chr21_40762624_ENST00000380708_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_15_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000397637_WRB_chr21_40762624_ENST00000398753_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_16_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000397637_WRB_chr21_40762624_ENST00000541890_length(amino acids)=356AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_17_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000397638_WRB_chr21_40762624_ENST00000333781_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_18_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000397638_WRB_chr21_40762624_ENST00000380708_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_19_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000397638_WRB_chr21_40762624_ENST00000398753_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_20_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000397638_WRB_chr21_40762624_ENST00000541890_length(amino acids)=356AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_21_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000440086_WRB_chr21_40762624_ENST00000333781_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_22_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000440086_WRB_chr21_40762624_ENST00000380708_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_23_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000440086_WRB_chr21_40762624_ENST00000398753_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_24_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000440086_WRB_chr21_40762624_ENST00000541890_length(amino acids)=356AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_25_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000451211_WRB_chr21_40762624_ENST00000333781_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_26_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000451211_WRB_chr21_40762624_ENST00000380708_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_27_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000451211_WRB_chr21_40762624_ENST00000398753_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_28_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000451211_WRB_chr21_40762624_ENST00000541890_length(amino acids)=356AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_29_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000458387_WRB_chr21_40762624_ENST00000333781_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_30_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000458387_WRB_chr21_40762624_ENST00000380708_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_31_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000458387_WRB_chr21_40762624_ENST00000398753_length(amino acids)=358AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

>68926_68926_32_PRMT2-WRB_PRMT2_chr21_48069651_ENST00000458387_WRB_chr21_40762624_ENST00000541890_length(amino acids)=356AA_BP=213
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE
YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV
LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:48069651/chr21:40762624)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PRMT2

chr21:48069651

chr21:40762624

ENST00000334494

30_89

218.0

285.0

Domain

SH3

Hgene

PRMT2

chr21:48069651

chr21:40762624

ENST00000355680

30_89

218.0

434.0

Domain

SH3

Hgene

PRMT2

chr21:48069651

chr21:40762624

ENST00000397637

30_89

218.0

434.0

Domain

SH3

Hgene

PRMT2

chr21:48069651

chr21:40762624

ENST00000397638

30_89

218.0

434.0

Domain

SH3

Hgene

PRMT2

chr21:48069651

chr21:40762624

ENST00000440086

30_89

218.0

332.0

Domain

SH3

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000333781

39_94

34.0

175.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000380708

39_94

0.0

141.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000398753

39_94

0.0

141.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000333781

121_148

34.0

175.0

Topological domain

Lumenal

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000333781

170_174

34.0

175.0

Topological domain

Cytoplasmic

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000380708

121_148

0.0

141.0

Topological domain

Lumenal

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000380708

170_174

0.0

141.0

Topological domain

Cytoplasmic

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000380708

1_8

0.0

141.0

Topological domain

Lumenal

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000380708

30_99

0.0

141.0

Topological domain

Cytoplasmic

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000398753

121_148

0.0

141.0

Topological domain

Lumenal

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000398753

170_174

0.0

141.0

Topological domain

Cytoplasmic

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000398753

1_8

0.0

141.0

Topological domain

Lumenal

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000398753

30_99

0.0

141.0

Topological domain

Cytoplasmic

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000333781

100_120

34.0

175.0

Transmembrane

Helical

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000333781

149_169

34.0

175.0

Transmembrane

Helical

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000380708

100_120

0.0

141.0

Transmembrane

Helical

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000380708

149_169

0.0

141.0

Transmembrane

Helical

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000380708

9_29

0.0

141.0

Transmembrane

Helical

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000398753

100_120

0.0

141.0

Transmembrane

Helical

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000398753

149_169

0.0

141.0

Transmembrane

Helical

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000398753

9_29

0.0

141.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PRMT2

chr21:48069651

chr21:40762624

ENST00000334494

99_432

218.0

285.0

Domain

SAM-dependent MTase PRMT-type

Hgene

PRMT2

chr21:48069651

chr21:40762624

ENST00000355680

99_432

218.0

434.0

Domain

SAM-dependent MTase PRMT-type

Hgene

PRMT2

chr21:48069651

chr21:40762624

ENST00000397637

99_432

218.0

434.0

Domain

SAM-dependent MTase PRMT-type

Hgene

PRMT2

chr21:48069651

chr21:40762624

ENST00000397638

99_432

218.0

434.0

Domain

SAM-dependent MTase PRMT-type

Hgene

PRMT2

chr21:48069651

chr21:40762624

ENST00000440086

99_432

218.0

332.0

Domain

SAM-dependent MTase PRMT-type

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000333781

1_8

34.0

175.0

Topological domain

Lumenal

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000333781

30_99

34.0

175.0

Topological domain

Cytoplasmic

Tgene

WRB

chr21:48069651

chr21:40762624

ENST00000333781

9_29

34.0

175.0

Transmembrane

Helical

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>701_PRMT2_48069651_WRB_40762624_ranked_0.pdb	PRMT2	48069651	48069651	ENST00000380708	WRB	chr21	40762624	+	MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDE YDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLV LQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKL	358

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PRMT2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PRMT2
WRB

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	PRMT2	chr21:48069651	chr21:40762624	ENST00000334494	+	6	7	133_275	218.0	285.0	ESR1
Hgene	PRMT2	chr21:48069651	chr21:40762624	ENST00000334494	+	6	7	1_277	218.0	285.0	ESR1
Hgene	PRMT2	chr21:48069651	chr21:40762624	ENST00000355680	+	7	12	133_275	218.0	434.0	ESR1
Hgene	PRMT2	chr21:48069651	chr21:40762624	ENST00000355680	+	7	12	1_277	218.0	434.0	ESR1
Hgene	PRMT2	chr21:48069651	chr21:40762624	ENST00000397637	+	6	11	133_275	218.0	434.0	ESR1
Hgene	PRMT2	chr21:48069651	chr21:40762624	ENST00000397637	+	6	11	1_277	218.0	434.0	ESR1
Hgene	PRMT2	chr21:48069651	chr21:40762624	ENST00000397638	+	6	11	133_275	218.0	434.0	ESR1
Hgene	PRMT2	chr21:48069651	chr21:40762624	ENST00000397638	+	6	11	1_277	218.0	434.0	ESR1
Hgene	PRMT2	chr21:48069651	chr21:40762624	ENST00000440086	+	6	9	133_275	218.0	332.0	ESR1
Hgene	PRMT2	chr21:48069651	chr21:40762624	ENST00000440086	+	6	9	1_277	218.0	332.0	ESR1

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Related Drugs to PRMT2-WRB

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to PRMT2-WRB

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source