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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PRR5-ARHGAP8

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PRR5-ARHGAP8
	FusionPDB ID: 69171
	FusionGDB2.0 ID: 69171
		Hgene	Tgene
	Gene symbol	PRR5	ARHGAP8
	Gene ID	55615	23779
	Gene name	proline rich 5	Rho GTPase activating protein 8
	Synonyms	FLJ20185k\|PP610\|PROTOR-1\|PROTOR1	BPGAP1\|PP610
	Cytomap	22q13.31	22q13.31
	Type of gene	protein-coding	protein-coding
	Description	proline-rich protein 5Rho GTPase activating protein 8proline rich 5 (renal)protein observed with Rictor-1	rho GTPase-activating protein 8BCH domain-containing Cdc42GAP-like proteinBNIP-2 and Cdc42GAP homology domain-containing, proline-rich and Cdc42GAP-like protein subtype-1rho-type GTPase-activating protein 8
	Modification date	20200313	20200313
	UniProtAcc	.	P85298
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000477331, ENST00000006251, ENST00000336985, ENST00000403581,	ENST00000336963, ENST00000356099, ENST00000389773, ENST00000389774, ENST00000517296, ENST00000469872,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 6 X 3=72	6 X 9 X 5=270
	# samples	5	7
	** MAII score	log2(5/72*10)=-0.526068811667588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/270*10)=-1.94753258010586 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PRR5 [Title/Abstract] AND ARHGAP8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ARHGAP8(45182486)-PRR5(45098372), # samples:1 PRR5(45110550)-ARHGAP8(45241148), # samples:1 PRR5(45122513)-ARHGAP8(45241148), # samples:1 PRR5(NA)-ARHGAP8(NA), # samples:1 PRR5(45122514)-ARHGAP8(45182337), # samples:1
Anticipated loss of major functional domain due to fusion event.	PRR5-ARHGAP8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PRR5-ARHGAP8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PRR5-ARHGAP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PRR5-ARHGAP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PRR5-ARHGAP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PRR5-ARHGAP8 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ARHGAP8	GO:0070374	positive regulation of ERK1 and ERK2 cascade	20179103

Fusion gene breakpoints across PRR5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ARHGAP8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-60-2698-01A	PRR5	chr22	45110550	+	ARHGAP8	chr22	45241148	+
ChimerDB4	LUSC	TCGA-60-2698-01A	PRR5	chr22	45122513	+	ARHGAP8	chr22	45241148	+
ChiTaRS5.0	N/A	HQ258425	PRR5	chr22	NA	+	ARHGAP8	chr22	NA	+
ChiTaRS5.0	N/A	NM_181334	PRR5	chr22	45122514	+	ARHGAP8	chr22	45182337	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000006251	PRR5	chr22	45110550	+	ENST00000517296	ARHGAP8	chr22	45241148	+	1199	382	41	1087	348
ENST00000006251	PRR5	chr22	45110550	+	ENST00000389773	ARHGAP8	chr22	45241148	+	1277	382	41	1087	348
ENST00000006251	PRR5	chr22	45110550	+	ENST00000389774	ARHGAP8	chr22	45241148	+	1277	382	41	1087	348
ENST00000006251	PRR5	chr22	45110550	+	ENST00000336963	ARHGAP8	chr22	45241148	+	1174	382	41	703	220
ENST00000006251	PRR5	chr22	45110550	+	ENST00000356099	ARHGAP8	chr22	45241148	+	1277	382	41	1087	348
ENST00000403581	PRR5	chr22	45110550	+	ENST00000517296	ARHGAP8	chr22	45241148	+	1710	893	588	1598	336
ENST00000403581	PRR5	chr22	45110550	+	ENST00000389773	ARHGAP8	chr22	45241148	+	1788	893	588	1598	336
ENST00000403581	PRR5	chr22	45110550	+	ENST00000389774	ARHGAP8	chr22	45241148	+	1788	893	588	1598	336
ENST00000403581	PRR5	chr22	45110550	+	ENST00000336963	ARHGAP8	chr22	45241148	+	1685	893	1295	627	222
ENST00000403581	PRR5	chr22	45110550	+	ENST00000356099	ARHGAP8	chr22	45241148	+	1788	893	588	1598	336
ENST00000336985	PRR5	chr22	45110550	+	ENST00000517296	ARHGAP8	chr22	45241148	+	1309	492	277	1197	306
ENST00000336985	PRR5	chr22	45110550	+	ENST00000389773	ARHGAP8	chr22	45241148	+	1387	492	277	1197	306
ENST00000336985	PRR5	chr22	45110550	+	ENST00000389774	ARHGAP8	chr22	45241148	+	1387	492	277	1197	306
ENST00000336985	PRR5	chr22	45110550	+	ENST00000336963	ARHGAP8	chr22	45241148	+	1284	492	277	813	178
ENST00000336985	PRR5	chr22	45110550	+	ENST00000356099	ARHGAP8	chr22	45241148	+	1387	492	277	1197	306

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000006251	ENST00000517296	PRR5	chr22	45110550	+	ARHGAP8	chr22	45241148	+	0.09376334	0.9062367
ENST00000006251	ENST00000389773	PRR5	chr22	45110550	+	ARHGAP8	chr22	45241148	+	0.09012462	0.9098754
ENST00000006251	ENST00000389774	PRR5	chr22	45110550	+	ARHGAP8	chr22	45241148	+	0.09012462	0.9098754
ENST00000006251	ENST00000336963	PRR5	chr22	45110550	+	ARHGAP8	chr22	45241148	+	0.025268128	0.9747319
ENST00000006251	ENST00000356099	PRR5	chr22	45110550	+	ARHGAP8	chr22	45241148	+	0.09012462	0.9098754
ENST00000403581	ENST00000517296	PRR5	chr22	45110550	+	ARHGAP8	chr22	45241148	+	0.068179004	0.93182105
ENST00000403581	ENST00000389773	PRR5	chr22	45110550	+	ARHGAP8	chr22	45241148	+	0.06208617	0.9379139
ENST00000403581	ENST00000389774	PRR5	chr22	45110550	+	ARHGAP8	chr22	45241148	+	0.06208617	0.9379139
ENST00000403581	ENST00000336963	PRR5	chr22	45110550	+	ARHGAP8	chr22	45241148	+	0.027141003	0.97285897
ENST00000403581	ENST00000356099	PRR5	chr22	45110550	+	ARHGAP8	chr22	45241148	+	0.06208617	0.9379139
ENST00000336985	ENST00000517296	PRR5	chr22	45110550	+	ARHGAP8	chr22	45241148	+	0.03638481	0.96361524
ENST00000336985	ENST00000389773	PRR5	chr22	45110550	+	ARHGAP8	chr22	45241148	+	0.03353861	0.96646136
ENST00000336985	ENST00000389774	PRR5	chr22	45110550	+	ARHGAP8	chr22	45241148	+	0.03353861	0.96646136
ENST00000336985	ENST00000336963	PRR5	chr22	45110550	+	ARHGAP8	chr22	45241148	+	0.015644744	0.98435533
ENST00000336985	ENST00000356099	PRR5	chr22	45110550	+	ARHGAP8	chr22	45241148	+	0.03353861	0.96646136

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>69171_69171_1_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000006251_ARHGAP8_chr22_45241148_ENST00000336963_length(amino acids)=220AA_BP=1
MSRVSELTPRRVQTSAKVAEQRRPVGWDSTCAHPGSIPPPESSRHPARLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHN
GVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPA

--------------------------------------------------------------

>69171_69171_2_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000006251_ARHGAP8_chr22_45241148_ENST00000356099_length(amino acids)=348AA_BP=1
MSRVSELTPRRVQTSAKVAEQRRPVGWDSTCAHPGSIPPPESSRHPARLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHN
GVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPA
VILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQ

--------------------------------------------------------------

>69171_69171_3_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000006251_ARHGAP8_chr22_45241148_ENST00000389773_length(amino acids)=348AA_BP=1
MSRVSELTPRRVQTSAKVAEQRRPVGWDSTCAHPGSIPPPESSRHPARLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHN
GVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPA
VILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQ

--------------------------------------------------------------

>69171_69171_4_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000006251_ARHGAP8_chr22_45241148_ENST00000389774_length(amino acids)=348AA_BP=1
MSRVSELTPRRVQTSAKVAEQRRPVGWDSTCAHPGSIPPPESSRHPARLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHN
GVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPA
VILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQ

--------------------------------------------------------------

>69171_69171_5_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000006251_ARHGAP8_chr22_45241148_ENST00000517296_length(amino acids)=348AA_BP=1
MSRVSELTPRRVQTSAKVAEQRRPVGWDSTCAHPGSIPPPESSRHPARLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHN
GVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPA
VILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQ

--------------------------------------------------------------

>69171_69171_6_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000336985_ARHGAP8_chr22_45241148_ENST00000336963_length(amino acids)=178AA_BP=0
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTV

--------------------------------------------------------------

>69171_69171_7_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000336985_ARHGAP8_chr22_45241148_ENST00000356099_length(amino acids)=306AA_BP=0
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTV
TYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQIL
RSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQ

--------------------------------------------------------------

>69171_69171_8_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000336985_ARHGAP8_chr22_45241148_ENST00000389773_length(amino acids)=306AA_BP=0
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTV
TYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQIL
RSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQ

--------------------------------------------------------------

>69171_69171_9_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000336985_ARHGAP8_chr22_45241148_ENST00000389774_length(amino acids)=306AA_BP=0
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTV
TYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQIL
RSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQ

--------------------------------------------------------------

>69171_69171_10_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000336985_ARHGAP8_chr22_45241148_ENST00000517296_length(amino acids)=306AA_BP=0
MRTLRRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFSLNEGVRLKDKNQGELIPPVLRFTV
TYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQIL
RSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQ

--------------------------------------------------------------

>69171_69171_11_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000403581_ARHGAP8_chr22_45241148_ENST00000336963_length(amino acids)=222AA_BP=0
MFRGTRALREETPWDGQIKFSPKTQARLELFILLKMLSRDTGDPENLLVGLEGQKRLGQLSQEGLQDHGRDVNVPVVVKVHGLPLVVEPL
DLADGLHAGGSPEQALGAQAFLSQVRHCEPQHRGDEFALIFVFEADALVEAEELLVGQPLALEDGDHPVVDAVPGGVGAGPALLRAPLVR

--------------------------------------------------------------

>69171_69171_12_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000403581_ARHGAP8_chr22_45241148_ENST00000356099_length(amino acids)=336AA_BP=1
MVRRHRAMVCLELSQREAWGSGSPEKMPAQPEGLYRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLP
DQELFSLNEGVRLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQ
PLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLN

--------------------------------------------------------------

>69171_69171_13_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000403581_ARHGAP8_chr22_45241148_ENST00000389773_length(amino acids)=336AA_BP=1
MVRRHRAMVCLELSQREAWGSGSPEKMPAQPEGLYRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLP
DQELFSLNEGVRLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQ
PLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLN

--------------------------------------------------------------

>69171_69171_14_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000403581_ARHGAP8_chr22_45241148_ENST00000389774_length(amino acids)=336AA_BP=1
MVRRHRAMVCLELSQREAWGSGSPEKMPAQPEGLYRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLP
DQELFSLNEGVRLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQ
PLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLN

--------------------------------------------------------------

>69171_69171_15_PRR5-ARHGAP8_PRR5_chr22_45110550_ENST00000403581_ARHGAP8_chr22_45241148_ENST00000517296_length(amino acids)=336AA_BP=1
MVRRHRAMVCLELSQREAWGSGSPEKMPAQPEGLYRLKFMSSPSLSDLGKREPAAAADERGTQQRRACANATWNSIHNGVIAVFQRKGLP
DQELFSLNEGVRLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQ
PLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLN

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:45182486/chr22:45098372)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ARHGAP8 P85298
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PRR5

chr22:45110550

chr22:45241148

ENST00000006251

24_27

62.666666666666664

380.0

Compositional bias

Note=Poly-Ala

Hgene

PRR5

chr22:45110550

chr22:45241148

ENST00000336985

24_27

71.66666666666667

389.0

Compositional bias

Note=Poly-Ala

Hgene

PRR5

chr22:45110550

chr22:45241148

ENST00000403581

24_27

94.66666666666667

412.0

Compositional bias

Note=Poly-Ala

Hgene

PRR5

chr22:45122514

chr22:45182337

ENST00000006251

24_27

98.33333333333333

380.0

Compositional bias

Note=Poly-Ala

Hgene

PRR5

chr22:45122514

chr22:45182337

ENST00000336985

24_27

107.33333333333333

389.0

Compositional bias

Note=Poly-Ala

Hgene

PRR5

chr22:45122514

chr22:45182337

ENST00000403581

24_27

130.33333333333334

412.0

Compositional bias

Note=Poly-Ala

Tgene

ARHGAP8

chr22:45110550

chr22:45241148

ENST00000356099

226_412

198.66666666666666

434.0

Domain

Rho-GAP

Tgene

ARHGAP8

chr22:45122514

chr22:45182337

ENST00000356099

13_199

434.0

Domain

CRAL-TRIO

Tgene

ARHGAP8

chr22:45122514

chr22:45182337

ENST00000356099

226_412

434.0

Domain

Rho-GAP

Tgene

ARHGAP8

chr22:45122514

chr22:45182337

ENST00000389774

13_199

465.0

Domain

CRAL-TRIO

Tgene

ARHGAP8

chr22:45122514

chr22:45182337

ENST00000389774

226_412

465.0

Domain

Rho-GAP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ARHGAP8

chr22:45110550

chr22:45241148

ENST00000356099

13_199

198.66666666666666

434.0

Domain

CRAL-TRIO

Tgene

ARHGAP8

chr22:45110550

chr22:45241148

ENST00000389774

13_199

229.66666666666666

465.0

Domain

CRAL-TRIO

Tgene

ARHGAP8

chr22:45110550

chr22:45241148

ENST00000389774

226_412

229.66666666666666

465.0

Domain

Rho-GAP

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PRR5
ARHGAP8

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	PRR5	chr22:45110550	chr22:45241148	ENST00000006251	+	3	9	10_95	62.666666666666664	380.0	RICTOR
Hgene	PRR5	chr22:45110550	chr22:45241148	ENST00000006251	+	3	9	188_218	62.666666666666664	380.0	RICTOR
Hgene	PRR5	chr22:45110550	chr22:45241148	ENST00000336985	+	2	8	10_95	71.66666666666667	389.0	RICTOR
Hgene	PRR5	chr22:45110550	chr22:45241148	ENST00000336985	+	2	8	188_218	71.66666666666667	389.0	RICTOR
Hgene	PRR5	chr22:45110550	chr22:45241148	ENST00000403581	+	4	10	188_218	94.66666666666667	412.0	RICTOR
Hgene	PRR5	chr22:45122514	chr22:45182337	ENST00000006251	+	5	9	188_218	98.33333333333333	380.0	RICTOR
Hgene	PRR5	chr22:45122514	chr22:45182337	ENST00000336985	+	4	8	188_218	107.33333333333333	389.0	RICTOR
Hgene	PRR5	chr22:45122514	chr22:45182337	ENST00000403581	+	6	10	188_218	130.33333333333334	412.0	RICTOR

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Related Drugs to PRR5-ARHGAP8

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to PRR5-ARHGAP8

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source