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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PTPN12-DYNC1I1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PTPN12-DYNC1I1
	FusionPDB ID: 70191
	FusionGDB2.0 ID: 70191
		Hgene	Tgene
	Gene symbol	PTPN12	DYNC1I1
	Gene ID	5782	1780
	Gene name	protein tyrosine phosphatase non-receptor type 12	dynein cytoplasmic 1 intermediate chain 1
	Synonyms	PTP-PEST\|PTPG1	DNCI1\|DNCIC1
	Cytomap	7q11.23	7q21.3
	Type of gene	protein-coding	protein-coding
	Description	tyrosine-protein phosphatase non-receptor type 12protein-tyrosine phosphatase G1	cytoplasmic dynein 1 intermediate chain 1DH IC-1cytoplasmic dynein intermediate chain 1dynein intermediate chain 1, cytosolicdynein, cytoplasmic, intermediate polypeptide 1
	Modification date	20200329	20200313
	UniProtAcc	.	O14576
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000248594, ENST00000415482, ENST00000435495,	ENST00000413338, ENST00000457059, ENST00000497626, ENST00000324972, ENST00000359388, ENST00000437599, ENST00000447467, ENST00000537881,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	22 X 21 X 16=7392	12 X 12 X 6=864
	# samples	44	13
	** MAII score	log2(44/7392*10)=-4.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/864*10)=-2.73251968913501 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PTPN12 [Title/Abstract] AND DYNC1I1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PTPN12(77166962)-DYNC1I1(95705369), # samples:3
Anticipated loss of major functional domain due to fusion event.	PTPN12-DYNC1I1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PTPN12-DYNC1I1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PTPN12	GO:0006470	protein dephosphorylation	27134172
Hgene	PTPN12	GO:0035335	peptidyl-tyrosine dephosphorylation	27134172

Fusion gene breakpoints across PTPN12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DYNC1I1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-DU-5855-01A	PTPN12	chr7	77166961	+	DYNC1I1	chr7	95705368	+
ChimerDB4	LGG	TCGA-DU-5855-01A	PTPN12	chr7	77166962	-	DYNC1I1	chr7	95705369	+
ChimerDB4	LGG	TCGA-DU-5855-01A	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+
ChimerDB4	LGG	TCGA-DU-5855	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705368	+
ChimerDB4	LGG	TCGA-DU-5855	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000248594	PTPN12	chr7	77166962	+	ENST00000447467	DYNC1I1	chr7	95705369	+	1580	371	2	748	248
ENST00000248594	PTPN12	chr7	77166962	+	ENST00000324972	DYNC1I1	chr7	95705369	+	1568	371	2	748	248
ENST00000248594	PTPN12	chr7	77166962	+	ENST00000537881	DYNC1I1	chr7	95705369	+	982	371	2	730	242
ENST00000248594	PTPN12	chr7	77166962	+	ENST00000437599	DYNC1I1	chr7	95705369	+	1580	371	2	748	248
ENST00000248594	PTPN12	chr7	77166962	+	ENST00000359388	DYNC1I1	chr7	95705369	+	1580	371	2	748	248
ENST00000248594	PTPN12	chr7	77166962	+	ENST00000447467	DYNC1I1	chr7	95705368	+	1580	371	2	748	248
ENST00000248594	PTPN12	chr7	77166962	+	ENST00000324972	DYNC1I1	chr7	95705368	+	1568	371	2	748	248
ENST00000248594	PTPN12	chr7	77166962	+	ENST00000537881	DYNC1I1	chr7	95705368	+	982	371	2	730	242
ENST00000248594	PTPN12	chr7	77166962	+	ENST00000437599	DYNC1I1	chr7	95705368	+	1580	371	2	748	248
ENST00000248594	PTPN12	chr7	77166962	+	ENST00000359388	DYNC1I1	chr7	95705368	+	1580	371	2	748	248
ENST00000248594	PTPN12	chr7	77166961	+	ENST00000447467	DYNC1I1	chr7	95705368	+	1580	371	2	748	248
ENST00000248594	PTPN12	chr7	77166961	+	ENST00000324972	DYNC1I1	chr7	95705368	+	1568	371	2	748	248
ENST00000248594	PTPN12	chr7	77166961	+	ENST00000537881	DYNC1I1	chr7	95705368	+	982	371	2	730	242
ENST00000248594	PTPN12	chr7	77166961	+	ENST00000437599	DYNC1I1	chr7	95705368	+	1580	371	2	748	248
ENST00000248594	PTPN12	chr7	77166961	+	ENST00000359388	DYNC1I1	chr7	95705368	+	1580	371	2	748	248

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000248594	ENST00000447467	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+	0.08947204	0.910528
ENST00000248594	ENST00000324972	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+	0.090662464	0.9093376
ENST00000248594	ENST00000537881	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+	0.006104045	0.99389595
ENST00000248594	ENST00000437599	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+	0.08947204	0.910528
ENST00000248594	ENST00000359388	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705369	+	0.08947204	0.910528
ENST00000248594	ENST00000447467	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705368	+	0.08947204	0.910528
ENST00000248594	ENST00000324972	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705368	+	0.090662464	0.9093376
ENST00000248594	ENST00000537881	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705368	+	0.006104045	0.99389595
ENST00000248594	ENST00000437599	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705368	+	0.08947204	0.910528
ENST00000248594	ENST00000359388	PTPN12	chr7	77166962	+	DYNC1I1	chr7	95705368	+	0.08947204	0.910528
ENST00000248594	ENST00000447467	PTPN12	chr7	77166961	+	DYNC1I1	chr7	95705368	+	0.08947204	0.910528
ENST00000248594	ENST00000324972	PTPN12	chr7	77166961	+	DYNC1I1	chr7	95705368	+	0.090662464	0.9093376
ENST00000248594	ENST00000537881	PTPN12	chr7	77166961	+	DYNC1I1	chr7	95705368	+	0.006104045	0.99389595
ENST00000248594	ENST00000437599	PTPN12	chr7	77166961	+	DYNC1I1	chr7	95705368	+	0.08947204	0.910528
ENST00000248594	ENST00000359388	PTPN12	chr7	77166961	+	DYNC1I1	chr7	95705368	+	0.08947204	0.910528

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>70191_70191_1_PTPN12-DYNC1I1_PTPN12_chr7_77166961_ENST00000248594_DYNC1I1_chr7_95705368_ENST00000324972_length(amino acids)=248AA_BP=123
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

--------------------------------------------------------------

>70191_70191_2_PTPN12-DYNC1I1_PTPN12_chr7_77166961_ENST00000248594_DYNC1I1_chr7_95705368_ENST00000359388_length(amino acids)=248AA_BP=123
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

--------------------------------------------------------------

>70191_70191_3_PTPN12-DYNC1I1_PTPN12_chr7_77166961_ENST00000248594_DYNC1I1_chr7_95705368_ENST00000437599_length(amino acids)=248AA_BP=123
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

--------------------------------------------------------------

>70191_70191_4_PTPN12-DYNC1I1_PTPN12_chr7_77166961_ENST00000248594_DYNC1I1_chr7_95705368_ENST00000447467_length(amino acids)=248AA_BP=123
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

--------------------------------------------------------------

>70191_70191_5_PTPN12-DYNC1I1_PTPN12_chr7_77166961_ENST00000248594_DYNC1I1_chr7_95705368_ENST00000537881_length(amino acids)=242AA_BP=123
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

--------------------------------------------------------------

>70191_70191_6_PTPN12-DYNC1I1_PTPN12_chr7_77166962_ENST00000248594_DYNC1I1_chr7_95705368_ENST00000324972_length(amino acids)=248AA_BP=123
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

--------------------------------------------------------------

>70191_70191_7_PTPN12-DYNC1I1_PTPN12_chr7_77166962_ENST00000248594_DYNC1I1_chr7_95705368_ENST00000359388_length(amino acids)=248AA_BP=123
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

--------------------------------------------------------------

>70191_70191_8_PTPN12-DYNC1I1_PTPN12_chr7_77166962_ENST00000248594_DYNC1I1_chr7_95705368_ENST00000437599_length(amino acids)=248AA_BP=123
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

--------------------------------------------------------------

>70191_70191_9_PTPN12-DYNC1I1_PTPN12_chr7_77166962_ENST00000248594_DYNC1I1_chr7_95705368_ENST00000447467_length(amino acids)=248AA_BP=123
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

--------------------------------------------------------------

>70191_70191_10_PTPN12-DYNC1I1_PTPN12_chr7_77166962_ENST00000248594_DYNC1I1_chr7_95705368_ENST00000537881_length(amino acids)=242AA_BP=123
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

--------------------------------------------------------------

>70191_70191_11_PTPN12-DYNC1I1_PTPN12_chr7_77166962_ENST00000248594_DYNC1I1_chr7_95705369_ENST00000324972_length(amino acids)=248AA_BP=123
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

--------------------------------------------------------------

>70191_70191_12_PTPN12-DYNC1I1_PTPN12_chr7_77166962_ENST00000248594_DYNC1I1_chr7_95705369_ENST00000359388_length(amino acids)=248AA_BP=123
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

--------------------------------------------------------------

>70191_70191_13_PTPN12-DYNC1I1_PTPN12_chr7_77166962_ENST00000248594_DYNC1I1_chr7_95705369_ENST00000437599_length(amino acids)=248AA_BP=123
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

--------------------------------------------------------------

>70191_70191_14_PTPN12-DYNC1I1_PTPN12_chr7_77166962_ENST00000248594_DYNC1I1_chr7_95705369_ENST00000447467_length(amino acids)=248AA_BP=123
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

--------------------------------------------------------------

>70191_70191_15_PTPN12-DYNC1I1_PTPN12_chr7_77166962_ENST00000248594_DYNC1I1_chr7_95705369_ENST00000537881_length(amino acids)=242AA_BP=123
LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:77166962/chr7:95705369)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DYNC1I1 O14576
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000324972

530_570

520.0

646.0

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000324972

576_615

520.0

646.0

Repeat

Note=WD 7

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000359388

482_527

483.0

609.0

Repeat

Note=WD 5

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000359388

530_570

483.0

609.0

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000359388

576_615

483.0

609.0

Repeat

Note=WD 7

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000447467

530_570

503.0

629.0

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000447467

576_615

503.0

629.0

Repeat

Note=WD 7

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000457059

530_570

503.0

629.0

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000457059

576_615

503.0

629.0

Repeat

Note=WD 7

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000324972

530_570

520.0

646.0

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000324972

576_615

520.0

646.0

Repeat

Note=WD 7

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000359388

482_527

483.0

609.0

Repeat

Note=WD 5

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000359388

530_570

483.0

609.0

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000359388

576_615

483.0

609.0

Repeat

Note=WD 7

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000447467

530_570

503.0

629.0

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000447467

576_615

503.0

629.0

Repeat

Note=WD 7

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000457059

530_570

503.0

629.0

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000457059

576_615

503.0

629.0

Repeat

Note=WD 7

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000324972

530_570

520.0

646.0

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000324972

576_615

520.0

646.0

Repeat

Note=WD 7

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000359388

482_527

483.0

609.0

Repeat

Note=WD 5

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000359388

530_570

483.0

609.0

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000359388

576_615

483.0

609.0

Repeat

Note=WD 7

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000447467

530_570

503.0

629.0

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000447467

576_615

503.0

629.0

Repeat

Note=WD 7

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000457059

530_570

503.0

629.0

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000457059

576_615

503.0

629.0

Repeat

Note=WD 7

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PTPN12

chr7:77166961

chr7:95705368

ENST00000248594

28_293

33.0

781.0

Domain

Tyrosine-protein phosphatase

Hgene

PTPN12

chr7:77166961

chr7:95705368

ENST00000435495

28_293

651.0

Domain

Tyrosine-protein phosphatase

Hgene

PTPN12

chr7:77166962

chr7:95705368

ENST00000248594

28_293

33.0

781.0

Domain

Tyrosine-protein phosphatase

Hgene

PTPN12

chr7:77166962

chr7:95705368

ENST00000435495

28_293

651.0

Domain

Tyrosine-protein phosphatase

Hgene

PTPN12

chr7:77166962

chr7:95705369

ENST00000248594

28_293

33.0

781.0

Domain

Tyrosine-protein phosphatase

Hgene

PTPN12

chr7:77166962

chr7:95705369

ENST00000435495

28_293

651.0

Domain

Tyrosine-protein phosphatase

Hgene

PTPN12

chr7:77166961

chr7:95705368

ENST00000248594

231_237

33.0

781.0

Region

Substrate binding

Hgene

PTPN12

chr7:77166961

chr7:95705368

ENST00000248594

63_67

33.0

781.0

Region

Substrate binding

Hgene

PTPN12

chr7:77166961

chr7:95705368

ENST00000435495

231_237

651.0

Region

Substrate binding

Hgene

PTPN12

chr7:77166961

chr7:95705368

ENST00000435495

63_67

651.0

Region

Substrate binding

Hgene

PTPN12

chr7:77166962

chr7:95705368

ENST00000248594

231_237

33.0

781.0

Region

Substrate binding

Hgene

PTPN12

chr7:77166962

chr7:95705368

ENST00000248594

63_67

33.0

781.0

Region

Substrate binding

Hgene

PTPN12

chr7:77166962

chr7:95705368

ENST00000435495

231_237

651.0

Region

Substrate binding

Hgene

PTPN12

chr7:77166962

chr7:95705368

ENST00000435495

63_67

651.0

Region

Substrate binding

Hgene

PTPN12

chr7:77166962

chr7:95705369

ENST00000248594

231_237

33.0

781.0

Region

Substrate binding

Hgene

PTPN12

chr7:77166962

chr7:95705369

ENST00000248594

63_67

33.0

781.0

Region

Substrate binding

Hgene

PTPN12

chr7:77166962

chr7:95705369

ENST00000435495

231_237

651.0

Region

Substrate binding

Hgene

PTPN12

chr7:77166962

chr7:95705369

ENST00000435495

63_67

651.0

Region

Substrate binding

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000324972

285_334

520.0

646.0

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000324972

338_378

520.0

646.0

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000324972

387_428

520.0

646.0

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000324972

437_477

520.0

646.0

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000324972

482_527

520.0

646.0

Repeat

Note=WD 5

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000359388

285_334

483.0

609.0

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000359388

338_378

483.0

609.0

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000359388

387_428

483.0

609.0

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000359388

437_477

483.0

609.0

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000447467

285_334

503.0

629.0

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000447467

338_378

503.0

629.0

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000447467

387_428

503.0

629.0

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000447467

437_477

503.0

629.0

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000447467

482_527

503.0

629.0

Repeat

Note=WD 5

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000457059

285_334

503.0

629.0

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000457059

338_378

503.0

629.0

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000457059

387_428

503.0

629.0

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000457059

437_477

503.0

629.0

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:77166961

chr7:95705368

ENST00000457059

482_527

503.0

629.0

Repeat

Note=WD 5

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000324972

285_334

520.0

646.0

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000324972

338_378

520.0

646.0

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000324972

387_428

520.0

646.0

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000324972

437_477

520.0

646.0

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000324972

482_527

520.0

646.0

Repeat

Note=WD 5

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000359388

285_334

483.0

609.0

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000359388

338_378

483.0

609.0

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000359388

387_428

483.0

609.0

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000359388

437_477

483.0

609.0

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000447467

285_334

503.0

629.0

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000447467

338_378

503.0

629.0

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000447467

387_428

503.0

629.0

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000447467

437_477

503.0

629.0

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000447467

482_527

503.0

629.0

Repeat

Note=WD 5

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000457059

285_334

503.0

629.0

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000457059

338_378

503.0

629.0

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000457059

387_428

503.0

629.0

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000457059

437_477

503.0

629.0

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:77166962

chr7:95705368

ENST00000457059

482_527

503.0

629.0

Repeat

Note=WD 5

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000324972

285_334

520.0

646.0

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000324972

338_378

520.0

646.0

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000324972

387_428

520.0

646.0

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000324972

437_477

520.0

646.0

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000324972

482_527

520.0

646.0

Repeat

Note=WD 5

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000359388

285_334

483.0

609.0

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000359388

338_378

483.0

609.0

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000359388

387_428

483.0

609.0

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000359388

437_477

483.0

609.0

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000447467

285_334

503.0

629.0

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000447467

338_378

503.0

629.0

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000447467

387_428

503.0

629.0

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000447467

437_477

503.0

629.0

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000447467

482_527

503.0

629.0

Repeat

Note=WD 5

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000457059

285_334

503.0

629.0

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000457059

338_378

503.0

629.0

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000457059

387_428

503.0

629.0

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000457059

437_477

503.0

629.0

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:77166962

chr7:95705369

ENST00000457059

482_527

503.0

629.0

Repeat

Note=WD 5

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>406_PTPN12_77166962_DYNC1I1_95705369_ranked_0.pdb	PTPN12	77166961	77166962	ENST00000359388	DYNC1I1	chr7	95705369	+	LGVGVGASAAARLVLWESGGCSWKLWCREPSRCRRSRRLGRWGGGGSRGAWRGREGGTCWGNELGKTERALCRAGGRRGGQRPQPGGRGR MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEG	248

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PTPN12_pLDDT.png

DYNC1I1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PTPN12
DYNC1I1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	PTPN12	chr7:77166961	chr7:95705368	ENST00000248594	+	1	18	345_438	33.0	781.0	TGFB1I1
Hgene	PTPN12	chr7:77166961	chr7:95705368	ENST00000435495	+	1	17	345_438	0	651.0	TGFB1I1
Hgene	PTPN12	chr7:77166962	chr7:95705368	ENST00000248594	+	1	18	345_438	33.0	781.0	TGFB1I1
Hgene	PTPN12	chr7:77166962	chr7:95705368	ENST00000435495	+	1	17	345_438	0	651.0	TGFB1I1
Hgene	PTPN12	chr7:77166962	chr7:95705369	ENST00000248594	+	1	18	345_438	33.0	781.0	TGFB1I1
Hgene	PTPN12	chr7:77166962	chr7:95705369	ENST00000435495	+	1	17	345_438	0	651.0	TGFB1I1
Tgene	DYNC1I1	chr7:77166961	chr7:95705368	ENST00000324972		13	17	2_123	520.0	646.0	DCTN1
Tgene	DYNC1I1	chr7:77166961	chr7:95705368	ENST00000359388		12	16	2_123	483.0	609.0	DCTN1
Tgene	DYNC1I1	chr7:77166961	chr7:95705368	ENST00000447467		13	17	2_123	503.0	629.0	DCTN1
Tgene	DYNC1I1	chr7:77166961	chr7:95705368	ENST00000457059		13	17	2_123	503.0	629.0	DCTN1
Tgene	DYNC1I1	chr7:77166962	chr7:95705368	ENST00000324972		13	17	2_123	520.0	646.0	DCTN1
Tgene	DYNC1I1	chr7:77166962	chr7:95705368	ENST00000359388		12	16	2_123	483.0	609.0	DCTN1
Tgene	DYNC1I1	chr7:77166962	chr7:95705368	ENST00000447467		13	17	2_123	503.0	629.0	DCTN1
Tgene	DYNC1I1	chr7:77166962	chr7:95705368	ENST00000457059		13	17	2_123	503.0	629.0	DCTN1
Tgene	DYNC1I1	chr7:77166962	chr7:95705369	ENST00000324972		13	17	2_123	520.0	646.0	DCTN1
Tgene	DYNC1I1	chr7:77166962	chr7:95705369	ENST00000359388		12	16	2_123	483.0	609.0	DCTN1
Tgene	DYNC1I1	chr7:77166962	chr7:95705369	ENST00000447467		13	17	2_123	503.0	629.0	DCTN1
Tgene	DYNC1I1	chr7:77166962	chr7:95705369	ENST00000457059		13	17	2_123	503.0	629.0	DCTN1
Tgene	DYNC1I1	chr7:77166961	chr7:95705368	ENST00000324972		13	17	147_163	520.0	646.0	DYNLT1
Tgene	DYNC1I1	chr7:77166961	chr7:95705368	ENST00000359388		12	16	147_163	483.0	609.0	DYNLT1
Tgene	DYNC1I1	chr7:77166961	chr7:95705368	ENST00000447467		13	17	147_163	503.0	629.0	DYNLT1
Tgene	DYNC1I1	chr7:77166961	chr7:95705368	ENST00000457059		13	17	147_163	503.0	629.0	DYNLT1
Tgene	DYNC1I1	chr7:77166962	chr7:95705368	ENST00000324972		13	17	147_163	520.0	646.0	DYNLT1
Tgene	DYNC1I1	chr7:77166962	chr7:95705368	ENST00000359388		12	16	147_163	483.0	609.0	DYNLT1
Tgene	DYNC1I1	chr7:77166962	chr7:95705368	ENST00000447467		13	17	147_163	503.0	629.0	DYNLT1
Tgene	DYNC1I1	chr7:77166962	chr7:95705368	ENST00000457059		13	17	147_163	503.0	629.0	DYNLT1
Tgene	DYNC1I1	chr7:77166962	chr7:95705369	ENST00000324972		13	17	147_163	520.0	646.0	DYNLT1
Tgene	DYNC1I1	chr7:77166962	chr7:95705369	ENST00000359388		12	16	147_163	483.0	609.0	DYNLT1
Tgene	DYNC1I1	chr7:77166962	chr7:95705369	ENST00000447467		13	17	147_163	503.0	629.0	DYNLT1
Tgene	DYNC1I1	chr7:77166962	chr7:95705369	ENST00000457059		13	17	147_163	503.0	629.0	DYNLT1

Top

Related Drugs to PTPN12-DYNC1I1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PTPN12-DYNC1I1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source